检索结果-南通市图书馆

Managing crawling-type gastric adenocarcinoma with endoscopic techniques and postoperative monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第43期30卷 4657-4659页

作者： jia-chen yang Liu-Xiang chen Bing Hu Department of Gastroenterology and Hepatology/Digestive Endoscopy Medical Engineering Research Laboratory West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Crawling-type gastric adenocarcinoma is a rare subtype of gastric cancer with diagnostic and therapeutic challenges due to its flat,ill-defined *** diagnostic techniques,such as narrow-band imaging and linear endoscopic ultrasonography,improve detection,but endoscopic submucosal dissection poses a risk of incomplete *** negative resection margins,vigilant postoperative monitoring is crucial due to the potential for *** letter highlights the importance of refined diagnostic criteria,individualized treatment approaches,and continuous follow-up to optimize management of this unique gastric cancer subtype.

关键词： Crawling-type gastric cancer Superficial flat tumor Positive resection margin Multiple biopsies Endoscopic submucosal dissection Postoperative monitoring

Effects of spinning parameters on microstructures of ellipsoidal heads during marginal-restraint mandrel-free spinning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Manufacturing 2020年第4期8卷 457-472页

作者： jia-yang chen Yong-cheng Lin Guo-Dong Pang Xin-He Li School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083People's Republic of China State Key Laboratory of High Performance Complex Manufacturing Changsha 410083People's Republic of China

Marginal-restraint mandrel-free spinning is an advanced technology for manufacturing ellipsoidal heads with large diameter-thickness *** effects of spinning parameters on the forming accuracy of ellipsoidal heads have been studied,and optimized spinning parameters have been *** microstructure evolution of a workpiece is usually very complicated in the spinning *** this work,the influence of spinning parameters on the microstructures of two-pass spun ellipsoidal heads is *** is found that the forming angle and feed rate of the first pass,angle between passes,and feed rate of the second pass significantly affect the ***,the evolution rule of the microstructures near the inner and outer surfaces of the spun parts is almost consistent.A large forming angle,large angle between passes,or large feed rate of the second pass are beneficial to obtain uniform microstructures.A small or large feed rate of the first pass reduces the microstructure *** improve the microstructure uniformity between the inner and outer surfaces,the optimized spinning parameters are determined.

关键词： Spinning Thin-walled ellipsoidal heads Spinning parameters Microstructure evolution

Residual-stress relaxation mechanism and model description of 5052H32 Al alloy spun ellipsoidal heads during annealing treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Manufacturing 2022年第1期10卷 87-100页

作者： Yong-cheng Lin jiang-Shan Zhu jia-yang chen Jun-Quan Wang School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083People’s Republic of China

Marginal-restraint mandrel-free spinning is an advanced technology for manufacturing ellipsoidal heads with large diameter-thickness ***,the spinning-induced residual stress,which greatly influences the in-service performance of spun heads,should be *** this study,the effects of annealing on the residual-stress relaxation behavior of 5052H32 aluminum alloy spun heads were *** is found that the residual stress first rapidly decreases and then remains steady with the increase in annealing time at the tested annealing *** relaxation of the residual stress becomes increasingly obvious with the increase in annealing *** the annealing temperature is less than 220℃,there are no obvious changes in grain ***,the spinning-induced dislocations are consumed by the static recovery behavior,which decreases the residual stress during *** the annealing temperature is approximately 300℃,the broken grains transform into equiaxed *** addition,static recrystallization and recovery behaviors occur simultaneously to promote the relaxation of the residual *** the different stress relaxation mechanisms,a model based on the Zener-Wert-Avrami equation was established to predict the residual-stress relaxation ***,the optimized annealing temperature and time were approximately 300C and 30 min,respectively.

关键词： Spinning Residual stress Annealing treatment Microstructure evolution Relaxation mechanism

An MSX infrared analysis of the superbubble around the giant HII region NGC3603

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2010年第S1期53卷 271-273页

作者： WANG jia & chen yang Department of Astronomy,Nanjing University,Nanjing 210093,China 1. Department of Astronomy Nanjing University Nanjing 210093 China

Using the MSX mid-infrared observations,we reveal a 100pc-scale superbubble surrounding the giant HII region *** suggest that the diffuse surrounding infrared emission in bands A,C,and D is dominated by that of PAH and the emission in band E is dominated by that of dust *** fitted dust temperature is consistent with heating by the central cluster's UV *** derived gas-to-dust mass ratio for the bubble shell is of order 102.

关键词： superbubble HII region cluster PAH dust

Network Pharmacology and in vitro Experimental Veriflcation on Intervention of Quercetin, Present in Chinese Medicine Yishen Qutong Granules, on Esophageal Cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2023年第3期29卷 233-243页

作者： LI Jie CHANG Jin-yuan jiaNG Zheng-long YIN Yu-kun chen jia-yang JIN Wei LI Hao FENG Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing(100021)China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing(100029)China

