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Explaining the dynamics of the sub-relativistic electron third belt in the Earth's radiation belts by using medium Earth orbit satellite observations

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Earth and Planetary Physics 2024年第5期8卷 762-775页

作者： jiali chen Hong Zou YuGuang Ye Institute of Space Physics and Applied Technology Peking University

The Earth's electron radiation belts typically exhibit a two-belt structure. However, observations from the Van Allen Probes revealed the existence of a three-belt structure. This structure consists of an inner belt, a slot region, a remnant belt, a “second slot,” and a new outer belt(or the “third belt”). The formation of the structure involves both the partial loss of the original outer belts and the formation of the third belts. These processes are likely associated with radial diffusion induced by ultra-low-frequency(ULF) waves. In this study, we mainly analyzed electron flux data from medium Earth orbit(MEO) navigation satellites M17–M19 to supplement the observational evidence for the sub-relativistic electron(～100–500 keV) three-belt structure. Evidence of substorm injections and ULF waves during the three-belt event was identified, suggesting they played significant roles in the formation and evolution of the third *** injections may introduce new electron populations to the third belt, whereas ULF waves may influence the evolution of the third belt through radial diffusion. Toward the end of the three-belt event, the compression of the magnetosphere by shocks may lead to the dropout of the third belt because of the magnetopause shadowing effect and outward radial diffusion, ultimately disrupting the three-belt structure. This study provides more evidence for the presence of a sub-relativistic electron three-belt structure and offers an analysis of the evolutionary mechanisms of the third belt, which may contribute to a comprehensive understanding of the electron three-belt structure in the radiation belts.

关键词： third belt sub-relativistic electrons three-belt structure radiation belts magnetic storms and substorms wave–particle interactions

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A comprehensive review on the potential therapeutic benefits of prospective probiotic Christensenella minuta

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Food Science and Human Wellness 2024年

作者： Yueyao Fan Yuhang Xiao Yingying Zhang Shiqing Zhang Weibin Bai jiali chen Department of Food Science and Engineering， Institute of Food Safety and Nutrition， Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection， Jinan University State Key Laboratory of Bioactive Molecules and Druggability Assessment， Jinan University Centre for Cancer and Inflammation Research， School of Chinese Medicine， Hong Kong Baptist University

Bacterial family Christensenellaceae performed high heritability and associated with human health status. Numerous studies observed that the abundance of Christensenellaceae could be significantly reduced in patients with intestinal diseases or metabolic disorders， inferred that it may be treated as an effective biomarker. Christensenella minuta (C. minuta) was the first member of Christensenellaceae family isolated from human fecal samples. Accumulating evidences suggested that C. minuta may demonstrate a positive bio-therapeutic effects toward unhealthy status. Hence， this review aimed to systematically summarize the characterization of Christensenellaceae under specific health or diseases， and discover its promising application. Besides， the latest studies on the pharmacological research of C. minuta also summarized. Current important literatures grasped the potential health benefits of C. minuta in managing metabolic disorders， gut ecosystem， and inflammation. Whereas， several critical knowledge gaps about the safe and clinical application remain should be addressed in future verification. C. minuta is worthy to be elevated as the next prospective probiotic star in nutraceutical or medical field and should not be overlooked.

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Exploring negative ion behaviors and their influence on properties of DC magnetron sputtered ITO films under varied power and pressure conditions

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Chinese Physics B 2024年第10期33卷 442-449页

作者： Maoyang Li Chaochao Mo Peiyu Ji Xiaoman Zhang jiali chen Lanjian Zhuge Xuemei Wu Haiyun Tan Tianyuan Huang School of Physical Science and Technology Soochow UniversitySuzhou 215000China Suzhou Maxwell Technologies Co. Ltd.Suzhou 215000China Jiangsu Key Laboratory of Frontier Material Physics and Devices Suzhou 215000China School of Optoelectronic Science and Engineering Soochow UniversitySuzhou 215000China Analysis and Testing Center Soochow UniversitySuzhou 215000China School of Optical and Electronic Information Suzhou City University&Suzhou Key Laboratory of BiophotonicsSuzhou 215104China

We deposited indium-tin-oxide(ITO)films on silicon and quartz substrates by magnetron sputtering technology in pure *** electrostatic quadrupole plasma diagnostic technology,we investigate the effects of discharge power and discharge pressure on the ion flux and energy distribution function of incidence on the substrate surface,with special attention to the production of high-energy negative oxygen ions,and elucidate the mechanism behind its *** the same time,the structure and properties of ITO films are systematically characterized to understand the potential effects of high energy oxygen ions on the growth of ITO *** with the kinetic property analysis of sputtering damage mechanism of transparent conductive oxide(TCO)thin films,this study provides valuable physical understanding of optimization of TCO thin film deposition process.

