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Nuclear Science and Techniques 2021年第8期32卷 67-77页

作者： Hao-Yang Lan Tan Song jia-lin zhang jian-Liang Zhou Wen Luo School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Exemplary Base for International Sci.&Tech. Collaboration of Nuclear Energy and Nuclear SafetyUniversity of South ChinaHengyang 421001China

The smuggling of special nuclear materials(SNMs)across national borders is becoming a serious threat to nuclear *** paper presents a feasibility study on the rapid interrogation of concealed SNMs by combining scattering and transmission nuclear resonance fluorescence(s NRF and t NRF)*** s NRF spectroscopy,SNMs such as^(235,238)U are excited by a wide-band photon beam of appropriate energy and exhibit unique NRF *** Carlo simulations show that one-dimensional scans can realize isotopic identification of concealed^(235,238)U when the detector array used for interrogation has sufficiently high energy *** simulated isotopic ratio^(235U/238)U is in good agreement with the theoretical value when the SNMs are enclosed in relatively thin *** interrogation is followed by t NRF spectroscopy using a narrow-band photon beam with the goal of obtaining tomographic images of the concealed *** reconstructed image clearly reveals the position of the isotope^(235)U inside an iron *** is shown that the interrogation time of s NRF and t NRF spectroscopy is one order of magnitude lower than that when only t NRF spectroscopy is used and results in a missed-detection rate of 10^(-3).The proposed method can also be applied for isotopic imaging of other SNMs such as^(239,240)Pu and^(237)Np.

关键词： Special nuclear material Nondestructive interrogation Nuclear resonance fluorescence

Basiliximab application on liver recipients:a meta-analysis of randomized controlled trials

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Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 139-146页

作者： Guo-Qing zhang Cheng-Shuo zhang Ning Sun Wu Lv Bao-Min Chen jia-lin zhang Department of Hepatobiliary and Transplantation Surgery First Affiliated Hospital of China Medical University Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital of Zhengzhou University

BACKGROUND： The benefits of the application of basiliximab induction therapy in liver transplantation are not clear. The present meta-analysis was to evaluate the pros and cons of basiliximab use in liver transplantation. DATA SOURCES： We searched the associated publications in English from July 1998 to December 2015 in the following databases： MEDlinE, Pub Med, Ovid, EMBASE, Web of Science and Cochrane ***： Basiliximab significantly decreased the incidence of de novo diabetes mellitus after liver transplantation（RR=0.56; 95% CI： 0.34-0.91; P=0.02）. Subgroup analysis showed that basiliximab in combination with steroids-free immunosuppressant significantly decreased the incidence of biopsy-proven acute rejection（RR=0.62; 95% CI： 0.39-0.97; P=0.04） and new-onset hypertension（RR=0.62; 95% CI： 0.42-0.93; P=0.02）.CONCLUSIONS： Basiliximab may be effective in reducing de novo diabetes mellitus. What is more, basiliximab in combination with steroids-free immunosuppressant shows statistical benefit to reduce biopsy-proven acute rejection and de novo hypertension.

关键词： liver transplantation basiliximab induction immunosuppression meta-analysis

Propagation of shaped beam through uniaxially anisotropic chiral slab

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Chinese Physics B 2020年第11期29卷 380-385页

作者： Ming-Jun Wang jia-lin zhang Hua-Yong zhang Zi-Han Wang School of Automation and Information Engineering Xi’an University of TechnologyXi’an 710048China School of Electronics and Information Engineering Anhui UniversityHefei 230039China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230039China School of Physics and Telecommunications Engineering Shaanxi University of TechnologyHanzhong 723001China

A general solution is obtained to a canonical problem of the reflection and refraction of an arbitrary shaped beam by using a uniaxially anisotropic chiral *** reflected,internal as well as refracted shaped beams are expanded in terms of cylindrical vector wave functions,and the expansion coefficients are determined by using the boundary conditions and method of moments *** two typical examples,the normalized field intensity distributions are evaluated for a fundamental Gaussian beam and Hermite-Gaussian beam,and some propagation properties,especially the negative refraction phenomenon,are discussed briefly.

