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Science China(Life Sciences) 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Experiment Center for Science and Technology Shanghai University of Traditional Chinese MedicineShanghai 201203China

Dear Editor,Phenotypic drug discovery,which observes compound effects on physiology,has given way to targeting specific molecules,but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al.,2022).Osteoarthritis(OA)is a prevalent chronic joint disorder,primarily affecting knee joints,with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).This imbalance and the discharge of inflammatory mediators perpetuate the cycle of inflammation and tissue ***,controlling inflammation and modulating osteoclastogenesis are critical therapeutic targets for managing OA.

关键词： inflammation drugs

Machine learning model-based prediction of postpancreatectomy acute pancreatitis following pancreaticoduodenectomy:A retrospective cohort study

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World Journal of Gastroenterology 2025年第8期31卷 9-23页

作者： Ji-Ming Ma Peng-Fei Wang Liu-Qing Yang Jun-Kai Wang jian-ping Song Yu-Mei Li Yan Wen Bing-Jun Tang Xue-Dong Wang Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Information Administration Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Radiology Beijing Tsinghua Changgung HospitalBeijing 102218China Organ Transplantation Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Otorhinolaryngology Xiangyang No.1 People’s HospitalXiangyang 441000Hubei ProvinceChina

BACKGROUND The International Study Group of Pancreatic Surgery has established the defi-nition and grading system for postpancreatectomy acute pancreatitis(PPAP).There are no established machine learning models for predicting PPAP following pancreaticoduodenectomy(PD).AIM To explore the predictive model of PPAP,and test its predictive efficacy to guide the clinical *** Clinical data from consecutive patients who underwent PD between 2016 and 2024 were retrospectively *** analysis of PPAP risk factors was performed,various machine learning algorithms[logistic regression,random forest,gradient boosting decision tree,extreme gradient boosting,light gradient boosting machine,and category boosting(CatBoost)]were utilized to develop predictive *** feature elimination was employed to select several variables to achieve the optimal machine *** The study included 381 patients,of whom 88(23.09%)developed *** patients exhibited a significantly higher incidence of postoperative pancreatic fistula(55.68%vs 14.68%,P<0.001),grade C postoperative pancreatic fistula(9.09%vs 1.37%,P=0.001).The CatBoost algorithm outperformed other algorithms with a mean area under the receiver operating characteristic curve of 0.859[95%confidence interval(CI):0.814-0.905]in the training cohort and 0.822(95%CI:0.717-0.927)in the testing *** to shapley additive explanations analysis,pancreatic texture,main pancreatic duct diameter,body mass index,estimated blood loss,and surgery time were the most important variables based on recursive feature *** CatBoost algorithm based on selected variables demonstrated superior performance,with an area under the receiver operating characteristic curve of 0.837(95%CI:0.788-0.886)in the training cohort and 0.812(95%CI:0.697-0.927)in the testing *** We developed the first machine learning-based predictive model for PPAP following *** predictive model can assist surgeons in an

关键词： Pancreaticoduodenectomy Postoperative complication Acute pancreatitis Machine learning Predictive value

技术调节理论视野下的“师-技”关系及其实践指向

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黑龙江高教研究 2025年第1期43卷 118-123页

作者：周建平绍兴文理学院浙江绍兴312000

从技术调节理论看,“师-技”关系本质上是一种“共塑”关系。在教师使用技术情境中,教师与技术相互形塑,不仅技术调节着教师的经验和行动,而且教师也在“处置”、重构乃至重塑技术。“共塑”论不仅拒斥“替代论”、消除“恐惧论”,而且... 详细信息

从技术调节理论看,“师-技”关系本质上是一种“共塑”关系。在教师使用技术情境中,教师与技术相互形塑,不仅技术调节着教师的经验和行动,而且教师也在“处置”、重构乃至重塑技术。“共塑”论不仅拒斥“替代论”、消除“恐惧论”,而且超越“代具论”和“互补论”,其实践意蕴在于让我们重新认识技术使用中教师的地位,明晰教师的技术使用责任,突破对技术的功能性认识,倡导技术“使用的技艺”,在技术设计中融入教师的教育价值诉求,真正让教师使用好技术。

关键词：技术调节 “师-技”关系 “共塑”

虚拟货币洗钱犯罪的治理方案——基于风险视角的分析

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北京社会科学 2025年第2期 105-116页

作者：卢建平刘嘉北京师范大学法学院

虚拟货币因其匿名性、跨国性、去中心化的特征而具有较高的固有洗钱风险,实践中利用虚拟货币洗钱的案件数量不断攀升。中国当前的禁止政策不仅未能充分应对其固有风险,反而加剧了虚拟货币交易的地下化与跨境化趋势,形成了独特的剩余风... 详细信息

