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Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells

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Chinese Medical Journal 2006年第10期119卷 801-808页

作者： ZHANG Ming-sheng ZHOU Yun-feng ZHANG Wen-jie ZHANG Xiao-lian PAN Qin JI Xue-mei LUO Zhi-guo wu jian-ping Department of Cancer Radio-Chemotherapy Zhongnan HospitalWuhan University Wuhan 430071 China Department of Surgery Pennsylvania State University College ofMedicine Hershey PA 17033 USA Department of Immunology Medical College of Wuhan UniversityWuhan 430071 China

Background The relationship between signal transduction and tumors has become one of the loci in cancer research. Signal transducer and activator of the transcription 6 （STAT6） signaling pathway is found to be activated in some cancer cells. But the function of the pathway in cancer cells is unknown. This study was undertaken to investigate the effect of the Stat6 signaling pathway on apoptosis in human colon cancer cells （HT-29 cells） and the possible mechanism of Stat6 by RNA interference techniques.

关键词： RNA interference short hairpin RNA signal transducer and activator of transcription 6 tumor apoptosis

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2384-2391页

作者： Zhijian Xu Danrong Shi jian-Bao Han Yun Ling Xiangrui jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li feng Ren-Rong Tian Jia Ji Miaojin Zhu Nanping wu Chunhui wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang wu Peipei Wang Jingshan Shen jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesFirst Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650107China Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Jinan Microecological Biomedicine Shandong Laboratory Jinan250117China

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by *** we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and *** of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the *** necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 *** antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19.

关键词： drugs infected treatment

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统一混沌系统的修改模型及同步设计

深圳大学学报（理工版） 2010年第1期27卷 37-42页

作者：丰建文何玲吴耿代安定深圳大学数学与计算科学学院深圳518060

通过用分段线性符号函数替换统一混沌系统中部分二次项,得到一个新分段连续的自治系统(称为统一混沌系统修改模型).对该系统性质做定性分析,验证其动力学性态为混沌,运用反馈控制和自适应控制方法,证明两个统一混沌系统的修改模型为同步... 详细信息

通过用分段线性符号函数替换统一混沌系统中部分二次项,得到一个新分段连续的自治系统(称为统一混沌系统修改模型).对该系统性质做定性分析,验证其动力学性态为混沌,运用反馈控制和自适应控制方法,证明两个统一混沌系统的修改模型为同步,数值模拟计算验证了所提同步设计的正确性.

关键词：系统学反馈控制自适应控制混沌同步统一混沌系统的修改模型

A bidirectional brain-computer interface for effective epilepsy control

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 839-847页

作者： Yu QI Fei-qiang MA Ting-ting GE Yue-ming WANG Jun-ming ZHU jian-min ZHANG Xiao-xiang ZHENG Zhao-hui wu Qiushi Academy for Advanced Studies Zhejiang University Department of Computer Science Zhejiang University Second Affiliated Hospital of Zhejiang University College of Medicine College of Biomedical Engineering and Instrument Science Zhejiang University

Brain-computer interfaces(BCIs) can provide direct bidirectional communication between the brain and a machine. Recently, the BCI technique has been used in seizure control. Usually, a closed-loop system based on BCI is set up which delivers a therapic electrical stimulus only in response to seizure onsets. In this way, the side effects of neurostimulation can be greatly reduced. In this paper, a new BCI-based responsive stimulation system is proposed. With an efficient morphology-based seizure detector, seizure events can be identified in the early stages which trigger electrical stimulations to be sent to the cortex of the brain. The proposed system was tested on rats with penicillin-induced epileptic seizures. Online experiments show that 83% of the seizures could be detected successfully with a short average time delay of 3.11 s. With the therapy of the BCI-based seizure control system, most seizures were suppressed within 10 s. Compared with the control group, the average seizure duration was reduced by 30.7%. Therefore, the proposed system can control epileptic seizures effectively and has potential in clinical applications.