关键词： shaped beam uniaxially anisotropic chiral slab reflection and refraction negative refraction phenomenon

Pharmacokinetics of Quinocetone and Its Major Metabolites in Swine After Intravenous and Oral Administration

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Agricultural Sciences in China 2011年第8期10卷 1292-1300页

作者： ZHONG jia-lin zhang Gui-jun SHEN Xiang-guang WANG lin FANG Bing-hu DING Huan-zhong Laboratory of Veterinary Pharmacology College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642P.R.China

The pharmacokinetics of quinocetone and its major metabolites in healthy swine was investigated in this *** was administered to 8 healthy cross-bread swine intravenously and orally at a dosage of 4 and 40 mg kg-1 body weight respectively in a randomized crossover design test with two-week washout period.A sensitive high-performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） method was developed for the determination of quinocetone and its metabolite 1-desoxyquinocetone in *** concentration versus time profiles of quinocetone and its metabolite 1-desoxyquinocetone were analyzed by non-compartmental analysis using Winnonlin 5.2 *** maximum concentrations （Cmax） for quinocetone was found to be （0.56±0.13） μg mL-1 at 2.92 h,after oral administration of *** maximum concentrations （Cmax） for 1-desoxyquinocetone after intravenous or oral administration of quinocetone were （0.0095±0.0012） μg mL-1 at 0.083 h and （0.0067±0.0053） μg mL-1 at 3.08 *** apparent elimination half-lives （T1/2） for quinocetone and its metabolite 1-desoxyquinocetone were （2.24±0.24） and （5.23±0.56） h after intravenous administration of quinocetone and （2.91±0.29） and （11.85±2.89） h after oral administration of quinocetone,*** areas under the plasma concentration-time curve （AUC0-∞） for quinocetone and 1-desoxyquinocetone were （2.02±0.15） and （0.2±0.002） μg h mL-1 respectively after intravenous administration of quinocetone,and （3.5±0.79） and （0.053±0.03） μg h mL-1 after oral administration of quinocetone,*** was rapidly absorbed and metabolized in swine after oral and intravenous *** plasma concentration-time curve （AUC0-∞） of 1-desoxyquinocetone were much smaller than those of quinocetone,while the elimination half-lives （T1/2） were much longer than those of quinocetone after intravenously （i.v.） or oral administration.

关键词： quinocetone metabolites pharmacokinetics HPLC-MS/MS swine

linking circular intronic RNA degradation and function in transcription by RNase H1

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Science China(Life Sciences) 2021年第11期64卷 1795-1809页

作者： Xiang Li jia-lin zhang Yun-Ni Lei Xiao-Qi Liu Wei Xue Yang zhang Fan Nan Xiang Gao Jun zhang jia Wei Li Yang ling-ling Chen School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Section on Integrative Physiology and Metabolism Joslin Diabetes CenterHarvard Medical SchoolBostonMA 02115USA

Circular intronic RNAs(ci RNAs) escaping from DBR1 debranching of intron lariats are co-transcriptionally produced from prem RNA splicing, but their turnover and mechanism of action have remained elusive. We report that RNase H1 degrades a subgroup of ci RNAs in human cells. Many ci RNAs contain high GC% and tend to form DNA:RNA hybrids(R-loops) for RNase H1 cleavage, a process that appears to promote Pol II transcriptional elongation at ci RNA-producing loci. One ci RNA, ciankrd52, shows a stronger ability of R-loop formation than that of its cognate pre-m RNA by maintaining a locally open RNA structure in vitro. This allows the release of pre-m RNA from R-loops by ci-ankrd52 replacement and subsequent ci RNA removal via RNase H1 for efficient transcriptional elongation. We propose that such an R-loop dependent ci RNA degradation likely represents a mechanism that on one hand limits ci RNA accumulation by recruiting RNase H1 and on the other hand resolves Rloops for transcriptional elongation at some GC-rich ci RNA-producing loci.

