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BIOCELL 2022年第6期46卷 1483-1491页

作者： YAO XU BIN WU JING YANG SHENG ZHANG LONGGEN LIU SUOBAO XU jiakai jiang Department of Intensive Care Unit Changzhou No.3 People’s HospitalChangzhou213000China Department of General Surgery Changzhou No.3 People’s HospitalChangzhou213000China Department of Gastroenterology Changzhou No.1 People’s HospitalChangzhou213000China Department of Liver Disease Changzhou No.3 People’s HospitalChangzhou213000China

To study the roles and association of murine double minute gene 2(MDM2)and fructose-1,6-biphosphatase(FBP1)in human hepatocellular carcinoma(HCC),growth response of human HCC cells was assessed using proliferation and apoptosis ***-survival AKT signaling associated proteins(p-AKT,survivin and cleaved caspase 3)were assessed using western *** correlation between MDM2 and FBP1 was assessed using coimmunoprecipitation combined with ubiquitination *** data suggested that low expression of FBP1 was correlated with high levels of MDM2 in HCC cell lines(Huh7 and Hep3B).Overexpression of FBP1 resulted in antiproliferation,pro-apoptosis,the up-regulation of cleaved caspase 3 while the downregulation of survivin and phosphor(p)-AKT,however,knockdown of FBP1 led to the ***,overexpression of MDM2 potently reversed FBP1-induced proliferation inhibition and apoptosis,while Nutlin-3(an MDM2 inhibitor)reversed the change trends induced by FBP1 knockdown in the aforementioned ***,but not least importantly,our data elucidated that MDM2 binds directly to FBP1 and promotes FBP1 *** conclusion,our data firstly suggested the involvement of FBP1 and its association with MDM2 in HCC cell ***2-FBP1-regulated HCC cell growth and the activation of AKT were mediated,at least in part,through FBP1 degradation.

关键词： Human hepatocellular carcinoma MDM2 FBP1 FBP1 ubiquitination

基于Excel进行机器人关节负载的校核计算

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现代制造技术与装备 2017年第3期53卷 40-42,44页

作者：江加凯林树军浙江钱江机器人有限公司温岭317500 钱江摩托股份有限公司温岭317500

基于Excel输入机器人各关节几何尺寸、重量、惯量等参数,设定机器人减速比、最大速度、最大加速度、运行动作,编制公式计算各轴重力矩、加速的惯性力矩,采用分段累计的方法,计算出各轴运行的平均负载和最大扭矩,以此校核各轴电机和减速... 详细信息

基于Excel输入机器人各关节几何尺寸、重量、惯量等参数,设定机器人减速比、最大速度、最大加速度、运行动作,编制公式计算各轴重力矩、加速的惯性力矩,采用分段累计的方法,计算出各轴运行的平均负载和最大扭矩,以此校核各轴电机和减速机的性能。

关键词： Excel 机器人负载

Methane hydrate crystal growth on shell substrate

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Chinese Journal of Chemical Engineering 2022年第3期35卷 50-61页

作者： Xin jiang Baojiang Sun Zhiyuan Wang Wantian Zhou jiakai Ji Litao Chen School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China Key Laboratory of Unconventional Oil and Gas Development China University of Petroleum(East China)Qingdao 266580China

Hydrate crystals growth on the surface of methane bubble(hydrate film)in pure water was studied by using a high-pressure visible microscope under the conditions of subcoolingΔT=5.44-13.72 K and methane concentration differenceΔC=2.92-8.19 mol·L^(-1).It was found the hydrate film is porous and the hydrate crystals grow towards the liquid phase on the film *** crystal morphology and growth rate are affected byΔT andΔ***ΔT8.82 K orΔC>4.12 mol·L^(-1),the hydrate crystals grow in dendritic shape,and the axial growth rate increases first and then *** perimeter and area of the growing hydrate crystals were measured,and the fractal dimension of hydrate crystal under differentΔC andΔT was *** results show that the fractal dimension of columnar hydrate crystal is greater than ***3.87 mol·L^(-1)4.77 mol·L^(-1),ΔT<8.52 K,the fractal dimension of dendritic hydrate crystal is less than 2.

