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Large deviation principle for a class of SPDE with locally monotone coefficients

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Science China Mathematics 2020年第6期63卷 1181-1202页

作者： Wei Liu Chunyan Tao jiahui zhu School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Zhejiang University of TechnologyHangzhou 310023China

This work aims to prove the large deviation principle for a class of stochastic partial differential equations with locally monotone coefficients under the extended variational framework, which generalizes many previous works. Using stochastic control and the weak convergence approach, we prove the Laplace principle,which is equivalent to the large deviation principle in our framework. Instead of assuming compactness of the embedding in the corresponding Gelfand triple or finite dimensional approximation of the diffusion coefficient in some existing works, we only assume some temporal regularity in the diffusion coefficient.

关键词： stochastic partial differential equation large deviation principle Laplace principle weak convergence approach locally monotone

Macroscopic electromagnetic synergy network-enhanced N-doped Ni/C gigahertz microwave absorber with regulable microtopography

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Nano Research 2023年第7期16卷 10666-10677页

作者： Yuelei Pan Qianqian zhu jiahui zhu Yuhang Cheng Bowen Yu Zirui Jia Guanglei Wu Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China

To achieve excellent electromagnetic wave(EMW)absorption properties,the microstructure design of the absorber is *** this work,six kinds of N-Ni/C nanostructures with different morphologies were prepared by one-step hydrothermal method and high temperature carbonization by adjusting the types of nickel salts and reaction *** EMW absorption performance of six different morphologies of N-Ni/C nanostructures was compared and *** them,it is found that the nanoflowerlike N-Ni/C composite has excellent dielectric loss and magnetic loss synergistic effect due to its polycrystalline structure,and can obtain excellent EMW absorption *** minimum reflection loss value at a thickness of 1.9 mm is-59.56 dB at 16.88 GHz,and the effective absorption bandwidth value reaches 6.0 GHz at a thickness of 2.2 *** research shows that different morphologies and multiple lattice structures of nanostructures with the same composition have a significant influence on EMW absorption performance,which provides new research ideas for developing high-performance EMW absorbing materials.

关键词： magnetic metal-carbon binary composition morphology control dielectric loss magnetic loss electromagnetic wave absorption

Nerve growth factor pretreatment against glutamate-induced hippocampal neuronal injury Action mechanism of phosphatase and tensin homologue deleted on chromosome 10

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Neural Regeneration Research 2010年第1期5卷 5-9页

作者： Yae Hu jiahui Mao Yan zhu Ailing Zhou Department of Pathophysiology Medical School of Nantong University Nantong 226001 Jiangsu Province China

BACKGROUND： Nerve growth factor （NGF） attenuates glutamate-induced injury to hippocampal neurons, and the human tumor suppressor gene phosphatase and tensin homologue deleted on chromosome 10 （PTEN） promotes neuronal apoptosis. However, effects of PTEN in NGF-mediated neuroprotection against glutamate excitotoxicity remain poorly understood. OBJECTIVE： To investigate the relationship between NGF inhibition of glutamate-induced injury and PTEN. DESIGN, TIME AND SE＇I＇rlNG： The randomized, controlled, in vitro study was performed at the Department of Pathophysiology, Medical School of Nantong University, China from October 2007 to March 2008. MATERIALS： Glutamate, NGF, 4, 6-diamidino-2-phenyl-indolediacetate, 3-[4, 5-dimethylthiazol-2-yl]- 2, 5-diphenyl tetrazoliumbromide （M-I-F）, and lactate dehydrogenase kit （Sigma, USA）, fluorescence microscope and inverted phase contrast microscope （Olympus, Japan） were used in this study. METHODS： Hippocampal neurons were obtained from newborn （〈 24 hours） Sprague Dawley rats and cultured for 7 days. The control group was not treated with any intervention factor, the glutamate group was treated with glutamate （0.2 mmol/L）, and NGF groups were treated with NGF （10, 50, 100, and 200 μg/L, respectively） prior to glutamate treatment. MAIN OUTCOME MEASURES： The MTT and lactate dehydrogenase assays were applied to evaluate viability of hippocampal neurons. Morphological changes in hippocampal neurons were observed using an inverted phase-contrast microscope, and neuronal apoptosis was detected by 4, 6-diamidino-2- phenyl-indolediacetate staining. PTEN mRNA and protein expression were measured by reverse transcription-polymerase chain reaction and Western blot analysis, respectively. RESULTS： Glutamate （0.2 mmol/L） induced significantly decreased neuronal viability and greater lactate dehydrogenase efflux compared with the control group （P 〈 0.01）. However, compared with the glutamate group, cell viability significantly increased and lac

