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GTS40, an active fraction of Gou Teng-San (GTS), protects PC12 from H2O2-induced cell injury through antioxidative properties

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Chinese Journal of Natural Medicines 2017年第7期15卷 495-504页

作者： chen Lei WEI Meng-Lin Zhao jiao-jiao HONG hao QU Wei FENG Feng LIU Wen-Yuan Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China Department of Pharmacology China Pharmaceutical University Nanjing 210009 China

Oxidative stress, a predominant cause of apoptosis cascades triggered in neurodegenerative disorders, has been regarded as a critical inducement in the pathogenesis of Alzheimer's disease(AD). Gou Teng-San(GTS) is a traditional Chinese herbs preparation commonly utilized to alleviate cognitive dysfunction and psychological symptoms of patients with dementia. The present study aimed to investigate the protective effects of GTS40, an active fraction of GTS, on H_2O_2-induced oxidative damage and identify the potential active ingredients. Our results revealed that GTS40 exhibited radical scavenging activity, elevated cell viability, decreased the levels of intracellular reactive oxygen species(ROS), and stabilized mitochondrial transmembrane potential(MMP) in H_2O_2-treated PC12 cells. In addition, GTS40 blocked the apoptotic cascade by reversing the imbalance of Bcl-2/Bax and inhibiting the activity of caspase-3. Furthermore, an HPLC-QTOFMS method was developed to characterize major chemical constituents in GTS40. Our results revealed twenty-seven identified or tentatively characterized compounds through comparing their retention time(t_R) and MS spectra with reference standards. These results suggested that GTS40 was a promising active fraction that may be beneficial in the prevention and treatment of oxidative stress-mediated neurodegenerative disorders.

关键词： GTS40 Oxidative stress Neuroprotective effects Apoptosis HPLC-QTOF-MS/MS

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Crosstalk of cold and gibberellin effects on bolting and flowering in flowering Chinese cabbage

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Journal of Integrative Agriculture 2019年第5期18卷 992-1000页

作者： SONG Shi-wei LEI Yu-ling HUANG Xin-min SU Wei chen Ri-yuan hao Yan-wei College of Horticulture South China Agricultural University

The flower stalk is the product organ of flowering Chinese cabbage(Brassica campestris *** *** Tsen et Lee),which is cultivated extensively in South *** stalk formation and development,including bolting and flowering,determine the yield of flowering Chinese cabbage;however,the bolting and flowering mechanisms remain to be *** elucidate these processes,we studied the effects of low-temperature and gibberellin(GA)treatments,and their interaction,on stem elongation,bolting time,flowering time,hormone content,and cell morphology in stem of flowering Chinese *** results showed that both cold and GA treatments accelerated bolting time,stem elongation,and flowering ***,cold and GA cotreated plants displayed additive positive *** addition,cold treatments increased the GA,indole-3-acetic acid,and cytokinin contents and altered cell size in the shoot apices of flowering Chinese *** with uniconazole,a GA synthesis inhibitor,strongly delayed bolting time,stem elongation,and flowering time,whereas GA,but not cold treatment,rescued this inhibition,indicating that low temperature accelerates bolting and flowering not only through inducing GA in the shoot apices,but also other *** results provide a theoretical basis for further dissecting the regulatory mechanism of bolting and flowering in flowering Chinese cabbage.

关键词： bolting flowering stem elongation cold gibberellin

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Stabilizing n-type cubic AgBiSe_(2) thermoelectric materials through alloying with PbS

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Journal of Materiomics 2024年第1期10卷 70-77页

作者： Lai Zhang Weixia Shen Zhuangfei Zhang Chao Fang Qianqian Wang Biao Wan Liangchao chen Yuewen Zhang Xiaopeng jia Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou450052China

