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A discovery of two slow pulsars with FAST:“Ronin”from the globular cluster M15

Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 166-180页

作者： Dengke Zhou Pei Wang Di Li Jianhua Fang Chenchen Miao Paulo CCFreire Lei Zhang Dandan Zhang Huaxi Chen Yi Feng Yifan Xiao Jintao Xie Xu Zhang Chenwu Jin Han Wang Yinan Ke Xuerong Guo Rushuang Zhao Chenhui Niu Weiwei Zhu Mengyao Xue Yabiao Wang jiafu wu Zhenye Gan Zhongyi Sun Chengjie Wang Jie Zhang Junshuo Zhang Jinhuang Cao Wanjin Lu Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China University of Chinese Academy of Sciences Beijing 100049China New Cornerstone Science Laboratory Shenzhen 518054China Max Planck Institut f¨ur Radioastronomie Bonn 53121Germany Centre for Astrophysics and Supercomputing Swinburne University of TechnologyHawthorn 3122Australia School of Mathematical Sciences School of Physics and Electronic SciencesGuizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guiyang 550001China School of Physics and Electronic Engineering Qilu Normal UniversityJinan 250200China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China College of Physical Science and Technology Central China Normal UniversityWuhan 430079China Tencent Youtu Lab Shanghai 201103China

Globular clusters harbor numerous millisecond pulsars,but long-period pulsars(P 100 ms)are rarely *** this study,we employed a fast folding algorithm to analyze observational data from multiple globular clusters obtained by the Five-hundredmeter Aperture Spherical radio Telescope(FAST),aiming to detect the existence of long-period *** estimated the impact of the median filtering algorithm in eliminating red noise on the minimum detectable flux density(S_(min))of ***,we successfully discovered two isolated long-period pulsars in M15 with periods approximately equal to 1.928451 and3.960716 s,*** the P-˙P diagram,both pulsars are positioned below the spin-up line,suggesting a possible history of partial recycling in X-ray binary systems disrupted by dynamical encounters later *** to timing results,these two pulsars exhibit remarkably strong magnetic *** the magnetic fields were weakened during the accretion process,then a short duration of accretion might explain the strong magnetic fields of these pulsars.

关键词： pulsar globular cluster FAST

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Permeable and robust polymer-silica hybrid armor on cell catalyst for sustainable biomanufacturing

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Particuology 2024年第9期92卷 106-112页

作者： Yiran Cheng Zhenhua wu Boyu Zhang Jiaxu Zhang jiafu Shi Zhongyi Jiang School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China

Inactivated cell catalysis is one of several central techniques in green biomanufacturing ***,the instability and leakage of enzymes in inactivated cell severely restrict the practical applications of inactivated cell *** armor on the surface of inactivated cells affords a feasible and effective strategy to enhance the stability of cells while commonly lowering the ***,polymer-silica hybrid armor(PSHA)is directly generated on the surface of enzyme-containing *** branched structure of PEI enables higher porosity of cell@PSHA,exhibiting 1.52-fold enhancement in substrate permeability by contrast with cell@silica armor(SA).The electrostatic interactions(NH_(3)^(+)with O^(−))and hydrogen bonding(N⋯H or O⋯H)interactions between structural units enables higher stability of cell@PSHA,showing 3.13-fold elevation in Young's modulus compared with cell@*** a result,the cell@PSHA can catalyze continuous conversion of starch to tagatose for 15 batches over 969 h,with an average yield of 77.76 g L^(−1).