关键词： Brain-computer interface Epilepsy Seizure detection Responsive neurostimulation

Angioimmunoblastic T-cell lymphoma-associated pure red cell aplasia with abdominal pain

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World Journal of Clinical Oncology 2013年第3期4卷 75-81页

作者： Jin Tao feng-Ping Zheng Hong Tian Ying Lin jian-Zhong Li Xiao-Liang Chen jian-Ning Chen Chun-Kui Shao Bin wu Department of Gastroenterology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Pathology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

Angioimmunoblastic T-cell lymphoma(AITL)is a unique type of peripheral T-cell lymphoma with a constellation of clinical symptoms and signs,including weight loss,fever,chills,anemia,skin rash,hepatosplenomegaly,lymphadenopathy,thrombocytopenia and polyclonal *** histological features of AITL are also *** red cell aplasia is a bone marrow failure characterized by progressive normocytic anemia and reticulocytopenia without leucopenia or ***,AITL with abdominal pain and pure red cell aplasia has rarely been ***,we report a rare case of AITL-associated pure red cell aplasia with abdominal *** diagnosis was verified by a biopsy of the enlarged abdominal lymph nodes with immunohistochemical staining.

关键词： Angioimmunoblastic T-cell lymphoma Anemia Pure red cell aplasia Abdominal pain

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四波混频光相位运算器原理及其噪声性能研究

物理学报 2018年第9期67卷 156-164页

作者：曹亚敏武保剑万峰邱昆电子科技大学通信与信息工程学院光纤传感与通信教育部重点实验室成都611731

推导了抽运消耗情形下简并和非简并四波混频(FWM)闲频光幅度和相位的统一解析表达式.采用极限方法,计算证明了非相敏放大模式下闲频光相位与输入光初始相位之间的关系,揭示了FWM相位加减混合运算器的工作原理.以四相相移键控信号为例,... 详细信息

推导了抽运消耗情形下简并和非简并四波混频(FWM)闲频光幅度和相位的统一解析表达式.采用极限方法,计算证明了非相敏放大模式下闲频光相位与输入光初始相位之间的关系,揭示了FWM相位加减混合运算器的工作原理.以四相相移键控信号为例,对基于非简并FWM的相位运算器进行了设计,重点分析了三种基本加减混合运算的噪声转移性能及其对光纤长度、输入光波长和功率的依赖特性.计算表明:该运算器的噪声指数约为1.1 dB;当输入光信号的信噪比大于24 dB时无纠错编码的符号错误率可低于10^(-3).

关键词：四波混频光学计算非相敏放大误差矢量幅度

Issues on Supply Chain Management

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厦门大学学报（自然科学版） 2002年第S1期41卷 281-282页

作者： wu Shun-xiang, ZHANG Min, CHEN jian-hui (Department of Automation, Xiamen University, Xiamen 361005, China)

Although supply chain is regarded as an integrated pr ocess, actually, researchers and practitioners have primarily investigated the v arious processes of the supply chain individually. The competitive field in most markets requires well-designed integrated supply chain instead of individual o perations. In this paper, some traditional thinking of supply chain is given fir st, then SCM (Supply Chain Management) is introduced, which views the entire sup ply chain as a whole rather than individual process and aims to increase transpa rency and alignment of the supply chain’s coordination and configuration, regar dless of functional or corporate boundaries. Secondly, issues regarding the significance and the situation of supply chain management in enterprises of Chin a are briefly described. In china, most enterprises haven’t established the ide a of supply chain management, supply chain are just focused on the step from sup pliers to manufacturers, which is a partial but not whole supply chain. Challeng ed by intense competition in the global market, further research on supply chain management is badly needed in China, if not, traditional pattern must be overwh elmed by world competition. Finally, suggestions for future research, especial ly the required conditions for a successful adoption of supply chain managemen t, are outlined. Organizations with Supply chain management can realize the advantages of backward vertical integration. However the following issues must b e paid attention to before supply chain management pattern is established.(1) Ch anging the corporate cultures of all members in the value chain to make it condu cive to supply chain management.(2) Developing long-term, cooperative and certi fied relationship with key suppliers.(3) Developing supply chain management soft ware that includes a completely integrated information system based on distr ibuted database throughout supply chain.(4) Reconstructing organization structur e adapting to supply chain

