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Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 62-88页

作者： Jie-Zhuang Huang jian-di Li Gang Chen Rong-Quan He Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Transcatheter arterial embolisation(TACE)is the primary treatment for intermediate-stage hepatocellular carcinoma(HCC)patients while some HCC cases have shown resistance to *** To investigate the key genes and potential mechanisms correlated with TACE refractoriness in *** The microarray datasets of TACE-treated HCC tissues,HCC and non-HCC tissues were collected by searching multiple public *** respective differentially expressed genes(DEGs)were attained via limma R *** gene co-expression network analysis was employed for identifying the significant modules related to TACE *** refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE *** key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences *** prognostic value of the key genes was evaluated by Kaplan-Meier *** analysis was utilised to investigate the independent prognostic factor in key ***-cell RNA(scRNA)sequencing analysis was conducted to explore the cell types in *** refractoriness-related genes activity was calculated via AUCell *** CellChat R package was used for the investigation of the cell–cell communication between the identified cell *** HCC tissues of TACE non-responders(n=66)and TACE responders(n=81),HCC(n=3941)and non-HCC(n=3443)tissues were *** five key genes,DLG associated protein 5(DLGAP5),Kinesin family member 20A(KIF20A),Assembly factor for spindle microtubules(ASPM),Kinesin family member 11(KIF11)and TPX2 microtubule nucleation factor(TPX2)in TACE refractoriness-related genes,were *** five key genes were all up-regulated in the TACE non-responders group and the HCC *** expression of the five key genes predicted poor prognosis in *** the key genes,TP

关键词： Hepatocellular carcinoma Transcatheter arterial embolisation refractoriness Weighted gene co-expression network analysis Single-cell RNA sequencing AUCell CellChat

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

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World Journal of Clinical Oncology 2024年第1期15卷 145-158页

作者： Lu Zhang Zu-Yuan Chen Xiao-Xian Wei jian-di Li Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Emerging research suggests that microRNAs(miRNAs)play an important role in the development of hepatocellular carcinoma(HCC).A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further *** To make a comprehensive analysis of recent studies concerning miRNAs in *** All relevant publications were retrieved from the Web of Science Core Collection *** software,VOSviewer software and CiteSpace software were used to visually analyze the distribution by time,countries,institutions,journals,and authors,as well as the keywords,burst keywords and thematic *** A total of 9426 publications on this topic were found *** to the keywords analysis,we found that the studies of miRNAs focused on their expression level,effects,and mechanisms on the biological behaviour of *** bursting analysis showed that in the early years(2013–2017),“micro-RNA expression”,“gene expression”,“expression profile”,“functional polymorphism”,“circulating microRNA”,“susceptibility”and“mir 21”started to attract *** the latest phase(2018–2022),the hot topics turned to“sorafenib resistance”,“tumor microenvironment”and so *** This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric *** hotspots in this field focus on miRNAs expression level,effects,and mechanisms on the biological behavior of *** frontiers turned to sorafenib resistance,tumor microenvironment and so on.

关键词： miRNA Hepatocellular carcinoma Bibliometric VOSviewer CiteSpace

Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer

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World Journal of Clinical Oncology 2024年第7期15卷 867-894页

作者： Jing-Yu Chen jian-di Li Rong-Quan He Zhi-Guang Huang Gang Chen Wen Zou Department of Pathology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Phosphoglycerate kinase 1(PGK1)has been identified as a possible biomarker for breast cancer(BC)and may play a role in the development and advancement of triple-negative BC(TNBC).AIM To explore the PGK1 and BC research status and PGK1 expression and mecha-nism differences among TNBC,non-TNBC,and normal breast *** PGK1 and BC related literature was downloaded from Web of Science Core Co-llection Core *** counts,key-word frequency,cooperation networks,and theme trends were *** breast,TNBC,and non-TNBC mRNA data were gathered,and differentially expressed genes *** under the summary receiver operating characteristic curves,sensitivity and specificity of PGK1 expression were *** Meier revealed PGK1’s prognostic ***1 co-expressed genes were explored,and Gene Onto-logy,Kyoto Encyclopedia of Genes and Genomes,and disease Ontology ***-protein interaction networks were *** genes *** PGK1 and BC related publications have surged since 2020,with China leading the *** most frequent keyword was“Expression”.Collaborative networks were found among co-citations,countries,institutions,and ***1 expression and BC progression were research hotspots,and PGK1 expression and BC survival were research *** 16 TNBC vs non-cancerous breast and 15 TNBC vs non-TNBC datasets,PGK1 mRNA levels were higher in 1159 TNBC than 1205 non-cancerous breast cases[standardized mean differences(SMD):0.85,95%confidence interval(95%CI):0.54-1.16,I²=86%,Pdire