关键词： Biomanufacturing Wholecell catalysis Polymer-silica hybrid armor Tagatose production Starch conversion

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校企联合单片机专项训练提升职业能力的探索与实践——以贵阳学院机械工程学院为例

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天津科技 2024年第6期51卷 64-67页

作者：吴家福刘征宏胡浩郑俊强徐玉梁贵阳学院机械工程学院贵州贵阳550005

为缩短理论知识与工程应用的距离、提高学生技能与知识综合应用能力,从课程与工程应用之间的差距出发,开展校企联合实践训练方面的研究。分析单片机应用能力与职业能力的关系,探索校企联合单片机专项训练的组织实施途径,讨论单片机专项... 详细信息

为缩短理论知识与工程应用的距离、提高学生技能与知识综合应用能力,从课程与工程应用之间的差距出发,开展校企联合实践训练方面的研究。分析单片机应用能力与职业能力的关系,探索校企联合单片机专项训练的组织实施途径,讨论单片机专项训练对提升职业能力的促进作用,旨在探讨校企联合单片机专项训练对于提升学生职业能力的效果。

关键词：校企联合单片机专项训练职业能力

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Dendrimer-induced synthesis of porous organosilica capsules for enzyme encapsulation

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 41-48页

作者： Ziyi Chu Boyu Zhang Zhenhua wu Jiaxu Zhang Yiran Cheng Xueying Wang jiafu Shi Zhongyi Jiang School of Environmental Science&Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Organic matter-induced mineralization is a green and versatile method for synthesizing hybrid nanostructured materials,where the material properties are mainly influenced by the species of natural biomolecules,linear synthetic polymer,or small molecules,limiting their ***,we adopted dendrimer poly(amidoamine)(PAMAM)as the inducer to synthesize organosilica-PAMAM network(OSPN)capsules for mannose isomerase(MIase)encapsulation based on a hard-templating *** structure of OSPN capsules can be precisely regulated by adjusting the molecular weight and concentration of PAMAM,thereby demonstrating a substantial impact on the kinetic behavior of the MIase@OSPN *** MIase@OSPN system was used for catalytic production of mannose from Dfructose.A mannose yield of 22.24% was obtained,which is higher than that of MIase in organosilica network capsules and similar to that of the free *** overall catalytic efficiency(kcat/Km)of the MIase@OSPN system for the substrate D-fructose was up to 0.556 s^(-1)·mmol^(-1)·***,the MIase@OSPN system showed excellent stability and recyclability,maintaining more than 50% of the yield even after 12 cycles.

关键词： enzyme immobilization enzyme catalysis organosilica networks capsules sugar biosynthesis

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GIMAP7在肺腺癌组织中的表达及其临床意义的生物信息学研究

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浙江医学 2024年第13期46卷 1387-1390,I0006,I0007页

作者：李安安吴佳富牟泠葳张继琛王斌梁郑森中陈巍台州市第一人民医院心胸外科 318020 台州市第一人民医院呼吸与危重症医学科 318020 温州医科大学第一临床医学院

目的探讨免疫相关蛋白GTP酶7(GIMAP7)蛋白在肺腺癌组织中的表达情况及其临床意义。方法通过癌症基因组图谱(TCGA)数据库下载539例肺腺癌患者GIMAP7转录组数据及相关临床资料,根据GIMAP7表达水平分为高表达组270例和低表达组269例,比较... 详细信息

目的探讨免疫相关蛋白GTP酶7(GIMAP7)蛋白在肺腺癌组织中的表达情况及其临床意义。方法通过癌症基因组图谱(TCGA)数据库下载539例肺腺癌患者GIMAP7转录组数据及相关临床资料,根据GIMAP7表达水平分为高表达组270例和低表达组269例,比较两组患者总生存期、无进展间隔期。回顾性收集2021年6月至2022年6月在台州市第一人民医院行手术治疗并经病理检查确诊为肺腺癌20例患者的手术组织标本进行免疫组化染色,验证其GIMAP7表达水平。利用TIMER和ESTIMATES算法分析GIMAP7表达水平与免疫细胞浸润的关系,单基因富集分析(ssGSEA)法分析GIMAP7相关的信号通路。结果TCGA数据库转录组学分析显示GIMAP7在肺腺癌组织中呈低表达(P<0.05)。GIMAP7低表达组患者总生存期、无进展间隔期均短于高表达组(P<0.001、0.013)。20例肺腺癌组织样本免疫组化结果表明85.00%(17/20)的患者GIMAP7在肺腺癌组织中呈低表达。GIMAP7的表达水平与CD4^(+)T细胞、CD8^(+)T细胞、B细胞、树突状细胞、巨噬细胞、中性核细胞丰度及ESTIMATES评分均相关(均P<0.001)。ssGSEA结果显示,GIMAP7主要参与适应性免疫、白细胞介导的免疫反应和淋巴细胞介导的免疫、核小体组装等通路。结论GIMAP7在肺腺癌中呈显著低表达,GIMAP7的表达水平与免疫细胞浸润相关,其有望成为肺腺癌免疫治疗的新型生物标志物。