关键词： nerve growth factor glutamate phosphatase and tensin homologue deleted on chromosome 10 hippocampus neurons nerve factor

Inimitable 3D pyrolytic branched hollow architecture with multi-scale conductive network for microwave absorption

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Journal of Materials Science & Technology 2024年第6期173卷 170-180页

作者： Jiajun Li Qianqian zhu jiahui zhu Yuhang Cheng Zirui Jia Feng Lu Chao Wang Guanglei Wu Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao266071China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao266071China Technical Center of Qingdao Customs Qingdao266002China

To solve the electromagnetic pollution problem,the reasonable structure design and component control of the electromagnetic absorber is *** this work,three-dimensional(3D)pyrolytic branched hollow architecture carbon PBHAC/MoS_(2)composites were prepared via a hydrothermal and calcination two-step *** narrow-gap nano-size MoS_(2)acquired after vulcanization and micro-size 3D branched carbon skeleton PBHAC possess intensified conduction ***,the presence of potential differences between different phases creates a space charge region at the heterogeneous interface,resulting in strong interfacial *** resulting 3D branched hollow PBHAC/MoS_(2)composites exhibit optimized impedance matching and multiple loss ***,the 3D branched hollow carbon PBHAC/MoS_(2)composites have the best electromagnetic wave(EMW)absorption *** minimum reflection loss(RLmin)is-57.8 dB at 1.93 mm and the maximum effective absorption bandwidth(EAB_(max))is 6.08 GHz at 2 mm,which indicates the excellent EMW absorption performance of the ***,this composite is expected to be a microwave absorber with the characteristics of“thin,light,wide,and strong”.

关键词： Dielectric loss MoS_(2) Impedance matching Schottky barrier Microwave absorption

Diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2’-pyrrolidin]-2-ones via tuneable Lewis base/Brønsted base-promoted(3+2)cycloadditions

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Organic Chemistry Frontiers 2022年第1期9卷 19-24页

作者： Ke Li Zhipeng Zhang jiahui zhu Yuxin Wang Jing Zhao Er-Qing Li Zheng Duana College of Chemistry Green Catalysis CenterInternational Phosphorus LaboratoryInternational Joint Research Laboratory for Functional Organophosphorus Materials of Henan ProvinceZhengzhou UniversityZhengzhou 450001P.R.China Xuchang Environmental Monitoring Center Henan ProvinceP.R.China

Herein we report a diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2’-pyrrolidin]-2-ones through base-promoted(3+2)***,the catalysts are found to have full control over the configuration of the *** a Lewis base(PCy3)is used as a catalyst,good yields and excellent diastereoselectivities are obtained,regardless of the properties of the substituents,whereas spiro[indoline-3,2’-pyrrolidin]-2-ones of a different diastereoisomer are produced in good yields when a Brønsted base(K_(2)CO_(3))is ***-MS experiments proved the existence of key zwitterionic intermediates.

关键词： base stereo substituted

Application of Organ-on-Chip in Drug Discovery

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Journal of Biosciences and Medicines 2020年第3期8卷 119-134页

作者： jiahui zhu School of Information & Electrical Engineering Zhejiang University City College Hangzhou China

Nowadays the pharmaceutical industry is facing long and expensive drug discovery processes. Current preclinical drug evaluation strategies that utilize oversimplified cell cultures and animal models cannot satisfy the growing demand for new and effective drugs. The microengineered biomimetic system, namely organ-on-chip (OOC), simulating both the biology and physiology of human organs, has shown greater advantages than traditional models in drug efficacy and safety evaluation. The microengineered co-culture models recapitulate the complex interactions between different types of cells in vivo. Organ-on-chip system has also avoided the substantial interspecies differences in key disease pathways and disease-induced changes in gene expression profiles between human and other animal models. Biomimetic microsystems representing different organs have been integrated into a single microdevice and linked by a microfluidic circulatory system in a physiologically relevant manner. In this review, I outline the current development of organ-on-chip, and their applications in drug discovery. This human-on-chip system can model the complex, dynamic process of drug absorption, distribution, metabolism and excretion, and more reliably evaluate drug efficacy and toxicity. I also discuss, for the next generation of organ-on-chip, more research is required to identify suitable materials that can be used to mass produce organs-on-chips at low cost, and to scale up the system to be suitable for high-throughput analysis and commercial applications. There are more aspects that need to be further studied, thereby bring a much better tool to patients, drug developers, and clinicians.

