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HPLC法同时测定不同产地半夏中7种核苷类成分的含量

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临床合理用药杂志 2024年第8期17卷 33-36页

作者：彭加兵张凤范慢利樊宗兵王梦严安定安徽医科大学附属阜阳医院安徽省阜阳市236000

目的建立高效液相色谱(HPLC)法同时测定不同产地半夏中鸟苷、胸腺嘧啶核苷、肌苷、尿苷、腺嘌呤、腺苷、尿嘧啶7种核苷类成分含量的方法。方法采用C 18色谱柱(赛默飞,5μm,4.6 mm×250 mm);流动相为乙腈(A)-0.05%磷酸溶液(B),梯度洗脱;... 详细信息

目的建立高效液相色谱(HPLC)法同时测定不同产地半夏中鸟苷、胸腺嘧啶核苷、肌苷、尿苷、腺嘌呤、腺苷、尿嘧啶7种核苷类成分含量的方法。方法采用C 18色谱柱(赛默飞,5μm,4.6 mm×250 mm);流动相为乙腈(A)-0.05%磷酸溶液(B),梯度洗脱;流速1.0 ml/min;检测波长250 nm;柱温30℃;进样量10μl。结果半夏中7种核苷类成分的分离度较好,鸟苷、胸腺嘧啶核苷、肌苷、尿苷、腺嘌呤、腺苷、尿嘧啶的线性方程分别为Y鸟苷=11.851 X+3.5621、Y胸腺嘧啶核苷=9.422 X+0.1915、Y肌苷=11.619 X+2.8160、Y尿苷=11.818 X-1.4051、Y腺嘌呤=14.849 X+0.5109、Y腺苷=16.471 X+1.9063、Y尿嘧啶=14.758 X+5.5625;平均加样回收率分别为99.41%、98.70%、98.84%、98.37%、97.83%、98.84%、98.46%;鸟苷、胸腺嘧啶核苷、肌苷、尿苷、腺嘌呤、腺苷、尿嘧啶的线性范围分别在1.130~56.475、1.324~66.188、0.807~40.350、1.041~52.050、0.944~47.200、0.557~27.828、1.025~51.250μg/μl内,线性关系良好。结论建立的HPLC法同时测定不同产地半夏中7种核苷类成分含量测定方法较稳定、样品处理简单,可为半夏的质量控制提供研究方法。

关键词：半夏核苷类高效液相色谱法

Atom-economic synthesis of an oligomeric P/N-containing fire retardant towards fire-retarding and mechanically robust polylactide biocomposites

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Journal of Materials Science & Technology 2023年第29期160卷 86-95页

作者： jiabing Feng Yixia Lu Hongyan Xie Yan Zhang Siqi Huo Xiaohuan Liu Matt Flynn Zhiguang Xu Paulomi Burey Mark Lynch Hao Wang Pingan Song China-Australia Institute for Advanced Materials and Manufacturing Jiaxing UniversityJiaxing 314001China China National Textile and Apparel Council Key Laboratory of Flame Retardancy Finishing of Textile Materials Soochow UniversitySuzhou 215123China Laboratory of Polymer Materials and Engineering NingboTech UniversityNingbo 315100China Centre for Future Materials University of Southern QueenslandSpringfieldQLD 4300Australia College of Life Science Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and ConservationTaizhou UniversityTaizhou 318000China School of Agriculture and Environmental Science University of Southern QueenslandSpringfieldQLD 4300Australia

Renewable and biodegradable polylactide (PLA) has excellent mechanical strength but is highly flammable which restricts its practical applications. Many phosphorus/nitrogen (P/N)-based flame retardants are ef- fective in PLA, but their high addition loading usually decreases the mechanical strength of the PLA bulk. For polyphosphoramides, despite high fire-retardant efficiency, their chemical synthesis often generates chemical wastes as byproducts. Herein, we report an atom-economic and highly efficient oligomeric P/N fire retardant (APN) prepared using a mild Michael addition polymerization with no byproducts. Using only 3 wt% APN, the resulting PLA exhibits desired fire retardancy including a UL-94 V-0 rating and a limiting oxygen index of 37.6%. Furthermore, the toughness of the fire-retardant PLA increases by 85% compared to pure PLA, with both tensile strength and thermal stability preserved. This work offers an atom-economic strategy for synthesizing highly efficient P/N fire retardants for use in the creation of fire-resistant PLA with robust mechanical properties.

