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AWells-Riley/based COVID-19 infectiousrisk assessment model combining both short rangeandroom scale effects

Building Simulation 2024年第1期17卷 93-111页

作者： Yinshuai Feng Yifan Fan Xiaoyu Luo jian ge College of Civil Engineering and Architecture Zhejiang UniversityHangzhouChina Center for Balance Architecture Zhejiang UniversityHangzhouChina International Research Center for Green Building and Low-Carbon City International CampusZhejiang UniversityHainingChina

There is growing evidence of the high transmission potential of COVID-19 through virus-laden *** aerosols are inhaled in various concentrations,an overall assessment of transmission risks at different indoor scales is ***,a comprehensive risk assessment method that evaluates the direct link between short-range and room-scale zones is stl *** this paper,a risk assessment model combining both short-range and room-scale effects is developed to obtain effective reproduction number in confined indoor environments,called Turbulent Jet Wells Riley(TJWR)*** with the viral load data and aerosol generation data of different human respiratory activities,the Monte Carlo simulation method is applied to calculate the quanta emission rate,which further provides the input parameters of the TJWR *** known outbreaks(Hangzhou banquet hall X,Guangzhou restaurant Y,and Hong Kong restaurant Z,China)are chosen to validate the TJWR *** show that the TJWR model is more efficient than the original Wells-Riley *** average relative error of the TJWR model ranges between 9%and 44%,while for the Wells-Riley model,it ranges between 57%and 78%.The TJWR model also proves that infection risk assessments using the well-mixed assumption can systematically underestimate the transmission risk for those close to the ***,there is a significant positive linear correlation between the total number of exposed individuals at the short-range and the effective reproduction *** newly developed TJWR model has great potential for rapid and real-time overall airborne transmission risk assessment in buildings and cities.

关键词： COVID-19 airborne transmission infection risk Wells-Riley model Monte Carlo simulation

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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda jian ge Lexiang Yu Zhongzhi Wu jianwen Que Wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity

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Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing Dong-Hui Wang Hai-Feng Zhang Li-Dan Liu Cheng-Ce Li Chao Wei Jun-Yu Liu Nai-jian ge Xuan-Yong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

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An improved analysis method for assessing the nuclear-heating impact on the stability of toroidal field magnets in fusion reactors

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Nuclear Science and Techniques 2024年第6期35卷 163-176页

作者： Yu-Dong Lu Jin-Xing Zheng Xu-Feng Liu Huan Wu jian ge Kun Xu Ming Li Hai-Yang Liu Lei Zhu Fei Liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

The superconducting magnet system of a fusion reactor plays a vital role in plasma confinement,a process that can be dis-rupted by various operational factors.A critical parameter for evaluating the temperature margin of superconducting magnets during normal operation is the nuclear heating caused by D-T *** study investigates the impact of nuclear heat-ing on a superconducting magnet system by employing an improved analysis method that combines neutronics and thermal *** the magnet system,toroidal field(TF)magnets are positioned closest to the plasma and bear the highest nuclear-heat load,making them prime candidates for evaluating the influence of nuclear heating on *** enhance the modeling accuracy and facilitate design modifications,a parametric TF model that incorporates heterogeneity is established to expedite the optimization design process and enhance the accuracy of the computations.A comparative analysis with a homogeneous TF model reveals that the heterogeneous model improves accuracy by over 12%.Considering factors such as heat load,magnetic-field strength,and cooling conditions,the cooling circuit facing the most severe conditions is selected to calculate the temperature of the *** selection streamlines the workload associated with thermal-hydraulic *** approach enables a more efficient and precise evaluation of the temperature margin of TF ***,it offers insights that can guide the optimization of both the structure and cooling strategy of superconducting magnet systems.

关键词： Superconducting magnet Nuclear heating Neutronics Thermal hydraulics

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Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-Ying Li Ning-Ning Zhao Yi-Xuan geng Qian Han jian-ge Qiu Bing-Hua jiang Zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer

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Building decarbonization based on building loads flexibility and clusters' collaboration

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National Science Open 2024年第3期3卷 7-12页

作者： jian ge Guoquan Lv Jiahuan Tang Kang Zhao Department of Architecture Zhejiang University International Research Center for Green Building and Low-Carbon City International CampusZhejiang University

The decarbonization of the building sector is crucial for global sustainable development because it is responsible for about 40%of global carbon emissions and has been growing continuously at a rate of 2%to 3%per year [1].Over time,significant energy-saving milestones have been achieved through technologies such as improving equipment efficiency,building envelope performance,and utilization of sustainable resources.

