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The diversity and evolution of retroviruses:Perspectives from viral“fossils”

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Virologica Sinica 2022年第1期37卷 11-18页

作者： jialu zheng Yutong Wei Guan-Zhu Han Jiangsu Key Laboratory for Microbes and Functional Genomics College of Life SciencesNanjing Normal UniversityNanjing210023China

Retroviruses exclusively infect vertebrates,causing a variety of *** replication of retroviruses requires reverse transcription and integration into host *** infecting germline cells,retroviruses become inherited vertically,forming endogenous retroviruses(ERVs).ERVs document past viral infections,providing molecular fossils for studying the evolutionary history of *** this review,we summarize the recent advances in understanding the diversity and evolution of retroviruses from the perspectives of viral fossils,and discuss the effects of ERVs on the evolution of host biology.

关键词： Retroviruses Endogenous retroviruses(ERVs) Origin and evolution Diversity

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红庆梁矿12301胶运巷耦合支护研究

煤 2024年第4期33卷 24-28页

作者：罗波远高瑞樊荣宁掌玄郑嘉璐杭锦旗西部能源开发有限公司内蒙古鄂尔多斯014300 山西大同大学煤炭工程学院山西大同037003

随着开采深度的增加,软岩巷道占比逐年加大,合理的软岩巷道支护方案为矿井安全高效开采提供了重要保障。为了研究掘进巷道不同数量锚杆、锚索耦合支护的效果,以鄂尔多斯红庆梁矿12301胶运巷掘进巷道为研究对象,利用FLAC^(3D)软件研究在... 详细信息

随着开采深度的增加,软岩巷道占比逐年加大,合理的软岩巷道支护方案为矿井安全高效开采提供了重要保障。为了研究掘进巷道不同数量锚杆、锚索耦合支护的效果,以鄂尔多斯红庆梁矿12301胶运巷掘进巷道为研究对象,利用FLAC^(3D)软件研究在不同数量锚杆、锚索联合支护条件下,12301胶运巷掘进巷道围岩塑性区和围岩应力规律。结果表明:在方案1的支护条件下,减少2根帮锚杆,围岩剪切破坏区明显增大,而在减少两根顶锚杆的情况下,围岩剪切破坏区变化不大。方案2在方案1减少两根顶锚杆的前提下,巷道顶板最大垂直应力增加了20%,巷道两帮最大垂直应力增加了0.3%.方案3在方案1减少2根帮锚杆的前提下,巷道顶板最大垂直应力增加了40%,巷道两帮最大垂直应力增加了0.93%.

关键词：巷道支护软岩巷道 FLAC^(3D) 围岩控制

Tenglong Buzhong granules(藤龙补中颗粒) inhibits the growth of SW620 human colon cancer in vivo

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Journal of Traditional Chinese Medicine 2022年第5期42卷 701-706页

作者： LI Miao zheng jialu WANG Shuangshuang CHEN Lei PENG Xiao CHEN Jinfang AN Hongmei HU Bing Institute of Traditional Chinese Medicine in Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Department of Science and Technology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

OBJECTIVE: To observe the anticancer effects of the granular preparation of Tenglong Buzhong decoction(藤龙补中汤,TBD), i.e Tenglong Buzhong granules(藤龙补中颗粒, TBG), in human SW620 colon cancer. METHODS: BALB/c nude mice were subcutaneously transplanted with SW620 cells, and treated with TBG(2.56 g/kg, once per day) and/or 5-Fu(104 mg/kg, once per week) for 21 d. Apoptosis, Caspase activities and cellular senescence were measured by commercial kits. The protein expression and phosphorylation were detected by Western blot or immunohistochemistry. RESULTS: TBG and 5-Fu inhibited tumor growth. The tumor inhibition rate of the TBG, 5-Fu, and TBG+5-Fu groups was 42.25%, 51.58%, and 76.08%, respectively. Combination of TBG and 5-Fu showed synergetic anticancer effects. TBG and 5-Fu induced apoptosis, activated caspase-3,-8, and-9, increased SMAC expression, inhibited XIAP expression. TBG induced cellular senescence, upregulated cyclin-dependent kinase inhibitor 1a(CDKN1a) and cyclin-dependent kinase inhibitor 2a(CDKN2a) expression, and inhibited phosphorylation of retinoblastoma-associated protein(RB) and expression of cyclin E1(CCNE1) and cyclindependent kinases(CDK) 2. TBG also inhibited angiogenesis accompanied by downregulation of vascular endothelial growth factor(VEGF) and hypoxiainducible factor-1α(HIF-1α). CONCLUSIONS: TBG inhibits SW620 colon cancer growth, induces apoptosis via SMAC-XIAP-Caspases signaling, induces cellular senescence through CDKN1a/CDKN2a-RB-E2F signaling, inhibits angiogenesis by down-regulation of HIF-1α and VEGF, and enhances the effects of 5-Fu.