关键词： Atom economy Fire retardant Polylactide Mechanical properties

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基于中医时间医学特色探析肺癌择时治疗

江西中医药大学学报 2024年第3期36卷 13-16页

作者：朱勇朱洁王秀高雅婷童佳兵李泽庚皖南医学院中西医结合研究中心安徽芜湖241000 安徽中医药大学中西医结合学院合肥230012 安徽省中医药科学院中医呼吸病防治研究所合肥230031 新安医学教育部重点实验室合肥230012 安徽中医药大学第一附属医院合肥230031

中医时间医学是以“天人相应”观点为基础,子午流注学说为指导,“因时施治”为治疗原则,根据体内气血阴阳节律变化,选择最佳疗效的时间进行施治的一门学科。与之相似,生物钟节律是在生物体中为适应昼夜交替,呈周期性、节律性表达的一种... 详细信息

中医时间医学是以“天人相应”观点为基础,子午流注学说为指导,“因时施治”为治疗原则,根据体内气血阴阳节律变化,选择最佳疗效的时间进行施治的一门学科。与之相似,生物钟节律是在生物体中为适应昼夜交替,呈周期性、节律性表达的一种生物现象。两者相合之处在于疾病时间节律性的归纳。生物钟紊乱是肺癌患者发病的重要诱因之一,中医时间医学通过最佳治疗时间点的施治调整生物钟的节律,具有减毒增效的积极作用。通过论述肺癌的中医认识,探讨肺癌与生物钟节律之间关系,根据中医理论探析肺癌择时治疗,为临床治疗肺癌提供新思路。

关键词：肺癌时间医学择时治疗子午流注生物钟

Study on moving target detection to passive radar based on FM broadcast transmitter

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Journal of Systems Engineering and Electronics 2007年第3期18卷 462-468页

作者： Zhu jiabing Tao Liang Hong yi Education Ministry Key Lab of Intelligent Computing and Signal Processing Anhui Univ. Hefei 230039 P. R. China Inst. of Signal Processing East China Research Inst. of Electronic Engineering Hefei 230031 P. R. China

Target detection by a noncooperative illuminator is a topic of general interest in the electronic warfare field. First of all, direct-path interference （DPI） suppression which is the technique of bottleneck of moving target detection by a noncooperative frequency modulation（FM） broadcast transmitter is analyzed in this article; Secondly, a space-time-frequency domain synthetic solution to this problem is introduced： Adaptive nulling array processing is considered in the space domain, DPI cancellation based on adaptive fractional delay interpolation （AFDI） technique is used in planned time domain, and long-time coherent integration is utilized in the frequency domain; Finaily, an experimental system is planned by considering FM broadcast transmitter as a noncooperative illuminator, Simulation results by real collected data show that the proposed method has a better performance of moving target detection.

关键词： passive radar direct path interference adaptive beamforming adaptive fractional delay interpolation,long-time coherent integration.

Net Damping Criterion for Stability Analysis of Grid-tied VSCs in DC Voltage Control Timescale

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CSEE Journal of Power and Energy Systems 2020年第3期6卷 601-609页

作者： Dong Wang Yunhe Hou jiabing Hu School of Automation Wuhan University of TechnologyWuhan 430070China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina HKU Shenzhen Institute of Research and Innovation Shenzhen 518057China State Key Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and TechnologyWuhan 430074China

Stability of grid-connected VSCs in DC voltage control(DVC)timescales(i.e.,the frequency range of dynamics covering converter outer controls)has recently caught increased attention,while the existing approaches,such as eigenvalue analysis and dq-domain impedance analysis,have respective limitations on addressing these types of stability *** paper proposes an alternative net damping criterion dedicated for analyzing the DVC timescale stability in a multi-VSC *** criterion is strictly mapped from the Nyquist stability criterion utilizing the gain margin concept,which preserves the advantages of the classical positive net damping criterion suggested by Canay[20]–allowing for decomposition analysis of a subsystem’s contribution to the closed-loop stability in a single-input single-output(SISO)framework,but overcomes its deficiency of possibly erroneous prediction of system dynamic *** studies show that the proposed criterion can correctly predict some unstable conditions(e.g.,monotonic divergence)which cannot be identified by the classical net damping ***,the condition for when the classical criterion is available is also pointed out,the proposed criterion can also act as a complement of the classical criterion for stability examination.

关键词： DC voltage control timescale multiple VSCs net damping criterion stability

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龙牙楤木多糖提取工艺优化及体外抗氧化活性

北华大学学报（自然科学版） 2024年第3期25卷 323-332页

作者：刘静颐邹文奇任晶王雅鑫刘佳兵盛瑜孙海明北华大学药学院吉林吉林132013

目的建立优化的龙牙楤木多糖水提取工艺,初步探讨其体外抗氧化活性。方法应用单因素试验结合响应面法分析料液比、提取温度、提取时间、提取次数对龙牙楤木多糖得率的影响;通过苯酚硫酸法、间羟基联苯法、考马斯亮蓝法检测龙牙楤木多糖... 详细信息

目的建立优化的龙牙楤木多糖水提取工艺,初步探讨其体外抗氧化活性。方法应用单因素试验结合响应面法分析料液比、提取温度、提取时间、提取次数对龙牙楤木多糖得率的影响;通过苯酚硫酸法、间羟基联苯法、考马斯亮蓝法检测龙牙楤木多糖各类成分组成;通过分析体外自由基清除能力考察龙牙楤木多糖的抗氧化活性,构建PC12细胞氧化损伤模型,考察龙牙楤木多糖体外抗氧化作用。结果按料液比m(g)V(mL)=110在91℃下水提3次,3.2 h/次,多糖得率预测值为4.38%,实际多糖得率为4.29%;响应面优化后所得多糖成分中多糖为21.39%,蛋白为7.9%,糖醛酸为1.08%;龙牙楤木多糖能够有效清除DPPH、超氧阴离子、羟基自由基,龙牙楤木多糖作用于氧化损伤的PC12细胞后,可显著提高细胞内SOD活性(P<0.05,P<0.01),降低MDA含量(P<0.05),提高细胞存活率。结论该提取方法稳定可靠,制备的龙牙楤木多糖具有明显的体外抗氧化活性,可为防治阿尔兹海默病(AD)提供一定的理论依据。