关键词： magnetron sputtering ion energy ITO thin film high energy oxygen anion

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： jiali chen Yiyang Li Xingping Quan Jinfen chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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低纹波空间可调高压电源设计

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北京大学学报（自然科学版） 2024年第2期60卷 195-202页

作者：陈佳黎邹鸿叶雨光北京大学空间物理与应用技术研究所北京100871

为了满足空间探测载荷(如质谱仪和能量粒子探测器等)对高压电源输出纹波的要求,设计一款小功率、低纹波、最大输出电压为10 kV的可调高压直流电源。设计中使用罗耶架构的逆变器和倍压整流电路,利用反馈回路,使纹波电压峰峰值小于2 V;使... 详细信息

为了满足空间探测载荷(如质谱仪和能量粒子探测器等)对高压电源输出纹波的要求,设计一款小功率、低纹波、最大输出电压为10 kV的可调高压直流电源。设计中使用罗耶架构的逆变器和倍压整流电路,利用反馈回路,使纹波电压峰峰值小于2 V;使用51系列单片机控制电源输出电压,监测电源的工作状态。除在原理设计方面降低输出电压纹波外,还提出其他降低输出电压纹波的措施。测试结果表明,所设计的高压电源具有输出电压稳定可调、纹波低的特点,可以满足空间探测载荷对高压电源的基本性能要求。

关键词：高压电源倍压整流低纹波可变输出单片机

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Amygdalin ameliorates apoptosis and imbalance of osteogenic/lipogenic homeostasis caused by NOX4/ROS/p38MAPK signaling activation to treat glucocorticoid-associated necrosis of the femoral head

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Food Science and Human Wellness 2024年

作者： Huihui Xu Kai'ao Zou Haipeng Huang Qinghe Zeng Xu Wang Ping'er Wang Wenhua Yuan Luwei Xiao jiali chen Peijian Tong Hongting Jin he First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) The First College of Clinical Medicine， Zhejiang Chinese Medical University Institute of Orthopaedics and Traumatology of Zhejiang Province

The study aimed to explore the efficacy and potential mechanisms of a naturally aromatic cyanogenic compound-amygdalin (AMY) in treating glucocorticoid (GC)-associated necrosis of the femoral head (GANFH). We demonstrated that GC exacerbates the oxidative stress (OS) microenvironment via promoting nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) expression in human， rat， and mesenchymal stem cells (MSCs) samples， thus generating excessive ROS， leading to increased apoptosis and unbalanced osteolipogenic differentiation. Furthermore， computational docking results revealed that AMY could bind specifically to the predicted binding sites of NOX4. Additionally， AMY ameliorated the OS microenvironment of MSCs via decreasing NOX4 expression and inhibiting NOX4/ROS/p38MAPK signaling， thereby reversing the GC-induced apoptosis and imbalanced osteolipogenic differentiation， and ultimately alleviating GANFH. In summary， we demonstrated for the first time that AMY attenuated apoptosis and maintained osteolipogenic differentiation balance in MSCs via specifically targeting NOX4， inhibiting NOX4/ROS/p38MAPK signaling， thereby treating GANFH.

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抗磨添加剂ZDDP在聚α-烯烃基础油中摩擦学性能的研究

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摩擦学学报（中英文） 2024年第7期44卷 912-924页

作者：裴孝虎刘晓玲陈加丽郭峰青岛理工大学机械与汽车工程学院山东青岛266520

为了研究二烷基二硫代磷酸锌(ZDDP)在润滑剂中的抗磨机理以及润滑成膜能力,利用四球摩擦磨损试验机分析了ZDDP对聚α-烯烃(PAO10)基础油摩擦磨损性能的影响,采用电子显微镜(SEM)和能谱仪(EDS)对摩擦副磨斑表面形貌以及化学元素进行表征... 详细信息

为了研究二烷基二硫代磷酸锌(ZDDP)在润滑剂中的抗磨机理以及润滑成膜能力,利用四球摩擦磨损试验机分析了ZDDP对聚α-烯烃(PAO10)基础油摩擦磨损性能的影响,采用电子显微镜(SEM)和能谱仪(EDS)对摩擦副磨斑表面形貌以及化学元素进行表征;利用原子力显微镜(AFM)对ZDDP热反应膜进行三维形貌扫描并测量其粗糙度,分析了热膜厚度与表面粗糙度之间的关系;采用球-盘点接触光干涉油膜厚度试验台,研究了ZDDP对PAO10润滑成膜性能的影响.结果显示,ZDDP在摩擦副表面形成的摩擦反应膜具有较好的抗磨性;摩擦膜的存在改变了接触区的形貌和磨斑表面粗糙度,对润滑剂卷吸到接触区产生了影响,表现出高摩擦特性;根据稳态下ZDDP热反应膜厚度与其表面粗糙度的关系,分析了摩擦膜中的摩擦化学作用机制.充分供油条件下,ZDDP形成的吸附膜对油膜厚度的影响不大,限量供油条件下,吸附膜的存在增加了接触区的油膜厚度,有效缓解了乏油状况.

