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Enhanced stability of nitrogen-doped carbon-supported palladium catalyst for oxidative carbonylation of phenol

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Chinese Journal of Chemical Engineering 2024年第1期65卷 19-28页

作者： Xiaojing Liu Ruohan zhao hao zhao Zhimiao Wang Fang Li Wei Xue Yanji Wang Hebei Provincial Key Laboratory of Green Chemical Technology and High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Hebei Industrial Technology Research Institute of Green Chemical Industry Huanghua 061100China

Enhancing the stability of supported noble metal catalysts emerges is a major challenge in both science and ***,a heterogeneous Pd catalyst(Pd/NCF)was prepared by supporting Pd ultrafine metal nanoparticles(NPs)on nitrogen-doped carbon;synthesized by using F127 as a stabilizer,as well as chitosan as a carbon and nitrogen *** Pd/NCF catalyst was efficient and recyclable for oxidative carbonylation of phenol to diphenyl carbonate,exhibiting higher stability than Pd/NC prepared without F127 *** hydrogen bond between chitosan(CTS)and F127 was enhanced by F127,which anchored the N in the free amino group,increasing the N content of the carbon material and ensuring that the support could provide sufficient N sites for the deposition of Pd *** process helped to improve metal *** increased metal-support interaction,which limits the leaching and coarsening of Pd NPs,improves the stability of the Pd/NCF ***,density functional theory calculations indicated that pyridine N stabilized the Pd^(2+)species,significantly inhibiting the loss of Pd^(2+)in Pd/NCF during the reaction *** work provides a promising avenue towards enhancing the stability of nitrogen-doped carbon-supported metal catalysts.

关键词： Supported Pd catalyst N-doped carbon Amphiphilic triblock copolymer Pyridinic nitrogen Stability

Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for Wound Healing

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Research 2024年第1期2023卷 107-118页

作者： Xiaocheng Wang Jinxuan jia Mengying Niu Wenzhao Li Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China

Biological scaffolds have been widely employed in wound healing applications,while their practical efficiency is compromised by insufficient oxygen delivery to the 3-dimensional constructs and inadequate nutrient supply for the long-term healing ***,we present an innovative living Chinese herbal scaffold to provide a sustainable oxygen and nutrient supply for promoting wound *** a facile microfluidic bioprinting strategy,a traditional Chinese herbal medicine(Panax notoginseng saponins[PNS])and a living autotrophic microorganism(microalgae Chlorella pyrenoidosa[MA])were successfully encapsulated into the *** encapsulated PNS could be gradually released from the scaffolds,which promoted cell adhesion,proliferation,migration,and tube formation in *** addition,benefiting from the photosynthetic oxygenation of the alive MA,the obtained scaffolds would produce sustainable oxygen under light illumination,exerting a protective effect against hypoxia-induced cell *** on these features,we have demonstrated through in vivo experiments that these living Chinese herbal scaffolds could efficiently alleviate local hypoxia,enhance angiogenesis,and thereby accelerate wound closure in diabetic mice,indicating their great potential in wound healing and other tissue repair applications.

关键词： healing wound protective

Energy-absorbing porous materials:Bioinspired architecture and fabrication

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Nano Research 2024年第2期17卷 679-690页

作者： Junheng zhao Meng Li Jiewei Chen Weiwei Gao hao Bai State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310058China

Energy-absorbing materials are widely used in transportations,sports,and the military ***,porous materials,including natural and artificial materials,have attracted tremendous attentions due to their light weight and excellent energy absorption *** review summarizes the recent progresses in the natural and artificial energy-absorbing porous ***,we review the typical natural porous materials including cuttlebone,bighorn sheep horn,pomelo peel,and sunflower stem *** architectures,energy absorption abilities,and mechanisms of these typical natural materials and their bioinspired materials are ***,we provide a review on the fabrication methods of artificial energy-absorbing porous materials,such as conventional foaming and three-dimensional(3D)***,we address the challenges and prospects for the future development of energy-absorbing porous *** importantly,our review provides a direct guidance for the design and fabrication of energy-absorbing porous materials required for various engineering applications.

关键词： energy-absorbing porous materials natural materials natural structures bioinspired materials

Joint alignment and steering to manage interference

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Digital Communications and Networks 2024年第2期10卷 429-438页

作者： zhao Li Xiujuan Liang Yinghou Liu jia Liu Zheng Yan School of Cyber Engineering Xidian UniversityXi'an710126China Technol.on Commun.Net.Lab. The 54th Research Inst.of China Elec.Technol.Group Corp.Shijiazhuang050081China School of Computer Science and Technology Xidian UniversityXi'an710126China The Department of Communications and Networking(Comnet) Aalto University02150EspooFinland

