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Tremella polysaccharide mitigates high fat diet-induced anxiety-like behavior through the microbiota-gut-brain axis

Food Science and Human Wellness 2024年

作者： Haicui Wu Shuyu Chen Wenxiu Zhang Yuqing Lu Jiayi Zheng Jinhui Chang jiachi chiou Research Institute for Future Food， The Hong Kong Polytechnic University Shenzhen Key Lab for Food Biological Safety Control， The Hong Kong Polytechnic University Shenzhen Research Institute Bo InnoHealth Biotechnology Company Limited， Hong Kong Science Park Department of Food Science and Nutrition， The Hong Kong Polytechnic University Department of Neurology， The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

High-fat diet (HFD) consumption induces gut microbiota dysbiosis and neuropsychiatric disorders， including anxiety. Previous research found that Tremella polysaccharide (TP) exhibited neuroprotective effects in vitro and in vivo. This study aimed to investigate the beneficial effects of TP on HFD-induced anxiety-like behaviors and elucidate the underlying mechanisms from the point view of the microbiota-gut-brain axis. Two groups of HFD-induced obese mice were orally gavaged with low dose (TPL， 40 mg/kg) and high dose (TPH， 400 mg/kg) of TP. A 12-week administration of TPH could significantly improve anxiety-like behaviors in HFD mice. In the hippocampus， microglia activation， the expression of blood-brain barrier (BBB) markers， and the levels of two neurotransmitters (serotonin and norepinephrine) were countered by TPH in mice consuming HFD. Furthermore， TPH improved the intestinal permeability and immune response of the enterocytes in HFD-fed mice. The gut microbiota dysbiosis induced by HFD was also rebalanced by TP treatments， especially in Proteobacteria and its lower taxa. The correlational analysis also suggested that shifts of some microbial genera were closely associated with body weight and the parameters of behavioral tests. Interestingly， fecal microbiota transplantation (FMT) results indicated that fecal microbiota from TPH-treated obese mice could prevent HFD-induced anxiety-like behaviors， suppressing microglia activation and intestinal permeability. In conclusion， the present study indicated that TP intake is a promising dietary intervention strategy to prevent HFD-induced anxiety via the microbiota-gut-brain axis.

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Rapid testing methods for food contaminants and toxicants

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Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： jiachi chiou Arthur Ho Hon Leung Hang Wai Lee Wing-tak Wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

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Cu-catalyzed regioselective diborylation of 1,3-enynes for the efficient synthesis of 1,4-diborylated allenes

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Chinese Chemical Letters 2024年第5期35卷 141-144页

作者： Wujun Jian Mong-Feng chiou Yajun Li Hongli Bao Song Yang National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China Strait Institute of Flexible Electronics(SIFE Future Technologies)Fujian Normal UniversityFuzhou 350117China Key Laboratory of Coal to Ethylene Glycol and Its Related Technology State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterUniversity of Chinese Academy of SciencesFuzhou 350002China

Borylation of 1,3-enynes with bis(boronate)compounds often ends up with the formation of hydroborylated products,leaving the diborylation of 1,3-enynes for the formation of 1,4-diborylated allenes to be ***,a copper-catalyzed chemo-,regio-,and stereo-selective diborylation of 1,3-enynes for the efficient construction of 1,4-diborylated allenes under base-free conditions was reported.A wide range of 1,3-enynes bearing various functional groups can participant in the reaction and afforded the corresponding 1,4-diborylated allenes in good to excellent yields,which was enabled by the protocol of Bpin to BF3K *** borylcopper species was supposed to selectively attack the C-C triple bond of the 1,3-enynes.

关键词： Copper catalysis Regioselective 1,3-Enynes Borylation Allenes

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Effects of flavone on the oxidation-induced injury of retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 99-103页

作者： George C Y chiou Institute of Ocular Pharmacology College of MedicineTexas A&M Health Science CenterCollege StationTX 77843USA

AIMTo investigate the effect of flavone on oxidation-induced injury in retinal pigment epithelium cells.

关键词： flavone age-related macular degeneration retinal pigment epithelium oxidation

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Effect of flavone on the ocular blood flow and formation of choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 95-98页

作者： George C Y chiou Institute of Ocular Pharmacology College of MedicineTexas A&M Health Science CenterCollege StationTX 77843USA

AIMTo investigate the effect of flavone on ocular blood flow in rabbit eyes and the formation of choroidal neovascularization (CNV) in rat model of age-related macular degeneration (AMD).

关键词： flavone age-related macular degeneration ocular blood flow choroidal neovascularization

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Low-complexity multiplexer-based normal basis multiplier over GF（2^m）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 834-842页

作者： Jenn-Shyong HORNG I-Chang JOU chiou-Yng LEE Institute of Engineering Science and Technology National Kaohsiung First University of Science and Technology Department of Computer Information and Network Engineering Lunghwa University of Science and Technology

We present a new normal basis multiplication scheme using a multiplexer-based algorithm. In this algorithm, the proposed multiplier processes in parallel and has a multiplexer-based structure that uses MUX and XOR gates instead of AND and XOR gates. We show that our multiplier for type-1 and type-2 normal bases saves about 8% and 16%, respectively, in space complexity as compared to existing normal basis multipliers. Finally, the proposed architecture has regular and modular con-figurations and is well suited to VLSI implementations.

关键词： Finite field multiplication Normal basis Gaussian normal basis Elliptic curve cryptosystem

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Water solubility enhancements of pyrene by single and mixed surfactant solutions

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Journal of Environmental Sciences 2001年第4期13卷 491-496页

作者： Zhu, L.-z. chiou, C.T. Department of Environmental Science Zhejiang University Hangzhou 310028 China

Water solubility enhancements of pyrene by both single-surfactant and mixed-surfactant solutions were compared and evaluated. The solubility of pyrene in water was greatly enhanced by each of Triton X-100 (TX100), Triton X-405 (TX405), Brij 35 and SDS, in which the water solubility enhancements increased with increasing surfactant concentrations. The extent of solubility enhancements at surfactant concentrations below. the CMC is the order of TX100 > Brij 35 > TX405 > SDS; the sequence at surfactant concentrations above the CMC is TX100 > Brij 35 > SDS > TX405. Pyrene was solubilized synergistically by anionic-nonionic mixed surfactant solutions, especially at low surfactant concentrations. The synergistic power of the mixed surfactants is SDS-TX405 > SDS-Brij 35 > SDS-TX100. The synergism as noted is attributed to increasing Kmc and/or decreasing the CMC of the mixed surfactant solution. For SDS-TX405 and SDS-Brij 35 mixed surfactant solutions, an increase in Kmc is coupled with a decrease in the CMC; for SDS-TX100, only a decreased in the CMC value is noted. Mixed-surfactant solutions may improve the performance of the surfactant-enhanced remediation (SER) of soils by increasing the bioavailability and biodegradation of non-aqueous-phase organic pollutants and reducing the level of surfactant pollution and remediation expenses.

关键词： Biodegradation Concentration (process) Solubility Water

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Clinical proteomics identifies potential biomarkers in Helicobacter pylori for gastrointestinal diseases

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World Journal of Gastroenterology 2014年第6期20卷 1529-1536页

作者： Chun-Hao Huang Shyh-Horng chiou Quantitative Proteomics Center and Graduate Institute of Medicine Kaohsiung Medical University Institute of Biological Chemistry Academia Sinica