Objective: To explore the potential mechanism of Yishen Qutong Granules(YSQTG) for the treatment of esophageal cancer using network pharmacology and experimental research. Methods: The effective components and molecular mechanism of YSQTG in treating esophageal cancer were expounded based on network pharmacology and molecular docking. The key compound was identified by high-performance liquid chromatography and mass spectrometry(HPLC-MS) to verify the malignant phenotype of the key compounds in the treatment of esophageal cancer. Then, the interaction proteins of key compounds were screened by pull-down assay combined with mass spectrometry. RNA-seq was used to screen the differential genes in the treatment of esophageal cancer by key compounds, and the potential mechanism of key compounds on the main therapeutic targets was verified. Results: Totally 76 effective compounds of YSQTG were found, as well as 309 related targets, and 102 drug and disease interaction targets. The drug-compound-target network of YSQTG was constructed, suggesting that quercetin, luteolin, wogonin, kaempferol and baicalein may be the most important compounds, while quercetin had higher degree value and degree centrality, which might be the key compound in YSQTG. The HPLC-MS results also showed the stable presence of quercetin in YSQTG. By establishing a protein interaction network, the main therapeutic targets of YSQTG in treating esophageal cancer were Jun proto-oncogene, interleukin-6, tumor necrosis factor, and RELA proto-oncogene. The results of cell function experiments in vitro showed that quercetin could inhibit proliferation, invasion, and clonal formation of esophageal carcinoma cells. Quercetin mainly affected the biological processes of esophageal cancer cells, such as proliferation, cell cycle, and cell metastasis. A total of 357 quercetin interacting proteins were screened, and 531 genes were significantly changed. Further pathway enrichment analysis showed that quercetin mainl

关键词： network pharmacology esophageal cancer Yishen Qutong Granule Chinese medicine quercetin nuclear factor kappa B

Clinical value of continuous administration of sorafenib in combination with modified transarterial chemoembolization in patients with unresectable hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第2期126卷 385-386页

作者： HUANG Yong-hui chen Wei LI jia-ping chen Bin yang jian-yong Department of Interventional Radiology First Affiliated Hospitalof Sun Yat-sen University Guangzhou Guangdong 510080 China

Hepatocellular carcinoma （HCC） is a major threat to human health in China with high morbidity andmortality. Surgical resection and liver transplantation are the most promising treatments for HCC. The majority of patients, however, are not eligible for surgery due to 1 advanced tumor, multifocal disease or poor liver reserve. Recently, transarterial chemoembolization （TACE） improved survival compared with best supportive care in two individual clinical trials.2 Sorafenib is a multikinase inhibitor that targets both tumor cell proliferation and angiogenesis. The current standard of practice is to treat BCLC stage B HCC with TACE alone and more advanced （BCLC stage C） HCC with sorafenib only.1

关键词： hepatocellular carcinoma, progression-free survival, sorafenib transarterial chemoembolization

Primary study on anther culture of balsum pear for callus and organ formation

在线全文

学校读者我要写书评

暂无评论

Journal of Life Sciences 2008年第1期2卷 12-18页

作者： LI Huan-xiu chen jia ZHENG yang-xia YAN Ze-sheng HE Yan Department of Horticulture College of Forestry and Horticulture Sichuan Agriculture University Ya＇an Sichuan 625014 China

The balsum pear （Momordica charantia L. ） anthers in the monokaryotic stage of microspore development were cultured in this experiment. Different Plant growth regulators＇ combinations, base media and carbon sources were studied for callus formation and organ differentiation from balsum pear anthers. The result showed that the best media for callus inducement was： MS＋BA 0.5 mg/L＋NAA 0.2 mg/L＋ 2, 4-D 0.5 mg/L＋KT 2.0 mg/L, with 3% sugar and 0.8% agar. The best media to induce roots from balsum pear anther callus was： MS＋NAA 0.05 rag/L＋ KT 0.5 rag/L, with 3% sugar and 0.8% agar. Most of adventitious roots from callus were triploid（2N=3X=33）

关键词： balsum pear (Momordica charantia L. ) antherculture callus inducement organ differentiation

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： yang Liu Huopo chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

在线全文

学校读者我要写书评

暂无评论

顶板动载冲击效应的相似模拟及理论解析

煤炭学报 2017年第2期42卷 335-343页

作者：杨胜利王家臣杨敬虎中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221008 中国矿业大学(北京)资源与安全工程学院北京100083 放顶煤开采煤炭行业工程研究中心北京100083

研制了工作面覆岩破断预测实验平台,对浅埋薄基岩条件顶板动载冲击效应进行了模拟;建立了顶板破断的弹性地基梁理论模型,计算出了基本顶破断时与煤壁的相对位置,得到了动载冲击的作用范围;建立顶板动载冲击的力学模型,结合岩石压缩曲线... 详细信息

研制了工作面覆岩破断预测实验平台,对浅埋薄基岩条件顶板动载冲击效应进行了模拟;建立了顶板破断的弹性地基梁理论模型,计算出了基本顶破断时与煤壁的相对位置,得到了动载冲击的作用范围;建立顶板动载冲击的力学模型,结合岩石压缩曲线,应用功能原理得到了不同条件下的最大冲击载荷和支架伸缩量的解析表达式,得到了不发生压架事故的判别准则,验证了相似模拟实验结果。结果表明:基本顶多超前直接顶支撑边界破断,且冲击易发生液压支架上方完成;冲击载荷大小与直接顶厚度与裂隙发育程度、支架刚度和初撑力大小等因素有关,其值远大于工作面静载荷形成对液压支架的压力,动载冲击效应模拟实验验证了理论分析结果。

关键词：动载冲击弹性地基梁初撑力动载系数相似模拟