检索结果-南通市图书馆

N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers: Design,structure–activity relationships and biological evaluations

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第2期36卷 256-261页

作者： Jian song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang School of Basic Medical Sciences Zhengzhou University Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital Zhengzhou Children's Hospital School of Pharmaceutical Sciences Institute of Drug Discovery & Development Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education) Zhengzhou University State Key Laboratory of Esophageal Cancer Prevention & Treatment

In this work,we employed a ring-opening strategy to develop a series of novel N-benzyl arylamide derivatives as tubulin polymerization ***,13n （MY-1388） exhibited remarkable antiproliferative potency on fifteen human cancer cell lines,with half maximal inhibitory concentration (IC50)values ranging from 8 nmol/L to 48 nmol/***,13n effectively suppressed tubulin polymerization by targeting the colchicine-binding site (IC50=0.62μmol/L).13n also exhibited significant inhibition of cell colony formation,as well as displayed potent effects on inducing G2/M phase cell cycle arrest and promoting ***,13n exhibited enhanced and adequate liver microsomal stability in human and rat liver microsomes,and also exhibited a moderate half-life (T1/2=0.938 h) in ***,13n demonstrated effective antitumor effects in vivo in suppressing tumor growth in the MGC-803xenograft model (tumor growth inhibition （TGI） value was 76.4%at the dosage of 30 mg kg-1day-1)with a good safety ***,these results revealed that 13n represents a promising tubulin polymerization inhibitor that deserves further investigation for its efficacy in treating gastric cancers.

关键词： Antiproliferative activities CA-4 Colchicine binding site N-Benzyl arylamide Tubulin

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge song Chuanbin Yang Yali song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care HospitalDongguan 523000China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s HospitalSouthern University of Science and TechnologyShenzhen 518020China State Key Laboratory for Quality Ensurance andSustainable Use of Dao-di Herbs Artemisinin Research CenterandInstitute of Chinese Materia MedicaChina Academyof Chinese Medical SciencesBeijing 100700China State Key Laboratory of Antiviral Drugs School of PharmacyHenan UniversityKaifeng 475004China Reproductive Medicine Center Foshan Women and Children HospitalFoshan 528000China

Ovarian endometrioma(OE),also known as“chocolate cysts,”is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus,leading to symptoms such as dysmenorrhea,pelvic pain,and ***,the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown,posing challenges for diagnosis and ***,we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell *** identified notable alterations in cell type-specific proportions and molecular signatures associated with ***,the activation of IGFBP5^(+) macrophages with pro-inflammatory properties,NK cell exhaustion,and aberrant proliferation of IQCG^(+) and KLF2^(+) epithelium are key features and may be the potential mechanisms underlying the pathogenesis of ***,our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

Optimizing hardware-software co-design based on non-ideality in memristor crossbars for in-memory computing

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年第2期68卷 354-369页

作者： Pinfeng JIANG Danzhe song Menghua HUANG Fan YANG Letian WANG Pan LIU Xiangshui MIAO Xingsheng WANG School of Integrated Circuits Huazhong University of Science and Technology Hubei Yangtze Memory Labs

The memristor crossbar, with its exceptionally high storage density and parallelism, enables efficient vector matrix multiplication(VMM), significantly improving data throughput and computational efficiency. However, its analog computing is vulnerable to issues like IR-drop, device-to-device(D2D) variation, and stuck-at-fault(SAF), leading to a substantial decrease in the inference accuracy of neural networks deployed on crossbars. This work presents a hardware-software co-design approach tailored to deal with memristor crossbar non-ideality. We introduce an end-to-end functional array simulator(FAST) for precise and ultra fast end-to-end training, mapping, and evaluation of neural networks on the memristor crossbar. Utilizing the sparsity of the memristor crossbar coefficient matrix, it achieves simulation with low storage and computational resource requirements,dynamically selecting the optimal solution to complete the process. It can also precisely simulate the impact of non-ideal effects such as IR-drop, retention, variation, SAF, and AD/DA precision. Using FAST, we assess memristor crossbar matrix operations under non-ideal conditions, identifying the max throughput and the most energy-efficient crossbar configurations. Additionally,we propose a comparator-based activation function modulation(CAFM) scheme and its corresponding hardware architecture with programmable activation function circuits to address the IR-drop issue, enabling low power and area overheads, resulting in the recovery of neural network accuracy by 54% or more. This is validated within FAST, demonstrating the success of our hardware-software optimization co-design.

关键词： memristor crossbar IR-drop neural network activation function hardware-software co-design

同方期刊数据库

CO_(2)-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan Li Andrew Li Qikun Hu Siyao song Bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Ordos Laboratory Inner Mongolia 017000China

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO_(2)emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO_(2)using alkaline solutions with reactive *** this work,we present a CO_(2)-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm^(2)electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

Galileo multi-day precise orbit determination using L-band and SLR data

在线全文

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2025年第1期16卷 99-110页

作者： Tianhe Xu Honglei Yang song Li Zhenlong Fang Wenfeng Nie Min Li Baoguo Yu Shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space Sciences Shandong University Navigation Laboratory of the 54th Research Institute of China Electronics Technology Group Corporation

The continuously available satellites of European Galileo currently reach more than 25. To explore the rationality and reliability of the L-band and satellite laser ranging(SLR) data processing strategies, we design the Galileo L-band, the SLR-only, and the combined L-band/SLR dynamic precise orbit determination(POD) strategies by using the normal equations(NEQs) stacking, and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023, based on the Bei Dou/GNSS analysis center platform of Shandong University by using the modified Bernese GNSS Software Version 5.4. The orbital consistency of the L-band 1-day solution is the best with the Three-dimensional Root-Mean-Square(3D-RMS) values of 3.6 cm compared with the Center for Orbit Determination in Europe Multi-GNSS Experiment(COM) orbits, the corresponding values is 1.4 cm, 2.5 cm, and 2.3 cm in Radial, the Tangential, and the Normal(RTN) direction, respectively. While the SLR-only 9-day arc length is optimal with the RTN values of 5.3 cm, 30 cm, and 38.2 cm,as well as the 3D-RMS values of 48.9 cm. Encouragingly, the difference of the orbital accuracy between the combined L-band/SLR multi-day solution and the COM orbits is reduced by 0.5 cm and 0.9 cm, 0.6 cm and 1.2 cm in T-, and N-direction for the 3-and 5-day solution respectively. The corresponding values improve 0.7 cm and 0.9 cm, 1.4 cm and 1.8 cm for the 3-and 5-day orbital overlaps difference between the combined L-band/SLR and the L-band solution. Take the E09 satellite as a case study, the SLR-only orbital accuracy is regularly optimized as the multi-day arc lengthens and with the sites ***, the SLR residuals of its three types of orbits further demonstrate the positive contribution of SLR to the combination of the GNSS and SLR techniques.

关键词： Galileo POD SLR L-band NEQs stacking

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

二乙苯脱氢制二乙烯基苯反应宏观动力学

精细石油化工 2022年第4期39卷 47-51页

作者：樊佳伟李瑞江朱学栋徐维辰宋佳琳华东理工大学大型工业反应器工程教育部工程研究中心上海200237

在等温积分反应器中,采用GS脱氢催化剂,研究了二乙苯脱氢反应宏观动力学。建立了二乙苯脱氢反应网络,根据不同反应机理,提出了4种二乙苯脱氢反应模型:L-H模型、Carra模型、经验模型、幂函数模型。通过模型筛选和统计学检验结果表明:L-H... 详细信息

在等温积分反应器中,采用GS脱氢催化剂,研究了二乙苯脱氢反应宏观动力学。建立了二乙苯脱氢反应网络,根据不同反应机理,提出了4种二乙苯脱氢反应模型:L-H模型、Carra模型、经验模型、幂函数模型。通过模型筛选和统计学检验结果表明:L-H模型中各关键组分的ρ^(2)均大于0.9,F检验值大于10倍F_(0.05),最终确定L-H模型为二乙苯脱氢反应最佳动力学模型。

关键词：二乙烯基苯二乙苯脱氢反应动力学

Insight into the activation of peroxymonosulfate by N-doped copper-based carbon for efficient degradation of organic pollutants:Synergy of nonradicals

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第1期36卷 513-520页

作者： Mengmeng Ao Jian Wei Chuan-Shu He Heng Zhang Zhaokun Xiong Yonghui song Bo Lai College of Environmental Sciences Liaoning UniversityShenyang 110036China State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

The contamination of water resources by phenolic compounds(PCs)presents a significant environmental hazard,necessitating the development of novel materials and methodologies for effective *** this study,a metallic copper-doped zeolitic imidazolate framework was pyrolyzed and designated as CuNC-20 for the activation of peroxymonosulfate(PMS)to degrade phenol(PE).Cu-NC-20 could effectively address the issue of metal agglomeration while simultaneously diminishing copper dissolution during the activation of PMS *** Cu-NC-20 catalyst exhibited a rapid degradation rate for PE across a broad pH range(3-9)and demonstrated high tolerance towards coexisting *** to scavenger experiments and electron paramagnetic resonance analysis,singlet oxygen(^(1)O_(2))and high-valent copperoxo(Cu(Ⅲ))were the predominant reactive oxygen species,indicating that the system was nonradicaldominated during the degradation *** quantitative structure-activity relationship(QSAR)between the oxidation rate constants of various substituted phenols and Hammett constants was *** indicated that the Cu-NC-20/PMS system had the optimal oxidation rate constant withσ^(-)correlation and exhibited a typical electrophilic reaction *** study provides a comprehensive understanding of the heterogeneous activation process for the selective removal of phenolic compounds.

关键词： N-doped copper-based carbon Phenolic compounds Peroxymonosulfate Nonradical pathway Quantitative structure-activity relationship(QSAR)

All-optical neuromorphic devices: materials, working mechanism,and applications

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： song Wang Hao Chen Hui Huang College of Materials Science and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering CAS Center for Excellence in Topological Quantum Computation CAS Key Laboratory of Vacuum Physics University of Chinese Academy of Sciences College of Chemistry and Molecular Engineering Peking University

Traditional von Neumann computing, with physical separation of memory and processing units, cannot satisfy the development of artificial intelligence and cloud computing. Neuromorphic computing, inspired by the human brain, has drawn much ***-optical neuromorphic (AON) devices employ optical signals as information carriers and leverage the neuromorphic functions to implement fast operation speed, low energy consumption, and high bandwidth of neuromorphic computing. Here, we discuss the recent progress in AON devices, including materials, device performance, working mechanisms, and applications. Moreover,the advantages and limitations of AON are presented and discussed. Finally, the perspective of AON devices points out the future research direction of neuromorphic computing.

关键词：

A High-Order Numerical Method Based on Legendre Polynomial Approximation for Fourth-Order Eigenvalue Problem in Cylinder Domain

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Mathematical Research with Applications 2025年第2期 195-219页

作者： Jun ZHANG Jihui ZHENG Fangying song Computational Mathematics Research Center Guizhou University of Finance and Economics School of Mathematical Sciences Guizhou Normal University School of Mathematics and Stastistics Fuzhou University

In this work, an efficient spectral method is proposed to solve the fourth-order eigenvalue problem in cylinder domain. Firstly, the key point of this method is to decompose the original model into a kind of decoupled two-dimensional eigenvalue problem by cylindrical coordinate transformation and Fourier series expansion, and deduce the crucial essential pole conditions. Secondly, we define a kind of weighted Sobolev spaces, and establish a suitable variational formula and its discrete form for each two-dimensional eigenvalue problem. Furthermore, we derive the equivalent operator formulas and obtain some prior error estimates of spectral theory of compact operators. More importantly, we further obtained error estimates for approximating eigenvalues and eigenfunctions by using two newly constructed projection operators. Finally,some numerical experiments are performed to validate our theoretical results and algorithm.

关键词：