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Comparison of hepatitis B prophylactic outcomes in living donor liver transplantation recipients who meet the Milan or UCSF criteria

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 494-499页

作者： Li jiang Lu-Nan Yan Tian-Fu Wen Bo Li jia-yin yang Liver Transplantation Center Department of Liver SurgeryWest China HospitalSichuan University

BACKGROUND:The tumor burden before liver transplantation indicates that hepatitis B virus(HBV) may hide in the extrahepatic and micrometastatic sites which serve as a source of HBV ***,many liver transplant centers,especially in Western countries,use the Milan or UCSF criteria to select patients with hepatocellular carcinoma for liver *** study was undertaken to compare the HBV prophylactic outcomes in two groups of living donor liver transplantation(LDLT) *** in group A met the Milan criteria and those in group B exceeded the Milan criteria but were within the UCSF ***:A database of adult-to-adult right-lobe LDLT performed at our institution for HBV-related hepatocellular carcinoma within the Milan or UCSF criteria between June 2002 and May 2012 was used to compare the HBV prophylactic outcomes between patients within the Milan criteria(group A,41 patients) and those exceeding the Milan criteria but within the UCSF criteria(group B,19 patients).RESULTS:The 1-,3-,and 5-year survival rates were similar between groups A and B(87.8%,85.1% and 74.0% vs 73.3%,61.1% and 61.1%,respectively,P=0.067).HBV recurred in 1 patient in 3.1 months after LDLT in group A and in 2 patients in group B(1 in 11.9 months and 1 in 24.1 months after LDLT).The 1-,3-,and 5-year HBV recurrence rates were 2.6%,2.6% and 2.6% in group A,and 7.3%,17.9% and 17.9% in group B,respectively(P=0.118).CONCLUSION:LDLT recipients who exceed the Milan criteria but remain within the UCSF criteria may have post-transplant HBV prophylactic outcomes similar to those who meet the Milan criteria.

关键词： living donor liver transplantation hepatitis B virus hepatocellular carcinoma antiviral therapy

Overexpression of transcription factor 3 drives hepatocarcinoma development by enhancing cell proliferation via activating Wnt signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 378-386页

作者： Xing-Yu Pu Dao-Feng Zheng Tao Lv Yong-Jie Zhou jia-yin yang Li jiang Department of Liver Surgery and Liver Transplantation Center West China HospitalSichuan UniversityChengdu 610041China Laboratory of Liver Transplantation Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Background:Transcription factor 3(TCF3)plays pivotal roles in embryonic development,stem cell maintenance and ***,its role in hepatocellular carcinoma(HCC)remains largely *** study aimed to analyze the correlation between TCF3 expression and clinicopathological features of HCC,and further explore the underlying mechanism in HCC ***:The expression of TCF3 was collected from the Cancer Genome Atlas(TCGA)and the Gene Expression Omnibus(GEO)HCC datasets,and further confirmed by immunostaining and Western blotting *** correlation between TCF3 expression and the clinicopathological features was *** analysis and in vitro experiments were conducted to explore the potential role of TCF3 in HCC ***:Both the mRNA and protein levels of TCF3 were significantly higher in HCC tumor tissues compared to tumor adjacent tissues(Pying mechanism might be that the silencing of TCF3 reduced the expression of critical regulating proteins towards cell cycle and proteins involved in Wnt signaling ***:TCF3 expression is significantly elevated in HCC and positively associated with the tumor size and TNM stage,as well as poor prognosis of HCC *** mechanism might be that TCF3 promotes cancer cell proliferation via activating Wnt signaling pathway.

关键词： Hepatocellular carcinoma Proliferation Cell and molecular biology

Role of the postoperative cholesterol in early allograft dysfunction and survival after living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 610-616页

作者： jian yang Hai-Qing Wang jia-yin yang Tian-Fu Wen Bo Li Wen-Tao Wang Lu-Nan Yan Department of Liver Transplantation Center West China Hospital of Sichuan University Chengdu 610041 China

