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上书房行走:家空间视野下书房的表征与非表征

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人文地理 2024年第4期39卷 118-127页

作者：宋佳倪刘培学张建新何家伟李佳敏南京大学地理与海洋科学学院南京210023 南京财经大学工商管理学院南京210023

“家”的地理学是近年来人文地理学的热点话题之一,其中书房作为具有中国传统文化特色的特定家屋空间值得关注。本研究以空间表征与非表征为视角,深入探讨家空间视野下高校知识分子的书房空间。研究发现,高校知识分子的书房空间以“文... 详细信息

“家”的地理学是近年来人文地理学的热点话题之一,其中书房作为具有中国传统文化特色的特定家屋空间值得关注。本研究以空间表征与非表征为视角,深入探讨家空间视野下高校知识分子的书房空间。研究发现,高校知识分子的书房空间以“文化与情怀”为符号表征,并呈现出“暂时性书房”—“准书房”—“独立书房”的阶段性、扩张性空间建构过程,部分出现了“超书房”空间建构;在高校知识分子的空间实践与情感氛围下,书房成为其身份建构下的物质文化空间、记忆怀旧空间以及情感象征空间。情感意义丰富但边界模糊的书房塑造出了一个独特的、矛盾的“家”空间,本研究将家空间研究延伸向书房微空间,并在中国视角下进一步延伸了“家”的意义与内涵。

关键词：家空间表征非表征书房空间高校知识分子

Resilience provides mediating effect of resilience between fear of progression and sleep quality in patients with hematological malignancies

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World Journal of Psychiatry 2024年第4期14卷 541-552页

作者： Yuan Tian ying-li Wang Department of Hematology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina Department of Cardiology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

BACKGROUND Hematological tumors are common malignant tumors,with high morbidity and mortality *** patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease,rapid progression,high recurrence rates,complex treatment methods,and treatment *** To explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological *** A cross-sectional analysis of 100 patients with hematological malignancies,treated in the First Affiliated Hospital of Jinzhou Medical University between August 2022 and August 2023,was *** were assessed using a general data survey,a simplified scale for the fear of progression(FoP)of disease,a resilience scale,and the Pittsburgh Sleep Quality *** analysis was conducted to determine the relationship between various patient characteristics and FoP,resilience,and sleep ***’s correlation analysis was used to examine the correlations between mental resilience,FoP,and sleep *** The total FoP score mean value in patients with hematological malignancies was 38.09±5.16;the total resilience score mean value was 40.73±7.04;and the Pittsburgh Sleep Quality Index score mean value was 10.72±***,resilience,and sleep quality of the patients were associated with family per capita monthly income and patient education level(Plience and sleep quality scores(r=-0.560,-0.537,Plience was significantly associated with sleep quality scores(r=0.688,Plience between FoP and sleep quality in patients with hematological malignancies was-0.100 and accounted for 50.51%of the total *** indicated that FoP directly and indirectly affected sleep quality through the mesomeric eff

关键词： Resilience Blood tumor Fear of progression Sleep quality Mediating effect

“数字鸿沟”对城市低龄老年人再就业的影响研究

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中国软科学 2024年第8期 189-199页

作者：李佳薛凯文赵建国东北财经大学公共管理学院辽宁大连116012

促进低龄老年人再就业,实现“银发红利”是实施积极应对人口老龄化国家战略的重要一环。随着数字经济的快速发展,“数字鸿沟”严重影响老年人平等享受数字红利的权利,阻碍了城市低龄老年人在退休后选择再就业。聚焦于“数字鸿沟”,选取2... 详细信息

促进低龄老年人再就业,实现“银发红利”是实施积极应对人口老龄化国家战略的重要一环。随着数字经济的快速发展,“数字鸿沟”严重影响老年人平等享受数字红利的权利,阻碍了城市低龄老年人在退休后选择再就业。聚焦于“数字鸿沟”,选取2018年和2020年中国家庭追踪调查数据,实证检验“数字鸿沟”和其他特征变量对城市低龄老年人再就业选择的影响,并利用机器学习算法预测未来“数字鸿沟”对其再就业行为的影响程度变化。研究发现:“数字鸿沟”会抑制城市低龄老年人再就业,且数字技术使用程度加深会增加其再就业的概率。在未来更多的城市低龄老年人会选择再就业,且“数字鸿沟”对其再就业行为的影响将加深。研究结论为填平老年人“数字鸿沟”,释放老龄人口二次红利,实践积极老龄化战略提供了新思路。

关键词：数字鸿沟老年人口退休再就业机器学习

Wild soybean(Glycine soja)transcription factor GsWRKY40 plays positive roles in plant salt tolerance

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The Crop Journal 2024年第3期12卷 766-775页

作者： Minglong li Man Xue Huiying Ma Peng Feng Tong Chen Xiaohuan Sun Qiang li Xiaodong Ding Shuzhen Zhang jialei Xiao Key Laboratory of Agricultural Biological Functional Genes Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Key Laboratory of Soybean Biology of Chinese Education Ministry Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China College of life Science Leshan Normal UniversityLeshan 614000SichuanChina Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudanjiang 157401HeilongjiangChina