关键词：肺腺癌肿瘤微环境肿瘤免疫治疗免疫相关蛋白GTP酶7

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MRI-guided photothermal/photodynamic immune activation combined with PD-1 inhibitor for the multimodal combination therapy of melanoma and metastases

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Regenerative Biomaterials 2024年第4期3卷 38-51页

作者： Changqiang wu Wei Chen Shuang Yan Jie Zhong Liang Du Chenwu Yang Yu Pu Yang Li jiafu Lin Mei Zeng Xiaoming Zhang Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging North Sichuan Medical CollegeNanchong 637000P.R.China Department of Radiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000P.R.China Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsSchool of PharmacyChengdu UniversityChengdu 610106P.R.China Institute of Basic Medicine and Forensic Medicine North Sichuan Medical College and Institute of Rheumatology and ImmunologyThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000P.R.China

Non-invasive image-guided precise photothermal/photodynamic therapy(PTT/PDT)has been proven to be an effective local treatment modality but incompetent against ***,the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor ***,a magnetic resonance imaging(MRI)-visualized PTT/PDT agent(SIDP NMs)was constructed,and the efficacy of its multimodal combination with a programmed cell death 1(PD-1)inhibitor in the treatment of melanoma and metastases was *** to the hydrophobic encapsulation of indocyanine green within the micellar core,SIDP NMs exhibited excellent photothermal/photodynamic properties and stability under an 808 nm near-infrared *** vitro cell experiments showed that SIDP NMs had a good killing *** incubating with B16-F10 cells for 24 h and irradiating with an 808-nm laser for 10 min,cell viability decreased *** resonance imaging experiments in melanoma-bearing mice have shown that the dynamic distribution of SIDP NMs in tumor tissue could be monitored by T2WI and T2-MAP non-invasively due to the presence of superparamagnetic iron oxide nanocrystal in SIDP *** the 808 nm laser was irradiated at the maximum focusing time point shown by MRI,the temperature of the tumor area rapidly increased from 32℃to 60.7℃in 5 *** mouse melanoma ablation and distant tumor immunotherapy studies,SIDP NMs provided excellent MRI-guided PTT/PDT results and,when combined with PD-1 inhibitor,have great potential to cure primary tumors and eradicate metastases.

关键词： photothermal therapy photodynamic therapy immunotherapy magnetic resonance imaging multimodal treatment

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Tuning on passive interfacial cooling of covalent organic framework hydrogel for enhancing freshwater and electricity generation

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SusMat 2024年第5期4卷 139-153页

作者： Jianfei wu Ziwei Cui Yuxuan Su Dongfang wu Jundie Hu jiafu Qu Jianzhang Li Fangyuan Kang Dan Tian Qichun Zhang Yahui Cai Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjingChina School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhouChina State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry UniversityBeijingChina Department of Materials Science and Engineering Department of ChemistryCenter of Super-Diamond and Advanced Films&Hong Kong Institute of Clean EnergyCity University of Hong KongHong KongChina

