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麒麟菜多糖体内抗肿瘤机理研究

现代食品科技 2017年第5期33卷 14-19页

作者：于娟纪海玉王玉芳贾贺威刘安军天津科技大学食品工程与生物技术学院天津300457

本文对麒麟菜多糖抑制小鼠体内H22肝癌细胞增殖的作用机理进行了研究。构建动物肿瘤模型,观察实验期内各组小鼠肿瘤体积及脏器指数的变化,并通过Elisa实验确定各组小鼠血清中肿瘤特异性抗体含量,流式细胞术检测小鼠胸腺、脾脏、外周血... 详细信息

本文对麒麟菜多糖抑制小鼠体内H22肝癌细胞增殖的作用机理进行了研究。构建动物肿瘤模型,观察实验期内各组小鼠肿瘤体积及脏器指数的变化,并通过Elisa实验确定各组小鼠血清中肿瘤特异性抗体含量,流式细胞术检测小鼠胸腺、脾脏、外周血及实体肿瘤内T细胞亚群比例,he染色和PI单染分析小鼠实体肿瘤内细胞状态。结果表明,灌喂600 mg/(kg?d)麒麟菜多糖可显著抑制荷瘤小鼠肿瘤的生长,有效保护其胸腺和脾脏,并可显著增强胸腺发育分化CD4^+T细胞的能力(p<0.05),提高小鼠血液中肿瘤特异性抗体的含量(p<0.05)和T细胞亚群比例(p<0.05);模型组和多糖组小鼠实体肿瘤浸润淋巴细胞中均主要是CD8^+T细胞,但多糖组小鼠实体瘤内细胞凋亡率显著升高(p<0.05)。因此初步断定麒麟菜多糖可显著提高荷瘤小鼠的抗肿瘤免疫水平,使CD8^+T细胞在CD4^+T细胞和肿瘤特异性抗体的辅助下有效抑制H22细胞体内增殖。

关键词：麒麟菜多糖抗肿瘤肿瘤特异性抗体 T细胞

茴香提取液对糖尿病大鼠血酯和心肌组织SOD、MDA和GSH的影响

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中国医院药学杂志 2017年第6期37卷 511-514页

作者：韦家河农生斌冯霞韩光顺黄春佳韦嘉敏李舒婷黄丽娟右江民族医学院临床医学院广西百色533000 右江民族医学院药学院广西百色533000 右江民族医学院生理教研室广西百色533000

目的:观察茴香提取液对糖尿病大鼠血酯水平和心肌组织超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽(GSH)的影响。方法:腹腔注射链脲佐菌素建立大鼠糖尿病模型,模型成功后,随机分为模型组、二甲双胍组、茴香低剂组和茴香高剂组,另设正常... 详细信息

目的:观察茴香提取液对糖尿病大鼠血酯水平和心肌组织超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽(GSH)的影响。方法:腹腔注射链脲佐菌素建立大鼠糖尿病模型,模型成功后,随机分为模型组、二甲双胍组、茴香低剂组和茴香高剂组,另设正常对照组。通过茴香水提取液灌胃干预30 d后,测定大鼠血糖、血酯和心肌组织SOD的活性、MDA和GSH的含量。结果:与模型组相比,茴香高剂组和茴香低剂组能明显降低大鼠的空腹血糖(FBG)(P<0.01),抑制血清中胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)的生成,提高高密度脂蛋白(HDL-C)的含量(P<0.01,P<0.05);SOD和GSH有所升高,MDA有所降低,但差异无显著性。结论:茴香具有降低血糖、调节血脂代谢紊乱的作用,对心肌组织SOD、MDA和GSH的影响不明显。

关键词：茴香糖尿病血脂心肌氧化应激

改良括约肌间瘘管结扎术治疗低位肛瘘的疗效观察

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临床外科杂志 2018年第4期26卷 277-279页

作者：郭佳何伟管甲生扬州大学临床医学院(江苏省苏北人民医院)肛肠科 225000

目的评价改良括约肌间瘘管结扎术(ligation of intersphincteric fistula tract,LIFT)治疗低位肛瘘的临床疗效。方法低位肛瘘病人40例,随机分成试验组和对照组,每组各20例。试验组采用改良LITF,对照组采用传统肛瘘切除术,比较两组临床... 详细信息