Wild soybean(Glycine soja),a relative of cultivated soybean,shows high adaptability to adverse environmental *** identified and characterized a wild soybean transcription factor gene,GsWRKY40,that promotes plant salt ***40 was highly expressed in wild soybean roots and was up-regulated by salt ***40 was localized in nucleus and demonstrated DNA-binding activities but without transcriptional *** and overexpression of GsWRKY40 altered salt tolerance of Arabidopsis *** understand the molecular mechanism of GsWRKY40 in regulating plant salt resistance,we screened a cDNA library and identified a GsWRKY40 interacting protein GsbHLH92 by using yeast two-hybrid *** physical interaction of GsWRKY40 and GsbHLH92 was confirmed by co-immunoprecipitation(co-IP),GST pull-down,and bimolecular fluorescence complementation(BiFC)***,co-overexpression of GsWRKY40 and GsbHLH92 resulted in higher salt tolerance and lower ROS levels than overexpression of GsWRKY40 or GsbHLH92 in composite soybean plants,suggesting that GsWRKY40 and GsbHLH92 may synergistically regulate plant salt resistance through inhibiting ROS ***-PCR data indicated that the expression level of GmSPOD1 gene encoding peroxidase was cooperatively regulated by GsWRKY40 and GsbHLH92,which was confirmed by using a dual luciferase report system and yeast one-hybrid *** study reveals a pathway that GsWRKY40 and GsbHLH92 collaboratively up-regulate plant salt resistance through impeding GmSPOD1 expression and reducing ROS levels,providing a novel perspective on the regulatory mechanisms underlying plant tolerance to abiotic stresses.

关键词： Wild soybean Transcription factor Salt stress ROS

Evaluation of oxaliplatin and tigio combination therapy in locally advanced gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1709-1716页

作者： Teng Wang li-Yun Zhang Department of Gastroenterology Xianyang HospitalYan’an UniversityXianyang 712000Shaanxi ProvinceChina

BACKGROUND Locally advanced gastric cancer(LAGC)is a common malignant *** recent years,neoadjuvant chemotherapy has gradually become popular for the treatment of *** To investigate the efficacy of oxaliplatin combined with a tigio neoadjuvant chemotherapy regimen vs a conventional chemotherapy regimen for *** Ninety patients with LAGC were selected and randomly divided into control and study groups with 45 patients in each group,according to the numerical table *** control group was treated with conventional chemotherapy,and the study group was treated with oxaliplatin combined with tigio-neoadjuvant *** primary outcome measures were the clinical objective response rate(ORR)and surgical resection rate(SRR),whereas the secondary outcome measures were safety and Karnofsky Performance Status *** The ORR in the study group was 80.00%,which was significantly higher than that of the control group(57.78%).In the study group,SRR was 75.56%,which was significantly higher than that of the control group(57.78%).There were 15.56%adverse reactions in the study group and 35.56%in the control *** differences were statistically significant between the two *** The combination of oxaliplatin and tigio before surgery as neoadjuvant chemotherapy for patients with LAGC can effectively improve the ORR and SRR and is safe.

关键词： Locally advanced gastric cancer Oxaliplatin and tigio Neoadjuvant chemotherapy Surgical resection rate Objective response rate Clinical efficacy

Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8^(+)T cell proportion in tumor-bearing mice through the USP9X signaling pathway

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Chinese Journal of Natural Medicines 2024年第4期22卷 329-340页

作者： FENG Yutao li Yuan MA Fen WU Enjiang CHENG Zewei ZHOU Shiling WANG Zhengtao YANG li SUN Xun ZHANG Jiwei Shanghai Key Laboratory of Compound Chinese Medicines The MOE Key Laboratory for Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Gastrointestinal surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

The management of colorectal cancer(CRC)poses a significant challenge,necessitating the development of innovative and effective *** research has shown that notoginsenoside Ft1(Ng-Ft1),a small molecule,markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8^(+)T cells in tumor-bearing mice,thus restraining tumor *** into the mechanism revealed that Ng-Ft1 selectively targets the deubiquitination enzyme USP9X,undermining its role in shieldingβ-*** leads to a reduction in the expression of downstream effectors in the Wnt signaling *** findings indicate that Ng-Ft1 could be a promising small-molecule treatment for CRC,working by blocking tumor progression via the Wnt signaling pathway and augmenting CD8^(+)T cell prevalence within the tumor environment.