关键词：龙牙楤木多糖抗氧化响应面提取工艺阿尔兹海默病

MicroRNA-29b suppresses TGF-β-induced epithelial-mesenchymal transition in renal interstitium of spontaneously hypertensive rats

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Chinese Medical Journal 2022年第7期135卷 857-859页

作者： Yihao Wu Zhi Zhang Zhe Chen Chen Fu Lu Huang jiabing Wang Jian Li Andrew Barszczyk Deye Yang Department of Cardiology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Department of Cardiology The First People’s Hospital of Yuhang DistrictHangzhouZhejiang 311100China Department of Cardiology the Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang 310000China Department of Applied Psychology and Human Development University of TorontoTorontoCanada

To the Editor:Hypertension is a well-known cardiovascular disease in which the kidney is an important target due to its role in the regulation of fluid,electrolyte balance,and blood pressure.^([1])Glomerulosclerosis,renal tubule interstitial fibrosis,and proteinuria are the main pathological characteristics of hypertensive kidney injury.^([2])

关键词： hypertensive kidney cardiovascular

十堰市某汽车制造企业工人肩部肌肉骨骼疾患影响因素及人群归因危险度分析

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职业与健康 2024年第4期40卷 433-437页

作者：钱小艺肖春梅吴家兵陈龙郑建如李秀楼湖北医药学院公共卫生与健康学院湖北十堰442000 湖北医药学院附属国药东风总医院体检中心湖北十堰442000 十堰市职业病防治院职业卫生科湖北十堰442000

目的探讨汽车制造企业工人肩部肌肉骨骼疾患(musculoskeletal disorders,MSDs)影响因素及人群归因危险度百分比(population attributable risk proportion,PAR%),为筛选重点干预措施提供理论依据。方法2022年10—11月,采用横断面调查法... 详细信息

目的探讨汽车制造企业工人肩部肌肉骨骼疾患(musculoskeletal disorders,MSDs)影响因素及人群归因危险度百分比(population attributable risk proportion,PAR%),为筛选重点干预措施提供理论依据。方法2022年10—11月,采用横断面调查法选择十堰市某汽车制造企业工人为研究对象,使用《中国肌肉骨骼疾患调查问卷》调查工人近1年肩部肌肉骨骼疾患的患病情况及相关因素,采用χ^(2)检验比较不同类型人群患病率差异,采用多因素log-binomial回归模型计算现患比(prevalence ratio,PR)值,进一步计算有统计学意义的职业影响因素的PAR%。结果该汽车制造企业工人肩部MSDs患病率为37.3%,多因素log-binomial回归分析结果显示,女性(PR=1.43,95%CI:1.29~1.58)、30~5 d(PR=1.11,95%CI:1.01~1.22)、每周工作时间>40 h(PR=1.10,95%CI:1.00~1.20)、工作环境不满意(PR=1.43,95%CI:1.31~1.57)、工作中涉及手腕弯曲的作业姿势(PR=1.26,95%CI:1.04~1.51)及伏案状态(PR=1.26,95%CI:1.15~1.37)均是汽车制造企业工人肩部MSDs患病的影响因素(均P<0.05)。主要职业危险因素的PAR%分别为工作压力大13.18%、工作中涉及手腕弯曲的作业姿势12.04%、伏案工作7.20%。结论该汽车制造企业工人肩部患病率较高,工作压力大、工作中涉及手腕弯曲的作业姿势、伏案工作均是企业预防和控制工人肩部MSDs的重点干预因素。

关键词：汽车制造肩部肌肉骨骼疾患影响因素人群归因危险度百分比

Multi-time scale dynamics in power electronics-dominated power systems

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Frontiers of Mechanical Engineering 2017年第3期12卷 303-311页

作者： Xiaoming YUAN jiabing HU Shijie CHENG State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology Wuhan 430074 China

Electric power infrastructure has recently undergone a comprehensive transformation from electromagnetics to semiconductors. Such a development is attributed to the rapid growth of power electronic converter applications in the load side to realize energy conservation and on the supply side for renewable generations and power transmissions using high voltage direct current transmission. This transformation has altered the fundamental mechanism of power system dynamics, which demands the establishment of a new theory for power system control and protection. This paper presents thoughts on a theoretical framework for the coming semiconducting power systems.

关键词： power electronics power systems multi-time scale dynamics mass-spring-damping model self-stabilizing and en-stabilizing property multi-time scale power system stabilizer