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分析师关注、员工社会比较与企业慈善捐赠

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当代财经 2024年第3期 97-110页

作者：吴畏葛建华西南政法大学商学院重庆401120 中国人民大学商学院北京100872

现有研究普遍强调利益相关者对企业社会责任实践的推动作用,忽视了不同利益相关者针对企业社会责任的可能冲突。当企业外部利益相关者(分析师)与内部利益相关者(员工)对企业捐赠持矛盾态度时,企业慈善捐赠有何变化?基于2006—2018年中... 详细信息

现有研究普遍强调利益相关者对企业社会责任实践的推动作用,忽视了不同利益相关者针对企业社会责任的可能冲突。当企业外部利益相关者(分析师)与内部利益相关者(员工)对企业捐赠持矛盾态度时,企业慈善捐赠有何变化?基于2006—2018年中国上市公司的实证分析显示,虽然分析师群体日益关注和期待企业的慈善表现,但当企业内部员工通过社会比较发现其在收入上被“苛待”时,他们会对企业捐赠产生抵制态度,在这种情况下,企业会平衡内外部利益诉求以调整捐赠额度。员工与企业高管团队的收入差距以及与同行(同行业、同地区企业员工)的收入差距均显著削弱分析师关注对企业捐赠的正向影响。上述研究结论通过揭示不同利益相关群体在企业社会责任态度方面的潜在冲突和员工社会比较的触发机制,有利于推动异质性利益相关者交互影响下的企业社会责任研究。

关键词：利益相关者企业慈善分析师关注员工薪酬社会比较

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高职院校学生党建工作引领思想政治教育的研究

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成才之路 2024年第23期 41-44页

作者：米剑各湖南有色金属职业技术学院湖南株洲412006

高职院校作为培养高素质技术技能人才的重要基地,应充分发挥学生党建工作的引领作用,优化思想政治教育的路径,不断提升育人质量。文章通过对高职院校学生党建工作和思想政治教育现状的深入调查,揭示二者之间的紧密关系,以及学生党建工... 详细信息

高职院校作为培养高素质技术技能人才的重要基地,应充分发挥学生党建工作的引领作用,优化思想政治教育的路径,不断提升育人质量。文章通过对高职院校学生党建工作和思想政治教育现状的深入调查,揭示二者之间的紧密关系,以及学生党建工作在思想政治教育中的重要作用,并提出从提升理论素养、加强实践锻炼、完善组织形式、创新工作方法、强化队伍建设、加强制度建设等六个方面入手,推动高职院校学生党建工作与思想政治教育深度融合的有效策略,以期培养德智体美劳全面发展的社会主义建设者和接班人。

关键词：高职院校党建工作思想政治教育理论素养实践锻炼组织形式工作方法队伍建设制度建设

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糖化血红蛋白变异指数和单核细胞/高密度脂蛋白胆固醇比值对2型糖尿病伴脑小血管病的预测价值

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中华糖尿病杂志 2024年第3期16卷 314-320页

作者：薛慧邓旭李颖刘婷婷葛坚韩远远宿迁市第一人民医院内分泌科宿迁223800 宿迁市第一人民医院神经内科宿迁223800

目的探讨糖化血红蛋白变异指数(HGI)和单核细胞/高密度脂蛋白胆固醇比值(MHR)对2型糖尿病(T2DM)伴脑小血管病(CSVD)的预测价值。方法为横断面研究。选取2020年1月至2022年12月在宿迁市第一人民医院内分泌科和神经内科住院的T2DM患者为... 详细信息