Phase transition generates rapid changes of transport parameters and poor mechanical property,and thus restricts the application of thermoelectric ***_(2) exhibits cubic phase at above 580 K with high-symmetry structure and low lattice thermal conductivity,indicating the potentiality of high thermoelectric *** this work,the cubic structure of AgBiSe_(2) was achieved at ambient conditions by alloying with PbS,enhancing the configurational entropy at both cationic and anionic *** cubic structure was rather stable after several measurement *** substitution at cationic sites effectively reduced band gap,and increased both carrier concentration and effective *** samples exhibited relatively low lattice thermal conductivity(0.68-0.34 W/(m·K))in the temperature range of 300-773 K,due to the nanoscale inhomogeneity and the random distribution of multiple species at some atomic sites.A maximum zT of 0.65 at 773 K was obtained for(Ag_(0.99)Nb_(0.01)BiSe_(2))_(0.8)(PbS)_(0.2) *** entropy-driven structural stabilization is a promising strategy to achieve stable structure for practical thermoelectric applications.

关键词： Thermoelectric AgBiSe_(2) Configurational entropy Phase transition

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Heterogeneous population distribution enhances resistance to wheat lodging by optimizing the light environment

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Journal of Integrative Agriculture 2024年第7期23卷 2211-2226页

作者： Yibo Hu Feng Qin Zhen Wu Xiaoqin Wang Xiaolong Ren Zhikuan jia Zhenlin Wang Xiaoguang chen Tie Cai College of Agronomy Northwest A&F UniversityYangling 712100China Key Laboratory of Crop Physi-Ecology and Tillage Science in Northwestern Loess Plateau Ministry of Agriculture and Rural AffairsNorthwest A&F UniversityYangling 712100China College of Agronomy Shandong Agricultural University/State Key Laboratory of Crop BiologyTai’an 271018China Xuzhou Institute of Agricultural Sciences in jiangsu Xuhuai Area Xuzhou 221131China

Lodging is still the key factor that limits continuous increases in wheat yields today,because the mechanical strength of culms is reduced due to low-light stress in populations under high-yield *** mechanical properties of the culm are mainly determined by lignin,which is affected by the light ***,little is known about whether the light environment can be sufficiently improved by changing the population distribution to inhibit culm ***,in this study,we used the wheat cultivar“Xinong 979”to establish a low-density homogeneous distribution treatment(LD),high-density homogeneous distribution treatment(HD),and high-density heterogeneous distribution treatment(HD-h)to study the regulatory effects and mechanism responsible for differences in the lodging resistance of wheat culms under different population *** with LD,HD significantly reduced the light transmittance in the middle and basal layers of the canopy,the net photosynthetic rate in the middle and lower leaves of plants,the accumulation of lignin in the culm,and the breaking resistance of the culm,and thus the lodging index values increased significantly,with lodging rates of 67.5%in 2020–2021 and 59.3%in 2021–*** HD-h,the light transmittance and other indicators in the middle and basal canopy layers were significantly higher than those under HD,and the lodging index decreased to the point that no lodging *** with LD,the activities of phenylalanine ammonia-Lyase(PAL),4-coumarate:coenzyme A ligase(4CL),catechol-O-methyltransferase(COMT),and cinnamyl-alcohol dehydrogenase(CAD)in the lignin synthesis pathway were significantly reduced in the culms under HD during the critical period for culm formation,and the relative expression levels of TaPAL,Ta4CL,TaCOMT,and TaCAD were significantly ***,the activities of lignin synthesis-related enzymes and their gene expression levels were significantly increased under HD-h compare

关键词： canopy light environment lignin lodging population distribution wheat

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A facile method for building fused quinoxaline-quinolinones via an acidless post-Ugi cascade reaction

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Chinese Chemical Letters 2017年第3期28卷 541-545页

作者： Yong Li Jie Lei jia Xu Dian-Yong Tang Zhong-Zhu chen Jin Zhua Chuan Xu Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine IATTIChongqing University of Arts and Sciences Department of Oncology Chengdu Military General Hospital

A series of quinolino[3,4-b]quinoxalin-6（5H）-ones have been synthesized using an Ugi/deprotection/cyclization（UDC） strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3,4-b]quinoxalin-6（5H）-ones for high-throughput screening in medicinal chemistry.