关键词： colonic neoplasms apoptosis cellular senescence signal transduction angiogenesis Tenglong Buzhong granules

Sensitive humidity sensor based on moisture-driven energy generation

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Nano Research 2024年第6期17卷 5578-5586页

作者： Qingchao Ni Qing Lou Chenglong Shen Guangsong zheng Runwei Song Jingnan Hao jialu Liu Jinyang Zhu Jinhao Zang Lin Dong Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of Educationand School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China State Centre for International Cooperation on Designer Low-Carbon&Environmental Materials and School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The emergence of novel self-powered humidity sensors has attracted considerable attention in the fields of smart electronic devices and personal ***,self-powered humidity sensors have been fabricated using a moisture-driven energy generation(MEG)device based on asymmetric tubular graphitic carbon nitride(g-CN)films prepared on anodized aluminum(AAO)*** a relative humidity(RH)of 96%,the MEG device can provide an open-circuit voltage of 0.47 V and a short-circuit current of 3.51μA,with a maximum output power of 0.08μ*** inherent self-powered ability and humidity response via current variation,an extraordinary response of 1.78×106%(41%-96%RH)can be gained from the MEG *** possible power generation mechanism is that g-CN/AAO heterostructure can form ion gradient and diffusion under the action of moisture to convert chemical potential into electrical potential,evoking a connaturally sensitive response to ***-powered respiration monitoring device based on the sensor is designed to monitor human movement(sitting,warming up,and running)and sleep status(normal,snoring,and apnea),maintaining excellent stability during cumulative 12-h respiration *** self-powered humidity sensing technology has promising potential for extensive integration into smart electronic and round-the-clock health monitoring devices.

关键词： graphitic carbon nitride moisture-driven energy generation humidity sensor respiration monitoring

Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy

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National Science Review 2024年第1期11卷 74-85页

作者： Chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao zheng Deng jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University Department of Interventional Radiology The First Afflliated Hospital of Soochow University

Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO3&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC.

关键词： CaCO3 nanoparticles Pickering emulsion ferroptosis lipid peroxidation transarterial ferro-embolization

Effect of Yanggan Jiedu Sanjie formula on human hepatocellular carcinoma Bel-7402 cells

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Journal of Traditional Chinese Medicine 2019年第1期39卷 26-33页

作者： Hu Bing Zhang Tong An Hongmei zheng jialu Yan Xia Huang Xiaowei Tian Jianhui Li Miao Institute of Traditional Chinese Medicine in Oncology Department of OncologyLonghua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Experiment Center for Teaching and Learning Shanghai University of Traditional Chinese MedicineShanghai 201204China Department of Science&Technology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

OBJECTIVE: To observe the effect of Yanggan Jiedu Sanjie(YGJDSJ) formula on human hepatocellular carcinoma Bel-7402 ***: Bel-7402 cells were treated with YGJDSJ. Cell proliferation was detected by cell counting kit-8 assay. Cell apoptosis was identified by Hoechst 33258 staining and flow cytometric analysis. Cell cycle distribution was quantified by flow cytometric analysis. Caspase activities were measured by commercial kit. Cell senescence was detected by senescence-associated β-galactosidase(SA-β-gal)staining. Protein expression and phosphorylation were identified by Western blot. Protein expression was knocked-down by ***: YGJDSJ inhibited proliferation of Bel-7402 cells in a dose-and time-dependent *** induced apoptosis and activated caspase-3, 8, and 9 in Bel-7402 cells. YGJDSJ-induced apoptosis was completely abrogated by a pan caspase inhibitor, Z-VAD-FMK. YGJDSJ also induced cell senescence, up-regulated cyclin-dependent kinase inhibitor 1 a(CDKN1 a) and CDKN2 a expression and down-regulated retinoblastoma protein(RB) phosphorylation in Bel-7402 cells. Specific knockdown of CDKN1 a and CDKN2 a significantly reduced YGJDSJ-induce cell senescence in Bel-7402 ***: YGJDSJ inhibited cell proliferation,induced caspase-dependent apoptosis and CDKN1 a/CDKN2 a-RB signalling mediated cell senescence in Bel-7402 cells. Our findings suggest that YGJDSJ might be potential for hepatocellular carcinoma treatment.