关键词： Organ-on-Chip Drug Discovery Microfluidic Platforms Automated Microengineered Models

Solvent-free nanocasting toward universal synthesis of ordered mesoporous transition metal sulfide@N-doped carbon composites for electrochemical applications

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Nano Research 2019年第9期12卷 2250-2258页

作者： jiahui zhu Zhi Chen Lin Jia Yuqi Lu Xiangru Wei Xiaoning Wang Winston Duo Wu Na Han Yanguang Li Zhangxiong Wu Suzhou Key Laboratory of Green Chemical Engineering School of Chemical and Environmental EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China

Transition metal sulfides (TMSs) have a wide range of applications owing to their intriguing *** efforts have been devoted to nanostructuring TMSs to enhance their properties and performance,still there is a high need in general synthesis of TMS ***,for the first time,a simple solvent free reactive nanocasting approach that integrates solid precursor loading,in-situ sulfuration and carbonization into a single heating step is developed for the universal synthesis of ordered mesoporous TMS@N-doped carbon composites (denoted as OM-TMS@NCs) with methionine (Met) and metal chlorides as the precursors and the mesoporous silica (SBA-15) as the hard template.A series of OM-TMS@NCs with a hexagonal mesostructure,ultra-high surface areas (430-754 m2·g-1),large pore volumes (0.85-1.32 cm3·g-1),and unique TMS stoichiometries,including MoS2,Fe7S8,Co9S8,NiS,Cu7S4 and ZnS,are *** distinct structure configurations,namely,highly dispersed ultrathin TMS nanosheets within NCs and TMS@NC co-nanowire arrays,can be obtained depending on different *** structure evolution of the OM-TMS@NCs over the solvent-free nanocasting process is studied in detail for a deep understanding of the *** demonstrations,these materials are promising for electrocatalytic hydrogen evolution reaction and lithium ion storage with high performances.

关键词： transition metal sulfides mesoporous materials solvent-free nanocasting in-situ sulfuration carbon-based composites electrochemical applicati ons

Safety and efficacy of vibrating capsule in the treatment of functional constipation:a single center randomized controlled study

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China Medical Abstracts(Internal Medicine) 2022年第1期39卷 42-43页

作者： zhu jiahui Dept Gastroenterol Changhai HospNaval Med UnivShanghai 200433

Objective Based on the previous animal experiments,to preliminarily explore the safety and efficacy of self-developed new smartphone-controlled vibrating capsule(VC)in the treatment of patients with functional constipation(FC).Methods At the Outpatient Department of Gastroenterology,Changhai Hospital,Naval Medical University,24 patients with FC were prospectively enrolled.

关键词： capsule vibrating constipation

转子偏心对凸极同步发电机主保护不平衡电流的影响

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电力系统自动化 2009年第7期33卷 57-60,85页

作者：诸嘉慧邱阿瑞中国电力科学研究院北京市100192 清华大学电机系电力系统国家重点实验室北京市100084

为了分析转子偏心对大型凸极同步发电机主保护不平衡电流的影响,提出了以"电磁场—多回路结合法"进行研究的思路,该分析方法将大型凸极同步发电机转子偏心问题分解成体现发电机外部特性的电压方程求解与体现内部特性的电磁参数计算的2... 详细信息

为了分析转子偏心对大型凸极同步发电机主保护不平衡电流的影响,提出了以"电磁场—多回路结合法"进行研究的思路,该分析方法将大型凸极同步发电机转子偏心问题分解成体现发电机外部特性的电压方程求解与体现内部特性的电磁参数计算的2个问题。建立了转子偏心凸极同步发电机的多回路数学模型,并采用电磁场有限元法计算了转子偏心下的电磁参数。在一台12极、3kW转子偏心的凸极同步发电机实验样机上进行了空载和带三相电阻负载实验,将实验结果与仿真结果进行对比,结果验证了数学模型和数值解法的正确性。

关键词：大型凸极同步发电机转子偏心多回路模型有限元法不平衡电流