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High-pressure capacity expansion and water injection mechanism and indicator curve model for fractured-vuggy carbonate reservoirs

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Petroleum 2024年第3期10卷 511-519页

作者： Lixin Chen Chengzao jia Rujie Zhang Ping Yue Xujian jiang Junfang Wang Zhou Su Yun Xiao Yuan lv Institute of Unconventional Oil and Gas Science and Technology China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Reservoir Geology and Development Southwest Petroleum UniversityChengdu610500China Tarim Oilfield Company PetroChinaKorla841000China

Water injection for oil displacement is one of the most effective ways to develop fractured-vuggy carbonate *** the increase in the number of rounds of water injection,the development effect gradually *** emergence of high-pressure capacity expansion and water injection technology allows increased production from old *** high-pressure capacity expansion and water injection technology has been implemented in practice for nearly 10 years in fractured-vuggy reservoirs,its mechanism remains unclear,and the water injection curve is not *** the past,evaluating its effect could only be done by measuring the injection-production *** this study,we analyze the mechanism of high-pressure capacity expansion and water *** propose a fluid exchange index for high-pressure capacity expansion and water injection and establish a discrete model suitable for high-pressure capacity expansion and water injection curves in fractured-vuggy *** propose the following mechanisms:replenishing energy,increasing energy,replacing energy,and releasing *** above mechanisms can be identified by the high-pressure capacity expansion and water injection curve of the well HA6X in the Halahatang Oilfield in the Tarim *** solving the basic model,the relative errors of Reservoirs I and II are found to be 1.9%and 1.5%,respectively,and the application of field examples demonstrates that our proposed high-pressure capacity expansion and water injection indicator curve is reasonable and *** research can provide theoretical support for high-pressure capacity expansion and water injection technology in fracture-vuggy carbonate reservoirs.

关键词： Fractured-vuggy carbonate reservoirs High-pressure capacity expansion and water injection Mechanism Water injection indicator curve

Macrophage exosomes modified by miR-365-2-5p promoted osteoblast osteogenic differentiation by targeting OLFML1

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Regenerative Biomaterials 2024年第3期3卷 134-147页

作者： Caiyao Hou Yujue Zhang Zhaoyong lv Yurun Luan Jun Li Chunxiu Meng Kun Liu xin Luo Liyu Chen Fengzhen Liu Department of Materials Science and Engineering Liaocheng UniversityLiaocheng 252000China Liaocheng People's Hospital Liaocheng Hospital Affliated Shandong First Medical UniversityLiaocheng 252000China The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250023China

In the bone immune microenvironment,immune cells can regulate osteoblasts through a complex communication *** play a central role in mediating immune osteogenesis,exosomes derived from them have osteogenic regulation and can be used as cariers in bone tissue ***,there are problems with exosomal therapy alone,such as poor targeting,and the content of loaded molecules cannot reach the therapeutic *** this study,macrophage-derived exosomes modified with miR-365-2-5p were developed to accelerate bone ***3T3-E1 cells were incubated with the culture supermatants of Mo,M1 and M2 macrophages,and it was found that the culture medium of M2 macrophages had the most significant effects in contributing to ***-throughput sequencing identified that miR-365-2-5p was significantly expressed in exosomes derived from M2 *** incubated MC3T3-E1 with exosomes overexpressing or kmocking down miR-365-2-5p to examine the biological function of exosome miR-365-2-5p on MC3T3-E1 *** findings suggested that miR-365-2-5p secreted by exosomes increased the osteogenesis of ***,miR-365-2-5p had a direct influence over osteogenesis for *** analysis combined with dual luciferase detection indicated that miR-365-2-5p binded to the 3'-UTR of *** summary,exosomes secreted by M2 macrophages targeted OLFML1 through miR-365-2-5p to facilitate osteogenesis.

