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IMAGGS: a radiogenomic framework for identifying multi-way associations in breast cancer subtypes

Journal of Genetics and Genomics 2024年第4期51卷 443-453页

作者： Shuyu Liang Sicheng Xu Shichong Zhou Cai Chang Zhiming shao Yuanyuan Wang Sheng Chen Yunxia Huang yi Guo Department of Electronic Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China The Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention(MICCAI)of Shanghai Shanghai 200032China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200433China Department of Ultrasound Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized *** present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic *** dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation *** better characterize tumor traits,12 multi-angle US images are fused using two distinct ***,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous *** radiomic and genomic features are screened using these *** addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC *** further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and *** together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.

关键词： IMAGGS Radiogenomic framework "lmage-gene-geneset"associations Molecular subtypes Breast cancer

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不同磁场对过氧化氢酶活性及酶促反应的影响

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天津大学学报 2009年第10期42卷 897-900页

作者：刘勇贾绍义吴松海天津大学化工学院天津300072

在不同的磁场条件下研究了Nu-Fe-B静磁场对过氧化氢酶活性和反应动力学参数及二级结构的影响.采用磁场强度为0.15.T、0.30.T、0.45.T的静磁场分别处理过氧化氢酶溶液,以曝磁时间为参数,对酶的活性、反应动力学参数、二级结构分别进行测... 详细信息

在不同的磁场条件下研究了Nu-Fe-B静磁场对过氧化氢酶活性和反应动力学参数及二级结构的影响.采用磁场强度为0.15.T、0.30.T、0.45.T的静磁场分别处理过氧化氢酶溶液,以曝磁时间为参数,对酶的活性、反应动力学参数、二级结构分别进行测定.结果表明,与对照样相比,处理过的过氧化氢酶活性增大,当作用时间为1.h时,活性最大,3个磁场下酶的活性分别增加了18.2%、23.5%和25.8%;用不同的磁场对过氧化氢酶溶液分别作用1.h,与对照样相比,随着磁场强度的增加,Km值从0.027.85,mol/L增加到0.087.24,mol/L,Vm值从0.035.97,mol/(L·min)增加到0.095.11,mol/(L·min);同时,圆二色光谱测定结果表明磁场处理过的过氧化氢酶的二级结构也发生变化,这可能是由于磁场对过氧化氢酶辅酶中的Fe3+影响而引起的.

关键词：稳恒磁场过氧化氢酶活性酶促反应二级结构

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Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1291-1298页

作者： Qi jia Jin Li Xiaofeng Guo yi Li You Wu Yuliang Peng Zongping Fang Xijing Zhang Department of Anesthesiology and Perioperative Medicine and Department of Intensive Care Unit Xijing Hospital The Fourth Military Medical University Department of Critical Care Medicine Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University

Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis, while providing nutrients and support for cell survival. Chaperone-mediated autophagy activity can be detected in almost all cells, including neurons. Owing to the extreme sensitivity of neurons to their environmental changes, maintaining neuronal homeostasis is critical for neuronal growth and survival. Chaperone-mediated autophagy dysfunction is closely related to central nervous system diseases. It has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy dysfunction. Under certain conditions, regulation of chaperone-mediated autophagy activity attenuates neurotoxicity. In this paper, we review the changes in chaperone-mediated autophagy in neurodegenerative diseases, brain injury, glioma, and autoimmune diseases. We also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases.

关键词： chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis neuroprotection

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采用有限元+边界元方法研究非饱和地基中群桩基础的动力阻抗

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岩土力学 2024年第3期45卷 895-907页

作者：李绍毅吉首大学土木工程与建筑学院湖南张家界427000

采用边界元结合有限元法研究了非饱和地基群桩基础动力阻抗。根据梁模型建立桩体动力控制方程,结合有限元方法建立群桩基础数值模型;基于非饱和多孔介质动力控制方程组,采用加权残余法和拉普拉斯变换,推导非饱和地基边界元法控制方程,... 详细信息

