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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Musielak–Orlicz–Lorentz Hardy Spaces:Maximal Function,Finite Atomic,and Littlewood–Paley Characterizations with Applications to Dual Spaces and Summability of Fourier Transforms

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Acta Mathematica Sinica,English Series 2025年第1期41卷 1-77页

作者： Hongchao jia Der-chen Chang Ferenc Weisz Dachun Yang Wen Yuan Laboratory of Mathematics and Complex Systems(Ministry of Education of China) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China Department of Mathematics and Statistics Georgetown UniversityWashingtonDC 20057USA Graduate Institute of Business Administration College of ManagementFu Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Numerical Analysis Eotvos L.UniversityP´azm´any P.s´et´any 1/C.Budapest 1117Hungary

Let q∈(0,∞]andϕbe a Musielak-Orlicz function with uniformly lower type p_(ϕ)^(−)∈(0,∞)and uniformly upper type p_(ϕ)^(−)∈(0,∞).In this article,the authors establish various realvariable characterizations of the Musielak-Orlicz-Lorentz Hardy space H^(ϕ,q)(R^(n)),respectively,in terms of various maximal functions,finite atoms,and various Little wood-Paley *** applications,the authors obtain the dual space of Hϕ,q(Rn)and the summability of Fourier transforms from Hϕ,q(Rn)to the Musielak-Orlicz-Lorentz space L^(ϕ,q)(R^(n))when q∈(0,∞)or from the Musielak-Orlicz Hardy space Hϕ(Rn)to Lϕ,∞(Rn)in the critical *** results are new when q∈(0,∞)and also essentially improve the existing corresponding results(if any)in the case q=∞via removing the original assumption thatϕis *** overcome the essential obstacles caused by both thatϕmay not be concave and that the boundedness of the powered Hardy-Littlewood maximal operator on associated spaces of Musielak-Orlicz spaces is still unknown,the authors make full use of the obtained atomic characterization of H^(ϕ,q)(R^(n)),the corresponding results related to weighted Lebesgue spaces,and the subtle relation between Musielak-Orlicz spaces and weighted Lebesgue spaces.

关键词： Musielak-Orlicz-Lorentz Hardy space finite atom duality Littlewood-Paley characterization Fourier transform

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Risk factors for biometry prediction error by Barrett Universal II intraocular lens formula in Chinese patients

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 74-78页

作者： Xu-Hao chen ying Hong Xiang-Han Ke Si-jia Song Yu-Jie Cen Chun Zhang Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Department of OphthalmologyPeking University Third HospitalBeijing 100191China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the influence of postoperative intraocular lens(IOL)positions on the accuracy of cataract surgery and examine the predictive factors of postoperative biometry prediction errors using the Barrett Universal II(BUII)IOL formula for ***:The prospective study included patients who had undergone cataract surgery performed by a single surgeon from June 2020 to April *** collected data included the best-corrected visual acuity(BCVA),corneal curvature,preoperative and postoperative central anterior chamber depths(ACD),axial length(AXL),IOL power,and refractive *** formula was used to calculate the IOL *** mean absolute error(MAE)was calculated,and all the participants were divided into two groups *** t-tests were applied to compare the variables between *** regression analysis was used to analyze the influence of age,AXL,corneal curvature,and preoperative and postoperative ACD on ***:A total of 261 patients were *** 243(93.1%)and 18(6.9%)had postoperative MAE1 D,*** number of females was higher in patients with MAE>1 D(χ^(2)=3.833,P=0.039).The postoperative BCVA(logMAR)of patients with MAE>1 D was significantly worse(t=-2.448;P=0.025).After adjusting for gender in the logistic model,the risk of postoperative refractive errors was higher in patients with a shallow postoperative anterior chamber[odds ratio=0.346;95% confidence interval(CI):0.164,0.730,P=0.005].CONCLUSION:Risk factors for biometry prediction error after cataract surgery include the patient’s sex and postoperative *** with a shallow postoperative anterior chamber are prone to have refractive errors.

关键词： intraocular lens power calculation gender anterior chamber depth biometry prediction error

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弯曲波导研究进展及其应用

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中国光学 2017年第2期10卷 176-193页

作者：高峰秦莉陈泳屹贾鹏陈超梁磊陈红张星宁永强中国科学院长春光学精密机械与物理研究所发光学及应用国家重点实验室吉林长春130033 中国科学院大学北京100049

本文主要分析了弯曲波导损耗机理,包括传输损耗、辐射损耗、模式转换损耗。重点综述了设计低损耗弯曲波导的方法,包括波导材料、弯曲波导的曲线形状、波导种类、脊型波导的宽度、脊高、弯曲半径、模场分布、弯曲波导曲线形状和其他新型... 详细信息

本文主要分析了弯曲波导损耗机理,包括传输损耗、辐射损耗、模式转换损耗。重点综述了设计低损耗弯曲波导的方法,包括波导材料、弯曲波导的曲线形状、波导种类、脊型波导的宽度、脊高、弯曲半径、模场分布、弯曲波导曲线形状和其他新型波导结构等。简要概括了近年来设计和制备低损耗弯曲波导的代表性工作。介绍了弯曲波导在集成光学中的应用。通过对弯曲波导的损耗及耦合机制理论的不断完善,实现光在较小弯曲半径的低损耗传输,从而提高集成光学的集成度是弯曲波导今后的发展趋势。

关键词：弯曲波导集成光学 SOI 低损耗波导

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Rapid assessment of avoidable blindness in Yueqing,an economically developed area in eastern China

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 510-517页

作者： Chun-Jie Lu Wei-He Zhou Yuan-Bo Liang yi-Ze chen Di Song yi-Hua Tang Juan Gu jia Qu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the prevalence and the causes of blindness,severe visual impairment(SVI),and visual impairment(VI)and to investigate the frequency of cataract surgery in people aged≥50y in Yueqing,Zhejiang Province,***:A population-based,cross-sectional study was performed using the Rapid Assessment of Avoidable Blindness ***-seven clusters,each consisting of 50 people aged≥50y,were selected by probabilityproportionate-to-size *** outreach teams conducted door-to-door *** acuity(VA)was measured using a tumbling E *** status and causes of VI were assessed by ophthalmologists for individuals with a VA of6/18).CONCLUSION:Prevalence rates of blindness,SVI,and VI in Yueqing are lower than other reported Chinese population-based *** remain the most common cause of blindness and VI.

关键词： visual impairment cataract surgery rapid assessment of avoidable blindness prevalence of blindness

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Dielectric-ion-conductive ZnNb_(2)O_(6) layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin cheng Qinghua Guan Jing Dong Bixian chen Lujie jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina i-Lab&CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina Helmholtz Institute Ulm(HIU) Ulm D89081Germany School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048ShaanxiChina Karlsruhe Institute of Technology(KIT) Karlsruhe D76021Germany State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

Rechargeable aqueous zinc-metal batteries (AZMBs) are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn(H_(2)O)_(6)^(2+)solvation ***,learnt from self-generated solid electrolyte interphase (SEI) in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface (ZNB@Zn),acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility (99.54%) even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g^(-1)and outstanding rate performance up to 10 A g^(-1).The large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectri cartificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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On using an aerosol thermodynamic model to calculate aerosol acidity of coarse particles

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Journal of Environmental Sciences 2025年第2期148卷 46-56页

作者： Zhengyang Fang Shuwei Dong chengpeng Huang Shiguo jia Fu Wang Haoming Liu He Meng Lan Luo yizhu chen Huanhuan Zhang Rui Li Yujiao Zhu Mingjin Tang State Key Laboratory of Organic Geochemistry Guangdong Key Laboratory of Environmental Protection and Resources UtilizationGuangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 101408China Longhua Center for Disease Control and Prevention of Shenzhen Shenzhen 518109China School of Atmospheric Sciences and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Sun Yat-sen UniversityZhuhai 519082China Institute for Environmental and Climate Research Jinan UniversityGuangzhou 510632China Qingdao Eco-environment Monitoring Center of Shandong Province Qingdao 266003China Environment Research Institute Shandong UniversityQingdao 266237China

Thermodynamic modeling is still themostwidely usedmethod to characterize aerosol acidity,a critical physicochemical property of atmospheric ***,it remains unclear whether gas-aerosol partitioning should be incorporated when thermodynamicmodels are employed to estimate the acidity of coarse *** this work,field measurements were conducted at a coastal city in northern China across three seasons,and covered wide ranges of temperature,relative humidity and NH_(3) *** examined the performance of different modes of ISORROPIA-II(a widely used aerosol thermodynamic model)in estimating aerosol acidity of coarse and fine *** M0 mode,which incorporates gas-phase data and runs the model in the forward mode,provided reasonable estimation of aerosol acidity for coarse and fine *** to M0,the M1 mode,which runs the model in the forward mode but does not include gas-phase data,may capture the general trend of aerosol acidity but underestimates pH for both coarse and fine particles;M2,which runs the model in the reverse mode,results in large errors in estimated aerosol pH for both coarse and fine particles and should not be used for aerosol acidity ***,M1 significantly underestimates liquid water contents for both fine and coarse particles,while M2 provides reliable estimation of liquid water *** summary,our work highlights the importance of incorporating gas-aerosol partitioning when estimating coarse particle acidity,and thus may help improve our understanding of acidity of coarse particles.

关键词： Aerosol acidity Coarse particles Thermodynamic model Aerosol liquid water ISORROPIA-II Gas-aerosol partitioning

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肥料和稻草氮利用率的三年定位研究

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土壤通报 2004年第6期35卷 763-766页

作者：王胜佳王家玉陈义浙江省农业科学院土壤肥料研究所浙江杭州310021

对氮肥和稻草氮的利用率进行了3年6季同位素15N田间定位研究。结果表明,首季单季水稻对氮肥的利用率为37.02%,050cm土壤中15N的残留率为25.81%。经过连续3年6季的种植,作物肥料N的累计回收率分别为40.15(秸杆还田)41.63%(秸杆不还田),05... 详细信息

对氮肥和稻草氮的利用率进行了3年6季同位素15N田间定位研究。结果表明,首季单季水稻对氮肥的利用率为37.02%,050cm土壤中15N的残留率为25.81%。经过连续3年6季的种植,作物肥料N的累计回收率分别为40.15(秸杆还田)41.63%(秸杆不还田),050cm土壤中15N的残留率仍达到23.62(秸杆不还田)28.33%(秸杆还田)。在不施氮肥条件下,小麦对稻草氮的吸收率为4.46%,第二季单季稻对稻草氮的吸收率为4.78%。5季作物累计吸收稻草氮11.76%,而土壤残留率为70.37%。

关键词：肥料稻草氮肥回收率氮素同位素

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Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes

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Chinese Journal of Natural Medicines 2025年第02期23卷 203-213页

作者： Ben Niu Xiaohong An Yongmei chen Ting He Xiao Zhan Xiuqi Zhu Fengfeng Ping Wei Zhang jia Zhou School of Traditional Chinese Pharmacy China Pharmaceutical University Wuxi People's Hospital Nanjing Medical University Yunnan Characteristic Plant Extraction Laboratory Yunnan Yunke Characteristic Plant Extraction Laboratory Co. Ltd. Drug Discovery and Development Laboratories Ningxia Hui Medicine Research Institute Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences & Peking Union Medical College

Nigella sativa L. seeds have been traditionally utilized in Chinese folk medicine for centuries to treat vitiligo. This study revealed that the ethanolic extract of Nigella sativa L.(HZC) enhances melanogenesis and mitigates oxidative stress-induced cellular senescence and dysfunction in melanocytes. In accordance with established protocols, the ethanol fraction from Nigella sativa L. seeds was extracted, concentrated, and lyophilized to evaluate its herbal effects via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays, tyrosinase activity evaluation, measurement of cellular melanin contents, scratch assays, senescence-associated β-galactosidase(SA-β-gal) staining, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis for expression profiling of experimentally relevant proteins. The results indicated that HZC significantly enhanced tyrosinase activity and melanin content while notably increasing the protein expression levels of Tyr, Mitf, and gp100 in B16F10 cells. Furthermore, HZC effectively mitigated oxidative stress-induced cellular senescence, improved melanocyte condition, and rectified various functional impairments associated with melanocyte dysfunction. These findings suggest that HZC increases melanin synthesis in melanocytes through the activation of the MAPK, PKA, and Wnt signaling *** addition, HZC attenuates oxidative damage induced by H2O2 therapy by activating the nuclear factor E2-related factor 2-antioxidant response element(Nrf2-ARE) pathway and enhancing the activity of downstream antioxidant enzymes, thus preventing premature senescence and dysfunction in melanocytes.

关键词： Cellular senescence Melanin Nigella sativa L. seed extract (HZC) ROS Vitiligo

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RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang Lin Gu Qiu-ying Han jia-Qing Xing Ming Zhao Shao-yi Huang Jun-Xi yi Jie Pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun Shao-Zhen jiang Dan Luo Ling chen Zheng-Jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

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