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Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

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Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： Dan Li Jinning jia Haibo Zeng Xiaoyan Zhong Hui Chen Chenju yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of Life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

In-situ polymerized PEO-based solid electrolytes contribute better Li metal batteries:Challenges,strategies,and perspectives

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Journal of Energy Chemistry 2024年第5期92卷 548-571页

作者： Zhihui jia Yong Liu Haoming Li yi Xiong yingjie Miao Zhongxiu Liu Fengzhang Ren School of Materials Science and Engineering Henan Key Laboratory of Non-Ferrous Materials Science&Processing TechnologyHenan University of Science and TechnologyLuoyang 471023HenanChina Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal new Materials and Advanced Processing Technology Henan University of Science and TechnologyLuoyang 471023HenanChina

Polyethylene oxide(PEO)-based solid polymer electrolytes(SPEs)with good electrochemical stability and excellent Li salt solubility are considered as one of the most promising SPEs for solid-state lithium metal batteries(SSLMBs).However,PEO-based SPEs suffer from low ionic conductivity at room temperature and high interfacial resistance with the electrodes due to poor interfacial contact,seriously hindering their practical *** an emerging technology,in-situ polymerization process has been widely used in PEO-based SPEs because it can effectively increase Li-ion transport at the interface and improve the interfacial contact between the electrolyte and ***,we review recent advances in design and fabrication of in-situ polymerized PEO-based SPEs to realize enhanced performance in *** merits and current challenges of various SPEs,as well as their stabilizing strategies are ***,various in-situ polymerization methods(such as free radical polymerization,cationic polymerization,anionic polymerization)for the preparation of PEO-based SPEs are *** addition,the application of in-situ polymerization technology in PEO-based SPEs for adjustment of the functional units and addition of different functional filler materials was systematically discussed to explore the design concepts,methods and working ***,the challenges and future prospects of in-situ polymerized PEO-based SPEs for SSLMBs are also proposed.

关键词： In-situ polymerization Polyethylene oxide Solid polymer electrolytes Lithium metal anodes

Remote ischemic conditioning prevents ischemic cerebrovascular events in children with moyamoya disease:a randomized controlled trial

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World Journal of Pediatrics 2024年第9期20卷 925-934页

作者： Shuang-Feng Huang jia-Li Xu Chang-Hong Ren Nathan Sim Cong Han yi-Qin Han Wen-Bo Zhao Yu-Chuan ding Xun-Ming Ji Si-Jie Li Department of Neurology Xuanwu HospitalCapital Medical UniversityNo 45Changchun StreetXicheng DistrictBeijing100053China Department of Rehabilitation Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityNo.10XitoutiaoYou’anmenwaiFengtai DistrictBeijing100053China Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Wayne State UniversityDetroitMIUSA Department of Neurosurgery The Fifth Medical CentreChinese PLA General HospitalBeijingChina Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina

Background Moyamoya disease(MMD)is a significant cause of childhood stroke and transient ischemic attacks(TIAs).This study aimed to assess the safety and efficacy of remote ischemic conditioning(RIC)in children with *** In a single-center pilot study,46 MMD patients aged 4 to 14 years,with no history of reconstructive surgery,were randomly assigned to receive either RIC or sham RIC treatment twice daily for a *** primary outcome measured was the cumulative incidence of major adverse cerebrovascular events(MACEs).Secondary outcomes included ischemic stroke,recurrent TIA,hemorrhagic stroke,revascularization rates,and clinical improvement assessed using the patient global impression of change(PGIC)scale during ***-related adverse events were also recorded,and cerebral hemodynamics were evaluated using transcranial *** All 46 patients completed the final follow-up(23 each in the RIC and sham RIC groups).No severe adverse events associated with RIC were ***-Meier analysis indicated a significant reduction in MACEs frequency after RIC treatment[log-rank test(Mantel-Cox),P=0.021].At 3-year follow-up,two(4.35%)patients had an ischemic stroke,four(8.70%)experienced TIAs,and two(4.35%)underwent revascularization as the qualifying *** clinical improvement rate in the RIC group was higher than the sham RIC group on the PGIC scale(65.2%vs.26.1%,P<0.01).No statistical difference in cerebral hemodynamics post-treatment was *** RIC is a safe and effective adjunct therapy for asymptomatic children with *** was largely due to the reduced incidence of ischemic cerebrovascular events.