目的探讨糖化血红蛋白变异指数(HGI)和单核细胞/高密度脂蛋白胆固醇比值(MHR)对2型糖尿病(T2DM)伴脑小血管病(CSVD)的预测价值。方法为横断面研究。选取2020年1月至2022年12月在宿迁市第一人民医院内分泌科和神经内科住院的T2DM患者为研究对象。根据是否伴有CSVD将患者分为单纯T2DM和T2DM伴CSVD组。收集两组患者的单核细胞计数、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、空腹血糖(FPG),并计算MHR和HGI。两组间比较采用两独立样本t检验、Mann‐WhitneyU检验或χ2检验,采用Spearman相关性分析法分析HGI和MHR与T2DM伴CSVD的相关性,采用多因素logistic回归分析法分析T2DM伴CSVD的影响因素,采用受试者工作特征(ROC)曲线评估HGI和MHR对T2DM伴CSVD的诊断价值。结果共纳入361例T2DM患者。其中,单纯T2DM组170例,T2DM伴CSVD组191例。与单纯T2DM组相比,T2DM伴CSVD组患者MHR和HGI均更高(P<0.001)。Spearman相关性分析结果显示,HGI(r=0.196,P<0.001)、MHR(r=0.349,P<0.001)与T2DM伴CSVD均呈正相关。多因素logistic回归分析结果显示,HGI(OR=1.314,95%CI 1.052~1.642,P=0.016)和MHR(OR=1.056,95%CI 1.039~1.073,P<0.001)均为T2DM伴CVSD的影响因素。ROC曲线分析结果显示,HGI、MHR预测T2DM伴CSVD的曲线下面积分别为0.613(95%CI 0.555~0.671,P<0.001)和0.702(95%CI 0.649~0.755,P<0.001),HGI和MHR联合预测T2DM伴CSVD的曲线下面积为0.729(95%CI 0.678~0.780,P<0.001)。结论HGI和MHR与T2DM患者的CSVD发病密切相关,对T2DM伴CSVD的预测均有一定的价值,两者联合预测价值更高。

关键词：糖尿病 2型脑小血管病糖化血红蛋白变异指数单核细胞/高密度脂蛋白胆固醇比值

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适于多物种的通用尾巴序列设计及通用体系的建立

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生物技术通报 2024年第5期40卷 94-102页

作者：孙擘王蕊霍永学葛建镕匡猛王凤格北京市农林科学院玉米研究所、农业农村部农作物DNA指纹创新利用重点实验室(部省共建)、玉米DNA指纹及分子育种北京市重点实验室北京100097 中国农业科学院棉花研究所、棉花生物学国家重点实验室安阳455000

【目的】荧光毛细管电泳由于其检测通量高、分辨率高等优点,被广泛应用于个体鉴定、品种鉴定、物种鉴定等多种应用场景中。尾巴序列为荧光毛细管电泳平台的广泛应用提供了高效的解决方案。为解决已有尾巴序列无法满足多物种使用需求,本... 详细信息

【目的】荧光毛细管电泳由于其检测通量高、分辨率高等优点,被广泛应用于个体鉴定、品种鉴定、物种鉴定等多种应用场景中。尾巴序列为荧光毛细管电泳平台的广泛应用提供了高效的解决方案。为解决已有尾巴序列无法满足多物种使用需求,本研究基于编码转译技术开发高效的通用尾巴序列(universal tailed-sequence,UTS)设计工具。基于此工具设计通用尾巴序列,构建适合多作物的通用型PCR体系和程序,提高荧光电泳通量和灵活性。【方法】基于编码转译技术开发高效的通用尾巴序列设计工具,并对3755个常用汉字进行编码转译,并设置序列GC含量、发卡结构及同源引物二聚体退火温度等筛选条件得到符合条件的UTS。使用BLAST工具对通用尾巴序列设计工具生成的UTS在多种生物基因组上进行同源性评估,并在玉米、番茄、辣椒、西瓜等作物上进行实验评估,构建物种通用型实验体系及程序。【结果】通过设计工具编码转译并筛选共得到7436833个高质量的候选UTS,占所有字组的52.74%。挑选6个UTS在20个作物基因组上的BLAST结果显示其与M13相比具有更好的特异性。通过对通用引物扩增程序进行优化,使通用引物在多个物种上的扩增成功率达到或超过95%,并具有较强的稳定性。【结论】利用编码转译技术开发通用尾巴序列,并为其搭配物种通用型扩增体系和程序,提供一种通量高、成本低的荧光电泳通用检测方法。

关键词： PCR 荧光电泳通用引物引物设计

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