关键词： macrophage exosomes osteogenesis osteoimmunology

MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

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Genes & Diseases 2024年第4期11卷 124-127页

作者： Junxia Luo Yun Li Yong lv xin Li Bing Qin Chuanfang Cheng Xiaorong Liu Weiping Liao Jie Wang Zaifen Gao Department of Epilepsy Center Children's Hospital Affiliated to Shandong UniversityJinanShandong 250022China Department of Epilepsy Center Jinan Children's HospitalJinanShandong 250022China Department of Brain Function and Neuroelectrophysiology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pediatrics The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)HefeiAnhui 230001China Department of Pediatrics The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Epilepsy Center and Department of Neurosurgery The First Affliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology The Second Afiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University GuangzhouGuangdong 510260China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China GuangzhouGuangdong 510260China

The multiple PDZ domain crumbs cell polarity complex component gene(MPDZ;MIM:603785),is highly expressed in the brain across the whole *** encodes the multiple PDZ domain protein,which is a member of the NMDAR signaling complex that may play a role in the control of AMPAR potentiation and synaptic plasticity in excitatory synapses."Previously,MPDZ variants have been demonstrated to be associated with autosomal recessive congenital hydrocephalus-2(HYC2;MIM:615219)which is commonly complicated by brain abnormalities and developmental *** were reported in only one *** association between MPDz and epilepsy requires clarification.

关键词： epilepsy febrile congenital

Electrochemical reconstruction of non-noble metal-based heterostructure nanorod arrays electrodes for highly stable anion exchange membrane seawater electrolysis

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Journal of Energy Chemistry 2024年第4期91卷 370-382页

作者： Jingchen Na Hongmei Yu Senyuan jia Jun Chi Kaiqiu lv Tongzhou Li Yun Zhao Yutong Zhao Haitao Zhang Zhigang Shao Fuel Cell System and Engineering Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Direct seawater electrolysis for hydrogen production has been regarded as a viable route to utilize surplus renewable energy and address the climate ***,the harsh electrochemical environment of seawater,particularly the presence of aggressive Cl^(-),has been proven to be prone to parasitic chloride ion oxidation and corrosion reactions,thus restricting seawater electrolyzer ***,hierarchical structure(Ni,Fe)O(OH)@NiCoS nanorod arrays(NAs)catalysts with heterointerfaces and localized oxygen vacancies were synthesized at nickel foam substrates via the combination of hydrothermal and annealing methods to boost seawater *** hiera rchical nanostructure of NiCoS NAs enhanced electrode charge transfer rate and active surface area to accelerate oxygen evolution reaction(OER)and generated sulfate gradient layers to repulsive aggressive Cl^(-).The fabricated heterostructure and vacancies of(Ni,Fe)O(OH)tuned catalyst electronic structure into an electrophilic state to enhance the binding affinity of hydroxyl intermediates and facilitate the structural transformation into amorphousγ-NiFeOOH for promoting ***,through operando electrochemistry techniques,we found that theγ-NiFeOOH possessing an unsaturated coordination environment and lattice-oxygen-participated OER mechanism can minimize electrode Cl^(-)corrosion enabled by stabilizing the adsorption of OH*intermediates,making it one of the best OER catalysts in the seawater medium reported to ***,these catalysts can deliver current densities of 100 and 500 mA cm-2for boosting OER at minimal overpotentials of 245and 316 mV,respectively,and thus prevent chloride ion oxidation ***,a highly stable anion exchange membrane(AEM)seawater electrolyzer based on the non-noble metal heterostructure electrodes reached a record low degradation rate under 100μV h-1at constant industrial current densities of 400 and 600 mA cm-2over 300 h,which exhibits a promi

关键词： Direct seawater electrolysis Anion exchange membrane water electrolysis Oxygen evolution reaction Oxygen vacancies Operando electrochemistry techniques

The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

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Genes & Diseases 2024年第3期11卷 452-467页

作者： Min Wang Yixue Gu Qiubo Li Bangzhe Feng xinke lv Hao Zhang Qingxia Kong Zhifang Dong xin Tian Yanke Zhang Department of Neurology Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China Department of Pediatrics Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China Department of Neurosurgery Affliated Hospital of Jining Medical UniversityJiningShandong 272000China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Epilepsy,one of the most common neurological disorders,is characterized by spon-taneous recurrent *** lobe epilepsy(TLE)is one of the most common medically intractable seizure ***2-and NcK-interacting kinase(TNIK)has recently attracted attention as a critical modulation target of many neurological and psychiatric disorders,but its role in epilepsy remains *** this study,we hypothesized the involvement of TNIK in epilepsy and investigated TNIK expression in patients with intractable TLE and in a pilocarpineinduced rat model of epilepsy by western blotting,immunofluorescence,and immunohistochemistry.A pentylenetetrazole(PTZ)-induced epilepsy rat model was used to determine the effect of the TNIK inhibitor NCB-0846 on behavioral manifestations of ***(Co-IP)/mass spectrometry(MS)was used to identify the potential *** Co-IP,we detected and confirmed the main potential TNIK *** fractionation was used to establish the effect of NCB-0846 on the expression of the main interactors in postsynaptic density(PSD)*** found that TNIK was primarily located in neurons and decreased significantly in epilepsy model rats and TLE patients compared with ***-0846 delayed kindling progression and decreased seizure ***-IP/MS identified 63 candidate TNIK interactors in rat hippocampi,notably ***-IP showed that TNIK might correlate with endogenous GRIA1,SYN2,PSD-95,CaMKIV,GABRG1,and *** addition,the significant decrease in GRIA1 in hippocampal total lysate and PSDs after NCB-0846 treatment might help modify the progression of PTZ *** results suggest that TNIK contributes to epileptic pathology and is a potential antiepileptic drug target.