关键词：二烷基二硫代磷酸锌添加剂摩擦膜热反应膜摩擦磨损润滑特性

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Medium-energy electron spectrometers on Macao Science Satellite-1

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Science China Technological Sciences 2024年第11期67卷 3324-3343页

作者： YE YuGuang LIU Ying ZOU Hong ZONG QiuGang chen jiali YU XiangQian SHI WeiHong OU JiaMing LIU JianBin YU LiJia ZHOU Jun HUANG He YUAN ShiGeng SU Wen SUO Le State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and TechnologyCNSA Macao Center for Space Exploration and Science School of Earth and Space Sciences Peking University Shandong Aerospace Electro-technology School of Astronautics Northwestern Polytechnical University DFH Satellite Co.Ltd. Institute of Remote Sensing Satellite China Academy of Space Technology

The Macao Science Satellite-1 is a two-satellite constellation specifically designed to study the geomagnetic field and particle radiation environment in low Earth orbit, particularly in the South Atlantic Anomaly region, with a low inclination orbit. Each of the two MSS-1 satellites carries a medium-energy electron spectrometer(MES). The MES sensor heads are based on pinhole imaging technology, which can simultaneously measure 50-600 keV electrons incident from nine directions with a field of view(FOV) of 180° × 30°. The two MESs can realize the pitch angle coverage of medium energy electrons at most positions in the orbit. The MSS-1 A/B MESs can realize direct observation of precipitating electrons and electrons near their loss cones. It can help to study the electron generation mechanism in the inner radiation belt and quantify the precipitation of magnetospheric energetic electrons. Combined with the geomagnetic index, solar wind parameters, interplanetary magnetic field conditions, etc.,it can also help to build a dynamic evolution model of energetic electrons in the near-Earth space, to realize the early warning and prediction of space weather based on the observation data, which can provide safety for spacecraft and astronauts in the nearEarth space.

关键词： Macao Science Satellite-1 medium-energy electron spectrometer inner radiation electrons Southern Atlantic Anomaly pitch angle distribution

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直井多段大规模压裂工艺技术研究与应用

采油工程

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采油工程 2024年第1期 8-11,77-78页

作者：陈佳丽大庆油田有限责任公司采油工艺研究院

低渗透难采储层物性差,常规改造工艺难以实现效益开发,采用多分支缝压裂工艺虽见到良好的效果,但是大规模压裂时,压裂工具磨损严重,管柱卡、工具断等问题频繁出现并影响安全施工,且还存在压裂施工防喷功能不配套问题。通过数值模拟、工... 详细信息

低渗透难采储层物性差,常规改造工艺难以实现效益开发,采用多分支缝压裂工艺虽见到良好的效果,但是大规模压裂时,压裂工具磨损严重,管柱卡、工具断等问题频繁出现并影响安全施工,且还存在压裂施工防喷功能不配套问题。通过数值模拟、工具结构优化设计、材料优选等,研制了Y344封隔器/混动坐封解封YK封隔器、耐磨蚀导压喷砂器、压控防喷器等关键压裂工具。经室内实验与现场试验,直井多段大规模压裂工艺满足耐温150℃、承压80MPa、施工排量8m^(3)/min、加砂规模516m^(3)、单趟管柱8段压裂技术指标,并在现场应用155口井,为海拉尔、塔木察格油田等难采储层低效开发治理提供了技术支持。

关键词：直井多段大规模分段压裂压控防喷器

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检测蛋白质相互作用方法的进展

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南京医科大学学报（自然科学版） 2024年第4期44卷 536-545页

作者：陈佳丽夏天周其冈南京医科大学药学院江苏南京211166

生物体的生命活动受蛋白质的控制和调节,而绝大部分蛋白质都是通过与其他蛋白相互作用来实现其功能。文章系统总结基于生物化学与分子生物学、生物物理学以及生物信息学等原理检测蛋白相互作用的研究方法,并对这些方法的特点进行了系统... 详细信息

生物体的生命活动受蛋白质的控制和调节,而绝大部分蛋白质都是通过与其他蛋白相互作用来实现其功能。文章系统总结基于生物化学与分子生物学、生物物理学以及生物信息学等原理检测蛋白相互作用的研究方法,并对这些方法的特点进行了系统性评述。

关键词：蛋白相互作用偶联氨基酸

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