In wireless communication networks,mobile users in overlapping areas may experience severe interference,therefore,designing effective Interference Management(IM)methods is crucial to improving network ***,when managing multiple disturbances from the same source,it may not be feasible to use existing IM methods such as Interference Alignment(IA)and Interference Steering(IS)*** is because with IA,the aligned interference becomes indistinguishable at its desired Receiver(Rx)under the cost constraint of Degrees-of-Freedom(DoF),while with IS,more transmit power will be consumed in the direct and repeated application of IS to each *** remedy these deficiencies,Interference Alignment Steering(IAS)is proposed by incorporating IA and IS and exploiting their advantages in *** IAS,the interfering Transmitter(Tx)first aligns one interference incurred by the transmission of one data stream to a one-dimensional subspace orthogonal to the desired transmission at the interfered Rx,and then the remaining interferences are treated as a whole and steered to the same subspace as the aligned ***,two improved versions of IAS,i.e.,IAS with Full Adjustment at the Interfering Tx(IAS-FAIT)and Interference Steering and Alignment(ISA),are *** former considers the influence of IA on the interfering user-pair's *** orthogonality between the desired signals at the interfered Rx can be maintained by adjusting the spatial characteristics of all interferences and the aligned interference components,thus ensuring the Spectral Efficiency(SE)of the interfering communication *** ISA,the power cost for IS at the interfered Tx is minimized,hence improving SE performance of the interfered *** the proposed methods are realized at the interfering and interfered Txs cooperatively,the expenses of IM are shared by both *** in-depth simulation results show that joint use of IA and

关键词： Interference Interference management Interference alignment Interference steering Spectral efficiency

Freeze-induced acceleration of iodide oxidation and consequent iodination of dissolved organic matter to form organoiodine compounds

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Journal of Environmental Sciences 2024年第10期144卷 67-75页

作者： Xuexin Gong Mei He Zhineng hao Rusong zhao Jingfu Liu School of Resources and Environment Yangtze UniversityWuhan 430100China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Qilu University of Technology(Shandong Academy of Sciences) Shandong Analysis and Test CenterKey Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong ProvinceJinan 250014China Institute of Environment and Health Jianghan UniversityWuhan 430056China

Freeze-induced acceleration of I–oxidation and the consequent iodination of dissolved organic matter(DOM)contribute to the formation of organoiodine compounds(OICs)in cold *** formed OICs may be a potentially important source of risk and are very closely with the environment and human ***,we investigated the acceleration effects of the freeze process on I–oxidation and the formation of *** comparison to reactive iodine species(RIS)formed in aqueous solutions,I–oxidation and RIS formation were greatly enhanced in frozen solution and were affected by pH,and the content of I–and ***-thaw process further promoted I–oxidation and the concentration of RIS reached 45.7μmol/L after 6 freeze-thaw *** consequent products of DOM iodination were greatly promoted in terms of both concentration and *** total content of OICs ranged from 0.02 to 2.83μmol/L under various *** 183–1197 OICs were detected by Fourier transform ion cyclotron resonance mass spectrometry,and more than 96.2%contained one or two iodine *** OICs had aromatic structures and were formed via substitution and addition *** findings reveal an important formation pathway for OICs and shed light on the biogeochemical cycling of iodine in the natural aquatic environment.

关键词： Freeze process Dissolved organic matter(DOM) Iodination Organoiodine compounds(OICs) Ultrahigh resolution mass spectrometry

Grain-boundary segregation and grain growth in nanocrystalline substitutional solid solution alloys

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Journal of Materials Science & Technology 2024年第1期168卷 239-249页

作者： Fawei Tang Chao Hou hao Lu Zhi zhao Xiaoyan Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing solute segregation at grain boundaries has been developed for substitutional solid solution alloys,which integrates multiple factors from atomic to microstructural scales.A concept of mo-lar Gibbs free energy of segregation was introduced to evaluate the segregating capability of the solute elements in a closed system,through which the influences of grain boundary structure,grain size,ma-terial composition,and external conditions were *** on the evaluation of various energy forms related to solute segregation and grain growth processes,the nature of the thermal stabilization of nanograin structures by solute segregation was disclosed.A criterion for the destabilization of nanostruc-tures,which is determined by the competition of the change rates between the molar Gibbs free energy of segregation and the total energy of grain boundaries with grain size,has been *** study provided guideline to achieve high-temperature stability of nanograin structures of solid solution alloys even for the weakly segregating nanocrystalline systems.

关键词： Substitutional solid solution Grain boundary segregation Thermal stabilization Solute concentration Grain size

Pathogenic genes associated with Parkinson’s disease:molecular mechanism overview

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BIOCELL 2024年第5期48卷 707-729页

作者： TINGTING LIU YIWEI hao LIFENG zhao School of Life Sciences Institute for Brain Sciences ResearchHenan UniversityKaifeng475004China Pharmaceutical Department Peking University Cancer Hospital Inner Mongolia HospitalHohhot010010China

