检索结果-南通市图书馆

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

Military Medical Research 2024年第3期11卷 400-429页

作者： jia-yi ding Min-jiang Chen Ling-Feng Wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang jian-Song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulating photothermal properties of near-infrared croconaine dyes by supramolecular assembly

引用

Nano Research 2024年第9期17卷 8560-8570页

作者： Yangge Ren Yue Lu Juanjuan Gao yi ding Bo Zhu Xinyu Hou Lin jia Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Department of Electronic Information Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The photochemical and photophysical properties of near-infrared(NIR)dyes are significantly influenced by their aggregation state and mesoscopic ***,beyond chemical synthesis,the regulation mechanisms for the properties of NIR dyes,particularly with respect to photothermal properties of the aggregates,are not yet fully ***,we investigate the photothermal behaviors of croconaine-based(CroA)NIR dyes containing dipeptide or amino acids *** introduction of hydrogen bonding promotesπ-πstacking of croconaine center,which can efficiently regulate aggregation states and assembly structures in *** laser irradiation,CroA aggregates undergo aggregation-dissociation transition,the in-situ monomer generation process regulates two parameters of photothermal performance:heating rates and plateau photothermal *** study reveals the regulation effect of non-covalent bonding interactions on CroA aggregates,highlighting supramolecular assembly strategy not only facilitates to construct of photothermal nanomaterials with well-defined structures,but also provides an alternative and effective method for regulating photothermal performance of NIR dyes.

关键词： croconaine dye hydrogen bonding photothermal performance supramolecular assembly chirality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apoptosis induction with polo-like kinase-1 antisense phosph-orothioate oligodeoxynucleotide of colon cancer cell line SW480

引用

World Journal of Gastroenterology 2005年第29期11卷 4596-4599页

作者： Yu Fan Shu Zheng Ze-Feng Xu jia-yi ding Cancer Institute 2^nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To investigate the effects of polo-like kinase-1 （PLK1） antisense phosphorothioate oligodeoxynucleotide （ASODN） on apoptosis and cell cycle of human colon cancer cell line SW480. METHODS： After SW480 colon cancer cells were transfected with PLK1 ASODN, Northern and Western blot analyses were used to examine PLK1 gene expression in cancer cells. We studied apoptosis using terminal uridine deoxynucleotidyl nick end labeling. Apoptosis and cell cycle of SW480 cells were examined by fluorescence-activated cell sorter scan. RESULTS： The levels of PLK1 mRNA and protein were greatly inhibited by PLK1 ASODN in SW480 cancer cells transfected with PLK1 ASODN. Apoptosis index （AI） induced PLK1 ASODN in a time- and dose-dependent manner. Results from FLM showed that sub-2N DNA content of transfected cancer cells was significantly increased and arrested at G2/M compared with control groups. CONCLUSION： PLK1 ASODN can induce apoptosis of human colon cancer cell line SW480.

关键词： Polo-like kinase-1 Antisense Apoptosis Cell cycle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aagab is required for zebrafish larval development by regulating neural activity

引用

Journal of Genetics and Genomics 2024年第6期51卷 630-641页

作者： Shihui ding Tursunjan Aziz Anming Meng Shunji jia State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Guangzhou Laboratory GuangzhouGuangdong 510320China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Clathrin-mediated endocytosis has been implicated in various physiological processes,including nutrient uptake,signal transduction,synaptic vesicle recycling,maintenance of cell polarity,and antigen *** prior knowledge of its importance as a key regulator in promoting clathrin-mediated endocytosis,the physiological function of α-and γ-adaptin binding protein(aagab)remains *** this study,we investigate the biological function of aagab during zebrafish *** establish a loss-of-function mutant of aagab in zebrafish,revealing impaired swimming and early larval *** the high expression level of aagab in the brain,we probe into its physiological role in the nervous *** mutants display subdued calcium responses and local field potential in the optic tectal neurons,aligning with reduced neurotransmitter release(e.g.,norepinephrine)in the tectal neuropil of aagab *** aagab mRNA or nervous stimulant treatment in mutants restores neurotransmitter release,calcium responses,swimming ability,and ***,our observations show delayed release of FM 1-43 in AAGAB knockdown differentiated neuroblastoma cells,pointing towards a probable link to defective clathrin-mediated synaptic vesicle *** conclusion,our study underscores the significance of Aagab in neurobiology and suggests its potential impacts on neurological disorders.

关键词： Aagab Endocytosis Neural activity Synaptic transmitter release Zebrafish

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interplay between Microscopic Structures and Macroscopic Viscoelastic Properties of Polyampholyte Gels

引用

Chinese Journal of Polymer Science 2024年第9期42卷 1360-1367,I0008页

作者： You-Cai Xue yi-Ming Yang Di jia Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Polyampholyte gels,which have hierarchical structures,exhibit excellent self-healing properties and have great promise for biomaterials and *** investigated the relationship between microscopic structures and macroscopic viscoelastic properties of polyampholyte gels and found three factors influencing their viscoelastic properties,including the chemical crosslinking bonds,topological entanglements controlled by monomer concentration,and the ionic *** strength plays a major role on the strength of ionic bonds.A crossover point of elastic modulus and loss modulus was observed in the dynamic frequency sweeps at low monomer concentration or low chemical crosslinking density for gels with intermediate strength of ionic *** solid-liquid transition signaled by the crossover point is a typical feature of dynamic associated gels,representing the dynamical association-dissociation of the ionic bonds and full relaxation of the topological entanglements in the gel *** the crossover point disappears when the ionic bonds are too weak or too strong to form“permanent”***,in the non-linear yielding measurement,gels with intermediate strength of the ionic bonds are ductile and yield at very large shear strain due to the self-healing properties and the dynamic association-dissociation of the ionic *** the self-healing properties disappear when the ionic bond strength is too weak or too *** work reveals the mechanism of how the dynamic association-dissociation of ionic bonds influences both the linear and non-linear viscoelastic properties of the polyampholyte gels.

