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The evolution and functional divergence of 10 Apolipoprotein D-like genes in Nilaparvata lugens

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Insect Science 2024年第1期31卷 91-105页

作者： jia-Bao Lu Peng-Peng Ren Qiao Li Fang he Zhong-Tian Xu Sai-Nan Wang jian-Ping chen Jun-Min Li Chuan-Xi Zhang Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina Technology Center of Wuhan Customs District HubeiChina Institute of Insect Science Zhejiang UniversityHangzhouChina

Apolipoprotein D(ApoD),a member of the lipocalin superfamily of proteins,is involved in lipid transport and stress *** only a single copy of the ApoD gene is found in humans and some other vertebrates,there are typically several ApoD-like genes in *** date,there have been relatively few studies that have examined the evolution and functional differentiation of ApoD-like genes in insects,particularly hemi-metabolous *** this study,we identified 10 ApoD-like genes(NlApoD1−10)with distinct spatiotemporal expression patterns in Nilaparvata lugens(BPH),which is an important pest of ***1−10 were found to be distributed on 3 chromosomes in a tandem array of NlApoD1/2,NlApoD3−5,and NlApoD7/8,and show sequence and gene structural divergence in the coding regions,indicating that multiple gene duplication events occurred during *** analysis revealed that NlApoD1−10 can be clustered into 5 clades,with NlApoD3−5 and NlApoD7/8 potentially evolving exclusively in the Delphacidae *** screening using an RNA interference approach revealed that only NlApoD2 was essential for BPH development and survival,whereas NlApoD4/5 are highly expressed in testes,and might play roles in ***,stress response analysis revealed that NlApoD3−5/9,NlApoD3−5,and NlApoD9 were up-regulated after treatment with lipopolysaccharide,H2O2,and ultraviolet-C,respectively,indicating their potential roles in stress resistance.

关键词： Apolipoprotein D BPH evolution functional divergence gene duplication NIApoD

Univariate Time Series Anomaly Detection Based on Hierarchical Attention Network

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Tsinghua Science and Technology 2024年第4期29卷 1181-1193页

作者： Zexi chen Dongqiang jia Yushu Sun Lin Yang Wenjie Jin Ruoxi Liu State Grid Beijing Electric Power Company Beijing 100031China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China

In order to support the perception and defense of the operation risk of the medium and low voltage distribution system, it is crucial to conduct data mining on the time series generated by the system to learn anomalous patterns, and carry out accurate and timely anomaly detection for timely discovery of anomalous conditions and early alerting. And edge computing has been widely used in the processing of Internet of Things (IoT) data. The key challenge of univariate time series anomaly detection is how to model complex nonlinear time dependence. However, most of the previous works only model the short-term time dependence, without considering the periodic long-term time dependence. Therefore, we propose a new Hierarchical Attention Network (HAN), which introduces seven day-level attention networks to capture fine-grained short-term time dependence, and uses a week-level attention network to model the periodic long-term time dependence. Then we combine the day-level feature learned by day-level attention network and week-level feature learned by week-level attention network to obtain the high-level time feature, according to which we can calculate the anomaly probability and further detect the anomaly. Extensive experiments on a public anomaly detection dataset, and deployment in a real-world medium and low voltage distribution system show the superiority of our proposed framework over state-of-the-arts.

关键词： edge computing anomaly detection univariate time series self-attention

Increase of chiral sensing ability in host-guest chemistry by magnetic anisotropy

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Science China Chemistry 2024年第8期67卷 2775-2782页

作者： jia-Liang chen Bin Li Feng Yang Tiesheng Shi Xun-cheng Su State Key Laboratory of Elemento-organic Chemistry Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry Chemical Engineering and Materials ScienceZaozhuang UniversityZaozhuang 277160China

Enantiomeric molecules generally play distinct functions in chemistry,biology,and *** physical and chemical properties of chiral analytes lay difficulty in discrimination and quantification of the *** report herein an efficient approach of increasing the chiral sensing ability ofβ-cyclodextrin(β-CD),a widely used host molecule,in the hostguest chemistry by magnetic anisotropy.A rigid and chiral lanthanide binding tag was attached to theβ-CD to amplify the changes of nuclear magnetic resonance(NMR)signals in the host-guest recognition *** installation of the paramagnetic lanthanide ion inβ-CD greatly enhances the enantiomeric discrimination up to 30-fold in comparison with the diamagneticβ-CD *** addition,the magnitude of the paramagnetic effects is tunable according to the diverse range of paramagnetic strength of the lanthanide *** reported method significantly increases the chiral sensing ability ofβ-CD,which can be applied to other host *** transferred paramagnetic effects,pseudocontact shifts(PCSs)and paramagnetic relaxation enhancements(PREs),from the host to the guest molecules,are valuable structural restraints to determine the absolute stereochemistry of the chiral *** strategy does not need modification of the analytes and is complementary to the reported analytical methods that rely on the functionalization of the chiral analytes.

