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Deep multiple instance selection

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Science China(Information Sciences) 2021年第3期64卷 18-32页

作者： Xin-Chun LI De-Chuan ZHAN jia-qi yang Yi SHI State Key Laboratory for Novel Software Technology Nanjing University

Multiple instance learning(MIL) assigns a single class label to a bag of instances tailored for some real-world applications such as drug activity prediction. Classical MIL methods focus on figuring out interested instances, that is, region of interests(ROIs). However, owing to the non-differentiable selection process, these methods are not feasible in deep learning. Thus, we focus on fusing ROIs identification with deep MILs in this paper. We propose a novel deep MIL framework based on hard selection, that is, deep multiple instance selection(DMIS), which can automatically figure ROIs out in an end-to-end *** be specific, we propose DMIS-GS for instance selection via gumbel softmax or gumbel top-k, and then make predictions for this bag without the interference of redundant instances. For balancing exploration and exploitation of key instances, we apply a cooling down approach to the temperature in DMIS-GS, and propose a variance normalization method to make this hyper-parameter tuning process much easier. Generally, we give a theoretical analysis of our framework. The empirical investigations reveal the proposed frameworks' superiorities against classical MIL methods on generalization ability, positioning ROIs, and comprehensibility on both synthetic and real-world datasets.

关键词： multiple instance learning instance selection gumbel softmax variance normalization hard attention

Paleoenvironment reconstruction of the Middle Ordovician thick carbonate from western Ordos Basin, China

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Petroleum Science 2023年第1期20卷 48-59页

作者： jia-qi yang Jun-Tao Zhang Zhi-Liang He Tao Zhang School of Energy Resources China University of GeosciencesBeijing100083China SINOPEC Exploration and Production Research Institute Beijing100083China China Petrochemical Corporation Ltd. Beijing100728China

Reconstructing paleoenvironments has long been considered a vital component for understanding the development and evolution of carbonate *** Middle Ordovician Period is considered the archetypical greenhouse interval,and also a critical period in biological *** Middle Darriwilian isotope carbon excursion has been observed in many areas of the world and may be related to the biological explosions caused by decreases in the *** thick carbonate rocks in the fifth member of the Middle Ordovician Majiagou Formation in the Dingbei area of the Ordos Basin were chosen as an example,based on the concentration of major,trace and rare earth elements as well as C,O and Sr isotopic analyses,the paleoenvironment was *** its impact on natural gas exploration was *** results show that the seawater paleotemperature was 29℃,suboxicanoxic paleoredox conditions were observed,and the seawater paleosalinity was high.A large number of plankton in the biological explosion caused a rapid increase in the total organic carbon in carbonate rocks,which provided natural gas as supplemental source *** by early meteoric water,the dissolution of gypsum laid the foundation for high-quality reservoirs,and the residual gypsum also further preserved natural *** study provides new data for the paleoenvironment and a theoretical basis for further natural gas exploration.

关键词： Middle darriwilian isotope carbon excursion Paleoenvironment Natural gas exploration Middle ordovician Ordos basin

Oligo-lysine Induced Formation of Silica Particles in Neutral Silicate Solution

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Chemical Research in Chinese Universities 2006年第3期22卷 368-370页

作者： ZHANG Xiao-dong SUN Ying-ying ZHUANG jia-qi yang Wen-sheng College of Chemistry Jilin University Changchun 130023 P.R. China

Oligo-（lysine） n （n = 1-4） containing different numbers of lysine residues was used to induce the condensation of silicic acid to form silica particles in neutral silicate solution. It was found that the condensation rate and the formation of silica particles are dependent on the number of lysine residues in an oligo-lysine. Oligo-lysine with more lysine residues can link more silicic acid together to form a matrix that promotes the effective aggregation of the condensed silica pieces to form large silica particles.

关键词： Biosilification Polylysine Silica

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： qian-Yun Guo jia-qi yang Xun-Xun Feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

Design, Synthesis and Biological Evaluation of Novel α-Acyloxycarboxamide-Based Derivatives as c-Met Inhibitors

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Chinese Journal of Chemistry 2021年第8期39卷 2241-2250页

作者： Yu-juan Feng Yu-Lin Ren Li-Ming Zhao Guo-qiang Xue Wen-Hao Yu jia-qi yang Jun-Wei Liu Northwest Minzu University LanzhouGansu 730030China Department of Public Health The Second Provincial People's Hospital of GansuLanzhouGansu 730030China

Dysregulated HGF/c-Met signalling has been associated with many human cancers,poor clinical outcomes,and even resistance acquisition to some approved targeted *** such,c-Met kinase has emerged as an attractive target ... 详细信息

关键词： 4-(2-Fluorophenoxy)quinoline derivatives c-Met inhibitors Passerini reaction a-Acyloxycarboxamide Biological evaluation

Donor safety in adult living donor liver transplantation using the right lobe: Single center experience in China

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World Journal of Gastroenterology 2007年第27期13卷 3752-3755页

作者： Fu-Gui Li Lu-Nan Yan Yong Zeng jia-Yin yang qi-Yuan Lin Xiao-Zhong jiang Bin Liu The Center of Liver Transplantation the Second Department of General Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM: To evaluate the safety of donors in adult living donor liver transplantation (LDLT) using the right lobe in a single liver transplantation center in China. METHODS: We investigated retrospectively 52 living donor liver resections performed from October 2003 to July 2006. All patients were evaluated by blood tests and abdominal CT. The mean donor age was 28.2 ± 7.4 years. Residual liver volume was 42.1% ± 4.7%. Mean operative time was 420 ± 76.2 min; mean ICU stay, less than 36 h; mean hospital stay, 16.4 ± 8.6 d; and mean follow-up period, 6 mo. RESULTS: There was no mortality. The overall complication rate was 40% (21 donors). Major complications included biliary leak in two, and pneumonia in 2 donors. Minor complications included mild pleural effusion in 12 donors, transient ascites in 6, mild depression in 4, intra-abdominal collections in 2, and wound infections in 1 donor. Residual liver volume did not affect the complication rate. None required re- operation. Return to pre-donation activity occurred within 5-8 wk. CONCLUSION: Right hemi-hepatectomy can be performed safely with minimal risk in cases of careful donor selection. Major complications occurred in only 7.7% of our series.