虚拟货币因其匿名性、跨国性、去中心化的特征而具有较高的固有洗钱风险,实践中利用虚拟货币洗钱的案件数量不断攀升。中国当前的禁止政策不仅未能充分应对其固有风险,反而加剧了虚拟货币交易的地下化与跨境化趋势,形成了独特的剩余风险状况。受此影响,虚拟货币洗钱犯罪案件在犯罪发现、犯罪侦查、追赃处置等一系列环节均面临着不同程度的治理困境。在此情形下,应当调整当前禁止型治理模式,加快制定《数字财产法》,明确虚拟货币非金融化商品属性,将虚拟货币交易作为个人境外投资行为纳入场景化多重监管,从而构建畅通的虚拟货币合法交易通路;以此为基础,应完善《反洗钱法》相关规定和涉虚拟货币程序法规则,为虚拟货币洗钱犯罪的预防与惩治提供充足的制度供给;与此同时,应统筹链上治理与链外治理、制度治理与技术治理、域内治理与域外治理,以保障虚拟货币反洗钱治理体系的有效运转。

关键词：虚拟货币反洗钱货币交易区块链跨境流动性

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The long noncoding RNA ALEX1 confers a functional phase state of ARF3 to enhance rice resistance to bacterial pathogens

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Molecular Plant 2025年第1期18卷 114-129页

作者： Meng-Qi Lei Rui-Rui He Yan-Fei Zhou Lu Yang Zhen-Fei Zhang Chao Yuan Wen-Long Zhao Yu Cheng jian-ping Lian Yu-Chan Zhang Wen-Tao Wang Yang Yu Yue-Qin Chen Guangdong Provincial Key Laboratory of Plant Stress Biology State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275P.R.China Guangdong Key Laboratory of Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China Plant Protection Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China

Rice bacterial blight is a devastating disease worldwide,causing significant yield *** how plants defend against microbial infection is critical for sustainable crop *** this study,we show that ALEX1,a previously identified pathogen-induced long noncoding RNA,localizes to the nucleus and directly binds AUXIN RESPONSE FACTOR 3(ARF3).We showed that ARF3 forms the condensates in the nucleus via its intrinsically disordered middle region(MR),and that these ARF3 condensates display solid-like *** further revealed that ALEX1 directly binds the MR of ARF3 to regulate ARF3 condensate dynamics and promote ARF3 *** dispersed,dimeric form of ARF3,referred to as its functional phase state,enhances its ability to transcriptionally repress the expression of downstream target genes such as JAZ13,thereby modulating the jasmonic acid signaling pathway and enhancing pathogen resistance in ***,this study reveals the role of a long noncoding RNA in regulating protein condensation and complex assembly,thus contributing to plant pathogen resistance.

关键词： lncRNA Xoo ARF3 protein condensates

中国地方政府参与澜湄区域减贫合作的逻辑机理与路径选择——基于韧性治理的视角

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中南民族大学学报(人文社会科学版) 2025年第1期45卷 127-139,186,187页

作者：阮建平明玉琳武汉大学政治与公共管理学院湖北武汉430062

推动地方政府参与减贫合作是澜湄区域减贫的重要方式。面对制度环境的复杂和参与主体的多元,区域减贫合作需要增加治理的韧性,以提升贫困治理的效能。韧性治理所包含的地方转向和自下而上的理念,契合了地方政府在国际合作中地位逐渐凸... 详细信息

推动地方政府参与减贫合作是澜湄区域减贫的重要方式。面对制度环境的复杂和参与主体的多元,区域减贫合作需要增加治理的韧性,以提升贫困治理的效能。韧性治理所包含的地方转向和自下而上的理念,契合了地方政府在国际合作中地位逐渐凸显的时代特征和实践逻辑。以中国地方政府参与澜湄减贫合作为例,从“环境-主体”“地方-全球”和“结构-行为”维度对其逻辑机理进行分析,研究发现,现行澜湄多层权力结构为地方政府参与区域减贫提供了动力机制,但地方政府丰富的减贫经验没有进一步向制度转化,地方在对接区域结构方面也存在权力障碍和资源缺乏等问题。据此,应在提升地方政府自我学习和自我组织能力的基础上,促进其在区域多边体系中发挥政策创新和制度扩散的作用,并增强其资源能力。

关键词：澜湄合作区域减贫韧性治理地方政府

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Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China

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World Journal of Stem Cells 2025年第2期17卷 42-52页

作者： Zi-Yan Luo Li-Qun Fan Wen-Ling Guo jian-ping Yang Zhuo-Yan Li Yong-Xian Huang Hua jiang Xiao-Hong Zhang Division of Hematology and Oncology Department of PediatricsGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Pediatric Hematology Oncology Guangdong Women and Children HospitalGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Despite advances in treatment,the prognosis for patients with high-risk pediatric solid tumors remains *** autologous stem cell transplantation(ASCT)offers promise for improving outcomes in these *** study aimed to examine the efficacy and prognostic factors of tandem ASCT in pediatric patients with high-risk solid *** To determine the survival outcomes and prognostic factors in pediatric patients with high-risk solid tumors undergoing tandem *** A total of 40 pediatric patients with high-risk solid tumors treated from March 2015 to August 2022 were included in this retrospective *** diagnoses of the patients included neuroblastoma,germ cell tumors,atypical teratoid/rhabdoid tumor,medulloblastoma,and *** induction chemotherapy,all patients received tandem ASCT and were allocated into two groups(group A and group B)based on high-dose chemotherapy *** relevance was evaluated by examining patient characteristics,such as sex,age,lactate dehydrogenase levels,primary site,the number of metastatic sites,and bone marrow *** The median follow-up duration since the first ASCT was 24 months(range:1-91 months),with 5-year overall survival(OS)and event-free survival(EFS)rates of 73%and 70%,respectively,for the entire *** 3-year OS rates were 67%for group A and 87%for group B(P=0.29),with corresponding 3-year EFS rates of 67%and 79%(P=0.57).Among neuroblastoma patients,the 5-year OS and EFS were 69%and 63%(P=0.23).Univariable analysis revealed a notable association of age≥36 months and elevated lactate dehydrogenase level at diagnosis with poorer *** acute adverse effects,all patients demonstrated good tolerance to the treatment,with no occurrences of transplant-related *** Tandem ASCT demonstrates promising survival outcomes for patients with high-risk solid tumors,particularly neuroblastoma,with manageable toxicity and no transplant-related mortali

关键词： Autologous stem cell transplantation Pediatric solid tumors Neuroblastoma Survival outcomes Prognostic factors

21世纪初期丁龙故事的深描、解构与重构——丁龙研究之三

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五邑大学学报(社会科学版) 2025年第1期27卷 8-12,92页

作者：石坚平五邑大学广东侨乡文化研究院广东江门529020

进入21世纪,随着丁龙故事在海内外的广泛传播,中外学者纷纷开展丁龙研究,形成了深描、解构和重构等三种不同研究范式,造成了附魅与祛魅并存的实践效果。一方面,无论是对丁龙故事所涉及的具体人物、事件真实性论证的深描,还是对丁龙事迹... 详细信息

进入21世纪,随着丁龙故事在海内外的广泛传播,中外学者纷纷开展丁龙研究,形成了深描、解构和重构等三种不同研究范式,造成了附魅与祛魅并存的实践效果。一方面,无论是对丁龙故事所涉及的具体人物、事件真实性论证的深描,还是对丁龙事迹的当代价值与文化意义的重构,均是持续建构丁龙形象、增添人物传奇魅力的新途径;另一方面,无论是对丁龙故事中部分史实、主要情节的解构研究,还是基于新史料的发掘成果、对丁龙个人生平的重新考证,均客观上造成了对既有丁龙形象的祛魅与解构效果。

关键词：丁龙中美文化交流建构解构

基于“微生物-肠-脑轴”探讨补肾通腑方对APP/PS1小鼠肠道菌群及LPS/TLR4/NF-κB通路的影响

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中国药理学通报 2025年第1期41卷 171-178页

作者：王旭张杰赵敏宋晓雨段建平河南中医药大学第一附属医院脑病科河南郑州450000 河南中医药大学第一临床医学院河南郑州450000 中西医防治重大疾病河南省协同创新中心河南郑州450046

目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小... 详细信息

目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小鼠肠道菌群丰度、多样性变化;HE染色观察海马病理形态学变化;免疫荧光检测海马区小胶质细胞活化情况;Western blot检测TLR4、NF-κB、IL-6等炎症因子表达。结果与模型组相比,补肾通腑方可以缩短AD模型小鼠逃避潜伏期、游泳路径,增加跨越平台次数(P<0.05),提升肠道菌群多样性,调节肠道菌群丰度,促进海马神经元细胞损伤修复,降低iNOS/Iba1共表达,提高Arg1/Iba1共表达(P<0.01),促进小胶质细胞从M1型向M2型转化,下调TLR4、NF-κB、IL-6等促炎因子的表达。结论补肾通腑方改善AD模型小鼠学习记忆能力的作用机制可能与调节肠道菌群介导的LPS/TLR4/NF-κB通路,从而抑制促炎型小胶质细胞活化、减轻中枢神经系统炎症、改善海马区神经元细胞损伤有关。

关键词：阿尔茨海默病补肾通腑方肠道菌群 LPS/TLR4/NF-κB通路 16S rDNA 微生物-肠-脑轴

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How far does China still need to go to internationalize her academic journals?

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第8期13卷 641-646页

作者： jian-ping LU School of International Studies Zhejiang UniversityHangzhou 310058China Publication Quality Supervsion and Inspection of General Admini-stration of Press and Publication(GAPP) Beijing 100073China

1 Purpose of the report When it comes to the volume of Englishlanguage articles published in international joumals, Chinese scientists are second only to those in the United States （Editorial, 2010）, but this is not... 详细信息

关键词： CLC number G237.5