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A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

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hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan Zhang jia-Jie Zhu Zong-Ming Liu Yu-Xuan Zhang jia-jia chen Ke-Da chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:hepatocellular carcinoma(HCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC ***-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

Design of acceleration control schedule for adaptive cycle engine based on direct simulation model

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Chinese Journal of Aeronautics 2024年第6期37卷 307-318页

作者： Keran SONG Linyuan jia Yuchun chen Tian TAN School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China

To design the optimum acceleration control schedule for the Adaptive Cycle Engine(ACE)in the full flight envelope,this paper establishes a direct simulation model of the ACE transient *** this model,geometric parameters are used to replace the component state *** corresponding relationship between geometric parameters and component state parameters is determined by sensitivity *** geometric variables are controlled when the geometric adjustment speed exceeds the limit,and at the same time the corresponding component state parameters are *** gradient optimization algorism is used to optimize the ground acceleration process of ACE,and the control schedule in terms of operating point of compression components and corrected acceleration rate is used as the full-envelope acceleration control schedule based on the similarity *** acceleration control schedules of the triple-bypass mode and the double-bypass mode are designed in this *** acceleration processes under various flight conditions are simulated using the acceleration control *** with the acceleration process with the linear geometric adjustment schedule,the acceleration performance of ACE is improved by the acceleration control schedule,with the impulse of the acceleration process of the triple-bypass mode being increased by 8.7%-12.3% and the impulse of the double-bypass mode acceleration process being increased by 11.8%-14.1%.

关键词： Adaptive Cycle Engine(ACE) Direct simulation method Acceleration Control schedule Full flight envelope

Systems science in the new era: intelligent systems and big data

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Science China(Information Sciences) 2024年第3期67卷 308-310页

作者： Wenwu YU Duxin chen Hongzhe LIU he WANG Jinde CAO Zengru DI Xiaojun DUAN Bin jia Xiaodong DING Yiguang HONG School of Mathematics Southeast University Purple Mountain Laboratories International Academic Center of Complex Systems Beijing Normal University College of Science National University of Defense Technology School of Systems Science Beijing Jiaotong University Business School University of Shanghai for Science and Technology Department of Control Science and Engineering Tongji University

This study introduces the emergence, research challenges,and future development of intelligent systems and big data(ISBD) and discusses the significance of ISBD to systems science. To this end, an overview of systems science is first presented, followed by the conclusion that the development of artificial intelligence(AI) has promoted the derivation and development of intelligent systems(ISs).

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A dynamical neural network approach for distributionally robust chance-constrained Markov decision process

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Science China Mathematics 2024年第6期67卷 1395-1418页

作者： Tian Xia jia Liu Zhiping chen School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049China

In this paper,we study the distributionally robust joint chance-constrained Markov decision *** the logarithmic transformation technique,we derive its deterministic reformulation with bi-convex terms under the moment-based uncertainty *** cope with the non-convexity and improve the robustness of the solution,we propose a dynamical neural network approach to solve the reformulated optimization *** results on a machine replacement problem demonstrate the efficiency of the proposed dynamical neural network approach when compared with the sequential convex approximation approach.

关键词： Markov decision process chance constraints distributionally robust optimization moment-based ambiguity set dynamical neural network

Towards efficient generative AI and beyond-AI computing:New trends on ISSCC 2024 machine learning accelerators

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Journal of Semiconductors 2024年第4期45卷 12-15页

作者： Bohan Yang jia chen Fengbin Tu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina AI Chip Center for Emerging Smart Systems The Hong Kong University of Science and TechnologyHong KongChina School of the Gifted Young University of Science and Technology of ChinaHefei 230026Chin

Compared to the last decade when the convolution neu-ral network(CNN)dominated the research field,machine learn-ing(ML)algorithms have reached a pivotal moment called the generative artificial intelligence(AI)*** the emer-gence of large-scale foundation models[1],such as large multi-modal model(LMM)GPT-4[2]and text-to-image generative model DALL·E[3].