关键词： Asymptomatic moyamoya disease Children Remote ischemic conditioning Stroke

Efficient photocatalytic NADH regeneration with Rh-loaded Z-scheme mediator-free system

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Chinese Chemical Letters 2024年第2期35卷 496-500页

作者： yi Zhou yiling He Ming Gao Ningkai ding Juying Lei Yanbo Zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery East China University of Science and TechnologyShanghai 200237China Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization East China University of Science and TechnologyShanghai 200237China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Nicotinamide adenine dinucleotide(NADH)regeneration is necessary for the sustainable application of enzymatic *** Rh-based complex[Cp^(*)Rh(bpy)(H)]+has been widely used as an important mediator in NADH regeneration systems,but it is limited by complexity and high ***,a Z-scheme was constructed by loading Rh onto carbon nitride nanosheets/carbon nitride quantum dots(CN-CNQD).The resultant catalyst achieved a high yield of NADH in a mediator-free(M-free)system of 0.283 mmol L^(−1) g^(−1) min^(−1),which is 5.29 times that of pure *** enzyme introduction experiments confirmed that the enzyme active product 1,4-NADH could reach 34.21%selectivity in the M-free *** research revealed that the heterojunction between CNs and CNQDs improved the NADH regeneration activity in the traditional M-involved system,while Rh loading was proved to optimize the yield and selectivity of 1,4-NADH in M-free *** immobilized Rh shows more competitiveness than[Cp^(*)Rh(bpy)(H)]^(+).This study contributes to the construction of an M-free system for further application in greener,lower-cost enzymatic processes.

关键词： Photocatalysis NADH regeneration Mediator-free Carbon nitride Z-scheme

Applicability and improvement of different potential evapotranspiration models in different climate zones of China

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Ecological Processes 2024年第1期13卷 262-282页

作者： Zedong Li yiran Li Xinxiao Yu Guodong jia Peng Chen Pengfei Zheng Yusong Wang Bingbing ding Key Laboratory of Soil & Water Conservation and Desertification Combating of Ministry of Education Beijing Forestry University College of Horticulture and Forestry Sciences Tarim University State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical Science Beijing Normal University

Background Accurate estimation of potential evapotranspiration(PET) is the key for studying land-air interaction hydrological processes. Several models are used to estimate the PET based on standardized meteorological data. Although combination-based models have the highest level performance estimation of PET, they require more meteorological data and may therefore be difficult to apply in areas lacking meteorological observation *** The results showed significant differences in the spatial trends of PET calculated by different models in China, the Doorenbots–Pruitts model revealed the highest PET(1902.6 mm), and the Kuzmin model revealed the lowest PET(349.6 mm), with the largest difference being 5.5 times. The Romanenko and the Rohwer models were the recommended temperature-based and aerodynamic-based models. On the other hand, the Abtew model was more suitable for arid and semi-arid regions, while the Priestley–Taylor model was more suitable for humid regions. Combination-based models revealed ideal calculation accuracies, among which the Penman–Monteith model was the best option for PET *** The accuracy range of Romanenko, Rohwer, Abten, Priestley Taylor, and Penman Monteith models improved in MPZ and TCZ is higher than that improved in TMZ and SMZ. This does not mean that the improved models have higher accuracy in MPZ and TCZ than in TMZ and SMZ. On the contrary, the original model performed poorly in MPZ and TCZ, so the improved accuracy was relatively large. The unimproved model was already more suitable in TMZ and SMZ, so the improved accuracy was relatively small. Therefore, regional calibration of the PET models can improve the accuracy and applicability of PET calculation, providing a reference for studying hydrological processes in different climatic zones.

关键词： Potential evapotranspiration Climatic zone Temperature-based model Aerodynamic-based model Radiation-based model Combination-based model Model calibration

Multi-stable straw-like carbon nanotubes for mechanical programmability at microscale

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International Journal of Smart and Nano Materials 2024年第1期15卷 95-109页

作者： jia Liu Yong Ma Wanjie Ren Fei Pan Shu Guo Yuli Chen Bin ding National Key Laboratory of Strength and Structural Integrity Institute of Solid MechanicsBeihang University(BUAA)BejingPR China Institute of Extreme Mechanics Northwestern Polytechnical UniversityXi'anShaanxiPR China Fuselage Department Shanghai Aircraft Design and Research InstituteShanghaiPR China School of Vehicle and Energy Yanshan UniversityQinhuangdaoPR China

Inspired by macroscale 3D pixel mechanical metamaterials and microscale straw-like carbon nanotube,we propose a design of multi-stable straw-like carbon nanotubes(MSCNT)via optimizing the structure of a unit to obtain multiple stable states under dis-placement loading by molecular *** unit of MSCNT is mirror-symmetrically connected two truncated graphene cones with specific apex *** switching the LJ term in AIREBO potential,we verify that the bistability of unit is co-determined by snap-through instability and microscale ***,we examine the validity of the multi-stability of the unit cells arranged in series and in *** results indicate that the MSCNT can achieve mechanical programmability in microscale,which triggers many potential applications in need of customizing nanos-cale mechanical behaviors.