关键词： circular intronic RNA ciRNA ci-ankrd52 ciRNA structure DNA:RNA hybrid R-loop RNase H1 transcriptional elongation

Controlled Fabrication of Uniform Digital Nanorods from Precise Sequence-Defined Amphiphilic Polymers in Aqueous Media

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Chinese Journal of Polymer Science 2023年第5期41卷 768-777,I0010页

作者： Qiang-Qiang Shi Xin Zhou Jie Xu Ning Wang jia-lin zhang Xiang-Long Hu Shi-Yong Liu CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China School of Biomedical Engineering and Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China

Compared with spherical micelles,rod/worm-like micelles not only have extended blood circulation duration,but also exhibit favorable cellular uptake behavior,which is promising for next-generation nanomedicine and ***,the controllable fabrication of narrowly dispersed nanorods in aqueous media is still ***,the methodology of thermal annealing was developed for the fabrication of helical nanorods as well as a series of nanorods with different *** thermal annealing process generally consisted of adding a percentage of organic solvent(10%(V/V)or 20%(V/V))to the digital micellar aqueous dispersion,followed by heating at 90℃for 1 h,then cooling naturally to room temperature,and dialyzing against water to remove the organic ***-handed helical nanorods were afforded by the treatment of 45 nm digital micelles in the presence of 10%(V/V)dioxane,while left-handed helical nanorods were obtained in the presence of 20%(V/V)***,the controlled growth of rod-like digital micelles was achieved after thermal annealing in the presence of different types of organic solvents,and the length of the annealed nanorods was correlated with the types of organic ***,no matter the size of initial digital micelles,they all exhibited similar trend of rod growth in the presence of a certain amount of organic solvent,allowing for controllable formulation of narrowly dispersed *** addition,supramolecular self-assembly by amphiphilic dendritic oligourethane readily fabricated diverse uniform nanorods in aqueous ***,this work provided an attractive methodology to fabricate uniform digital nanorods.

关键词： Sequence-defined amphiphilic polymers Digital nanorods Thermal annealing Dendritic oligourethane Self-assembly

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu lin He lin-Sen Ye Xiao-Feng Yang jia-jia zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

Single-molecule imaging of dinitrogen molecule adsorption on individual iron phthalocyanine

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Nano Research 2020年第9期13卷 2393-2398页

作者： Chengding Gu jia lin zhang jian Qiang Zhong Qian Shen Xiong Zhou Kaidi Yuan Shuo Sun Xu Lian Zhirui Ma Wei Chen Department of Chemistry National University of SingaporeSingapore 117543Singapore Department of Physics National University of SingaporeSingapore 117542Singapore Department of Interface Science Fritz-Haber-Institut der Max-Planck-GesellschaftBerlin 14195Germany Institute of Advanced Materials Nanjing Tech UniversityNanjing 210009China BNLMS College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China School of Physical Science and Technology Shanghai Tech UniversityShanghai 200031China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China National University of Singapore(Suzhou)Research Institute Suzhou 215123China

Nitrogen fixation is a vital process for both nature and *** the nitrogenase can reduce nitrogen in ambient environment in nature,the industrialized Haber-Bosch process is a high temperature and high-pressure *** the discovery of the first dinitrogen complex in 1965,many dinitrogen complexes are prepared in a homogeneous solution to mimic the nitrogenase enzyme in ***,studies of the heterogeneous process on surface are rarely ***,molecular scale characterization for such dinitrogen complex is ***,we present a simple model system to investigate,at the single-molecule level,the binding of dinitrogen on a surface confined iron phthalocyanine(FePc)monolayer through the combination of in-situ low-temperature scanning tunneling microscopy(LT-STM)and X-ray photoelectron spectroscopy(XPS)*** iron center in FePc molecule deposited on Au(111)and highly oriented pyrolytic graphite(HOPG)surface can adsorb dinitrogen molecule at room temperature and low pressure.A comparative study reveals that the adsorption behaviors of FePc on these two different substrates are *** bond is formed between the dinitrogen and the Fe atom in the FePc molecule,which greatly modifies the electronic structure of *** bonding is reversible and can be manipulated by applying bias using a STM tip or by thermal annealing.

