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Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 76-93页

作者： Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin Qin-Yan Su Yi-Wu Dang Gang Chen jia-liang wei Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Surgery Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant ***,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC *** This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in *** regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell *** enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in *** sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC *** The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,P<0.05)and protein(SMD=2.85,95%CI:1.19-4.50,P<0.05)were significantly overexpressed in HCC *** integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,P<0.05).PSMD6 knockout inhibited HCC cell growth(chronos scores<-1).Functional enrichment implicated ribosome biogenesis and RNA *** enrichment of signalling pathways such as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen *** sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and *** PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC ***6 is essential for the growth of HCC cell

关键词： Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing

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Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups

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Chemical Research in Chinese Universities 2006年第4期22卷 459-464页

作者： ZHAI Xin ZHAO Yan-fang WANG jia HONG wei HUANG liang GONG Ping School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic（imidazo[ 1,2-b] pyridazine/ imidazo[2,1-b] thiazole） groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by ^1H NMR, IR and MS, and their in vitro antibacterial activities against staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid.

关键词： Oxazolidinone analog Synthesis Antibacterial activity

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Unusual presentation of bladder neuroblastoma in a child: A case report

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World Journal of Clinical Cases 2020年第1期8卷 194-199页

作者： jia-Bin Cai Jin-Hu Wang Min He Fa-liang Wang Jie-Ni Xiong Jun-Qing Mao Min-Ju Li Kun Zhu jia-wei liang Division of Surgical Oncology Department of Pediatric SurgeryChildren’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina Department of Pathology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina Department of Radiology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Neuroblastoma is an extracranial malignant tumor in children that is most often located in the adrenal gland and sympathetic ***,we present a rare case of neuroblastoma originating from the urinary *** SUMMARY A 3-year-old girl presented with lower abdominal pain with *** revealed a lower abdominal *** computed tomography scan displayed a solitary mass at the top of the urinary *** levels of neuron-specific enolase and lactate dehydrogenase were *** treated the child with partial cystectomy and six courses of chemotherapy,and the outcome at 4-year follow-up was *** Neuroblastoma should be considered when tumors are located in the urinary bladder,especially in the dome;although this presentation is rare,the prognosis is very good.

关键词： Neuroblastoma Urinary bladder Pelvic neoplasms Prognosis Child Case report

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Application of voxel-based morphometric method to detect brain changes in children with non-cyanotic congenital heart disease

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World Journal of Radiology 2020年第9期12卷 204-212页

作者： Xuan jia Xiao-Hui Ma jia-wei liang Department of Radiology The Children's HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Congenital heart disease(CHD)is a cardiovascular malformation caused by abnormal heart and/or vascular development in the *** children with CHD,abnormalities in the development and function of the nervous system are *** present,there is a lack of research on the preoperative neurological development and injury in young children with non-cyanotic *** To determine the changes in white matter,gray matter,and cerebrospinal fluid(CSF)by magnetic resonance imaging(MRI)in children with non-cyanotic CHD as compared with healthy *** Children diagnosed with non-cyanotic CHD on ultrasonography(n=54)and healthy control subjects(n=35)were included in the *** the subjects were aged 1-3 *** MRI was performed prior to surgery for *** SPM v12 software was used to calculate the volumes of the gray matter,white matter,CSF,and the whole brain(sum of the gray matter,white matter,and CSF volumes).Volume differences between the two groups were ***-based morphometry was used to compare specific brain regions with statistically significant *** Compared with the control group,the study group had significantly reduced whole-brain white matter volume(P0.05).As compared with the healthy controls,children with non-cyanotic CHD had mild underdevelopment in the white matter of the anterior central gyrus,the posterior central gyrus,and the *** Children with non-cyanotic CHD show decreased white matter volume before surgery,and this volume reduction is mainly concentrated in the somatosensory and somatic motor nerve regions.

关键词： Voxel-based morphometry Non-cyanotic congenital heart disease Young children Magnetic resonance imaging

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Internet-Based Optimization and Choice of Insert Grooves for Face-Milling

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厦门大学学报（自然科学版） 2002年第S1期41卷 37-38页

作者： DONG Li-hua 1, XU Xiao-cun 1, LI Zhen-jia 1, wei Hua-liang 2 (1. Department of Mechanical Engineering, Harbin University of Science and Technology, Harbin 150080, China 2. Harbin Measuring and Cutting Works, Harbin 150040, China)

Manufacture is facing more furiously competition in the new century. It tends to be globalized. Rapid response and technology innovation have become the key factor to the success of manufacture enterprise. At present, internet-based manufacturing develops rapidly. With the development of engineering material and machining techniques, better cutting properties of metal cutting tools are required. The world is paying more attention to the study of indexable carbide inserts with three-dimensional complex grooves which can affect cutting properties directly and chip-controlling. So the variety and specification of indexable insert develop quickly and the application of insert with three-dimensional complex chip-former becomes wider and wider. Because milling is an interrupted cutting, the process of milling is complicated and the failure of the milling inserts is severe. It is important to choose suitable milling inserts groove for particular machining conditions before actual machining, it will extend tool life and raise productivity. Optimization and choice of inserts with complex groove via internet may serve for manufacture enterprises all over the world. The milling inserts with three-dimensional complex grooves are optimized and chosen via Internet in this paper. The face-milling process is studied, with the mathematics models of cutting force for different shape of cutting edges established, the cutting forces predicted and stress-fields of different insert grooves analyzed by FEM, according to the predictable results and the most suitable insert groove for particular machining conditions are optimized and chosen. The complex groove optimization and choice are based on a client/server model, with the client and server being on different machines across the internet. Communication between the client and server uses the TCP/IP. The result of optimization and choice will be sent to the users via Internet. Manufacturers all over the world can get the desired insert g

