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Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy(NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： ZHANG Yi-lu jiao li-jing GONG Ya-bin XU Jian-fang NI Jian SHEN Xiao-yong ZHANG Jie ZHOU Di QIAN Cheng-xin WANG Qin YAO Jia-lin YANG Wen-xiao SU ling-zi WANG li-yu li Jia-qi YAO Yi-qin ZHANG Yuan-hui WANG Yi-chao CHEN Zhi-wei XU ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese Medicine Oncology Department Shanghai Pulmonary Hospital Shanghai Tongji University Thoracic Surgery Department Huadong Hospital Shanghai Fudan University Thoracic Surgery Department Shanghai Cancer Hospital Shanghai Fudan University Oncology Department Shanghai Chest Hospital Shanghai Jiao Tong University

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,Plization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P<0.001).The median time to deterioration

关键词： Chinese herbal medicine adjuvant chemotherapy health-related quality of life non-small-cell lung cancer patient-reported outcome

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Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zhihong Luo Weiyong li Chong Guo Ya Song Mingxia Zhou Yan Shi jing Xu Long li Bin Shi Quansheng Ouyang jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering Research Center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with liNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a *** incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled liFePO4||li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes Fillerslithium metal batteries

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调补脾肾中药复方治疗原发性骨质疏松症临床研究

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河北中医药学报 2024年第4期39卷 19-22,44页

作者：张玉孙玉凤高志红焦丽静赵会琪河北医科大学第二医院石家庄050000 石家庄市中医院石家庄050051

目的:观察调补脾肾中药复方治疗原发性骨质疏松症(primary osteoporosis,POP)的临床疗效。方法:POP患者共计60例,采用随机数字表法随机分为对照组(30例)和治疗组(30例)。对照组治疗方法为常规综合治疗,治疗组治疗方法为在对照组的基础... 详细信息

目的:观察调补脾肾中药复方治疗原发性骨质疏松症(primary osteoporosis,POP)的临床疗效。方法:POP患者共计60例,采用随机数字表法随机分为对照组(30例)和治疗组(30例)。对照组治疗方法为常规综合治疗,治疗组治疗方法为在对照组的基础上加用调补脾肾中药复方。比较2组患者的骨密度、血清碱性磷酸酶(ALP)、血红蛋白(Hb)、白蛋白(ALB)、血钙(Ca)、血磷(P)及临床疗效。结果:治疗组总有效率高于对照组(P<0.05)。治疗后,2组的ALP水平均降低,治疗组低于对照组(P<0.05),Hb、ALB水平及骨密度均提高,三个指标相比较治疗组高于对照组(P<0.05)。结论:POP用调补脾肾中药复方治疗效果明确,能有效调节ALP、Hb、ALB水平,提高骨密度。

关键词：原发性骨质疏松症中药疗法疗效

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Defect-modulated synthesis and optoelectronic properties in chemical vapor deposited CsPbBr_(3) microplates

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Nano Research 2024年第5期17卷 4610-4615页

作者： Yanan Bao Hengshan Wang Meiqi An Huayi Tang jing li Jianliang li Conghui Tan Yingmin Luo jiao Xu Yiming Yang School of Microelectronics Dalian University of TechnologyDalian 116024China Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China

The remarkable optoelectronic features of halide perovskite promote their potential applications in semiconductor devices beyond solar cells,which require high-quality single crystals with controlled defect ***,we investigated the synthesis mechanism of chemical vapor deposited single-crystalline all-inorganic perovskite microplates(MPs),and reported a defect-modulated photocurrent which is closely related to the growth sequence of the *** MP synthesis initiates from island-like nano-disks,and subsequently transits to a layer-by-layer fashion,resulting in a defect-rich area at the center of the *** elevated temperatures,these central defects may be thermally activated and become highly mobile,leading to photoluminescence quenching and degression of local and overall optoelectronic attributes,as evidenced by the spatial resolved optical and electrical scanning probe ***,this work shines light on the formation,proliferation and dynamics of defects in perovskites,and offers guidance for preparation of high-quality perovskites micro-crystals for functional semiconductor devices with high temperature stability.