关键词： Notoginsenoside Ft1 Colorectal cancer CD8^(+)T cell Ubiquitin-specific peptidase 9 X-linked β-Catenin Wnt

Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model

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Journal of Genetics and Genomics 2024年第4期51卷 419-432页

作者： Qing Yang Qiang Cao Yue Yu Xianxin Lai jiahao Feng Xinjie li yinan jiang Yazhou Sun Zhong-Wei Zhou Xin li School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong 518107China

The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous *** methylation and hydroxymethylation play important roles in regulating cerebral cortex ***,it remains unclear whether abnormal cerebral cortex development,such as microcephaly,could rescale the epigenetic landscape,potentially contributing to dysregulated gene expression during brain *** this study,we characterize and compare the DNA methylome/hydroxymethylome and transcriptome profiles of the cerebral cortex across several developmental stages in wild-type(WT)mice and Mcph1 knockout(Mcph1-del)mice with severe ***,we discover a global reduction of 5′-hydroxymethylcytosine(5hmC)level,primarily in TET1-binding regions,in Mcph1-del mice compared to WT mice during juvenile and adult ***,genes exhibiting diminished 5hmC levels and concurrently decreased expression are essential for neurodevelopment and brain ***,genes displaying a delayed accumulation of 5hmC in Mcph1-del mice are significantly associated with the establishment and maintenance of the nervous system during the adult *** findings reveal that aberrant cerebral cortex development in the early stages profoundly alters the epigenetic regulation program,which provides unique insights into the molecular mechanisms underpinning diseases related to cerebral cortex development.

关键词： Microcephaly Epigeneticmodification Tet1 Cerebral cortexdevelopment DNA hydroxymethylome Transcriptome

The cytosolic isoform of triosephosphate isomerase,ZmTPI4,is required for kernel development and starch synthesis in maize(Zea mays L.)

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The Crop Journal 2024年第2期12卷 401-410页

作者： Wenyu li Han Wang Qiuyue Xu Long Zhang Yan Wang Yongbiao Yu Xiangkun Guo Zhiwei Zhang Yongbin Dong Yuling li State Key Laboratory of Wheat and Maize Crop Science Collaborative Innovation Center of Henan Grain CropsCollege of AgronomyHenan Agricultural UniversityLongzi Lake CampusZhengzhou 450046HenanChina

Triosephosphate isomerase(TPI)is an enzyme that functions in plant energy production,accumulation,and *** understand its function in maize,we characterized a maize TPI mutant,*** comparison to the wild type,zmtpi4 mutants showed altered ear development,reduced kernel weight and starch content,modified starch granule morphology,and altered amylose and amylopectin ***,ATP,and pyruvate contents were reduced,indicating ZmTPI4 was involved in *** subcellular localization confirmed ZmTPI4 as a cytosolic rather than a plastid isoform of TPI,the zmtpi4 mutant showed reduced leaf size and chlorophyll *** of ZmTPI4 in Arabidopsis led to enlarged leaves and increased seed weight,suggesting a positive regulatory role of ZmTPI4 in kernel weight and starch *** conclude that ZmTPI4 functions in maize kernel development,starch synthesis,glycolysis,and photosynthesis.

关键词： Maize Kernel Starch Weight Photosynthesis

传统村落人居环境有机更新的行动逻辑与实践路径

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自然资源学报 2024年第8期39卷 1815-1834页

作者：窦银娣刘悦滢李伯华衡阳师范学院地理与旅游学院衡阳421002 湖南省人居环境学研究基地衡阳421002 古村古镇文化遗产数字化传承湖南省协同创新中心衡阳421002 传统村落遗产保护与活态利用湖南省普通高等学校哲学社会科学重点研究基地衡阳421002

随着新型城镇化快速发展,传统村落人居环境的功能属性与结构特征面临着诸多不确定性,探索其更新演进的行动逻辑就显得尤为重要。从行动科学理论视角,分析了传统村落人居环境有机更新与行动逻辑表达式的耦合关系,构建了有机更新的行动逻... 详细信息

随着新型城镇化快速发展,传统村落人居环境的功能属性与结构特征面临着诸多不确定性,探索其更新演进的行动逻辑就显得尤为重要。从行动科学理论视角,分析了传统村落人居环境有机更新与行动逻辑表达式的耦合关系,构建了有机更新的行动逻辑框架和实践路径。研究表明:(1)行动逻辑表达式的三个要素“主体、场合、行动”与传统村落人居环境有机更新的“行动主体、行动领域、行动本身”之间存在明显的要素耦合关系。(2)以多元主体视角为研究起点,借鉴马克思主义理论,从需求、系统、时间、空间四个维度构建行动逻辑框架,梳理了传统村落人居环境有机更新的内在逻辑规律。(3)将需求协调逻辑、系统互促逻辑、时间控制逻辑、空间支撑逻辑作为基点,形成了“主体需求协调与主体治理协同、主体系统升级与主体关系重构、更新时序控制与更新节律平衡、空间更新优化与场域资本互动”的优化路径。本文以探究传统村落人居环境有机更新行动逻辑的未来演变趋向,形成具有客观性、能动性与规律性特征的行动路径,为中国传统村落人居环境有机更新的理论框架和创新路径提供了经验借鉴与决策依据。

关键词：有机更新传统村落人居环境行动逻辑实践路径