Parkinson’s disease(PD)is a common neurodegenerative disease in the elderly,accounting for more than 1%of the population aged 65 *** inheritance is relatively rare in PD,accounting for approximately 5%to 10%of PD patients,and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of *** groups have identified and reported a number of genes carrying mutations associated with affected family *** genes associated with PD are also candidates for idiopathic PD,and these genes may also carry other mutation sites that increase *** multiple genetic risk factors are combined,the risk of PD is increased to a greater extent,and to unravel the pathogenic pathways that lead to different forms of *** review focuses on the association of PD genes,such as Parkinson Disease 1-24(PARK1-24),glucosylceramidase(GBA),GTP cyclohydrolase 1(GCH1),fibroblast growth factor 20(FGF20),nuclear receptor-related factor 1(NURR1),NUS1 dehydrodolichyl diphosphate synthase subunit(NUS1),diacylglycerol Lipase Beta(DAGLB),transmembrane protein(TMEM),ubiquinol-cytochrome c reductase core protein 1(UQCRC1),glycoprotein non-metastatic melanoma protein B protein(GPNMB),dynactin 1(DCTN1),LDL receptor related protein 10(LRP10),monoamine oxidase(MAO),ataxin 2(ATXN2),microtubule associated protein tau(MAPT),pantothenate kinase 2(PANK2),spastic parapplegia type 11(SPG11),polymer gamma(POLG),TATA-box binding protein associated factor 1(TAF1),dual specificity tyrosine phosphorylation regulated kinase 1A(Dyrk1a),and crystallin alpha A(CRYAA),with the pathogenesis of *** introduce what is currently known about the molecular genetics of PD to help explain the molecular mechanisms leading to the neurodegenerative disease.

关键词： Parkinson’s disease(PD) Molecular genetics Mutation

All-dielectric terahertz metasurface governed by bound states in the continuum with high-Q factor

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 44-54页

作者： Li Kun zhao Xu Wang Meng jia Xingning zhao Ruiqi Lu Guizhen School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300384China School of Electronic and Electrical Engineering Ningxia UniversityYinchuan 750021China QILU Aerospace Information Research Institute Chinese Academy of Sciences(CAS)Jinan 250101China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing 100024China

The method of terahertz(THz)resonance with a high-quality(high-Q)factor offers a vital physical mechanism for metasurface sensors and other high-Q factor ***,it is challenging to excite the resonance with a high-Q factor in metasurfaces with proper sensitivity as well as figure of merit(FOM)***,an all-dielectric metasurface composed of two asymmetrical rectangular blocks is *** and silicon are the materials applied for the substrate and cuboids *** distinct resonance governed by bound states in the continuum(BIC)is excited by forming an asymmetric cluster by a novel hybrid method of cutting and moving the *** investigation focuses on analyzing the transmission spectra of the metasurface under different variations in structural parameters and the loss of silicon refractive *** the proposed defective metasurface serves as a transmittance sensor,it shows a Q factor of 1.08×10^(4)and achieves an FOM up to 4.8×10^(6),which is obtained under the asymmetric parameter equalling 1μ***,the proposed defective metasurface is sensitive to small changes in refractive *** the thickness of the analyte is 180μm,the sensitivity reaches a maximum value of 578 GHz/***,the proposed defective metasurface exhibits an extensive number of possible applications in the filters,biomedical diagnosis,security screening,and so on.

关键词： terahertz(THz)metasurface high-quality(high-Q)factor bound states in the continuum figure of merit(FOM)

SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors

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Cellular & Molecular Immunology 2024年第3期21卷 213-226页

作者： Sixin Liang Rui Zheng Baile Zuo jia Li Yiyi Wang Yujie Han hao Dong Xiaojuan zhao Yiting Zhang Pengju Wang Ruotong Meng Lintao jia Angang Yang Bo Yan State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’anShaanxi710032China School of Medicine Technology Xinxiang Medical UniversityXinxiangHenan453003China Department of Obstetrics and Gynecology Xijing Hospital of Fourth Military Medical UniversityXi’anShaanxi710032China College of Life Science Yan’an UniversityYan’anShaanxi716000China Department of Immunology Fourth Military Medical UniversityXi’anShaanxi710032China

Despite the tremendous progress of chimeric antigen receptor T(CAR-T)cell therapy in hematological malignancies,their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment(TME)and systemic toxicity caused by excessive cytokine *** a key regulator of the immunosuppressive TME,TGF-βpromotes cytokine synthesis via the NF-κB ***,we coexpressed SMAD7,a suppressor of TGF-βsignaling,with a HER2-targeted CAR in engineered T *** novel CAR-T cells displayed high cytolytic efficacy and were resistant to TGF-β-triggered exhaustion,which enabled sustained tumoricidal capacity after continuous antigen ***,SMAD7 substantially reduced the production of inflammatory cytokines by antigen-primed CAR-T ***,SMAD7 downregulated TGF-βreceptor I and abrogated the interplay between the TGF-βand NF-κB pathways in CAR-T *** a result,these CAR-T cells persistently inhibited tumor growth and promoted the survival of tumor-challenged mice regardless of the hostile tumor microenvironment caused by a high concentration of TGF-β.SMAD7 coexpression also enhanced CAR-T-cell infiltration and persistent activation in patient-derived tumor ***,our study demonstrated the feasibility of SMAD7 coexpression as a novel approach to improve the efficacy and safety of CAR-T-cell therapy for solid tumors.

关键词： TGF-βpathway SMAD7 NF-κB pathway CAR-T-cell therapy Cytokine release syndrome(CRS)