关键词： Safety Donor Liver transplantation Complication

Fractionation characteristics of magnesium isotope in the ancient weathering crust

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Petroleum Science 2023年第3期20卷 1446-1457页

作者： jia-qi yang Jun-Tao Zhang Zhi-Liang He Ni-Na Luo Xiao-Hui Jjin Tao Zhang Ning Gu Kang-Jun Huang jian Gao School of Energy Resources China University of GeosciencesBeijing100083China SINOPEC Exploration and Production Research Institute Beijing100083China China Petrochemical Corporation Ltd. Beijing100728China Key Laboratory of Deep Geology and Resources SINOPECBejing102206China Chongqing Gas Field of Petro China Southwest Oil and Gas Field Company Chongqing400021China Shaanxi Key Laboretory of Early Life and Environments Department of GeologyNorthwest UniversityXi'anShaanxi710069China

Weathering has always been a concerned around the world,as the first and most important step in the global cycle of elements,which leads to the fractionation of isotopes on the scale of geological *** Middle Ordovician Majiagou Formation in Daniudi area of the Ordos Basin had experienced weathering for>130 *** thin section observation,major and trace element analysis,carbon,oxygen,and magnesium isotopes composition analysis,the dolomitization modes and weathering of ancient dolo-mite in Daniudi area were analyzed in *** results showed that the Sabkha and brine-reflux dolomitization modes had developed,and the Mg isotopes in different layers of the karst crust were fractionated by various *** vertical vadose zone was affected by weathering,the Mg isotope of dolomite(δ^(26)Mgdol)showed a downward decreasing trend;the horizontal underflow zone was controlled by diagenesis and formation fluid,δ^(26)Mgdol showed a vertical invariance and negative;the main reason for Mg isotope fractionation in the deep slow-flow zone was the brine-reflux dolomitization mode during early burial period,which showed a vertical downward ***,the Mg isotope characteristic data of the ancient weathering crust were provided and the process of Mg isotope frac-tionationinthekarstcrust was explained.

关键词： Magnesium isotope Dolomitization mode Weathering Ancient weathering crust Ordos Basin

Identification of SNPs and Their Effects on Swine Growth and Carcass Traits for Porcine IGFBP-3 Gene

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Agricultural Sciences in China 2008年第5期7卷 630-635页

作者： LIU De-wu ZHANG Hao WU Zhen-fang LI jia-qi yang Guan-fu ZHANG Xi-quan College of Animal Science South China Agricultural University Guangzhou 510642 P.R.China

The insulin-like growth factor binding protein-3 （IGFBP-3） was known as a key factor that regulates the effect of insulin- like growth factors （IGF-1 and IGF-2） on pig growth and development. We first identified 38 single nucleotide polymorphisms （SNPs） from a fragment of the IGFBP-3 gene spanning 1 823 bp using the denaturing high-performance liquid chromatography （DHPLC） method and confirmed them by direct sequencing. Among these SNPs, 36 located in introns and the remaining 2 in the 3 prime untranslated region （3UTR）. In addition, 16 PCR-RFLP polymorphisms were identified within these SNPs. Three SNPs were then selected to genotype 272 F2 individuals with PCR-RFLP method and the association of polymorphism with growth and carcass traits were analyzed. The results showed that no significant associations were observed between polymorphisms of A265G and A952G and traits. However, the A2670G significantly related with live body length, loin muscle area, and skin and fat percentage （P〈0.05）; highly significantly associated with weight of carcass lean and lean percentage （P〈 0.01）.

关键词： pig IGFBP-3 gene single nucleotide polymorphism (SNP) denaturing high-performance liquid chromatography(DHPLC) performance

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汽车电子节气门系统无抖振滑模控制方法研究

机械设计与制造 2024年第6期400卷 30-37,41页

作者：贾启阳天津交通职业学院汽车工程学院天津300393

针对电子节气门(ET)系统非线性特性对节流阀控制精度的影响,提出了一种鲁棒自适应无抖振滑模控制(ACFSM)方法。该控制方法考虑了ET系统非线性和参数不确定性的影响,引入了遗传算法(GA)优化了ACFSM控制器的控制参数获得了平滑的控制信号... 详细信息

针对电子节气门(ET)系统非线性特性对节流阀控制精度的影响,提出了一种鲁棒自适应无抖振滑模控制(ACFSM)方法。该控制方法考虑了ET系统非线性和参数不确定性的影响,引入了遗传算法(GA)优化了ACFSM控制器的控制参数获得了平滑的控制信号,结合所设计的自适应控制律减轻了不确定性的影响。为验证所提控制方法的有效性,通过实验表明ASCFM控制器不仅在闭环系统响应中不存在抖振现象,而且可以很好地保持良好的瞬态和稳态跟踪性能。通过对比表明ASCFM控制器在跟踪性能上优于ASM控制器,尤其在节流阀遇到外部干扰时,所提出的ASCFM控制器具有较强的鲁棒性。

关键词：电子节气门自适应滑模控制跟踪性能抖振