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Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells

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World Journal of Gastroenterology 2021年第29期27卷 4784-4801页

作者： Di Cao jian-Yun ge Yun Wang Tatsuya Oda Yun-Wen Zheng Institute of Regenerative Medicine and Affiliated Hospital of jiangsu University Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine and School of Biotechnology and Heath SciencesWuyi UniversityJiangmen 529020Guangdong ProvinceChina School of Medicine Yokohama City UniversityYokohama 234-0006KanagawaJapan

Chronic infection with hepatitis B virus(HBV)remains a global health concern despite the availability of *** date,the development of effective treatments has been severely hampered by the lack of reliable,reproducible,and scalable in vitro modeling systems that precisely recapitulate the virus life cycle and represent virus-host *** the progressive understanding of liver organogenesis mechanisms,the development of human induced pluripotent stem cell(iPSC)-derived hepatic sources and stromal cellular compositions provides novel strategies for personalized modeling and treatment of liver ***,advancements in three-dimensional culture of self-organized liver-like organoids considerably promote in vitro modeling of intact human liver tissue,in terms of both hepatic function and other physiological *** with our experiences in the investigation of HBV infections using liver organoids,we have summarized the advances in modeling reported thus far and discussed the limitations and ongoing challenges in the application of liver organoids,particularly those with multi-cellular components derived from human *** review provides general guidelines for establishing clinical-grade iPSC-derived multi-cellular organoids in modeling personalized hepatitis virus infection and other liver diseases,as well as drug testing and transplantation therapy.

关键词： Hepatitis B virus Induced pluripotent stem cells Liver organoid Multicellular organoid Modeling Transplantable

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Endovascular treatment of delayed arterial hemorrhage after radical operation for hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 403-405页

作者： Xiang-Dong Wang Nai-jian ge Cheng-jian He Jun-Jun Zhu Wei Xu Ye-Fa Yang Department of Interventional Radiology Shanghai Eastern Hepatobiliary Surgery HospitalShanghai 200438China

Radical operation for hilar cholangiocarcinoma(HCCA)is the most effective treatment,but high rates of severe postoperative complication and death remain concerns due to the complexity of biliary and vascular anatomy of the hepatobiliary ***-layed arterial hemorrhage(DAH)occurring>24 h postoperatively usually causes life-threatening bleeding,and relaparotomy for DAH would be difficult and hazardous because of postoperative adhe-sions and critical general *** endovascular technique is less invasive and has improved over the recent decades,clini-cians have begun to prefer endovascular treatment(EVT)to surgi-cal treatment of DAH after hepatobiliary pancreatic ***-ever,to our knowledge,a relatively large series of patients dealing with the outcomes of EVT of DAH after surgery for HCCA has not been ***,we analyzed the technical and clinical out-comes of EVT in 17 patients to evaluate the efficacy and safety of EVT.

关键词： operation arterial hemorrhage treatment after

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Relationship between species richness and biomass on environmental gradient in natural forest communities on ***,northwest China

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Forestry Studies in China 2008年第4期10卷 212-219页

作者： SUO An-ning JU Tian-zhen ge jian-ping College of Life Sciences Beijing Normal University Beijing 100875 P. R. China National Marine Environmental Monitoring Center Dalian 116023 E R. China College of geography and Environment Sciences Northwest Normal University Lanzhou 730070 P. R. China

We analyzed the relationship between species richness and biomass in natural forest communities at two similar sites on Mt. Xiaolongshan, northwest China. At both sites, a wide range of tree layer biomass levels was available by local biomass estimation models. In order to identify underlying mechanism of the species richness-biomass relationship, we included different water resource levels and number of individuals in each plot in our analysis. We sampled 15 and 20 plots （20 m ×20 m）, respectively, at both two sites. These plots were sampled equally on the sunny slope and the shady slope. Species richness, number of individuals of each species and diameter at breast height （DBH） as a substitute of biomass of tree layer were recorded in each sample. At one site, the relationship between species richness and biomass was significant on the sunny slope, and this relationship disappeared on the shady slope due to more environmental factors. The relations between species richness and number of individuals and between number of individuals and biomass paralleled the species richness-biomass relation on both slopes. The difference in number of individuals-biomass relationships on the sunny slope and the shady slope revealed ＂interspecific competitive exclusion＂ even though the species richness-biomass relationships were not hump-shaped. At the other site, species richness was not related to biomass or to number of individuals. Our study demonstrated the importance of environmental stress and succession of community in the understanding of species diversity-productivity patterns.

关键词： biomass species richness environmental factors forest community

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Formation of adiabatic shear band and deformation mechanisms during warm compression of Ti–6Al–4V alloy

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Rare Metals 2016年第8期35卷 598-605页

作者： Jiao Luo Lin-Feng Wang Miao-Quan Li Chang-jian ge Xiao-Xiao Ma Yong-Ting Yang School of Materials Science and Engineering Northwestern Polytechnical UniversityXi'an 710072China

Adiabatic shear band （ASB） was narrow region where softening occurred and concentrated plastic defor- mation took place. In present study, the effects of height reduction and deformation temperature on ASB were investigated by means of optical microscopy （OM） and scanning electron microscopy （SEM）. And the deformation mechanisms within the shear band were discussed thor- oughly with the help of transmission electron microscopy （TEM）. There is a critical strain for the formation of ASB during warm compression of Ti-6AI-4V alloy. The width of ASB increases with height reduction increasing. Elon- gated alpha grains within shear band grow up with defor- mation temperature increasing. Some ultrafine grains that confirm the occurrence of dynamic recrystallization are observed within shear band during warm compression of Ti-6AI-4V alloy.

关键词： Titanium alloy Adiabatic shear band Deformation mechanisms Dynamic recrystallization

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Expression of protein kinase C isoforms in retinoic acid-induced differentiation of mouse embryonic stem cells into neuron-like cells

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Chinese Medical Journal 2007年第18期120卷 1639-1642页

作者： GAO Qian-ying WU Jun-shu WANG Zhi-chong ge jian HUANG Dan-ping State Key Laboratory of Ophthalmology Zhongshan OphthalmicCenter Sun Yat-sen University Guangzhou 510060 China

Protein kinases C （PKCs）, a big family including 12 isoenzymes, are divided into three major groups according to the variability of their regulatory domains^1.2 The classical PKCs （cPKC） including PKCα, PKCβI, PKCβ2, and PKC7 need calcium, phosphatidylserine, and diacylglycerol or phorbol esters for full activation. The novel PKCs （nPKC） including PKCδ, PKCε, PKCη, PKCθ, and PKC, do not require calcium for their activation. The third group is the atypical PKCs （aPKC） including PKCζ, PKCλ and PKC~ whose activation depends on phosphatidylserine but not on diacylglycerol, calcium or phorbol esters. The differences in function of specific PKC isoforms are mainly due to their different subcellular localization, activation or inhibition by different stimuli, and transcriptional regulation.

关键词： embryo stem cells protein kinase C retinoic acid

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Winding Function Theory Based Thrust Calculation on Nested-loop Secondary Linear Machine Adapted to Linear Metro

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CES Transactions on Electrical Machines and Systems 2023年第2期7卷 153-162页

作者： Yaping Zhang jian ge Wei Xu Hao Tang Yang Gao Xiaoliang Chen Shihu Su Zhen Bao the State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China IEEE Xiangyang CRRC Motor Technology Co. Ltd.Xiangyang 441000China CRRC Zhuzhou Institute Co. Ltd.Zhuzhou 412001China Guangzhou Metro Group Co. Ltd.Guangzhou 510330China the Zhuzhou CRRC Times Electric Co. Ltd.and CRRC Zhuzhou Motor Co.Ltd.Zhuzhou 412001China

With advantages of strong drive capability,nested-loop secondary linear machine(NLS-LM)has great potentiality in linear *** its secondary structure with multiple loops,it is difficult to calculate the electromagnetic thrust of NLS-LM ***,in this paper,one thrust calculation method is proposed considering variable loop inductance and transient loop ***,to establish the secondary winding function,the modeling domain is confined to a limited range,and the equivalent loop span is employed by analyzing the coupling relationship between primary and ***,in order to obtain the secondary flux density,the transient secondary current is solved based on the loop impedance and induced ***,the electromagnetic thrust can be calculated reasonably by the given primary current sheet and the calculated secondary flux *** simulations and experiments have demonstrated the effectiveness of the proposed method.

关键词： Nested-loop secondary Linear metro Electro-magnetic thrust Finite element algorithm(FEA) Transient nested-loop current Winding function

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超声剪切波成像联合白细胞介素-10及趋化因子受体7对甲状腺病变性质的评估价值

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现代生物医学进展 2024年第8期24卷 1520-1524页

作者：杨迪刘丹蔡波葛建行刘彩梅联勤保障部队第九六四医院超声诊断科吉林长春130062

目的:探讨超声剪切波成像(2D-SWE)联合白细胞介素-10(IL-10)及趋化因子受体7(CXCR7)对甲状腺病变性质的评估价值。方法:选取2022年1月-2023年10月行甲状腺手术治疗的甲状腺患者89例,对所有患者行术前2D-SWE检查,术后病理组织IL-10及CXCR... 详细信息

目的:探讨超声剪切波成像(2D-SWE)联合白细胞介素-10(IL-10)及趋化因子受体7(CXCR7)对甲状腺病变性质的评估价值。方法:选取2022年1月-2023年10月行甲状腺手术治疗的甲状腺患者89例,对所有患者行术前2D-SWE检查,术后病理组织IL-10及CXCR7表达检测;探讨2D-SWE杨氏模量指标E_(Mean)、E_(Max)、IL-10及CXCR7表达与甲状腺病变性质的关系。建立2D-SWE结合IL-10及CXCR7对甲状腺病变性质预测的二元Logistic回归风险评估模型,接收者工作特征曲线(ROC)分析回归模型的评估效能。结果:89个甲状腺病灶中,良性病灶54例,恶性病变35例,IL-10阳性表达33例,CXCR7阳性表达33例。以病理检查结果为金标准,根据病灶性质将病变分为良性病变组(n=54)和恶性病变组(n=35)。恶性病变组2D-SWE杨氏模量指标E_(Mean)、E_(Max)高于良性病变组,IL-10、CXCR7阳性表达率高于良性病变组(P<0.05)。E_(Mean)、E_(Max)、IL-10、CXCR7四指标构建的回归风险评估模型对甲状腺病变性质评估价值的曲线下面积(AUC)(0.95CI)为0.854(0.723~0.982),截断值为0.225。结论:2D-SWE杨氏模量指标E_(Mean)、E_(Max)、IL-10及CXCR7阳性表达率的升高与甲状腺病变性质密切相关,2D-SWE结合IL-10及CXCR7对甲状腺疾病良恶性具有一定的鉴别价值。

关键词：甲状腺疾病剪切波弹性成像 IL-10 CXCR7 病变性质评估模型

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Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes

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World Journal of Stem Cells 2019年第9期11卷 650-665页

作者： jian-Yun ge Yun-Wen Zheng Li-Ping Liu Hiroko Isoda Tatsuya Oda Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukubaIbaraki 305-8575Japan Institute of Regenerative Medicine and Affiliated Hospital Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Regenerative Medicine School of MedicineYokohama City UniversityYokohama 236-0004Japan Faculty of Life and Environmental Sciences University of TsukubaTsukubaIbaraki 305-8572Japan

In the field of regenerative medicine,generating numerous transplantable functional cells in the laboratory setting on a large scale is a major ***,the in vitro maintenance and expansion of terminally differentiated cells are challenging because of the lack of specific environmental and intercellular signal stimulations,markedly hindering their therapeutic ***,the generation of stem/progenitor cells or functional cells with effective proliferative potential is markedly in demand for disease modeling,cell-based transplantation,and drug *** the potent genetic manipulation of transcription factors,integration-free chemically defined approaches for the conversion of somatic cell fate have garnered considerable attention in recent *** review aims to summarize the progress thus far and discuss the advantages,limitations,and challenges of the impact of full chemicals on the stepwise reprogramming of pluripotency,direct lineage conversion,and direct lineage expansion on somatic *** to the current chemical-mediated induction,reprogrammed pluripotent stem cells with reproducibility difficulties,and direct lineage converted cells with marked functional deficiency,it is imperative to generate the desired cell types directly by chemically inducing their potent proliferation ability through a lineagecommitted progenitor state,while upholding the maturation and engraftment capacity posttransplantation in *** with the comprehensive understanding of the mechanism of chemical drives,as well as the elucidation of specificity and commonalities,the precise manipulation of the expansion for diverse functional cell types could broaden the available cell sources and enhance the cellular function for clinical application in future.

关键词： Chemical induction Pluripotent reprogramming Direct lineage conversion Direct lineage expansion Hepatocyte expansion Cell fate specificity Transcriptional memory In vivo induction

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Ocular manifestations of Alport syndrome

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 149-151页

作者： jian-Min Xu Shi-Sheng Zhang Qiong Zhang Ying-Ming Zhou Cai-Hong Zhu jian ge and Ling Wang Department of Ophthalmology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 China

AIMTo analyze the clinical manifestation of Alport syndrome, especially the ocular features.

关键词： Alport syndrome anterior lenticonus macular flecks

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新型多载波光通信系统研究进展(特邀)

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光通信研究 2024年第1期1期(12)卷 42-47页

作者：葛坚黄雍涛余建国中国信息通信研究院技术与标准研究所互联网中心北京100098 北京邮电大学电子工程学院北京100876

为了满足当前日益增长的通信容量需求,新型多载波光纤通信技术成为科研人员关注的焦点。文章回顾了近20年来传统正交频分复用(OFDM)在光纤通信领域的发展历程,梳理了近年来滤波器组多载波(FBMC)和通用滤波多载波(UFMC)在光纤通信领域的... 详细信息

为了满足当前日益增长的通信容量需求,新型多载波光纤通信技术成为科研人员关注的焦点。文章回顾了近20年来传统正交频分复用(OFDM)在光纤通信领域的发展历程,梳理了近年来滤波器组多载波(FBMC)和通用滤波多载波(UFMC)在光纤通信领域的相关研究。自2016年以来,针对光通信中OFDM存在的问题,如:带外泄漏高、依赖循环前缀(CP),峰均功率比(PAPR)值过高和系统同步要求高等,国内外众多学者以新型多载波为突破口展开了研究。FBMC光通信具有旁瓣功率最低和频谱利用率高等特点,但是由于使用了偏移正交幅度调制(OQAM),对应的数字信号处理(DSP)算法需要针对虚部干扰重新设计。UFMC光通信具备强大的时间同步偏差容忍性,对频率偏移不敏感,可以复用OFDM的DSP算法,但也存在如何进一步抑制带外功率和降低计算复杂度等问题。最后,文章结合当前的研究现状,对下一代光纤通信系统的诉求提出了研究方向和建议。

关键词：多载波光通信正交频分复用滤波器组多载波通用滤波多载波

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