BACKGROUND:Many studies have confirmed that serum total cholesterol(sTC) concentrations were associated with underlying liver damage and the synthesis capacity of ***, the role of postoperative sTC level on evaluating graft function and predicting survival of recipients who underwent liver transplantation has not been ***:Clinical data of 231 living donor liver transplantation recipients from May 2003 to January 2015 were retrospectively collected. Patients were stratified into the low sTC group(sTC <1.42 mmol/L, 57 recipients) and high sTC group(sTC ≥1.42 mmol/L, 174 recipients) according the sTC level on postoperative day 3 based on receiver-operating characteristic curve analysis. The clinical characteristics and postoperative short-and long-term outcomes were compared between the two ***:Recipients with sTC <1.42 mmol/L experienced more severe preoperative disease conditions, a higher incidence of postoperative early allograft dysfunction(38.6% vs 10.3%, P<0.001), 90-day mortality(28.1% vs 10.9%, P=0.002)and severe complications(29.8% vs 17.2%, P=0.041) compared to recipients with sTC ≥1.42 mmol/L. The multivariate analysis demonstrated that sT C <1.42 mmol/L had a 4.08-fold(95% CI:1.83-9.11, P=0.001) and 2.72-fold(95% CI:1.23-6.00,P=0.013) greater risk of developing allograft dysfunction and 90-day mortality, and patients with sTC <1.42 mmol/L had poorer overall recipient and graft survival rates at 1-, 3-, and 5-year than those with sTC ≥1.42 mmol/L(67%, 61% and 61% vs 83%, 71% and 69%, P=0.025; 65%, 59% and 59% vs 81%,68% and 66%, P=0.026, respectively). Cox multivariate anal-ysis showed that sTC <1.42 mmol/L was an independent predicting factor for total recipient survival(HR=2.043; 95% CI:1.173-3.560; P=0.012) and graft survival(HR=1.905; 95% CI:1.115-3.255; P=0.018).CONCLUSIONS:sTC <1.42 mmol/L on postoperative day 3 was an independent risk factor of postoperative early allograft dysfunction, 90-day mortality, recipient a

关键词： lipid metabolism graft survival early allograft dysfunction morbidity mortality

Reduced-right posterior sector salvage liver transplantation using a moderate steatotic graft from one obese donor after cardiac death

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Chinese Medical Journal 2021年第5期134卷 596-598页

作者： Zhi-Xi Zhang Xing-Yu Pu jian yang Li jiang jia-yin yang Lu-Nan Yan West China School of Medicine Sichuan UniversityChengduSichuan 610041China Liver Transplantation Center Department of Liver SurgeryWest China Hospital of Sichuan UniversityChengduSichuan 610041China

To the Editor:Compared with the majority of reduced-size liver transplantations(RSLTs)performed in pediatric recipients,[1-3]the experience of RSLTs in adult recipients and surgical strategies for the reduction of grafts are relatively ***,we report a successful case of adult-to-adult RSLT,in which a unique method for removing the right posterior sector while preserving the right hepatic vein(RHV)was *** study was approved by the West China Hospital Ethics Committee(No.2019-718)and was conducted in accordance with the ethical guidelines of the Declaration of Helsinki.

关键词： donor removing graft

Living donor liver transplantation does not increase tumor recurrence of hepatocellular carcinoma compared to deceased donor transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10953-10959页

作者： Guang-qin Xiao Jiu-lin Song Shu Shen jia-yin yang lu-nan yan Liver Transplantation Center West China Hospital of Sichuan University

AIM: to compare the recurrence-free survival (RFS) and overall survival (OS) of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT). METHODS: We retrospectively collected clinical data from 408 liver cancer patients from February 1999 to September 2012. We used the chi-squared test or Fisher's exact test to analyze the characteristics of LDLT and DDLT. Kaplan-Meier analysis was used to compare the RFS and OS in HCC. RESULTS: Three hundred sixty HBV-positive patients (276 DDLT and 84 LDLT) were included in this study. The mean follow-up time was 27.1 mo (range 1.1-130.8 mo). One hundred eighty-five (51.2%) patients died during follow-up. The 1-, 3-, and 5-year RFS rates for LDLT were 85.2%, 55.7%, and 52.9%, respectively; for DDLT, the RFS rates were 73.2%, 49.1%, and 45.3% (P = 0.115). The OS rates were similar between the LDLT and DDLT recipients, with 1-, 3-, and 5-year survival rates of 81.8%, 49.5%, and 43.0% vs 69.5%, 43.0%, and 38.3%, respectively (P = 0.30). The outcomes of HCC according to the Milan criteria after LDLT and DDLT were not significantly different (for LDLT: 1-, 3-, and 5-year RFS: 94.7%, 78.7%, and 78.7% vs 89.2%, 77.5%, and 74.5%, P = 0.50; for DDLT: 86.1%, 68.8%, and 68.8% vs 80.5%, 62.2%, and 59.8% P = 0.53). CONCLUSION: The outcomes of LDLT for HCC are not worse compared to the outcomes of DDLT. LDLT does not increase tumor recurrence of HCC compared to DDLT. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Hepatocellular carcinoma Living donor Deceased donor Liver transplantation Hepatitis B virus

Donafenib as a first-line monotherapy for advanced hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 737-740页

作者： Bo-Han Zhang Yun-Shi Cai Li jiang jia-yin yang Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengduChina

We are optimistic about Professor Shukui Qin and colleagues’electrifying results regarding the efficacy and safety of donafenib(a modified form of sorafenib)over sorafenib in treating advanced hepatocellular carcinoma(aHCC)(1).Following the landmark sorafenib trial in 2008(2),the present ZGDH3 trial is the first and only first-line head-to-head phase 2-3 trial to demonstrate that monotherapy is superior to sorafenib in terms of overall survival(OS)for *** the ZGDH3 trial,Qin et *** assigned 668 eligible patients to receive 200 mg of donafenib or 400 mg of sorafenib,orally,twice daily,with open-label administration[donafenib(n=334),sorafenib(n=334)].The primary endpoint was OS and secondary endpoints included progression-free survival(PFS),time to progression,objective response rate(ORR),disease control rate(DCR),survival rates at 6,9,12,and 18 months,and safety.

关键词： hepatocellular endpoint

Machine learning-based performance predictions for steels considering manufacturing process parameters:a review

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Journal of Iron and Steel Research International 2024年第7期31卷 1555-1581页

作者： Wei Fang jia-xin Huang Tie-xu Peng yang Long Fu-xing yin Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300132China Institute of New Materials Guangdong Academy of ScienceGuangzhou 510651GuangdongChina

Steels are widely used as structural materials,making them essential for supporting our lives and ***,further improving the comprehensive properties of steel through traditional trial-and-error methods becomes challenging due to the continuous development and numerous processing parameters involved in steel *** address this challenge,the application of machine learning methods becomes crucial in establishing complex relationships between manufacturing processes and steel *** review begins with a general overview of machine learning methods and subsequently introduces various performance predictions in steel *** classification of performance pre-diction was used to assess the current application of machine learning model-assisted *** important issues,such as data source and characteristics,intermediate features,algorithm optimization,key feature analysis,and the role of environmental factors,were summarized and *** insights will be beneficial and enlightening to future research endeavors in this field.

关键词： Steel Manufacturing process Machine learning Performance prediction Algorithm

Self-assembly Induced by Complexation of Diblock Copolyelectrolytes and Oppositely Charged Homopolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1321-1332,I0006页

作者： Ling Zhao Zhi-Yuan yin jia-Di jiang Er-Qiang Chen Shuang yang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Mater Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are *** electrostatic complexation between oppositely charged polymers drives the formation of many ordered *** microstructures and phase diagrams are calculated using self-consistent field theory(SCFT)based on an ion-pair model with an equilibrium constant K to characterize the strength of binding between positively and negatively charged *** effects of the charge ratio,representing the ratio of charges from the homopolymer over all charges from polymers in the system,on the ordered structure are systematically studied,both for hydrophobic and hydrophilic A *** charge ratio plays an important role in determining the phase boundaries in the phase diagram of salt concentration versus polymer *** also provide information about the varying tendency of the domain spacing and core size of the spherical phase when the charge ratio is changed,and the results are in good agreement with *** studies provide a deep understanding of the self-assembled microstructures of oppositely charged diblock copolymer-homopolymer systems.

关键词： Self-assembly Polyelectrolyte complexation Self-consistent field theory Ion-pair

Combined hepatectomy and radiofrequency ablation versus TACE in improving survival of patients with unresectable BCLC stage B HCC

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 378-385页

作者： Yi-Fu Hou Yong-Gang Wei jia-yin yang Tian-Fu Wen Ming-Qing Xu Lu-Nan Yan Bo Li Department of Hepatic Surgery West China HospitalSichuan University

BACKGROUND： Combined hepatectomy and radiofrequency ablation（RFA） provides an additional treatment for patients with Barcelona Clinic Liver Cancer（BCLC） stage B hepatocellular carcinoma（HCC） who are conventionally deemed unresectable. This study aimed to analyze the outcome of this combination therapy by comparing it with transarterial chemoembolization（TACE）. METHODS： We retrospectively reviewed 51 patients with unresectable BCLC stage B HCC who had received the combination therapy. We compared the survival of these patients with that of 102 patients in the TACE group（control）. Prognostic factors associated with worse survival in the combination group were ***： No differences in tumor status and liver function were observed between the TACE group and combination group. The median survival time for the combination group and TACE group was 38（6-54） and 17（3-48） months, respectively（P〈0.001）. The combination group required longer hospitalization than the TACE group [8（5-14） days vs 4（2-9） days,P〈0.001]. More than two ablations decreased the survival rate in the combination group. CONCLUSIONS： Combined hepatectomy and RFA yielded a better long-term outcome than TACE in patients with unresectable BCLC stage B HCC. Patients with a limited ablated size（≤2 cm）, a limited number of ablations（≤2）, and adequate surgical margin should be considered candidates for combination therapy.

关键词： hepatocellular carcinoma hepatectomy radiofrequency ablation transarterial chemoembolization Barcelona Clinic Liver Cancer system