关键词： Phosphoglycerate kinase 1 Breast cancer Triple-negative breast cancer Bibliometric analysis Computational pathology

利用BERT和覆盖率机制改进的HiNT文本检索模型

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智能系统学报 2024年第3期19卷 719-727页

作者：邸剑刘骏华曹锦纲华北电力大学控制与计算机工程学院河北保定071003 复杂能源系统智能计算教育部工程研究中心河北保定071003

为有效提升文本语义检索的准确度,本文针对当前文本检索模型衡量查询和文档的相关性时不能很好地解决文本歧义和一词多义等问题,提出一种基于改进的分层神经匹配模型(hierarchical neural matching model,HiNT)。该模型先对文档的各个... 详细信息

为有效提升文本语义检索的准确度,本文针对当前文本检索模型衡量查询和文档的相关性时不能很好地解决文本歧义和一词多义等问题,提出一种基于改进的分层神经匹配模型(hierarchical neural matching model,HiNT)。该模型先对文档的各个段提取关键主题词,然后用基于变换器的双向编码器(bidirectional encoder representations from transformers,BERT)模型将其编码为多个稠密的语义向量,再利用引入覆盖率机制的局部匹配层进行处理,使模型可以根据文档的局部段级别粒度和全局文档级别粒度进行相关性计算,提高检索的准确率。本文提出的模型在MS MARCO和webtext2019zh数据集上与多个检索模型进行对比,取得了最优结果,验证了本文提出模型的有效性。

关键词：基于变换器的双向编码器分层神经匹配模型覆盖率机制文本检索语义表示特征提取自然语言处理相似度多粒度

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高耐性水性单组分全亚光清面漆的制备及其性能研究

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中国涂料 2024年第5期39卷 26-30页

作者：狄建军南京长江涂料有限公司南京210047

系统地对水性单组分全亚光清面漆类木器涂料开展了制漆性能研究。以原材料筛选为切入点,探讨水性树脂、消光剂对涂膜耐性等的影响。并且通过对涂膜冷热循环的抗泛白性能研究,优选出具备优异装饰效果的高性能水性单组分全亚光透明木器面... 详细信息

系统地对水性单组分全亚光清面漆类木器涂料开展了制漆性能研究。以原材料筛选为切入点,探讨水性树脂、消光剂对涂膜耐性等的影响。并且通过对涂膜冷热循环的抗泛白性能研究,优选出具备优异装饰效果的高性能水性单组分全亚光透明木器面漆技术方案。

关键词：全亚光耐化学品高硬度单组分

关节置换术后假体周围感染病原菌分布特点及耐药情况

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中国感染控制杂志 2024年第5期23卷 586-591页

作者：郑文丽方朕张文梅狄建忠上海市第六人民医院医院感染控制办公室上海200030 上海市第六人民医院院长办公室上海200030

目的分析髋膝关节置换术后假体周围感染病原菌分布特点和耐药情况,为临床预防和合理使用抗菌药物提供参考。方法回顾性收集并分析2020年1月—2022年12月某院收治的髋膝关节置换术后假体周围感染患者的临床资料,分析病原菌分布及对常用... 详细信息

目的分析髋膝关节置换术后假体周围感染病原菌分布特点和耐药情况,为临床预防和合理使用抗菌药物提供参考。方法回顾性收集并分析2020年1月—2022年12月某院收治的髋膝关节置换术后假体周围感染患者的临床资料,分析病原菌分布及对常用抗菌药物的耐药情况。结果共纳入105例关节置换术后假体周围感染患者,其中,髋关节置换67例,膝关节置换38例。共检出病原菌124株,以革兰阳性菌株为主,占74.19%(92株);其次是革兰阴性菌,占16.13%(20株);最常见的病原菌是金黄色葡萄球菌(37.90%,47株)和凝固酶阴性葡萄球菌(22.58%,28株)。药敏试验结果显示,革兰阳性球菌中,金黄色葡萄球菌、凝固酶阴性葡萄球菌对苯唑西林的耐药率分别为26.67%、73.08%,对万古霉素均敏感;革兰阴性菌对环丙沙星、哌拉西林/他唑巴坦、头孢曲松耐药率分别为33.33%、41.18%、55.56%,对美罗培南敏感。结论关节置换术后,假体周围感染主要病原菌为金黄色葡萄球菌和凝固酶阴性葡萄球菌,后者对苯唑西林耐药率较高。经验性治疗对金黄色葡萄球菌假体周围感染可能有效,但对凝固酶阴性葡萄球菌假体周围感染可能效果差。