关键词： Carcinoma,hepatocellular Chinese herbal formula Apoptosis Cell senescence Cell cycle Cyclin-dependent kinase inhibitor p21 Cyclindependent kinase inhibitor p16 Retinoblastoma protein

一种LCCL滤波器及其在半桥电力有源滤波器中的应用

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电工技术学报 2016年第22期31卷 125-136页

作者：方旌扬肖国春郑力夫郑家禄西安交通大学电气工程学院西安710049

提出一种新型高阶电力滤波器,将其命名为LCCL滤波器。与传统的LCL滤波器相比,LCCL滤波器通过在网侧电感支路并联一个小电容,使网侧电感与并联电容在开关频率处发生并联谐振。谐振使LCCL滤波器网侧支路在开关频率处呈现无穷大的阻抗,相比... 详细信息

提出一种新型高阶电力滤波器,将其命名为LCCL滤波器。与传统的LCL滤波器相比,LCCL滤波器通过在网侧电感支路并联一个小电容,使网侧电感与并联电容在开关频率处发生并联谐振。谐振使LCCL滤波器网侧支路在开关频率处呈现无穷大的阻抗,相比LCL滤波器可以更好地抑制开关频率附近电网电流纹波,减小电网电流THD。与LLCL滤波器相比,LCCL滤波器具有较好的抑制参数变化的能力,在考虑电网内阻抗时,拥有更好的高频纹波抑制性能。同时,可以更容易地进行基于电容电流反馈有源阻尼的控制器设计。LCCL滤波器作为电压源型逆变器(VSI)与电网的接口,可应用于PWM整流器、有源电力滤波器(APF)和通用电能质量控制器(UPQC)等多种场合。通过以半桥APF为例,讨论了LCCL滤波器的参数选择方法和控制器设计。最后,通过仿真和实验验证了LCCL滤波器的可行性。

关键词： LCCL滤波器 LLCL滤波器 LCL滤波器半桥电力有源滤波器并联谐振

Circ_0084927通过miR-623/EZH2轴调控乳腺癌免疫逃逸

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中华内分泌外科杂志 2021年第5期15卷 472-477页

作者：许杨宝郑佳露浙江省台州市中医院上海中医药大学台州医院急诊科 318000 上海中医药大学附属龙华医院肿瘤科 200320

目的探讨circ_0084927作为分子海绵吸附miR-623靶向调控EZH2基因对乳腺癌(breast cancer,BC)细胞免疫逃逸的影响。方法生物信息学网站预测circ_0084927/miR-623/EZH2调控轴并借助双荧光素酶报告试验进行验证。BC细胞与CD8+T细胞共培养,... 详细信息

目的探讨circ_0084927作为分子海绵吸附miR-623靶向调控EZH2基因对乳腺癌(breast cancer,BC)细胞免疫逃逸的影响。方法生物信息学网站预测circ_0084927/miR-623/EZH2调控轴并借助双荧光素酶报告试验进行验证。BC细胞与CD8+T细胞共培养,流式细胞术检测探测T细胞的凋亡情况和在共转染的微环境下的占比。结果与癌旁组织相比,BC患者组织样本中EZH2和circ_0084927的表达明显上调,而miR-623的表达减弱(P<0.05)。circ_0084927能作为BC的一个有效诊断指标(AUC=0.8138,P<0.0001)。与si-NC组的CD8+T细胞凋亡率(34.17±3.06)和细胞占比(26.55±2.83)比较,circ_0084927的抑制会造成CD8+T细胞凋亡率的下降(22.37±2.05),CD8+T细胞在共转染环境中的占比增高(31.88±3.03),但该效果可被过表达EZH2部分挽救。miR-623抑制CD8+T细胞凋亡,过表达circ_0084927减弱miR-623对免疫逃逸的抑制作用(均P<0.05)。结论circ_0084927调控miR-623/EZH2轴促进BC细胞免疫逃逸,提示靶向circ_0084927可能是提高BC免疫治疗疗效的一种潜在途径。

关键词： circ_0084927 乳腺癌免疫逃逸

宗教即信仰的神学时代——巴特自由主义神学时期宗教思想探究

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基督教文化学刊 2019年第2期42卷 188-209页

作者：郑佳露中国人民大学哲学院

导言在卡尔·巴特对宗教的诸多神学批判中,最让人印象深刻的莫过于《教会教义学》(Kirchliche Dogmatik)第17章"上帝的启示即是对宗教的扬弃"(Gottes Offenbarung als Aufhebung der Religion)第二部分的标题“宗教即不信”(Religion is... 详细信息

导言在卡尔·巴特对宗教的诸多神学批判中,最让人印象深刻的莫过于《教会教义学》(Kirchliche Dogmatik)第17章"上帝的启示即是对宗教的扬弃"(Gottes Offenbarung als Aufhebung der Religion)第二部分的标题“宗教即不信”(Religion ist Unglaube)这一判断。

关键词：自由主义神学上帝的启示教义学思想探究卡尔·巴特神学批判