The development of gastrointestinal diseases has been found to be associated with Helicobacter pylori (H. pylori) infection and various biochemical stresses in stomach and intestine. These stresses, such as oxidative, osmotic and acid stresses, may bring about bi-directional effects on both hosts and H. pylori, leading to changes of protein expression in their proteomes. Therefore, proteins differentially expressed in H. pylori under various stresses not only reflect gastrointestinal environment but also provide useful biomarkers for disease diagnosis and prognosis. In this regard, proteomic technology is an ideal tool to identify potential biomarkers as it can systematically monitor proteins and protein variation on a large scale of cell’s translational landscape, permitting in-depth analyses of host and pathogen interactions. By performing two-dimensional polyacrylamide gel electrophoresis (2-DE) followed by liquid chromatography-nanoESI-mass spectrometry (nanoLC-MS/MS), we have successfully pinpointed alkylhydroperoxide reductase (AhpC), neutrophil-activating protein and non-heme iron-binding ferritin as three prospective biomarkers showing up-regulation in H. pylori under oxidative, osmotic and acid stresses, respectively. Further biochemical characterization reveals that various environmental stresses can induce protein structure change and functional conversion in the identified biomarkers. Especially salient is the antioxidant enzyme AhpC, an abundant antioxidant protein present in H. pylori. It switches from a peroxide reductase of low-molecular-weight (LMW) oligomers to a molecular chaperone of high-molecular-weight (HMW) complexes under oxidative stress. Different seropositivy responses against LMW or HMW AhpC in H. pylori-infected patients faithfully match the disease progression from disease-free healthy persons to patients with gastric ulcer and cancer. These results has established AhpC of H. pylori as a promising diagnostic marker for gastroin

关键词： Proteomics Biomarker Helicobacter pylori Gastritis Gastric ulcer Gastric cancer Alkylhydroperoxide reductase Neutrophil-activating protein Non-heme iron-binding ferritin

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Application of magnetic particles modified with amino groups to adsorb copper ions in aqueous solution

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Journal of Environmental Sciences 2011年第1期23卷 44-50页

作者： Yafen Lin Huawei Chen Kaelong Lin Boryann Chen Chyowsan chiou Department of Chemical and Materials Engineering 'National' l-Lan University I-Lan 260 Taiwan China Department of Cosmetic Application and Management St. Mary's Medicine Nursing and Management College l-Lan 260 Taiwan China Department of Environmental Engineering 'National' LLan University I-Lan 260 Taiwan China

A magnetic adsorbent can be easily recovered from treated water by magnetic force, without requiring further downstream treatment. In this research, amine-functionalized silica magnetite has been synthesized using N-[3-（trimethoxysilyl）propyl]-ethylenediamine （TPED） as a surface modification agent. The synthesized magnetic amine adsorbents were used to adsorb copper ions in an aqueous solution in a batch system, and the maximum adsorption was found to occur at pH 5.5± 0. 1. The adsorption equilibrium data fitted the Langmuir isotherm equation reasonably well, with a maximum adsorption capacity of 10.41 mg/g. A pseudo second-order model could best describe the adsorption kinetics, and the derived activation energy was 26.92 kJ/mol. The optimum condition to desorb Cu2＋ from NH2/SiO2/Fe304 was provided by a solution with 0.1 mol/L HNO3.

关键词： magnetic adsorbent SiO2 amine adsorb copper ion

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Data-Hiding Based on Sudoku and Generalized Exploiting Modification Direction

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Journal of Electronic Science and Technology 2018年第2期16卷 123-128页

作者： Jiin-chiou Cheng Wen-Chung Kuo Bo-Rong Su Department of Computer Science and Information Engineering Southern Taiwan University of Science and TechnologyTainan City 710 Department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin 64002

Division arithmetic and generalized exploiting modification direction （DA-GEMD） method has perfect efficiency in data-hiding. However, there exist some weaknesses in DA-GEMD. Because the benchmarks are their median of nine pixels in each block of cover-image, it will give a hint for the attacker to hack the stego-image. In the paper, we utilize the Sudoku table to randomize the benchmark for each 3×3 block of cover-image. It will mix up the pixels in each image block and prevent the secret information from being extracted. The proposed method still keeps the original efficiency as DA-GEMD while promoting the security for data-hiding.

关键词： Cover-image division arithmetic and generalized exploiting modification direction(DAGEMD) stego-image Sudoku

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