关键词： Internet-based face-milling insert groove optimization and choice

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高血压脑出血微创手术治疗进展

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第二军医大学学报 2015年第12期36卷 1333-1338页

作者：魏嘉良董艳侯立军第二军医大学长征医院神经外科上海200003

高血压脑出血具有高发病率、高残死率,给社会、家庭带来了沉重的健康及经济负担。高血压脑出血也是脑卒中亚分类中仅有的没有明确治疗标准的疾病,传统开颅手术在高血压脑出血中应用广泛,但目前没有明确证据支持其可以提升患者的神经功... 详细信息

高血压脑出血具有高发病率、高残死率,给社会、家庭带来了沉重的健康及经济负担。高血压脑出血也是脑卒中亚分类中仅有的没有明确治疗标准的疾病,传统开颅手术在高血压脑出血中应用广泛,但目前没有明确证据支持其可以提升患者的神经功能及预后;微创手术逐渐得到了越来越广泛的应用,显示出明显优势。本文主要就目前常用的高血压脑出血微创手术,包括立体定向血肿抽吸、神经内镜技术及纤溶药物治疗等的发展及现状作一综述。

关键词：高血压性颅内出血微创性外科手术立体定向血肿抽吸神经内镜术组织型纤溶酶原激活物尿纤溶酶原激活物

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On Top of the World—Twice!

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Women of China 2000年第5期 17-页

作者： YU jia wei liang

A MONG the representatives from various quarters on the parade float celebrating the 50th anniversary of the founding of the People's Republic of China at Tian'anmen Square, was a tall, handsome and energetic figure in Tibetan national dress. Guisang, one of the ten outstanding Chinese women, is a notable mountaineer from Xigaze City, Tibet. The honour of seeing top state leaders waving and greeting them with her own eyes made Guisang beside herself with excitement.

关键词： In Twice On Top of the World

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纳米铝酸锶长余辉发光粉体的制备与性能表征

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功能材料 2008年第7期39卷 1074-1077页

作者：刘晓林魏家良陈建峰邹新阳北京化工大学纳米材料先进制备技术与应用科学教育部重点实验室北京100029

采用共沉淀法首先制得铝酸锶前驱体,经水热处理后煅烧获得了颗粒尺寸约为50nm的SrAl2O4∶Eu2+,Dy3+长余辉发光粉体。利用X射线衍射仪、透射电镜、荧光分光光度计和余辉测试仪等手段对粉体进行了表征。结果表明,在相同的煅烧条件下,与直... 详细信息

采用共沉淀法首先制得铝酸锶前驱体,经水热处理后煅烧获得了颗粒尺寸约为50nm的SrAl2O4∶Eu2+,Dy3+长余辉发光粉体。利用X射线衍射仪、透射电镜、荧光分光光度计和余辉测试仪等手段对粉体进行了表征。结果表明,在相同的煅烧条件下,与直接煅烧前驱体获得的粉体相比,经水热处理的粉体不仅颗粒尺寸小、粒度分布均匀而且发光性能(亮度和余辉)优异。

关键词：发光 SrAl2O4 共沉淀法水热处理纳米

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MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： jiaen Wang wei Ming Longfu Chen Tianliang Song Moxi Yele Hao Zhang Long Yang Gegen Sarula Benliang liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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改良小脑扁桃体切除联合后颅窝小骨窗减压扩容术治疗Chiari-Ⅰ畸形合并脊髓空洞症

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第二军医大学学报 2015年第10期36卷 1127-1132页

作者：黄巍魏嘉良黄勇李乾陈亚坤顾进茂黄承光第二军医大学长征医院神经外科上海200003

目的探讨软膜下切除小脑扁桃体联合后颅窝小骨窗减压扩容术治疗合并脊髓空洞症的Chiari-Ⅰ畸形的手术改良方式及疗效。方法回顾性分析2012年1月至2014年1月采用显微外科技术行软脑膜下小脑扁桃体切除联合小骨窗减压扩容改良术治疗29例... 详细信息

目的探讨软膜下切除小脑扁桃体联合后颅窝小骨窗减压扩容术治疗合并脊髓空洞症的Chiari-Ⅰ畸形的手术改良方式及疗效。方法回顾性分析2012年1月至2014年1月采用显微外科技术行软脑膜下小脑扁桃体切除联合小骨窗减压扩容改良术治疗29例合并脊髓空洞症的Chiari-Ⅰ畸形患者的临床资料。手术方法:取俯卧头颈同轴位,术中行后颅窝小骨窗减压,打开寰椎后弓;在保持软脑膜完整的前提下将小脑扁桃体下疝入颈椎管内部分作软膜下切除;行四脑室正中孔处粘连松解;切开的蛛网膜与硬膜缘缝合避免形成医源性死腔;最后用自体筋膜修补减张缝合硬膜,全程控制脑脊液释放速度。结果术后随访24例,失访5例。23例患者术后近期(1年内)疗效评价为有效(有效率95.8%),术后6个月后复查MRI见延髓和上颈髓后方压迫解除,小脑扁桃体下缘升至枕骨大孔以上平面,下疝解除,脊髓空洞明显缩小或消失。结论显微神经外科手术改良软脑膜下小脑扁桃体切除联合后颅窝小骨窗减压扩容术是治疗Chiari-Ⅰ畸形并脊髓空洞症的一种有效方法。

关键词： Chiari畸形脊髓空洞症小脑扁桃体下疝后颅窝重建

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