关键词： supply chain Supply Chain Management (SCM)

考虑动圈偏心的电动振动台等效电磁力计算方法

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西安交通大学学报 2020年第8期54卷 132-139页

作者：左曙光潘健吴旭东冯朝阳同济大学汽车学院上海201804

为了反映动圈激励电磁力对偏载工况下电动振动台横向振动的影响,提出了一种考虑动圈偏心影响的电动振动台等效电磁力计算方法。综合选取动圈通电电流、垂向位置、翻转偏心角度、径向平移偏心距及方向等5个因素,通过求取径向平移偏心距... 详细信息

为了反映动圈激励电磁力对偏载工况下电动振动台横向振动的影响,提出了一种考虑动圈偏心影响的电动振动台等效电磁力计算方法。综合选取动圈通电电流、垂向位置、翻转偏心角度、径向平移偏心距及方向等5个因素,通过求取径向平移偏心距极限及假设虚拟偏心距进行变量代换,解决了现有正交试验设计方法难以应用于多个因素之间存在取值相互约束情况的问题。通过电磁有限元仿真获得了与动圈分布电磁力等效的集中电磁力样本,采用神经网络方法进行样本拟合获得了动圈全运动工况等效电磁力。仿真结果表明:径向等效电磁力主要随翻转偏心角度的增加而增加,且在大电流工况增加更迅速;采用所提方法获得的等效电磁力相对误差均在10%以内,可在满足工程误差要求的同时快速实时获得动圈全运动工况等效电磁力,解决了由有限元及精确解析方法计算等效电磁力速度慢所导致的无法进行电动振动台电磁-结构双向耦合仿真的问题。该方法也可应用于其他相似的运动系统受力计算问题。

关键词：电动振动台等效电磁力偏心计算方法正交试验设计

M_(23)C_(6)precipitation and Si segregation promoted by deep cryogenic treatment aggravating pitting corrosion of supermartensitic stainless steel

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Journal of Iron and Steel Research International 2021年第5期28卷 629-640页

作者： Xiao He Xin-yang Lu Zhi-wei wu Shao-hong Li Qi-long Yong jian-xiong Liang Jie Su Lie-xing Zhou Jun Li Kun-yu Zhao Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Institute for Special Steels Central Iron and Steel Research InstituteBeijing 100081China Research Center for Analysis and Measurement Kunming University of Science and TechnologyKunming 650093YunnanChina

The microstructure evolution and the pitting corrosion resistance of a supermartensitic stainless steel after deep cryogenic treatment process were clarified through X-ray diffraction,field emission scanning electron microscopy,transmission electron microscopy(TEM)and electrochemical *** results showed that the microstructure of supermartensitic stainless steel mainly consisted of reversed austenite,tempered martensite,and M_(23)C_(6)carbides after *** deep cryogenic treatment promoted the refinement of the martensite laths and the precipitation of the carbides in comparison with the traditional *** analysis indicated that the segregation of Si atoms at the boundary was found at the interface between carbide and *** pitting corrosion potential of the specimens subjected to deep cryogenic treatment decreased with the elevated tempering temperature,and the lowest pitting corrosion potential was found at the tempering temperature of 650℃.The sensitivity of the pitting corrosion potential was attributed to the precipitation of M_(23)C_(6)carbides and Si atoms *** atoms segregation engendered the formation of Cr-depleted zone near M_(23)C_(6)and impeded the recovery of Cr-depleted zone.

关键词： 15Cr supermartensitic stainless steel Deep cryogenic treatment Si segregation Pitting corrosion Microstructure