关键词： chiral recognition nuclear magnetic resonance host-guest chemistry magnetic anisotropy lanthanide ions

Optimal Scheduling of Regional Integrated Energy Systems Considering Hybrid Demand Response

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1208-1219页

作者： Ganyun Lyu Bin Cao Dexiang jia Nan Wang Jun Li Guangyu chen Department of Electrical Engineering Nanjing Institute of TechnologyNanjing 211167China State Grid Energy Research Institute Co. LTDBeijing 102209China State Grid Integrated Energy Service Group Co. LTDBeijing 100032China IEEE CSEE

Flexible load can optimize the load curve,which is an important means to promote renewable energy *** peculiarities of electricity,heat,cooling and gas loads are analyzed in this paper,considering the fuzzy degree of human perception for water temperature,and the characteristic model of hot water load is *** the fuzzy degree of human perception of ambient temperature,the characteristic model of cooling load is established by using PMV and PPD ***,considering four combinations of cut load,translatable load,transferable load and alternative load,and considering the coupling relationship of composite parts,different response models of load are established *** the minimum cost of the system,including operation and compensation costs as the objective function,the optimization scheduling model of the regional integrated energy system is established,and the Gurobi solver is used for simulation analysis to solve the optimal output and load response curve of each piece of *** results show that the load curve can be optimized,the flexible regulation ability of the regional integrated energy system can be enhanced,the energy loss of the system can be reduced,and the wind power consumption ability of the system can be increased by considering the integrated demand response.

关键词： Alternative load day ahead optimal scheduling integrated demand response PMV and PPD index regional integrated energy system

Simultaneous Bulk-and Surface-initiated Living Polymerization Studied with a heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： jia-Shu Ma Zhi-Ning Huang jia-Hao Li Bang-Ping jiang Yan-Da Liao Shi-chen Ji Xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model heterogeneous polymerization Simultaneous polymerization

Enhancing cancer immunotherapy:Nanotechnology-mediated immunotherapy overcoming immunosuppression

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3834-3854页

作者： Yunna chen Qianqian Zhou Zongfang jia Nuo cheng Sheng Zhang Weidong chen Lei Wang Key Laboratory of Molecular Biology(Brain diseases) Anhui University of Chinese MedicineHefei 230012China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Hefei 230012China Anhui Province Key Laboratory of Chinese Medicinal Formul1 Hefei 230012China

Immunotherapy is an important cancer treatment method that offers hope for curing cancer *** immunotherapy has achieved initial success,a major obstacle to its widespread adoption is the inability to benefit the majority of *** success or failure of immunotherapy is closely linked to the tumor’s immune ***,there has been significant attention on strategies to regulate the tumor immune microenvironment in order to stimulate anti-tumor immune responses in cancer *** distinctive physical properties and design flexibility of nanomedicines have been extensively utilized to target immune cells(including tumor-associated macrophages(TAMs),T cells,myeloid-derived suppressor cells(MDSCs),and tumor-associated fibroblasts(TAFs)),offering promising advancements in cancer *** this article,we have reviewed treatment strategies aimed at targeting various immune cells to regulate the tumor immune *** focus is on cancer immunotherapy models that are based on nanomedicines,with the goal of inducing or enhancing anti-tumor immune responses to improve *** is worth noting that combining cancer immunotherapy with other treatments,such as chemotherapy,radiotherapy,and photodynamic therapy,can maximize the therapeutic ***,we have identified the challenges that nanotechnology-mediated immunotherapy needs to overcome in order to design more effective nanosystems.

关键词： Immunotherapy Nanomedicine Tumor immunosuppressive microenvironment Cancer T cells Immunogenic cell death Immune checkpoint inhibitors Extracellular matrix

In-situ measurement via the flow-through method and numerical simulations for radon exhalation during measurements of the radon exhalation rate

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Nuclear Science and Techniques 2024年第7期35卷 192-207页

作者： Ming Xia Yong-Jun Ye Shan-Wei Shang Ting Yu Dai-jia chen School of Resources Environment and Safety Engineering University of South ChinaHengyang421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang421001China

Small-scale measurements of the radon exhalation rate using the flow-through and closed-loop methods were conducted on the surface of a uranium tailing pond to better understand the differences between the two *** abnormal radon exhalation behavior was observed,leading to computational fluid dynamics(CFD)-based simulations in which dynamic radon migration in a porous medium and accumulation chamber was *** on the in-situ experimental and numerical simulation results,variations in the radon exhalation rate subject to permeability,flow rate,and insertion depth were quantified and *** in-situ radon exhalation rates measured using the flow-through method were higher than those measured using the closed-loop method,which could be explained by the negative pressure difference between the inside and outside of the chamber during the *** consistency of the variations in the radon exhalation rate between the experiments and simulations suggests the reliability of CFD-based techniques in obtaining the dynamic evolution of transient radon exhalation rates for diffusion and convection at the porous medium-air *** synergistic effects of the three factors(insertion depth,flow rate,and permeability)on the negative pressure difference and measured exhalation rate were quantified,and multivariate regression models were established,with positive correlations in most cases;the exhalation rate decreased with increasing insertion depth at a permeability of 1×10^(−11) m^(2).CFD-based simulations can provide theoretical guidance for improving the flow-through method and thus achieve accurate measurements.

关键词： Radon exhalation Flow-through Numerical simulation Accumulation chamber Multivariate regression

Special Unipotent Representations of Simple Linear Lie Groups of Type A

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Acta Mathematica Sinica,English Series 2024年第3期40卷 707-716页

作者： Dan BARBASCH jia Jun MA Bin Yong SUN chen Bo ZHU Department of Mathematics Cornell UniversityIthacaNY 14853USA School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China Department of Mathematics Xiamen University Malaysia CampusSepangSelangor Darul Ehsan43900Malaysia Institute for Advanced Study in Mathematics&New Cornerstone Science Laboratory Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics National University of Singapore10 Lower Kent Ridge RoadSingapore 119076

Let G be a special linear group over the real,the complex or the quaternion,or a special unitary *** this note,we determine all special unipotent representations of G in the sense of Arthur and Barbasch-Vogan,and show... 详细信息

关键词： Special unipotent representations unitary representations coherent continuation Weyl group representations

Improving the hydrostability of zeolitic imidazolate framework coatings using a facile silk fibroin protein modification method

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Nano Research 2024年第7期17卷 6247-6257页

作者： Xiuming Wei Ting chen Siyu chen Qian jia Nurul Ain Mazlan Allana Lewis Norbert Radacsi Yi Huang School of Engineering Institute for Materials&ProcessesThe University of EdinburghRobert Stevenson RoadEdinburghEH93FBUK EASTCheM School of Chemistry The University of St AndrewsPurdie BuildingNorth HaughSt AndrewsKY169STUK

Zeolitic imidazolate frameworks(ZIFs)are an important subclass of metal-organic frameworks(MOFs)with zeolite-type topology,which can be fabricated under ambient synthesis ***,the applications of ZIFs are commonly limited due to the weak hydrostability of their metal–ligand coordination bonds,particularly under humid and aqueous *** this work,as an example,the hydrolysis behaviours of ZIF-L with a special focus on ZIF-L coatings were tested at aqueous conditions with a wide range of pHs to systematically study and fundamentally understand their structural stability and degradation *** ZIF-L powder and ZIF-L coatings were severely damaged after only 24 h in aqueous ***,the ZIF-L coatings showed two distinct hydrolyzation pathways regardless of pH conditions,exhibiting either a ring-shaped etching or unfolding *** the ZIF-L powders were hydrolyzed almost identically across all pH *** this new understanding,a facile silk fibroin(SF)protein modification method was developed to enhance the hydrostability of ZIF-L coatings in aqueous *** effect of protein concentration on surface coating was systemically ***-L coating retained its surface morphology after soaking in water and demonstrated switchable super wetting properties and superior separation performance for oil/water *** a result,the quick SF protein modification significantly enhanced the stability of ZIF-L coatings under various pHs,while retaining their switchable wetting property and excellent separation performance.

关键词： zeolitic imidazole framework-L(ZIF-L) ZIF-L coatings silk fibroin protein hydrostability enhancement oil/water separation