关键词： Quinoxaline Quinolino[3 4-b]quinoxalin-6(5H)-one Ugi/deprotection/cyclization(UDC) strategy Nucleophilic substitution reaction One-pot

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Partition method for impact dynamics of flexible multibody systems based on contact constraint

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Applied Mathematics and Mechanics(English Edition) 2013年第11期34卷 1393-1404页

作者：段玥晨章定国洪嘉振 School of Mechanical Engineering Zhengzhou University School of Science Nanjing University of Science and Technology Department of Engineering Mechanics Shanghai Jiao Tong University

The impact dynamics of a flexible multibody system is investigated. By using a partition method, the system is divided into two parts, the local impact region and the region away from the impact. The two parts are connected by specific boundary conditions, and the system after partition is equivalent to the original system. According to the rigid-flexible coupling dynamic theory of multibody system, system＇s rigid-flexible coupling dynamic equations without impact are derived. A local impulse method for establishing the initial impact conditions is proposed. It satisfies the compatibility con- ditions for contact constraints and the actual physical situation of the impact process of flexible bodies. Based on the contact constraint method, system＇s impact dynamic equa- tions are derived in a differential-algebraic form. The contact/separation criterion and the algorithm are given. An impact dynamic simulation is given. The results show that system＇s dynamic behaviors including the energy, the deformations, the displacements, and the impact force during the impact process change dramatically. The impact makes great effects on the global dynamics of the system during and after impact.

关键词： flexible multibody system impact dynamics partition method impulse-momentum method contact constraint

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Impact of fast-track surgery on perioperative care in patients undergoing hepatobiliary surgery

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3155-3162页

作者： Xiao-Hong Wang Fang-Fang chen jia Pan Yun-Fei jiang Min-Yue Yao jia-Li Mao Ya-Feng Xu Department of General Surgery Kecheng District People's HospitalQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Fast-track surgery(FTS)is a modern nursing approach that has gained popularity in the perioperative phase of *** To investigate the impact of FTS on perioperative care for hepatobiliary *** A retrospective analysis was performed on 98 patients who underwent hepato-biliary surgery and were admitted to our hospital from August 2021 to October *** were divided into an observation group and a control group with 49 patients in each group according to different nursing *** control group was treated with standard nursing and the observation group was treated with FTS concept *** length of hospital stay,visual analog scale(VAS)score,wound complications,nursing satisfaction,self-rating scale(SAS)score,and SF-36 quality of life(QoL)score were compared between the two groups before and after *** The duration of hospitalization,hospitalization cost,operation time,first im-plantation time,exhaust time,and first defecation time were shorter than the observation group(P<0.05).Additionally,the observation group showed a sig-nificant difference between the VAS and SAS scores on days 1,3,and 7(P<0.05).The complication rate in the observation group was 4.05%was significantly lower than the 18.36%in the control group,and the comparison groups were statistically significant(χ2=5.018,P=0.025).The observation group had a significantly higher level of nurse satisfaction(94.92%)than the control group(79.59%;χ2=6.078,P=0.014).Both groups showed higher QoL scores after nursing care,with higher scores in the observation group than in the control group(P=0.032).CONCLUSION FTS in patients undergoing hepatobiliary surgery can effectively improve negative mood,QoL,and nursing sa-tisfaction;reduce wound complications;and accelerate patient rehabilitation.