关键词： Multi-stable state straw-shaped carbon nanotube microscale adhesions mechanical programmability

Toxicity of the disinfectant benzalkonium chloride(C_(14))towards cyanobacterium Microcystis results from its impact on the photosynthetic apparatus and cell metabolism

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Journal of Environmental Sciences 2024年第1期135卷 198-209页

作者： Yunlu jia yi Huang Jin Ma Shangwei Zhang Jin Liu Tianli Li Lirong Song Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China School of Environmental Studies China University of GeosciencesWuhan 430074China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Quaternary ammonium compounds(QACs)are commonly used in a variety of consumer and commercial products,typically as a component of *** the COVID-19 pandemic,QACs became one of the primary agents utilized to inactivate the SARS CoV-2 virus on ***,the ecotoxicological effects of QACs upon aquatic organisms have not been fully *** this study,we examined the effects of a widely used QAC(benzalkonium chloride-C_(14),BAC-14)on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary,adaptive and compensatory stress responses at apical(growth and photosynthesis)and metabolic *** analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain,with 96 hr-EC_(50)values of 0.70,0.76,and 0.38 mg/L BAC-14 for toxigenic *** FACHB-905,toxigenic *** FACHB-469,and non-toxigenic *** FACHB-908,*** photosynthetic activities of the Microcystis,assessed via F_(v)/F_(m) values,were significantly suppressed under 0.4 mg/L ***,this analysis revealed that BAC-14 altered 14,12,and 8 metabolic pathways in *** FACHB-905,*** FACHB-469,and *** FACHB-908,*** is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains,although cell growth was not significantly ***,these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin,which could result in damage to aquatic systems.

关键词： Disinfectants Quaternary ammonium compounds Microcystis Cyanotoxin Metabolomics Chlorophyll fluorescence

An electron-transfer[Fe_(2)Co_(2)]square complex exhibiting unprecedented wide room-temperature hysteresis

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Science China Chemistry 2024年第4期67卷 1198-1207页

作者： Xin-Hua Zhao yi-Fei Deng jia-Tao Chen Jiong Yang Yuan-Zhu Zhang Department of Chemistry Southern University of Science and Technology(SUSTech)Shenzhen 518055China

Switchable molecules with magnetic bistability that can function at standard conditions are highly desirable from the perspective of practical *** the last decade,significant progress has been made in modulating thermally induced electrontransfer-coupled spin transition(ETCST)events between diamagnetic{Fe_(LS)^(Ⅱ)(μ-CN)Co_(LS)^(Ⅲ)}and paramagnetic{Fe_(LS)^(Ⅲ)(μ-CN)-Co_(HS)^(Ⅱ)}electron configurations(named LS and HS,respectively,for short)within the Fe/Co mixed-valence cyanometallate ***,we prepared a novel[Fe_(2)Co_(2)]square complex[(pzTp)Fe(CN)_(3)Co(bnbpen)]_(2)[NO_(3)]_(2)·4CH_(3)OH·2.5H_(2)O(1·Solv)and its desolvated phase[(pzTp)Fe(CN)_(3)Co(bnbpen)]_(2)[NO_(3)]_(2)(1),obtained via single-crystal-to-single-crystal(SCSC)*** 1·Solv remaining in the diamagnetic state below room temperature exhibits an irreversible ETCST behavior accompanied by desolvation upon ***,complex 1 displays an unprecedented rate-dependent ETCST behaviour involving with two diamagnetic LS states(a dynamically favoured LS1 state and a thermodynamically favoured LS2state),between which a net one-way transition from LS1 to LS2 is accessible likely via a structural phase transition(SPT)above255 ***,two well separated transition channels(HS?LS1 at around 255 K and HS←→LS2 in the temperature range of 317-350 K)are achieved according to either fast(>20 K/min)or slow rate(ding a new strategy for manipulating bistability within this fascinating cyanometallate family.

关键词： switchable molecules cyanometallate complexes electron transfer hysteresis structural phase transition

SAPO-34 facilitates the formation of benzene,toluene and xylenes in direct syngas conversion over MnCrO_(x)-SAPO-34-ZSM-5

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Science China Chemistry 2024年第2期67卷 732-740页

作者： Shuchi Zhang Dengyun Miao yi ding Mengyuan Li Shujing Guo Yujuan Zhang Xiulian Pan Xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China University of Chinese Academy of Sciences Beijing100049China Shaanxi Yanchang Petroleum(Group)Co. Ltd.&Dalian Institute of Chemical Physics Xi’an Clean Energy(Chemical Industry)Research InstituteXi’an710000China

Direct conversion of syngas to aromatics over metal oxide and zeolite(OXZEO) composite catalysts is ***,the selectivity of more valuable products such as benzene,toluene and xylenes(BTX) is limited due to undesired secondary methylation of ***,we report that the introduction of SAPO-34 into MnCrO_(x)-ZSM-5 catalyst enhances significantly the formation of BTX without sacrificing the aromatics *** optimized conditions,the fraction of BTX in aromatics reaches 64.7% versus 28.9% over the catalyst without SAPO-34.A number of model reaction tests and characterizations reveal that SAPO-34 consumes partially the intermediates such as ketene,by converting them to light ***,the methylation of BTX by ketene to heavy aromatics is inhibited over the external acid sites of ZSM-5,leading to an enhanced BTX selectivity in the *** hybrid catalyst provides an efficient method for highly selective synthesis of BTX from syngas.

关键词： selective syngas conversion OXZEO aromatics BTX multi-functional catalysts