关键词： Epilepsy NCB-0846 Rat TLE TNIK Traf2-and NcK-interacting kinase

A novel responsive stabilizing Janus nanosilica as a nanoplugging agent in water-based drilling fluids for exploiting hostile shale environments

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Petroleum Science 2024年第2期21卷 1190-1210页

作者： Alain Pierre Tchameni lv-Yan Zhuo Lesly Dasilva Wandji Djouonkep Robert Dery Nagre Lu-xin Chen Lin Zhao Chao Ma Bin-Qiang Xie College of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Key Laboratory of Drilling and Production Engineering for Oil and Gas HubeiChina Lost Circulation Control Laboratory National Engineering Laboratory for Petroleum Drilling EngineeringYangtze UniversityWuhan430100HubeiChina College of Petroleum Engineering Shandong Institute of Petroleum and Chemical TechnologyDongying257061ShandongChina Petroleum Engineer Research Institute of Petrochina Dagang Oilfield Tianjin300280China Department of Chemical Engineering Kumasi Technical UniversityP.O.Box 854KumasiGhana

Thermo-responsive nanocomposites have recently emerged as potential nanoplugging agents for shale stabilization in high-temperature water-based drilling fluids(WBDFs). However, their inhibitory properties have not been very effective in high-temperature drilling operations. Thermo-responsive Janus nanocomposites are expected to strongly interact with clay particles from the inward hemisphere of nanomaterials, which drive the establishment of a tighter hydrophobic membrane over the shale surface at the outward hemisphere under geothermal conditions for shale stabilization. This work combines the synergistic benefits of thermo-responsive and zwitterionic nanomaterials to synchronously enhance the chemical inhibitions and plugging performances in shale under harsh conditions. A novel thermoresponsive Janus nanosilica(TRJS) exhibiting zwitterionic character was synthesized, characterized,and assessed as shale stabilizer for WBDFs at high temperatures. Compared to pristine nanosilica(Si NP)and symmetrical thermo-responsive nanosilica(TRS), TRJS exhibited anti-polyelectrolyte behaviour, in which electrolyte ions screened the electrostatic attraction between the charged particles, potentially stabilizing nanomaterial in hostile shaly environments(i.e., up to saturated brine or API brine). Macroscopically, TRJS exhibited higher chemical inhibition than Si NP and TRS in brine, prompting a better capability to control pressure penetration. TRJS adsorbed onto the clay surface via chemisorption and hydrogen bonding, and the interactions became substantial in brine, according to the results of electrophoretic mobility, surface wettability, and X-ray diffraction. Thus, contributing to the firm trapping of TRJS into the nanopore structure of the shale, triggering the formation of a tight hydrophobic membrane over the shale surface from the outward hemisphere. The addition of TRJS into WBDF had no deleterious effect on fluid properties after hot-treatment at 190℃, implying that TRJ

关键词： Janus nanosilica Thermo-responsive copolymer Anti-polyelectrolyte effect Shale stabilizer Inhibition Plugging Drilling fluid

Expression level of myocardial enzymes in patients with schizophrenia: Predictive value in the occurrence of violence

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World Journal of Psychiatry 2024年第9期14卷 1346-1353页