关键词： Rapid rehabilitation surgery concept Hepatobiliary surgery Quality of life Wound complications Fast track surgery

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Sources of particulate organic matter in the Chukchi and Siberian shelves: clues from carbon and nitrogen isotopes

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Acta Oceanologica Sinica 2020年第9期39卷 96-108页

作者： Renming jia Xinyue Mu Min chen Jing Zhu Bo Wang Xiaopeng Li A S Astakhov Minfang Zheng Yusheng Qiu College of Ocean and Earth Sciences Xiamen UniversityXiamen 361005China V.I.Il’ichev Pacific Oceanological Institute Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russia

The stable isotopic composition(δ13C andδ15N)and carbon/nitrogen ratio(C/N)of particulate organic matter(POM)in the Chukchi and East Siberian shelves from July to September,2016 were measured to evaluate the spatial variability and origin of ***δ13CPOC values were in the range of−29.5‰to−17.5‰with an average of−25.9‰±2.0‰,and theδ15NPN values ranged from 3.9‰to 13.1‰with an average of 8.0‰±1.6‰.The C/N ratios in the East Siberian shelf were generally higher than those in the Chukchi shelf,while theδ13C andδ15N values were just the *** low C/N ratios(10‰)values were observed in the Wrangel Island polynya,which was attributed to the early bloom of small *** contributions of terrestrial POM,bloom-produced POM and non-bloom marine POM were estimated using a three end-member mixing *** spatial distribution of terrestrial POM showed a high fraction in the East Siberian shelf and decreased eastward,indicating the influence of Russian *** distribution of non-bloom marine POM showed a high fraction in the Chukchi shelf with the highest fraction occurring in the Bering Strait and decreased westward,suggesting the stimulation of biological production by the Pacific inflow in the Chukchi *** fractions of bloom-produced POM were highest in the winter polynya and gradually decreased toward the periphery.A negative relationship between the bloom-produced POM and the sea ice meltwater inventory was observed,indicating that the net sea ice loss promotes early bloom in the *** the high fraction of bloom-produced POM,the early bloom of phytoplankton in the polynyas may play an important role on marine production and POM export in the Arctic shelves.

关键词： particulate organic matter carbon isotope nitrogen isotope Chukchi Shelf East Siberian Shelf polynya

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Facile Synthetic Method and Crystal Structure of 2,3,3',4'-Biphenyltetracarboxylic Dianhydride

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Chemical Research in Chinese Universities 2012年第2期28卷 234-238页

作者： YI Shi-xu GAO Guo-wei YANG Mei-jia chen Hua WU Di-feng MEN jian College of Chemistry Siehuan UniversityChengdu 610064P.R.China

A facile method for the synthesis of 2,3,3＇,4＇-biphenyltetracarboxylic dianhydride（a-BPDA） was reported,which comprises the steps of the dehalogenative coupling of dimethyl 4-chlorophthalate（4-DMCP） and dimethyl 3-chlorophthalate（3-DMCP） catalyzed by low-cost（Ph 3 P） 2 NiCl 2,the hydrolysis of tetra-ester and the dehydration of *** contrast to the conventional methods,this method has the advantage of low cost,convenient manipulation,available condition,high purity and good overall ***,the single crystal structure of a-BPDA was analyzed by X-ray diffraction *** X-ray data suggest that a-BPDA is a rigid,non-coplanar and non-linear *** contains three crystallographically independent molecules,in which the dihedral angles of the two linked phenyl rings are 44.75（4）°,46.37（3）° and 42.32（3）°,*** title molecule is governed by a stronger intermolecular interaction in contrast to van der Waals interaction because of the special positions of anhydride groups.

关键词： 2 3 3' 4'-Biphenyltetracarboxylic dianhydride Crystal structure Ni-catalyzation Dehalogenative coupling

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Defect characterization of amorphous silicon thin film solar cell based on low frequency noise

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Science China(Information Sciences) 2018年第6期61卷 253-255页

作者： Linna HU Liang HE Hua chen Xiaofei jia Ying HU Hongmei MA DANDan GUO Yu QIN School of Advanced Materials and Nanotechnology Xidian University School of Electronic and Information Engineering Ankang University

Dear editor,The reliability of solar cells is the key factor to determine the performance and lifetime of photovoltaic *** to the insensitivity of traditional electrical detection and the limitations of in-situ charac... 详细信息

关键词： Defect characterization of amorphous silicon thin film solar cell based on low frequency noise GR

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