采用边界元结合有限元法研究了非饱和地基群桩基础动力阻抗。根据梁模型建立桩体动力控制方程,结合有限元方法建立群桩基础数值模型;基于非饱和多孔介质动力控制方程组,采用加权残余法和拉普拉斯变换,推导非饱和地基边界元法控制方程,根据伴随矩阵性质推导其Green函数基本解答。基于桩体和地基土接触面作用力平衡条件和位移相容原理,建立非饱和地基边界元模型和群桩基础有限元模型的耦合数值模型;研究土体饱和度、桩体间距、长度、数目和地基分层等参数对群桩基础动力阻抗的影响。研究发现:地基饱和度增加可降低群桩基础刚度系数;荷载频率较低时增大饱和度可减小群桩基础阻尼系数。增加桩基数目和地基饱和度可增大桩基与地基土相互作用。下卧基岩分层地基可提高桩基与土体的相互作用,且对群桩水平阻抗影响显著。

关键词：非饱和介质群桩基础动力阻抗有限元+边界元方法分层地基

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Risk factors,prognostic factors,and nomograms for distant metastasis in patients with diagnosed duodenal cancer:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1384-1420页

作者： jia-Rong Shang Chen-yi Xu Xiao-Xue Zhai Zhe Xu Jun Qian Department of Oncology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Proctology Nanjing Hospital of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Digestive Cancer Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Duodenal cancer is one of the most common subtypes of small intestinal cancer,and distant metastasis(DM)in this type of cancer still leads to poor *** nomograms have recently been used in tumor areas,no studies have focused on the diagnostic and prognostic evaluation of DM in patients with primary duodenal *** To develop and evaluate nomograms for predicting the risk of DM and person-alized prognosis in patients with duodenal *** Data on duodenal cancer patients diagnosed between 2010 and 2019 were extracted from the Surveillance,Epidemiology,and End Results *** and multivariate logistic regression analyses were used to identify independent risk factors for DM in patients with duodenal cancer,and univariate and multivariate Cox proportional hazards regression analyses were used to determine independent prognostic factors in duodenal cancer patients with *** novel nomograms were established,and the results were evaluated by receiver operating characteristic(ROC)curves,calibration curves,and decision curve analysis(DCA).RESULTS A total of 2603 patients with duodenal cancer were included,of whom 457 cases(17.56%)had DM at the time of *** analysis revealed independent risk factors for DM in duodenal cancer patients,including gender,grade,tumor size,T stage,and N stage(P<0.05).Univariate and multivariate COX analyses further identified independent prognostic factors for duodenal cancer patients with DM,including age,histological type,T stage,tumor grade,tumor size,bone metastasis,chemotherapy,and surgery(P<0.05).The accuracy of the nomograms was validated in the training set,validation set,and expanded testing set using ROC curves,calibration curves,and DCA *** results of Kaplan-Meier survival curves(P<0.001)indicated that both nomograms accurately predicted the occurrence and prognosis of DM in patients with duodenal *** The two nomograms are expected as effective tools fo

关键词： Duodenal cancer Distant metastasis Nomogram Risk factors Prognostic factors

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Unveiling the geometric site dependent activity of spinel Co_(3)O_(4)for electrocatalytic chlorine evolution reaction

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Journal of Energy Chemistry 2024年第5期92卷 95-103页

作者： Linke Cai Yao Liu Jingfang Zhang Qiqi jia jiacheng Guan Hongwei Sun Yu Yu yi Huang Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079HubeiChina Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationHubei Key Laboratory of Novel Reactor and Green Chemical TechnologySchool of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan 430205HubeiChina College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108FujianChina School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601AnhuiChina

Spinel cobalt oxide(Co_(3)O_(4)),consisting of tetrahedral Co^(2+)(CoTd)and octahedral Co^(3+)(CoOh),is considered as promising earth-abundant electrocatalyst for chlorine evolution reaction(CER).Identifying the catalytic contribution of geometric Co site in the electrocatalytic CER plays a pivotal role to precisely modulate electronic configuration of active Co sites to boost ***,combining density functional theory calculations and experiment results assisted with operando analysis,we found that the Co_(Oh) site acts as the main active site for CER in spinel Co_(3)O_(4),which shows better Cl^(-)adsorption and more moderate intermediate adsorption toward CER than CoTd site,and does not undergo redox transition under CER condition at applied *** by above findings,the oxygen vacancies were further introduced into the Co_(3)O_(4) to precisely manipulate the electronic configuration of Co_(Oh) to boost Cl^(-)adsorption and optimize the reaction path of CER and thus to enhance the intrinsic CER activity *** work figures out the importance of geometric configuration dependent CER activity,shedding light on the rational design of advanced electrocatalysts from geometric configuration optimization at the atomic level.

关键词： Chlorine evolution reaction Geometry effects Active chlorine Electronic configuration optimization Spinel oxides

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Degradation of o-dichlorobenzene by DBD-NTP co-modified titanium gel catalyst

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Journal of Environmental Sciences 2024年第9期143卷 71-84页

作者： Wenbo Zhang yi Xing Wei Su jiaqing Wang Haoqi jia Yongkang Cui Jing Chen Hui Zhang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science and Technology BeijingBeijing 100083China Guangdong Province Engineering Laboratory for Air Pollution Control Guangzhou 510530China College of Environmental and Resource Sciences Shanxi UniversityTaiyuan 030006China Sinosteel Maanshan Mine Research Institute Co.Ltd. Anhui 243071China

In order to study the degradation process of dioxins in industrial flue gas,the decomposition of o-dichlorobenzene(o-DCB)in a DBD plasma catalytic reactor was *** results showed that an NTP-catalyzed system,especially using the Cu Mn Ti Oxcatalyst,had better o-DCB degradation performance compared to plasma *** combination of the Cu Mn Ti Oxcatalyst with NTP can achieve a degradation efficiency of up to 97.2%for o-DCB;the selectivity of CO and CO_(2)and the carbon balance were 40%,45%,and 85%,*** dielectric constant and electrical property results indicated that the surface discharge capacity of the catalysts played a major role in the degradation of o-DCB,and a higher dielectric constant could suppress the plasma expansion and enhance the duration of the plasma discharge per discharge *** to the O1s XPS and O_(2)-TPD results,the conversion of CO to CO_(2)follows the M-v-K mechanism;thus,the active species on the catalyst surface play an important ***,the Cu Mn Ti Oxand NTP mixed system exhibited excellent stability,which is probably because Cu doping improved the lifetime of the *** work can provide an experimental and theoretical basis for research in the degradation of o-DCB by plasma catalyst systems.

关键词： o-dichlorobenzene(o-DCB) Non-thermal plasma catalysis Ozone concentration

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Electrochemical reconstruction of non-noble metal-based heterostructure nanorod arrays electrodes for highly stable anion exchange membrane seawater electrolysis

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Journal of Energy Chemistry 2024年第4期91卷 370-382页

作者： Jingchen Na Hongmei Yu Senyuan jia Jun Chi Kaiqiu Lv Tongzhou Li Yun Zhao Yutong Zhao Haitao Zhang Zhigang shao Fuel Cell System and Engineering Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Direct seawater electrolysis for hydrogen production has been regarded as a viable route to utilize surplus renewable energy and address the climate ***,the harsh electrochemical environment of seawater,particularly the presence of aggressive Cl^(-),has been proven to be prone to parasitic chloride ion oxidation and corrosion reactions,thus restricting seawater electrolyzer ***,hierarchical structure(Ni,Fe)O(OH)@NiCoS nanorod arrays(NAs)catalysts with heterointerfaces and localized oxygen vacancies were synthesized at nickel foam substrates via the combination of hydrothermal and annealing methods to boost seawater *** hiera rchical nanostructure of NiCoS NAs enhanced electrode charge transfer rate and active surface area to accelerate oxygen evolution reaction(OER)and generated sulfate gradient layers to repulsive aggressive Cl^(-).The fabricated heterostructure and vacancies of(Ni,Fe)O(OH)tuned catalyst electronic structure into an electrophilic state to enhance the binding affinity of hydroxyl intermediates and facilitate the structural transformation into amorphousγ-NiFeOOH for promoting ***,through operando electrochemistry techniques,we found that theγ-NiFeOOH possessing an unsaturated coordination environment and lattice-oxygen-participated OER mechanism can minimize electrode Cl^(-)corrosion enabled by stabilizing the adsorption of OH*intermediates,making it one of the best OER catalysts in the seawater medium reported to ***,these catalysts can deliver current densities of 100 and 500 mA cm-2for boosting OER at minimal overpotentials of 245and 316 mV,respectively,and thus prevent chloride ion oxidation ***,a highly stable anion exchange membrane(AEM)seawater electrolyzer based on the non-noble metal heterostructure electrodes reached a record low degradation rate under 100μV h-1at constant industrial current densities of 400 and 600 mA cm-2over 300 h,which exhibits a promi