关键词： Methane Hydrate Crystal growth Morphology Fractal dimension

哈拉哈塘油田塔河北区块奥陶系断裂发育特征及断控区储层类型与分布预测

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石油科学通报 2024年第3期9卷 408-421页

作者：陈利新王胜雷姜振学朱光有苏洲侯佳凯中国石油大学(北京)非常规油气科学技术研究院北京102249 中国石油塔里木油田分公司东河油气开发部库尔勒841000 中国石油勘探开发研究院北京100083

塔里木盆地哈拉哈塘油田奥陶系碳酸盐岩储层非均质性复杂,亟需开展评价预测研究。本文基于哈拉哈塘油田地质及地震资料,开展了碳酸盐岩缝洞储层归位、储层空间展布、储层与断裂的匹配关系、井间连通性研究。在此基础上,依据实钻、测录... 详细信息

塔里木盆地哈拉哈塘油田奥陶系碳酸盐岩储层非均质性复杂,亟需开展评价预测研究。本文基于哈拉哈塘油田地质及地震资料,开展了碳酸盐岩缝洞储层归位、储层空间展布、储层与断裂的匹配关系、井间连通性研究。在此基础上,依据实钻、测录井资料及生产动态分析,开展了断控区碳酸盐岩储层缝洞雕刻。研究结果表明:哈拉哈塘油田断裂系统发育包括加里东早-中时期、加里东晚期-海西早期、海西晚期、燕山期4个阶段;断裂走向和断裂发育的多期次性是断裂系统的通源性的主控因素;断块水平滑移的增大将使走滑断裂具有较好的连通性;断裂的平面扩溶宽度受断裂活动强度以及深部通源分支断层发育程度控制。此外,为明确潜山岩溶区、层间岩溶区、断控岩溶区碳酸盐岩储层的空间形态与分布特征,开展了针对性的储层预测,以反演成果为主,结合属性、沉积、钻井等资料,对储层进行多属性综合预测。预测结果显示,哈拉哈塘油田塔河北区块的潜山岩溶区断裂带的通源性、连通性及扩溶性整体较好,有利于大型溶蚀孔-缝-洞储集体的形成,储层平面展布呈连片特征,储层质量最优,是未来油气勘探开发的重点区域。研究认识揭示了哈拉哈塘油田塔河北区块奥陶系断裂发育特征及断控区有利储层的分布区域,以期为有效指导深层-超深层断控区碳酸盐岩油气勘探与开发工作提供依据。

关键词：奥陶系断裂系统碳酸盐岩储层预测哈拉哈塘油田

鬼针草提取物对PRRSV诱导炎症反应的抑制作用

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中国兽医杂志 2024年第6期60卷 117-123页

作者：李佳铠广倩张龙泽江雨蔓曹翀陈洪博邱龙新龙岩学院生命科学学院福建龙岩364012 福建农林大学动物科学学院(蜂学学院) 福建福州350002 预防兽医学与生物技术福建省高等学校重点实验室福建龙岩364012

为研究鬼针草提取物(BPE)对猪繁殖与呼吸综合征病毒(PRRSV)诱导炎症反应的抑制作用,以非洲绿猴胚胎肾细胞(Marc-145)为研究对象,将其分为4个不同浓度(100、200、400和800μg/mL)BPE处理组、空白对照组和病毒对照组,通过观察细胞病变(CPE... 详细信息

为研究鬼针草提取物(BPE)对猪繁殖与呼吸综合征病毒(PRRSV)诱导炎症反应的抑制作用,以非洲绿猴胚胎肾细胞(Marc-145)为研究对象,将其分为4个不同浓度(100、200、400和800μg/mL)BPE处理组、空白对照组和病毒对照组,通过观察细胞病变(CPE)和CCK-8法测定PRRSV感染后的细胞活力;实时荧光定量PCR(qPCR)检测BPE对PRRSV诱导Marc-145细胞IL-6、IL-8和TNF-α mRNA相对表达量的影响;将21日龄断奶仔猪分为空白组、病毒对照组、鬼针草高剂量组、中剂量组和低剂量组,空白组和病毒对照组饲喂基础日粮,给药组待仔猪出现临床症状后分别饲喂添加量为0.4%、0.8%和1.2%BPE的基础日粮,分别于第7、14、28天分离血清,使用ELISA试剂盒检测IL-6、IL-8和TNF-α含量,qPCR检测PRRSV载量,第28天剖检并采集肺脏进行组织病理学观察。结果显示,BPE可改善PRRSV诱导Marc-145细胞产生的病变,提高Marc-145细胞活力,有效降低PRRSV诱导的IL-6和TNF-α mRNA相对表达量;BPE能够降低攻毒仔猪血清中的炎症因子含量和PRRSV载量;肺脏组织病理学观察结果显示,病毒对照组仔猪的肺脏呈现典型的间质性肺炎,肺泡壁增厚,成纤维细胞增生,有大量炎性细胞浸润,肺中可见散在大小不一的出血灶,而各给药组仔猪肺脏的病理组织学变化有所改善。结果表明,BPE可通过抑制PRRSV诱导的炎症因子产生,降低PRRSV对仔猪肺脏的损伤。本试验结果可为鬼针草用于猪繁殖与呼吸综合征的临床治疗提供参考。