关键词： halide perovskites nanomaterials optoelectronics scanning photocurrent microscope chemical vapor deposition

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中医外治法治疗肺癌相关性咳嗽临床疗效的Meta分析

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中医肿瘤学杂志 2024年第1期6卷 97-104页

作者：甘姗珊姜靖洁韩阳刘睿潮阿格尔刘玉焦丽静许玲龚亚斌上海中医药大学附属岳阳中西医结合医院上海200437 上海市宝山区月浦盛桥卫生服务中心上海200942

目的系统评价中医外治法治疗肺癌相关性咳嗽的临床疗效。方法计算机检索中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据库(Wanfang Data)、中国生物医学数据库(SinoMed)、Embase、Cochrane图书馆及Pubmed数据库中中医外治... 详细信息

目的系统评价中医外治法治疗肺癌相关性咳嗽的临床疗效。方法计算机检索中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据库(Wanfang Data)、中国生物医学数据库(SinoMed)、Embase、Cochrane图书馆及Pubmed数据库中中医外治法治疗肺癌相关性咳嗽的随机对照试验文献,文献发表时间为建库至2022年2月28日。采用相对危险度(relative risk,RR)或均数差(mean difference,MD)及对应的95%置信区间(confidence interval,CI)作为效应量指标。使用Cochrane风险偏倚评估工具进行文献质量评价,使用RevMan 5.4及Stata 14.0软件进行数据分析。结果本研究共纳入8篇文献,研究对象723例,其中试验组362例,对照组361例。Meta分析结果显示,与对照组相比,试验组可提高总有效率[RR=1.30,95%CI(1.09,1.55),P=0.004],可提高LCQ评分[WMD=2.97,95%CI(2.36,3.58),P<0.00001],可降低VAS评分[WMD=-1.63,95%CI(-3.16,-0.09),P<0.00001],可降低咳嗽症状积分[WMD=-0.93,95%CI(-1.09,-0.77),P<0.00001]。共报告3例不良反应/事件,均为轻度不良反应。结论与单纯使用西医常规治疗相比,单纯采用中医外治或中医外治联合常规西医治疗肺癌相关性咳嗽能够获得更好的临床疗效,能更好地改善患者临床症状,提高患者生活质量,且安全性较好。

关键词：肺癌相关性咳嗽中医外治 Meta分析

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Defined organic-octamolybdate crystalline superstructures derived Mo_(2)C@C as efficient hydrogen evolution electrocatalysts

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Chinese Chemical Letters 2024年第6期35卷 201-205页

作者： jiao li Chenyang Zhang Chuhan Wu Yan liu Xuejian Zhang Xiao li Yongtao li jing Sun Zhongmin Su School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130018China School of Chemical and Environmental Engineering Changchun University of Science and TechnologyChangchun 130022China

Hydrogen evolution electrocatalysts derived from metal-organic crystalline frameworks can inherit the merits of ordered and adjustable structures with high surface *** this paper,organic-octamolybdate crystalline superstructures(OOCS)with a fixed stoichiometric ratio of Mo_(8)(L)_(2) and high Mo content(>40 wt%)were synthesized using flexible ligands with controllable lengths(named as OOCS-1-3).Then,molybdenum carbides coated with carbon layers as electrocatalysts(Mo_(2)C@C-1-3)can be obtained directly from a one-step high-temperature carbonization process using OOCS-1-3 as *** a typical example,Mo_(2)C@C-3 exhibits satisfactory hydrogen evolution activity with a low overpotential of 151 m V(1.0 mol/L KOH)at 10 m A/cm^(2) and stability for 24 *** electrocatalytic activity is mainly from the synergistic interactions between the carbon layers and molybdenum carbide ***,compared with the initial content of C,N,Mo in OOCS and Mo_(2)C@C,the catalytic activity increases with the N *** work makes organic-octamolybdate crystalline superstructures used as general precursors to product high Mo content electrocatalysts applied in energy storage and conversion fields.

关键词： Molybdenum carbides Electrocatalysts Organic-octamolybdate crystalline superstructures Synergistic interactions Hydrogen evolution reaction(HER)

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New perspectives on the therapeutic potential of quercetin in non-communicable diseases:Targeting Nrf2 to counteract oxidative stress and inflammation

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Journal of Pharmaceutical Analysis 2024年第6期14卷 805-822页

作者： li Zhang li-Yue Xu Fei Tang Dong liu Xiao-Lan Zhao jing-Nan Zhang Jia Xia jiao-jiao Wu Yu Yang Cheng Peng Hui Ao State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

Non-communicable diseases(NCDs),including cardiovascular diseases,cancer,metabolic diseases,and skeletal diseases,pose significant challenges to public health *** complex pathogenesis of these diseases is closely linked to oxidative stress and inflammatory *** factor erythroid 2-related factor 2(Nrf2),a critical transcription factor,plays an important role in regulating antioxidant and anti-inflammatory responses to protect the cells from oxidative damage and inflammation-mediated ***,Nrf2-targeting therapies hold promise for preventing and treating ***(Que)is a widely available flavonoid that has significant antioxidant and anti-inflammatory *** modulates the Nrf2 signaling pathway to ameliorate oxidative stress and *** modulates mitochondrial function,apoptosis,autophagy,and cell damage biomarkers to regulate oxidative stress and inflammation,highlighting its efficacy as a therapeutic agent against ***,we discussed,for the first time,the close association between NCD pathogenesis and the Nrf2 signaling pathway,involved in neurodegenerative diseases(NDDs),cardiovascular disease,cancers,organ damage,and bone ***,we reviewed the availability,pharmacokinetics,pharmaceutics,and therapeutic applications of Que in treating *** addition,we focused on the challenges and prospects for its clinical *** represents a promising candidate for the treatment of NCDs due to its Nrf2-targeting properties.

关键词： Quercetin Nrf2 Non-communicable diseases Antioxidant Anti-inflammatory Availability

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An active learning workflow for predicting hydrogen atom adsorption energies on binary oxides based on local electronic transfer features

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Green Energy & Environment 2024年第10期9卷 1489-1496页

作者： Wenhao jing Zihao jiao Mengmeng Song Ya liu liejin Guo International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University Department of Energy and Power Engineering Shandong University of Technology

Machine learning combined with density functional theory（DFT） enables rapid exploration of catalyst descriptors space such as adsorption energy, facilitating rapid and effective catalyst screening. However, there is still a lack of models for predicting adsorption energies on oxides,due to the complexity of elemental species and the ambiguous coordination environment. This work proposes an active learning workflow（Le NN） founded on local electronic transfer features（e） and the principle of coordinate rotation invariance. By accurately characterizing the electron transfer to adsorption site atoms and their surrounding geometric structures, Le NN mitigates abrupt feature changes due to different element types and clarifies coordination environments. As a result, it enables the prediction of *H adsorption energy on binary oxide surfaces with a mean absolute error（MAE） below 0.18 e V. Moreover, we incorporate local coverage（θl） and leverage neutral network ensemble to establish an active learning workflow, attaining a prediction MAE below 0.2 e V for 5419 multi-*H adsorption structures. These findings validate the universality and capability of the proposed features in predicting *H adsorption energy on binary oxide surfaces.

关键词： Machine learning Adsorption energy Binary oxide Electron transfer Active learning

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Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 463-471页

作者： Yu Nie Jin-Bo Huang Shu-jiao He Hua-Di Chen Jun-Jun Jia jing-jing li Xiao-Shun He Qiang Zhao General Surgery Center Department of Hepatobiliary Surgery IIResearch Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou 510080China Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou 510080China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use

关键词： Primary non-function Early allograft failure Risk predicting model liver transplantation

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Paroxysmal Kinesigenic Dyskinesia:Genetics and Pathophysiological Mechanisms

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Neuroscience Bulletin 2024年第7期40卷 952-962页

作者： jiao-jiao Xu Hong-Fu li Zhi-Ying Wu Department of Medical Genetics and Center for Rare Diseases The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology in the Second Affiliated Hospital Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310009China

Paroxysmal kinesigenic dyskinesia(PKD),the most common type of paroxysmal movement disorder,is characterized by sudden and brief attacks of choreoathetosis or dystonia triggered by sudden voluntary *** is mainly caused by mutations in the PRRT2 or TMEM151A *** exact pathophysiological mechanisms of PKD remain unclear,although the function of PRRT2 protein has been well characterized in the last *** on abnormal ion channels and disturbed synaptic transmission in the absence of PRRT2,PKD may be channelopathy or synaptopathy,or *** addition,the cerebellum is regarded as the key pathogenic *** depolarization in the cerebellum is tightly associated with dyskinetic ***,in PKD,other than the cerebellum,the role of the cerebrum including the cortex and thalamus needs to be further investigated.

关键词： Paroxysmal kinesigenic dyskinesia PRRT2 TMEM151A Genetics Pathophysiological mechanisms

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