关键词： Direct seawater electrolysis Anion exchange membrane water electrolysis Oxygen evolution reaction Oxygen vacancies Operando electrochemistry techniques

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Noninvasive Diagnostic Technique for Nonalcoholic Fatty Liver Disease Based on Features of Tongue Images

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Chinese Journal of Integrative Medicine 2024年第3期30卷 203-212页

作者： WANG Rong-rui CHEN jia-liang DUAN shao-jie LU ying-xi CHEN Ping ZHOU Yuan-chen YAO Shu-kun Graduate School of Beijing University of Chinese Medicine Beijing100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing100029China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Nanjing Linkwah Micro-electronics Institute Beijing100191China Institute of Microelectronics Tsinghua UniversityBeijing100084China Peking University China-Japan Friendship School of Clinical Medicine Beijing100029China

Objective:To investigate a new noninvasive diagnostic model for nonalcoholic fatty liver disease(NAFLD) based on features of tongue ***:Healthy controls and volunteers confirmed to have NAFLD by liver ultrasound were recruited from China-Japan Friendship Hospital between September 2018 and May 2019,then the anthropometric indexes and sampled tongue images were *** tongue images were labeled by features,based on a brief protocol,without knowing any other clinical data,after a series of corrections and data *** algorithm was trained on images using labels and several anthropometric indexes for inputs,utilizing machine learning ***,a logistic regression algorithm and a decision tree model were constructed as 2 diagnostic models for ***:A total of 720 subjects were enrolled in this study,including 432 patients with NAFLD and 288 healthy *** them,482 were randomly allocated into the training set and 238 into the validation *** diagnostic model based on logistic regression exhibited excellent performance:in validation set,it achieved an accuracy of 86.98%,sensitivity of 91.43%,and specificity of 80.61%;with an area under the curve(AUC) of 0.93 [95% confidence interval(CI) 0.68–0.98].The decision tree model achieved an accuracy of 81.09%,sensitivity of 91.43%,and specificity of 66.33%;with an AUC of 0.89(95% CI 0.66–0.92) in validation ***:The features of tongue images were associated with *** the 2 diagnostic models,which would be convenient,noninvasive,lightweight,rapid,and inexpensive technical references for early screening,can accurately distinguish NAFLD and are worth further study.

关键词： nonalcoholic fatty liver disease noninvasive diagnosis tongue image tongue diagnosis Chinese medicine machine learning

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A highly reduced Mo_(74) polyoxometalate featuring high proton conductivity accessed by building block strategy

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Science China Chemistry 2024年第3期67卷 862-868页

作者： Shi-yi Liu Xue-Xin Li Wei-Chao Chen Kui-Zhan shao Xin-Long Wang Chao Qin Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Highly reduced polyoxometalates(POMs) are predicted to be used as rather high energy density materials;however,it still suffers from the limited cluster species and reduction *** we demonstrate that it is possible to employ the building block strategy to generate a highly reduced polyoxomolybdate(C_(2)H_(8)N)_(14)(NH_(4))_(4)H_(14)[Mo_(48)-ⅤMo_(26)ⅥO_(202)(OH)_(12)(SO_(4))_(6)]·46H_(2)O(Mo_(74)).The fundamental Mo-based{Mo_x}(x=4,5,and 6) building blocks,which are templated by tetra-coordinated anions{MoO_(4)}or{SO_(4)},not only lay foundation for the formation of Mo_(74) featuring an unprecedented reduction ratio of 65%,but also give rise to SBBs-mediated(secondary building blocks) supramolecular dense packing interactions among the isolated Mo_(74) clusters that are favorable for proton ***,high proton conductivity(2.04×10^(-2)S cm^(-1)) had been realized at 50℃ and 90% relative humidity,revealing one of the well-known POMs-based crystalline proton conducting *** result highlights that this building block approach possesses great potential in producing highly reduced POM systems that can achieve controllable reduced ratio and desirable properties.

关键词： polyoxometalate building block molybdenum highly reduced state proton conduction

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