关键词：猪繁殖与呼吸综合征病毒鬼针草提取物炎症反应猪

Microstructure Characteristics of Super-Eutectic Zn-Al Alloy Plate Joints Welded by Pulse Fiber Laser

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Wuhan University Journal of Natural Sciences 2020年第1期25卷 52-58页

作者： TAO Junhui WANG jiakai jiang Kai DAI Wei LI Jie WU Tian School of Physics and Mechanical&Electronical Engineering Hubei University of EducationWuhan 430205HubeiChina School of Materials Science and Engineering Hubei UniversityWuhan 430062HubeiChina School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074HubeiChina

In this study, we present the experimental laser welding of super-eutectic Zn-Al(ZA) alloy. Microstructure characteristics of the ZA alloy’s bond area welded by pulsed laser were investigated using an optical microscope, scanning electron microscope, energy diffraction spectrum and X-Ray diffraction. The results showed that the microstructures in the weld mainly consisted of threadlike columnar crystals, coarse dendrites and fine equiaxed grains. Secondary particles were produced in the interdendritic zones due to the composition segregation. A poor Al area was formed in η grain inside while a rich Al area took shape outside the η grain. The occurrence of the composition segregation increased the grain boundary cracking tendency. The existence of a large number of η phases greatly increased the brittle of this material. The presence of many cleavage steps in the fractograph principally depended on the secondary cleavage effect between two cleavage cracks in different planes. The evolution of cracks along the twinning plane was the result of the secondary cleavage substituting for the twinning deformation in the vicinity of the crack tip.

关键词： ZA alloy laser welding microstructure composition segregation secondary cleavage effect

The Principle of Detect SO2 Concentration by Using the Electrochemical Method in Ionic Liquid

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Wuhan University Journal of Natural Sciences 2019年第5期24卷 400-404页

作者： HUANG Qing HU Yang WANG jiakai jiang Kai WU Tian College of Chemistry and Life Science Hubei University of Education Wuhan 430205 Hubei China Institute of Materials Research and Engineering(IMRE) Hubei University of Education Wuhan 430205 Hubei China College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 Hubei China School of Materials Science and Engineering Hubei University Wuhan 430062 Hubei China School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 HubeiChina

The reduction of SO2 with different concentrations at a platinum microelectrode was investigated by cyclic voltammetry(CV) in 1-(butyl)-3-methylimidazolium hexafluorophosphate([Bmim]PF6). We speculated that the reaction mechanism of reduction may form a macromolecular complex, and the higher the concentration of SO2, the larger the molecular weight of the complex. The higher the concentration of SO2, the greater the diffusion coefficient of SO2 in [Bmim]PF6. There is a good quadratic function relationship between the reduction peak current and SO2 concentrations in the range from 2% to 100%, which promises a kind of ionic liquid electrolyte for the detection of SO2 gas with a wide range of concentrations.

关键词： ionic liquids sulfur dioxide cyclic voltammetry chronoamperometric

Penile erectile dysfunction after brachial plexus root avulsion injury in rats

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Neural Regeneration Research 2014年第20期9卷 1839-1843页

作者： Guo Fu Bengang Qin Li jiang Xijun Huang Qinsen Lu Dechun Zhang Xiaolin Liu jiakai Zhu Jianwen Zheng Xuejia Li Liqiang Gu Department of Orthopedic Trauma & Microsurgery the First Affiliated Hospital of Sun Yat-sen University Orthopedic Institute Eastern Hospitalthe First Affiliated Hospital of Sun Yat-sen University Department of Upper Limb Orthopedics Eastern Hospitalthe First Affiliated Hospital of Sun Yat-sen University Emergency Department Shandong Provincial Hospital Department of Orthopedics the Affiliated Hospital of Binzhou Medical College Office of Research Service the First Affiliated Hospital of Sun Yat-sen University