关键词：关节置换假体周围感染微生物耐药性

Synthesis and DFT Calculation of a Four- coordinated Manganese Compound Mn_2(BPTC)

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Chinese Journal of Structural Chemistry 2015年第8期34卷 1170-1178页

作者： RONG Cheng LIU Jin-Ying LIN jian-di LI Qing-Lu Department of Applied Chemistry Fujian Agriculture and Forestry University State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

A new four-coordinated manganese compound Mn2（BPTC）（BPTC =- biphenyl- 2,4,4＇,6-tetracarboxylate） with flu topology net was synthesized under hydrothermal conditions. Single-crystal X-ray diffraction analysis confirms its crystal belongs to the monoclinic system, space group C2/c with a = 12.2092（11）, b = 14.6932（9）, c = 8.9998（10） A, t= 108.256（12）°, Z= 4, V= 1533.2（2） A3, Dc = 1.889 mg/m3,μ = 1.69, F（O00） = 864, the final R = 0.063 and wR = 0.201 for 1407 observed reflections （I 〉 20（/））. UV-Vis absorption spectrum shows the title compound has a strong absorption at 326 and 238 nm and the optical diffuse reflectance determination shows the band gap of the title compound is 3.15 eV. The theory calculation elucidated that the UV absorptions of the title compound mainly arise from the electron transition from bonding orbitals of BPTC4- ligand to the empty orbitals of BPTC4- and Mn（II） ions.

关键词： four-coordinated manganese compound steric hindrance metal-organic

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番茄酵素发酵工艺优化及营养成分变化分析

中国调味品 2024年第4期49卷 11-17,24页

作者：王瑞陈洁如刘亚平李泽珍孙胜狄建兵山西农业大学食品科学与工程学院山西晋中030801 山西农业大学园艺学院山西晋中030801

以番茄为原料,植物乳杆菌为发酵菌种,超氧化物歧化酶(SOD)和总酸为评价指标,采用单因素试验和Box-Behnken试验优化番茄酵素的发酵工艺,并分析监测番茄酵素发酵过程中营养成分和相关酶活性变化。结果表明,在最佳接种量0.3%、发酵温度37... 详细信息

以番茄为原料,植物乳杆菌为发酵菌种,超氧化物歧化酶(SOD)和总酸为评价指标,采用单因素试验和Box-Behnken试验优化番茄酵素的发酵工艺,并分析监测番茄酵素发酵过程中营养成分和相关酶活性变化。结果表明,在最佳接种量0.3%、发酵温度37℃、初始pH值5.5、发酵时间40 h的条件下,番茄酵素SOD活性达147.63 U/g,总酸含量为48.60 g/kg。发酵过程中,pH值和可溶性固形物含量均随着发酵时间的增加而持续下降,总酸含量持续上升,还原糖、总酚含量及SOD活性、脂肪酶活性均先上升后下降,番茄红素含量先持续下降后上升再下降;同时对各营养成分与酶活性进行相关性分析,结果表明各营养成分之间存在一定相关性。

关键词：番茄酵素发酵工艺优化营养成分

Microstructure and mechanical properties of two-stage aged Al-Cu-Mg-Ag-Sm alloy

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Rare Metals 2019年第1期38卷 42-51页

作者： Wen-Long Zhang Dai-Hong Xiao Ting Li jian-di Du Dong-Yan ding State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Science and Technology on High Strength Structural Materials Laboratory Central South University

High-strength Al-Cu-Mg-Ag-Sm alloy was fabricated and subjected to single-stage aging and pre-aging(two-stage aging). Effect of pre-aging on micros tructure and mechanical properties of the alloy was investigated. It is found that the alloy is mainly composed of α-Al, Al_2Cu, Al_2CuMg and AlCu_4Sm. The number of plate-like Ω Al_2Cu precipitates is comparable to that of rod-like S Al_2 CuMg precipitates in the single-stage aged alloy, whereas, in the two-stage aged alloy, it is much higher than that of S precipitates. Q precipitates have a smaller plate thickness and distribute more uniformly in the two-stage aged alloy than in the single-stage aged *** tensile strength(UTS) and yield strength of the two-stage aged alloy are 12% higher than those of the single-stage aged one, indicating a better aging hardening caused by the two-stage aging. The increased tensile properties mainly come from both stronger precipitation strengthening caused by more Ω precipitates in the twostage aged alloy and stronger solution strengthening from Mg atoms. The fracture surfaces consist of both dimple zones composed of microscale dimples and platform zones composed of nanoscale dimples. The total area of dimple zones for single-stage aged alloy is much higher than that for two-stage aged alloy, which can be attributed to different numbers of Ω precipitates in the two alloys.

关键词： Rare earth aluminum alloy: Aging behavior Tensile property Fractography