目的评价改良括约肌间瘘管结扎术(ligation of intersphincteric fistula tract,LIFT)治疗低位肛瘘的临床疗效。方法低位肛瘘病人40例,随机分成试验组和对照组,每组各20例。试验组采用改良LITF,对照组采用传统肛瘘切除术,比较两组临床疗效。结果试验组和对照组创面愈合时间分别为(17.8±4.5)天和(24.7±5.8)天,疼痛持续时间分别为(6.9±1.5)天和(4.0±1.3)天,术后肛门功能评分分别为(3.7±2.5)分和(2.9±1.8)分,两组比较,差异有统计学意义(P0.05)。随访6~12个月,两组复发率比较差异无统计学意义(P>0.05)。结论改良LITF是一种疗效好、创伤小、痛苦小、病程短、术后复发率低、肛门控便功能影响小的新型手术方式。

关键词：改良括约肌间瘘管结扎术低位肛瘘疼痛肛门功能复发

跨越新生适应障碍:中国大学入学教育的运行机制及其成效

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华东师范大学学报（教育科学版） 2025年第1期43卷 49-66页

作者：鲍威何元皓何峰厦门大学高等教育发展中心厦门361005 厦门大学教育研究院厦门361005 北京大学教育经济研究所北京100871 北京大学未来教育管理研究中心北京100871 北京大学研究生院北京100871

入学教育是帮助新生适应大学环境、形成自我与社会认知、充分融入大学生活的重要桥梁。鉴于我国大学新生普遍存在学术性、社会性双重适应障碍,在通过国际比较清晰认识中国入学教育运行机制特征的基础上,利用全国大一学生调查数据,科学... 详细信息

入学教育是帮助新生适应大学环境、形成自我与社会认知、充分融入大学生活的重要桥梁。鉴于我国大学新生普遍存在学术性、社会性双重适应障碍,在通过国际比较清晰认识中国入学教育运行机制特征的基础上,利用全国大一学生调查数据,科学评估入学教育在缓减新生适应障碍中的干预成效。研究表明,采用长期深度教育形式,传递专业学科认知、学习方法习得、心理健康建设3大教育内容向度的入学教育运行机制,对缓减学生学术性、社会性双重适应障碍具有积极效用。囿于精准化帮扶举措欠缺,入学教育对弱势学生的补偿效应有待加强。结论为完善大学入学教育、保障人才培养质量提供科学启示。

关键词：入学教育大学新生学术性适应社会性适应

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia Zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： wei-Min Qin Zhongliang Li Wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

黄果树风景名胜区低效林分改造措施及生态恢复对策

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水土保持通报 2004年第4期24卷 81-84,93页

作者：周家维安和平贵州省林业科学研究院贵州贵阳550005 贵州大学贵州贵阳550025

阐述了黄果树风景名胜区低效林分的现状、特征。根据现有林分和立地条件,将研究区的低效林分划分为低产经济林、低效落叶阔叶林、低效常绿针阔混交林、低效灌木林、低效石山灌丛等5种类型,又把低效石山灌丛分为封山育林和困难地段造林... 详细信息

阐述了黄果树风景名胜区低效林分的现状、特征。根据现有林分和立地条件,将研究区的低效林分划分为低产经济林、低效落叶阔叶林、低效常绿针阔混交林、低效灌木林、低效石山灌丛等5种类型,又把低效石山灌丛分为封山育林和困难地段造林。采用封、补、改、造、抚等措施对不同的低效林分类型,采取不同的改造方式进行改造。并结合该区自然、社会、经济发展的实际情况,从生态、生活和生产方面提出了黄果树风景名胜区石灰岩山地生态建设的对策建议。

关键词：黄果树风景名胜区林分改造生态恢复发展对策

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song he Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes