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NON-LCL AND TRACER TEST FOR GROUNDWATER FLOW IN A SINGLE FRACTURE

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Journal of Hydrodynamics 2006年第1期18卷 104-108页

作者： QIAN jia-zhong LIU Yong wang jian-hua GUAN Hou-chun CHEN Shi-jun wang jia-quan School of Resources and Environmental Engineering Hefei University of Technology Hefei 230009China School of Biotechnology and Food Engineering Hefei University of Technology Hefei 230009 China

The validity of Local Cubic Law （LCL） is an important issue to study groundwater flow and transport in fractured media. According to laboratory simulaion tests, the average velocity with a lower gradient in a single fracture is calculated by the LCL, which is compared with the measured average velocity. Then dye tracer test is designed and completed. The evidence for non-LCL, is drawn from the results of the simulation tests and the dye tracer tests. Then the Reynolds number of groundwater is calculated, the critical value of Re for laminar flow is discussed in a single fracture under different conditions. The motion types for groundwater flow have been discussed.

关键词： non-Local Cubic Law (LCL) tracer test,groundwater flow in a single fracture

Instantaneous deformation characteristics of a single bubble in immiscible fluids

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Journal of Iron and Steel Research International 2022年第10期29卷 1601-1612页

作者： jia-rui Xu Xiao-hui Zhang Shan Qing Hao Zhang hua wang Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093YunnanChina National Local Joint Engineering Research Center of Energy Saving and Environmental Protection Technology in Metallurgy and Chemical Engineering Industry Kunming University of Science and TechnologyKunming650093YunnanChina

The passage of a rising bubble through immiscible fluids is encountered in bath *** order to investigate characteristics of bubble deformation in immiscible fluids,the bubble shape change at the interface and the relationship between the bubble aspect ratio(E)and dimensionless number of forces were obtained.A three-dimensional model was established,and the free-floating behavior of a single bubble in immiscible fluids was numerically simulated by phase-field *** simulation results are in good agreement with experimental *** results indicate that when the bubble passes through the interface,the bubble shape is divided into four types in turn:“pear”,inverted“pear”,“convex”and“droplet”*** the lower liquid,the relationship of E to Weber number(We),Tadaki number(Ta),and Reynolds number(Re)is distributed between two intersecting *** relationship of E to Eötvös number(Eo),a dimensionless group,and Galilei number(Ga)is distributed near the lines with slopes of−3.325×10^(-5),−0.0855,and−8.73×10^(-4),*** the upper liquid,the relationship of E to We,Ta,and Re is distributed between two parallel *** with gravity,the inertial force plays a leading role in the bubble shape in the lower and upper *** with the viscous force,the surface tension dominates the bubble shape in the lower liquid.

关键词： Bubble shape Immiscible fluid Dimensionless number Phase-field method

Effect of grain size on the mechanical properties of Mg foams

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Journal of Materials Science & Technology 2020年第23期58卷 46-54页

作者： Yinchuan wang hua huang Gaozhi jia Guizhou Ke jian Zhang Guangyin Yuan National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Innovation Medical Technology Co. Ltd.Shanghai 201306China

The grain size of Mg foams was innovatively refined without alteration of pore structure and relative density by subjecting multi-axial forging(MAF)process to Ti-Mg composite,an intermediary product of the fabrication process of Mg foams where the spherical Ti particles were utilized as the replication *** feasibility of the MAF process and the grain size effect on the mechanical properties of Mg foams were *** results showed that,with the appropriate strain of 0.24 applied in the MAF process,Ti-Mg composites returned to original physical appearance without generating *** complete recrystallization was achieved after heat treatment,with the grain size of the MAFprocessed Mg foams two to three orders of magnitude smaller than that of as-cast *** mechanical properties of Mg foams were enhanced extensively after grain refinement with the yield strength and the plastic collapse strength increased by 147%and 50.7%,respectively.A revised model integrated by the Hall-Petch law and Gibson-Ashby model was proposed,which gave a good estimation of the yield strength and the plastic collapse strength of Mg foams from the compressive behavior of the corresponding parent material,though a knockdown factor of 0.45 was introduced for the yield strength.

关键词： Mg foam MAF process Static recrystallization Mechanical properties Grain size effect

长病程继发性癫痫患者的生活质量及影响因素调查分析

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海南医学 2017年第2期28卷 319-322页

作者：卢颖瑜王金良巫碧佳秦兴华王鹏佛山市第二人民医院神经内科广东佛山528000

目的调查长病程继发性癫痫患者生活质量及其影响因素。方法对2013年1月至2016年1月于佛山市第二人民医院门诊及住院的76例病程≥10年的继发性癫痫患者生活质量进行调查。采用癫痫患者生活质量量表-31(QOLIE-31)评估患者的生活质量、评... 详细信息

目的调查长病程继发性癫痫患者生活质量及其影响因素。方法对2013年1月至2016年1月于佛山市第二人民医院门诊及住院的76例病程≥10年的继发性癫痫患者生活质量进行调查。采用癫痫患者生活质量量表-31(QOLIE-31)评估患者的生活质量、评估患者基本特征及各量表评分对继发性癫痫患者生活质量的影响。同时选取76例健康自愿者作为健康对照组。结果病程≥10年的继发性癫痫患者QOLIE-31总分为(68.27±8.62)分,明显低于健康对照组的(92.45±10.08)分,差异有统计学意义(P<0.05);影响QOLIE-31总分的相关因素包括年龄(r=0.412,P=0.021)、病程(r=-0.353,P=0.006)、不良反应量表(SEP)评分(r=-0.364,P=0.000)、蒙特利尔认知评估量表(Mo CA)评分(r=0.815,P=0.000)、斯特鲁普(Stroop)效应得分(r=0.754,P=0.005)、词汇流畅性得分(r=0.423,P=0.000)、汉密尔顿焦虑量表(HAMA)评分(r=-0.506,P=0.000)、贝克抑郁问卷(BDI)评分(r=-0.440,P=0.001);进一步分析发现对QOLIE-31得分有影响的独立危险因素有SEP评分(r=-0.356,P=0.017)、Mo CA评分(r=0.202,P=0.007)及BDI评分(r=-0.248,P=0.076)。结论长病程继发性癫痫患者生活质量明显下降,其中SEP评分、Mo CA评分、BDI评分是影响癫痫患者远期生活质量的独立危险因素,SEP评分的独立贡献远大于其他两项,提示临床上应重点注意病程≥10年的患者治疗药物方案的选择。

关键词：长病程继发性癫痫生活质量影响因素

Etoposide Induces Mitochondria-Associated Apoptotic Cell Death in Human Gastric Carcinoma Cells

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Chemical Research in Chinese Universities 2008年第5期24卷 597-602页

作者： LI Jing-hua CHEN Yue wang jia-si KONG Wei JIN Ying-hua Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Life Science School of Public Health Jilin University Changchun 130012 P R. China

Recent observations indicate that the resistance of apoptosis is an important process of tumor metastasis and metastases are the cause of 90% of human cancer death. Etoposide, a semisynthetic derivative of the podophyllotoxins, is a clinically used anti-cancer reagent, but the effects of it on metastatic gastric carcinoma cells are totally unknown. In this study, etoposide induced apoptotic cell death in human gastric adenocarcinoma cell line SGC-7901, derived from metastatic lymph nodes, as evidenced by the analysis of DNA fragmentation, apoptotic body formation, caspase activation, and apoptosis specific changes in cell morphology is demonstrated. The depolarization of mitochondrial membrane and the release of cytochrome c were most early events in etoposide treated SGC-7901 cells, and were followed by caspase-3 activation and PARP cleavage. Caspase-8 activation was not detected under the same condition. Thus, it was proposed that etoposide induces caspase-associated apoptotic cell death in human metastatic gastric carcinoma, which is initiated by mitochondrial cytochrome c release.

关键词： Apoptosis Caspase Cytochrome c Etoposide SGC-7901 cells

Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome:a systematic review and Metaanalysis

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1651-1656页

作者： jia-Song wang hua-Tao Xie Ye jia Ming-Chang Zhang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

AIM： To evaluate the retinal nerve fiber layer（RNFL）thickness changes in patients with obstructive sleep apnoea syndrome（OSAS）, and detect possible prevalence of glaucoma in this ***： Comprehensive studies were conducted on the Cochrane Library, Pub Med and Embase through March, 2015. Only studies that fit the selection criteria about RNFL and OSAS would be included. For the measures, we calculated the 95% confidence interval（CI）and weighted mean differences（WMD）. The systematic review and Meta-analysis was performed by Rev Man ***： Nine case-control studies were analyzed containing a total of 1086 cases and 580 *** RNFL thickness in OSAS was reduced significantly compared with healthy controls in random effects model（WMD =-2.56, 95% CI：-4.82 to-0.31, P =0.003, I2=57%）. A significant RNFL thickness reduction were found between the two groups in inferior quadrant（WMD =-3.11, 95% CI：-5.53 to-0.69, P =0.01）, superior quadrant（WMD =-2.37, 95% CI：-4.7 to 0.04, P =0.05）. In nasal quadrant（WMD =-2.54, 95% CI：-6.53 to 1.45, P =0.21） and temporal quadrant（WMD=-1.26, 95% CI：-2.19 to 0.47, P =0.15） there was no difference of RNFL thickness between the two ***： The results show that RNFL thickness is lower in patients with moderate or severe OSAS than in normal subjects or patients with mild OSAS according to the nine homogeneity studies.

关键词： retinal nerve fiber layer thickness obstructive sleep apnea syndrome Meta-analysis

Small-incision lenticule extraction versus femtosecond lenticule extraction for myopic:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 115-121页

作者： jia-Song wang hua-Tao Xie Ye jia Ming-Chang Zhang Department of Ophthalmology Union HospitalTongji MedicalCollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

AIM： To examine differences in efficacy, accuracy, safety, aberrations and corneal biomechanical between Small incision lenticule extraction （SMILE） and femtosecond lenticule extraction （FLEx） for myopia. METHODS： Comprehensive studies were conducted on the PubMed, MEDLINE, EMBASE, and Cochrane Controlled Trials Register before 31 July, 2015. Meta-analyses were performed on the primary outcomes [loss of ≥2 lines of corrected distance visual acuity （CDVA）, uncorrected distance visual acuity （UDVA） ≥20/20, spherical equivalent （SE） within ±0.50 diopters （D）, final refractive SE], secondary outcomes were high-order aberrations （HOAs） and corneal biomechanical [central corneal thickness （CCT）, corneal hysteresis （CH） and corneal resistance factor （CRF）]. RESULTS： Seven trials describing a total of 320 eyes with myopia were included in this Meta-analysis. No significant differences were found in the efficacy [UDVA weighted mean difference （WMD） -0.01; 95%CI： -0.04 to 0.01; P=0.37, UDVA ≥20/20, OR 1.49; 95%CI： 0.78 to 2.86; P=0.23], accuracy （SE WMD -0.03; 95%CI： -0.12 to 0.07; P=0.58 , SE within ±0.5 D OR 1.25; 95%CI： 0.34 to 4.65; P=0.74）, HOAs （WMD -0.04; 95%CI： -0.09 to 0.01; P=0.14） and CCT WMD 1.83; 95%CI： -7.07 to 10.72; P=0.69, CH WMD -0.01; 95%CI： -0.42 to 0.40; P=0.97, CRF WMD 0.17; 95%CI： -0.33 to 0.67; P=0.50） in the last fellow-up. But for safety, FLEx may achieve fewer CDVA lost two or more two lines （OR 11.11; 95%CI： 1.27 to 96.86; P=0.03） than SMILE, however CDVA （WMD 0.00; 95%CI： -0.03 to 0.02; P=0.77） is similar. CONCLUSION： SMILE and FLEx are comparable in terms of both efficacy, accuracy, aberrations and corneal biomechanical measures in the follow-up,but FLEx seems to be better in safety measures. The results should be interpreted cautiously since relevant evidence is still limited, although it is accumulating. Further large-scale, well-designed randomized controlled trials are urgently needed.

关键词： myopia small-incision lenticule extraction femtosecond lenticule extraction Meta-analysis

Characteristics of central visual field defect after macular hole surgery

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 451-456页

作者： jia-Nan Li jia-Xing wang Xin-Lei Zhu hua Yan Department of Ophthalmology Tianjin Medical University General Hospital Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Department of Ophthalmology Emory University

AIM: To investigate the characteristics of postoperative central visual field defect(cVFD) in patients with macular hole(MH).METHODS: Eighteen eyes from 18 MH patients were involved in this retrospective study which reviewed square root of loss variance(sLV) and mean defect(MD) of the visual field test in all subjects. The relationship between cVFD and MH stage, as well as the postoperative ellipsoid zone disruption were evaluated using Spearman's correlation test. RESULTS: Our analysis determined Spearman coefficient is 0.705 for the correlation between sLV and MH stage(P<0.01), 0.877 for the correlation between sLV and postoperative ellipsoid zone disruption(P<0.01) and 0.721 for the correlation between MD and postoperative ellipsoid zone disruption(P<0.01). A significant relationship was also detected between postoperative ellipsoid zone disruption and MH stage(r=0.470, P<0.05). Univariate regression analysis indicated that sLV and MD were associated with postoperative ellipsoid zone disruption(P<0.01, P<0.01, respectively). CONCLUSION: Postoperative cVFD is highly correlated with MH stage and postoperative ellipsoid zone disruption in patients with MH.

关键词： central visual field defect macular hole photoreceptor regeneration ellipsoid zone

A New Protocol for Solubilization, Refolding and Purification of Recombinant Human Granulocyte Colony-stimulating Factor in Inclusion Bodies

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Chinese Chemical Letters 2006年第6期17卷 799-802页

作者： jia hua LIU Chao Zhan wang Xin Du GENG Institute of Modem Separation Science Key Laboratory of Separation Science in Shaanxi Province Northwest University Xi＇an 710069

Recombinant human granulocyte colony-stimulating factor （rhG-CSF） in inclusion bodies was solubilized by 8 mol/L urea solution and subsequently precipitated by acetone to improve its purity. After that, the precipitates were solubilized by sodium hydroxide solution containing 2 mol/L urea. Then the solubilized rhG-CSF was passed through a size exclusion chromatography for refolding and extensive purification, and further purified by a weak anion exchange chromatography. The purity and mass recovery of refolded rhG-CSF were 96.5% and 75.6%, respectively. The bioactivity was 8.4x10^7 IU/mg.

关键词： Recombinant human granulocyte colony-stimulating factor alkaline solution,solubilization of inclusion bodies protein refolding.