关键词： single-molecule dinitrogen iron phthalocyanine axial coordination

Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats

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World Journal of Gastroenterology 2007年第20期13卷 2862-2866页

作者： Ying Cheng Yong-Feng Liu jia-lin zhang Tie-Min Li Ning Zhao Organ Transplant Unit of First Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM: To determine whether the elevated vascular endothelial growth factor (VEGF) expression produced by the transfected vascular endothelial cells (VECs) could stimulate angiogenesis of the graft islets and exert its effect on the graft function. METHODS: Thirty diabetic recipient rats were divided into three groups (n = 10 per group). In the control group,300 IEQ islets were transplanted in each rat under the capsule of the right kidney,which were considered as marginal grafts. In the VEC group,VEC together with the islets were transplanted in each rat. In the VEGF group,VEC transfected by pIRES2-EGFP/ VEGF165 plasmid and the islets were transplanted in each rat. Blood glucose and insulin levels were evaluated every other day after operation. Intravenous glucose tolerance test (IVGTT) was performed 10 d after the transplantation. Hematoxylin and eosin (HE) staining was used to evaluate the histological features of the graft islets. Immunohistochemical staining was used to detect insulin-6,VEGF and CD34 (MVD) expression in the graft islets. RESULTS: Blood glucose and insulin levels in the VEGF group restored to normal 3 d after transplantation. In contrast,diabetic rats receiving the same islets with or without normal VECs displayed moderate hyperglycemia and insulin,without a significant difference between these two groups. IVGTT showed that both the amplitude of blood glucose induction and the kinetics of blood glucose in the VEGF group restored to normal after transplantation. H&E and immunohistochemical staining showed the presence of a large amount of graft islets under the capsule of the kidney,which were positively stained with insulin-6 and VEGF antibodies in the VEGF group. In the cell masses,CD34-stained VECs were observed. The similar masses were also seen in the other two groups,but with a fewer positive cells stained with insulin-6 and CD34 antibodies. No VEGF-positive cells appeared in these groups. Microvessel density (MVD) was significantly higher in

关键词： Islet transplantation Revascularization, Vascular endothelial growth factor Gene transfer Vascular endothelial cells

Binding of PLCδ1PH-GFP to Ptdlns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of Ptdlns(4,5)P2 by neomycin

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Acta Pharmacologica Sinica 2005年第12期26卷 1485-1491页

作者： Chuan WANG Xiao-na DU Qing-zhong jia Hai-lin zhang~2 Department of Pharmacology Hebei Medical University,Shijiazhuang 050017,China Department of Pharmacology Hebei Medical University Shijiazhuang China

Aim:To investigate the effects of the pleckstrin homology(PH)domain of phos-pholipase Cδ1(PLCδ1PH)on inhibition of phospholipase C(PLC)-mediated hy-drolysis of phosphatidylinositol 4,5-bisphosphate[PtdIns(4,5)P2]by ***:A fusion construct of green fluorescent protein(GFP)and PLCδ1PH(PLCδ1PH-GFP),which is known to bind PtdIns(4,5)P2specifically,together withlaser-scanning confocal microscopy,was used to trace PtdIns(4,5)***:Stimulation of the type 1 muscarinic receptor and the bradykinin 2 recep-tor induced a reversible PLCδ1PH-GFP translocation from the membrane to thecytosol in COS-7 *** inhibitor U73122 blocked the ***,a known PtdIns kinase inhibitor,did not affect the translocationinduced by ACh,but blocked recovery after translocation,indicating thatPtdIns(4,5)P2hydrolysis occurs through receptor-mediated PLC ***,a commonly used phospholipase C blocker,failed to block the recep-tor-induced PLCδ1PH-GFP translocation,indicating that neomycin is unable toblock PLC-mediated Ptdlns(4,5)Pe ***,in the absence of PLCδ1PH-GFP expression,neomycin abolished the receptor-induced hydrolysis ofPtdIns(4,5)P2 by ***:Although PLCδ1PH and neomycin bind toPtdIns(4,5)P2 in a similar way,they have distinct effects on receptor-mediatedactivation of PLC and PtdIns(4,5)P2 hydrolysis.

关键词： phosphatidylinositol 4,5-bisphosphate neomycin phospholipase C pleckstrin homology domains competitive binding acetylcholine green fluorescent proteins