Our previous studies have demonstrated that some male patients suffering from brachial plexus injury, particularly brachial plexus root avulsion, show erectile dysfunction to varying degrees. However, the underlying mechanism remains poorly understood. In this study, we evaluated the erectile function after establishing brachial plexus root avulsion models with or without spinal cord injury in rats. After these models were established, we administered apomorphine （via a sub- cutaneous injection in the neck） to observe changes in erectile function. Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation. Expression of neuronal nitric oxide synthase did not change in brachial plexus root avulsion rats. However, neuronal nitric oxide synthase expression was significantly decreased in brachial plexus root avulsion ＋ spinal cord injury rats. These findings suggest that a decrease in neuronal nitric oxide synthase expression in the penis may play a role in erectile dysfunction caused by the combi- nation of brachial plexus root avulsion and spinal cord injury.

关键词： nerve regeneration brachial plexus avulsion spinal cord injury peripheral nerve injury penis neuronal nitric oxide synthase erectile dysfunction rat model neural regeneration

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外径千分尺测量误差占比分析

光纤与电缆及其应用技术 2024年第1期 37-39,41页

作者：蒋春晨高铭晶田进鑫申娴方佳凯徐守华中天科技装备电缆有限公司江苏南通226010

为了确保导体电阻率测量准确性,对线缆产品使用性能作出判定,必须减小导体单丝外径测量误差。导体单丝外径千分尺测量误差主要由系统误差和随机误差组成。在千分尺标准要求误差许可内,对系统误差和人为误差的占比情况以及误差出现原因... 详细信息

为了确保导体电阻率测量准确性,对线缆产品使用性能作出判定,必须减小导体单丝外径测量误差。导体单丝外径千分尺测量误差主要由系统误差和随机误差组成。在千分尺标准要求误差许可内,对系统误差和人为误差的占比情况以及误差出现原因进行了试验研究。研究结果发现,测量误差围绕千分尺系统误差值上下波动,千分尺系统误差占比约72.5%,人为误差占比约27.5%;同时因检验人员测量能力不同,所获测量结果标准偏差存在明显差异。为提升导体单丝外径测量结果准确性,宜选用系统误差较小的外径千分尺,并根据标准要求适当加严误差要求。

关键词：外径千分尺测量误差系统误差人为误差测量不确定度

张拉整体机器人构型与运动控制研究现状及进展

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机器人外科学杂志（中英文） 2024年第2期5卷 130-137页

作者：曹心言李润源陈嘉郡李傢楷易江孙中波段晓琴吉林大学汽车工程学院吉林长春130021 吉林大学护理学院吉林长春130021 吉林大学机械与航空航天工程学院吉林长春130021 吉林大学第二医院康复医学科吉林长春130041 长春工业大学控制工程系吉林长春130021

研究发现张拉整体结构存在于细胞骨架、肌肉-骨骼系统等生物体,并将其原理广泛应用于建筑、雕塑、空间探测等工程结构中。张拉整体结构具有形态可调性、受力可控性、绳索抗拉性和结构轻质、结构自稳定等优势,因此在机器人领域极具应用... 详细信息

研究发现张拉整体结构存在于细胞骨架、肌肉-骨骼系统等生物体,并将其原理广泛应用于建筑、雕塑、空间探测等工程结构中。张拉整体结构具有形态可调性、受力可控性、绳索抗拉性和结构轻质、结构自稳定等优势,因此在机器人领域极具应用前景。而软体机器人作为一种新型、仿生、能与人安全交互的机器人,近年来成为力学、材料学、医学、生物学等多学科交叉领域的研究热点之一。但是,要想实现灵活准确的运动、高效地承受外载、迅速地适应环境等复杂特性和功能,张拉整体机器人在其构型、运动步态及控制研究等方面依旧面临着巨大挑战。本研究选取张拉整体机器人的三大典型类别(棱柱形张拉整体机器人、球形张拉整体机器人及构型较复杂的张拉整体机器人),对其构型、运动步态及控制的国内外相关研究现状和发展趋势进行综述,旨在为机器人的仿生学研究提供科学依据。

关键词：张拉整体机器人结构形态运动控制

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