关键词： ISSCC beyond AI

Single-atom Pd anchored in the porphyrin-center of ultrathin 2D-MOFs as the active center to enhance photocatalytic hydrogen-evolution and NO-removal

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Chinese Chemical Letters 2024年第9期35卷 364-368页

作者： Xingyan Liu Chaogang jia Guangmei jiang chenghua Zhang Mingzuo chen Xiaofei Zhao Xiaocheng Zhang Min Fu Siqi Li Jie Wu Yiming jia Youzhou he Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China School of Pharmacy North Sichuan Medical CollegeNanchong 637100China Carbon Neutrality Technology Application Research Center College of River and Ocean EngineeringChongqing Jiaotong UniversityChongqing 400074China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Local Joint Engineering Research Center for Road Engineering and Disaster Prevention and Reduction Technology in Mountainous Areas China Merchants Chongqing Communications Technology Research and Design Institute Co.Ltd.Chongqing 400067China Chongqing Culture Relics and Archaeology Research Institute Chongqing 400013China

Single-atom catalysts were widely used to treat atmospheric pollution and alleviate energy crises through ***,how to prevent the aggregation of single atoms during the preparation and catalytic processes remained a great ***,a novel ultrathin two-dimensional porphyrin-based single-atom photocatalyst Ti-MOF(abbreviated as TMPd)obtained through a simple hydrothermal synthesis strategy was used for photocatalytic hydrogen evolution and NO removal,in which the singleatom Pd tightly anchored in the center of porphyrin to ensure single-atom Pd stable *** with most reported MOFs-based photocatalysts,the TMPd showed an excellent hydrogen evolution rate(1.32 mmol g^(-1)h^(-1))and the NO removal efficiency(62%)under visible light *** high-angle annular dark-field scanning transmission electron microscope(HAADF-STEM)and synchrotron-radiation-based X-ray absorption fine-structure spectroscopy(XAFS)proved that pd in TMPd existed in an isolated state,and the atomic force microscope(AFM)proved the ultrathin morphology of *** calculations had demonstrated that single-atom Pd could serve as the active center and more effectively achieve electron transfer,indicating that single-atom Pd played a vital role in photocatalytic hydrogen *** addition,a possible photocatalytic pathway of NO removal was proposed based on ESR and in-situ infrared spectra,in which the catalysts anchored with single-atom Pd could produce more active substances and more effectively oxidize NO to NO_(2)^(-)or NO_(3)^(-).The results suggested that coordinating single-atom metal species as the active site in the center of porphyrin could be a feasible strategy to obtain various ultrathin porphyrin-based single-atom photocatalysts to acquire excellent photocatalytic performance further.

关键词： Porphyrin-based MOFs Single-atom Pd Ultrathin 2D nanosheets Hydrogen evolution NO removal

Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-kB-MGMT signaling axis in human glioma

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Genes & Diseases 2024年第3期11卷 385-399页

作者： Zongze he Bo Peng Qi Wang Jie Tian Ping Liu Jie Feng Yiwei Liao Longyi chen Ping jia jian Tang Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Rehabilitation Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Glioma is a common tumor originating in the brain that has a high mortality ***(TMZ)is the first-line treatment for high-grade ***,a large pro-portion of gliomas are resistant to TMZ,posing a great challenge to their *** the study,the specific functions and mechanism(s)by which cortistatin(CORT)regulates TMZ resis-tance and glioma progression were *** decreased expression of CoRT was detected in glioma tissues,and highly expressed CORT was associated with a better survival rate in pa-tients with *** overexpression notably decreased the capacity of glioma cells to pro-liferate and migrate in vitro and to form tumors in *** overexpression also markedly suppressed the viability and enhanced the apoptosis of TMZ-resistant U251 cells by regulating MGMT,p21,and Puma ***,CORT overexpression reduced the resistance of gliomas to TMZ in *** expression Was negatively correlated with MGMT expression in both glioma tissues and cells,and it was found that CORT inhibited NF-kB pathway activation in glioma cells,thereby inhibiting MGMT *** conclusion,CORT regulates glioma cell growth,migration,apoptosis,and TMZ resistance by weakening the activity of NF-kB/p65 and thereby regulating MGMT *** CORT/NF-kB/MGMT axis might be regarded as a molecular mechanism contributing to the resistance of glioma to *** data also suggest that CORT regulates the viability and metastatic potential of glioma cells,independent of its effects on TMZ resistance,providing evidence of novel therapeutic targets for glioma that should be evaluated infurther studies.