Developing an efficient freshwater and electricity co-generation device(FECGD)can solve the shortage of freshwater and ***,the poor salt resistance and refrigeration properties of the materials for FECGD put big challenges in the efficient and stable operation of these *** address these issues,we propose the covalent organic framework(COF)confined co-polymerization strategy to prepare COF-modified acrylamide cationic hydrogels(ACH-COF),where hydrogen bonding interlocking between negatively charged polymer chains and COF pores can form a salt resistant hydrogel for stabilizing tunable passive interfacial cooling(TPIC).The FECPDs based on the TPIC and salt resistance of ACH-COF display a maximum output power density of 2.28 W m-2,which is 4.3 times higher than that of a commercial thermoelec-tric generator under one solar *** production rate of freshwater can reach 2.74 kg m-2 *** results suggest that the high efficiency and scala-bility of the FECGD can hold the promise of alleviating freshwater and power shortages.

关键词： COF confined co-polymerization environmental sensing freshwater and electricity co-generation passive interfacial cooling salt resistance

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轧钢机耐磨导板的磨损试验研究

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热加工工艺 2016年第18期45卷 109-111页

作者：吴家福贵阳学院机械工程学院贵州贵阳550005

采用等离子体渗氮技术对导板进行了氮化处理,研究了材料渗氮前后的组织,通过耐磨试验研究了渗氮前后试样的耐磨性。结果表明,离子渗氮处理可极大提高导板的耐磨性,580℃渗氮时,该导板材料耐磨性最优,组织中的石墨片层最细。

关键词：导板组织耐磨性

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ON THE VALENCE STATE OF COPPER IN HIGH T_c SUPERCONDUCTOR YBa_2Cu_3O_x

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Journal of Rare Earths 1990年第1期8卷 26-30页

作者： Song Zengfu Wang jiafu Lei Zimin wu Jinguang Xu Guangxian(Department of Chemistry,Department of Physics,Peking University,Beijing 100871,P.R.China)

Various optical luminescence spectroscopic techniques were used to characterize the high T_c superconductor YBa_2Cu_3O_*** emission bands reveal that Cu^(3+) coexist with Cu^(2+) and Cu^+ in this material.

关键词： YBCO ON THE VALENCE STATE OF COPPER IN HIGH Tc SUPERCONDUCTOR YBa2Cu3Ox Cu

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Genomic characterization of peritoneal lavage cytology-positive gastric cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 66-77页

作者： Zhouqiao wu Tingfei Gu Changxian Xiong Jinyao Shi Jingpu Wang Ting Guo Xiaofang Xing Fei Pang Ning He Rulin Miao Fei Shan Yuan Zhou Ziyu Li jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China Department of Biomedical Informatics Department of Physiology and PathophysiologyCenter for Noncoding RNA MedicineMOE Key Lab of Cardiovascular SciencesSchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Positive peritoneal lavege cytology(CY1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of CY1and there is a continuous debate on CY1 therapy. Therefore, exploring the mechanism of CY1 is crucial for treatment strategies and targets for CY1 gastric ***: In order to figure out specific driver genes and marker genes of CY1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of CY1, 17 cytology-positive gastric cancer patients and 31matched cytology-negative gastric cancer patients were enrolled in this study. The enrollment criteria were based on the results of diagnostic laparoscopy staging and cytology inspection of exfoliated cells. Whole exome sequencing was then performed on tumor samples to evaluate genomic characterization of cytology-positive gastric ***: Least absolute shrinkage and selection operator(LASSO) algorithm identified 43 cytology-positive marker genes, while Mut Sig CV identified 42 cytology-positive specific driver genes. CD3G and CDKL2 were both driver and marker genes of CY1. Regarding mutational signatures, driver gene mutation and tumor subclone architecture, no significant differences were observed between CY1 and negative peritoneal lavege cytology(CY0).Conclusions: There might not be distinct differences between CY1 and CY0, and CY1 might represent the progression of CY0 gastric cancer rather than constituting an independent subtype. This genomic analysis will thus provide key molecular insights into CY1, which may have a direct effect on treatment recommendations for CY1and CY0 patients, and provides opportunities for genome-guided clinical trials and drug development.

关键词： Cytology gastric carcinoma peritoneal metastasis whole exome sequencing

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