作者： Wei-Min He xin-Yuan Zhang Wei-Gen Xie Dan-Ping lv Qun-Di Shen Department of Rehabilitation Ward Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of Laboratory Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of Medical Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina Department of General Affairs Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND Schizophrenic patients are prone to violence,frequent recurrence,and difficult to *** and behavioral abnormalities during the onset of the disease,resulting in active myocardial enzyme *** To explored the expression level of myocardial enzymes in patients with schizo-phrenia and its predictive value in the occurrence of *** A total of 288 patients with schizophrenia in our hospital from February 2023 to January 2024 were selected as the research object,and 100 healthy people were selected as the control ***’information,clinical data,and labo-ratory examination data were *** to Modified Overt Aggression Scale score,patients were further divided into the violent(123 cases)and non-violent group(165 cases).RESULTS The comparative analysis revealed significant differences in serum myocardial enzyme levels between patients with schizophrenia and healthy *** the schizophrenia group,the violent and non-violent groups also exhibited different levels of serum myocardial *** levels of myocardial enzymes in the non-violent group were lower than those in the violent group,and the patients in the latter also displayed aggressive behavior in the *** Previous aggressive behavior and the level of myocardial enzymes are of great significance for the diagnosis and prognosis analysis of violent behavior in patients with *** detecting changes in these indicators,we can gain a more comprehensive understanding of a patient’s condition and treatment.

关键词： Schizophrenia Myocardial enzyme index Act of violence Predict Violence prediction Aggressive behavior Clinical data analysis Biochemical markers

Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China

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Chinese Herbal Medicines 2024年第2期16卷 248-262页

作者： Chunyan Guo Lingfei Wang Namuhan Chen Mingxu Zhang Junying jia Lijuan lv Minhui Li College of Pharmacy Qiqihar Medical UniversityQiqihar 161000China Department of Basic Science Tianjin Agricultural UniversityTianjin 300384China Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Hohhot 010110China Inner Mongolia Academy of Chinese and Mongolian Medicine Hohhot 010010China University Engineering Research Center of Chinese(Mongolia)Ecological Planting Medicinal Materials(Nurture)in Inner Mongolia Autonomous Region Inner Mongolia Minzu UniversityTongliao 028000China Baotou Medical College Baotou 014060China Naiman Banner Medicinal Materials Research and Development Center Tongliao 028300China

Traditional Chinese herbal medicines not only cure human diseases,but also play an important role as *** with conventional chemical agents,traditional Chinese herbal medicines are characterized by low toxicity,low residues,and being eco-friendly,and they have become a research *** Chinese herbal medicines have tremendous flexibility and indefinite ***,this paper reviewed the types of insecticides belonging to traditional Chinese herbal medicines in Inner Mongolia,China,including their traditional uses,secondary metabolites,biological activities,action mechanisms,application methods,and development *** addition,the most relevant issues involved in the development of traditional Chinese herbal medicines was *** believe that traditional Chinese herbal medicines can be better implemented and developed;such that its other advantages,such as an insect repellent,can be ***,this study lays a solid foundation for further research on traditional Chinese herbal medicines in Inner Mongolia,China.

关键词： botanical pesticides organic agriculture pest management plant-derived biological products secondary metabolites

Engineering catalytic defects via molecular imprinting for high energy Li-S pouch cells

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National Science Review 2024年第7期11卷 239-251页

作者： Yufei Zhao Chuannan Geng Li Wang Yun Cao Haotian Yang Linkai Peng xin jiang Yong Guo Xiaolin Ye Wei lv Quan-Hong Yang Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon Materials Tsinghua Shenzhen International Graduate School Tsinghua University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy StorageSchool of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University

Heterogeneous catalysis promises to accelerate sulfur-involved conversion reactions in lithium-sulfur batteries. Solid-state Li2S dissociation remains as the rate-limiting step because of the weakly matched solid-solid electrocatalysis interfaces. We propose an electrochemically molecular-imprinting strategy to have a metal sulfide（MS） catalyst with imprinted defects in positions from which the pre-implanted Li2S has been electrochemically removed. Such tailor-made defects enable the catalyst to bind exclusively to Li atoms in Li2S reactant and elongate the Li–S bond, thus decreasing the reaction energy barrier during charging. The imprinted Ni3S2catalyst shows the best activity due to the highest defect concentration among the MS catalysts examined. The Li2S oxidation potential is substantially reduced to 2.34 V from 2.96 V for the counterpart free of imprinted vacancies, and an Ah-level pouch cell is realized with excellent cycling performance. With a lean electrolyte/sulfur ratio of 1.80 μL mgS–1, the cell achieves a benchmarkedly high energy density beyond 500 Wh kg–1.

关键词： lithium-sulfur battery catalysts defects energy density metal sulfide