关键词： Cortistatin Glioma MGMT NF-kB pathway Temozolomide

Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation,fluid sheer stress,and inflammatory pathways in obesity-related glomerulopathy

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Genes & Diseases 2024年第4期11卷 314-326页

作者： Yinyin chen Yushun Gong jia Zou Guoli Li Fan Zhang Yiya Yang Yumei Liang Wenni Dai Liyu he hengcheng Lu Department of Nephrology Hunan Provincial People's HospitalThe First Affliated Hospital of Hunan Normal UniversityHunan Clinical Research Center for Chronic Kidney DiseaseChangshaHunan 410000China Department of Nephrology The Second Xiangya Hospital of Central South UniversityHunan Key Laboratory of Kidney Disease and Blood PurificationChangshaHunan 410011China Cardiovascular Research Institute of jiangxi Province Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi 330006China

Obesity-related glomerulopathy(ORG)is an independent risk factor for chronic kid-ney disease and even progression to end-stage renal *** have been undertaken to elucidate the mechanisms underlying the development of ORG and substantial advances have been made in the treatment of ORG,but relatively little is known about cell-specific changes in gene *** define the transcriptomic landscape at single-cell resolution,we analyzed kidney samples from four patients with ORG and three obese control subjects without kidney disease using single-cell RNA *** report for the first time that immune cells,including T cells and B cells,are decreased in ORG *** analysis indicated that SPP1 was significantly up-regulated in T cells and B *** gene is related to inflammation and cell *** of differential gene expression in glomerular cells(endothelial cells,mesangial cells,and podocytes)showed that these cell types were mainly enriched in genes related to oxidative phosphorylation,cell adhesion,thermogenesis,and inflammatory pathways(PI3K-Akt signaling,MAPK signaling).Furthermore,we found that the podocytes of ORG patients were enriched in genes related to the fluid shear stress ***,an evaluation of cell-cell communications revealed that there were interactions between glomerular parietal epithelial cells and other cells in ORG patients,with major interactions between parietal epithelial cells and ***,our identification of molecular events,cell types,and differentially expressed genes may facilitate the development of new preventive or therapeutic approaches for ORG.

关键词： Fluid shear stress Inflammation Obesity-related glomerulopathy Oxidative phosphorylation Single-cell RNA seq

Quantitative Analysis of Frosting Characteristics on the Drip Tray of A Cryogenic Valve for LNG Ships

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China Ocean Engineering 2024年第4期38卷 572-585页

作者： BAI Xu chen Guan-yu DU Yue XU Cao chen jia-jing School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Cryogenic valves play a crucial role in the production and transportation of liquefied natural gas(LNG),and are primarily responsible for efficiently controlling the inflow and outflow of LNG and regulating ***,due to their operation in low-temperature and high-humidity environments,crucial components such as drip trays are susceptible to frosting,which may lead to LNG leakage,thereby causing severe safety *** this study,the user-defined function(UDF)is employed to redevelop Fluent,which integrates the frost growth model with the Eulerian multiphase flow model,to conduct a quantitative analysis of frosting on drip trays of cryogenic *** effects of environmental parameters,such as wind speed,ambient temperature,air humidity,and cold surface temperature on the growth of the frost layer were *** study reveals a limiting wind speed between 1 m/s and 2 m/*** reaching this limit speed,the growth of the frost layer reaches its maximum,and further increases in the wind speed have no significant effect on the growth of the frost ***,the influence of the change in the flow field on droplet impingement and freezing during the growth of the frost layer is considered through the coupling method of the kinematic characteristics of water droplets and the collection coefficient of water *** study identifies the influence of different parameters on the droplet impact efficiency,leading to the modification of the frost layer on the drip tray.

关键词： LNG carrier drip tray frost effective impact coefficient