关键词： Polyampholyte gel Ionic bond Topological entanglement Self-healing Hierarchical structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

引用

Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG Zhibin LI Zilong jia Lisi ding Bin CHEN ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine Learning Security Defense Algorithms Based on Metadata Correlation Features

引用

Computers, Materials & Continua 2024年第2期78卷 2391-2418页

作者： Ruchun jia jianwei Zhang yi Lin College of Computer Science Sichuan UniversityChengdu610065China

With the popularization of the Internet and the development of technology,cyber threats are increasing day by *** such as malware,hacking,and data breaches have had a serious impact on *** network security environment in the era of big data presents the characteristics of large amounts of data,high diversity,and high real-time *** security defense methods and tools have been unable to cope with the complex and changing network security *** paper proposes a machine-learning security defense algorithm based on metadata association *** control over unauthorized users through privacy,integrity,and *** user model is established and the mapping between the user model and the metadata of the data source is *** analyzing the user model and its corresponding mapping relationship,the query of the user model can be decomposed into the query of various heterogeneous data sources,and the integration of heterogeneous data sources based on the metadata association characteristics can be *** and classify customer information,automatically identify and perceive sensitive data,build a behavior audit and analysis platform,analyze user behavior trajectories,and complete the construction of a machine learning customer information security defense *** experimental results show that when the data volume is 5×103 bit,the data storage integrity of the proposed method is 92%.The data accuracy is 98%,and the success rate of data intrusion is only 2.6%.It can be concluded that the data storage method in this paper is safe,the data accuracy is always at a high level,and the data disaster recovery performance is *** method can effectively resist data intrusion and has high air traffic control *** can not only detect all viruses in user data storage,but also realize integrated virus processing,and further optimize the security defense effect of user big data.

关键词： Data-oriented architecture metadata correlation features machine learning security defense data source integration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chiral quantum heating and cooling with an optically controlled ion

引用

Light(Science & Applications) 2024年第7期13卷 1393-1400页

作者： Jin-Tao Bu jian-Qi Zhang Ge-yi ding jia-Chong Li jia-Wei Zhang Bin Wang Wen-Qiang ding Wen-Fei Yuan Liang Chen Qi Zhong Ali Keçebaş Şahin KÖzdemir Fei Zhou Hui Jing Mang Feng State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy of Precision Measurement Science and TechnologyChinese Academy of Sciences430071 WuhanChina. University of the Chinese Academy of Sciences 100049 BeijingChina. Research Center for Quantum Precision Measurement Guangzhou Institute of Industry Technology511458 GuangzhouChina. Department of Engineering Science and Mechanics and Materials Research InstitutePennsylvania State UniversityUniversity ParkState CollegePA 16802USA. Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal University410081 ChangshaChina. Department of Physics Zhejiang Normal University321004 JinhuaChina

Quantum heat engines and refrigerators are open quantum systems,whose dynamics can be well understood using a non-Hermitian formalism.A prominent feature of non-Hermiticity is the existence of exceptional points(EPs),which has no counterpart in closed quantum *** has been shown in classical systems that dynamical encirclement in the vicinity of an EP,whether the loop includes the EP or not,could lead to chiral mode ***,we show that this is valid also for quantum systems when dynamical encircling is performed in the vicinity of their Liouvillian EPs(LEPs),which include the effects of quantum jumps and associated noise—an important quantum feature not present in previous *** demonstrate,using a Paul-trapped ultracold ion,the first chiral quantum heating and refrigeration by dynamically encircling a closed loop in the vicinity of an *** witness the cycling direction to be associated with the chirality and heat release(absorption)of the quantum heat engine(quantum refrigerator).Our experiments have revealed that not only the adiabaticity breakdown but also the Landau–Zener–Stückelberg process play an essential role during dynamic encircling,resulting in chiral thermodynamic *** observations contribute to further understanding of chiral and topological features in non-Hermitian systems and pave a way to exploring the relation between chirality and quantum thermodynamics.

关键词： quantum chiral dynamical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction of RuO2-Ru/MoO2@carbon cloth bifunctional electrocatalyst for efficient overall water splitting

引用

Rare Metals 2024年第10期43卷 5095-5104页

作者： jia-Lin Cai Jing-yi Fan Xu-Dong Zhang Xin Xie Wan-Yu Tian Xin-Gang Zhang Jie ding Yu-Shan Liu College of Material Henan Key Laboratory of Aeronautical Materials and Application TechnologyZhengzhou University of Aeronautics The Green Catalysis Center and College of ChemistryZhengzhou University

Efficient bifunction electrocatalyst is extremely interesting for electrochemical overall water splitting （OWS）.Herein,a new RuO2-Ru/MoO2@CC（RRM/CC） bifunctional electrocatalyst was prepared via a solid phase reaction *** obtain a suitable precursor for SPR,MoS2nanosheets and RuO2nanoparticles （NPs）were sequentially loaded onto carbon cloth conductive ***,the prepared RuO2/MoS2/CC precursor was sealed in a furnace and annealed in Ar to trigger the redox *** SPR,active RuO2-Ru/MoO2units containing metal–metal oxide interfaces were formed on CC substrate *** optimized RRM/CC sample annealed at 400℃ exhibited a overpotential of 13 m V for hydrogen evolution reaction （HER） and 231 mV for oxygen evolution reaction （OER） at 10 mA·cm-2under alkaline condition,respectively,which can be deduced to the modulated electronic structure and unique hierarchica *** addition,a low cell voltage of 1.48 V for OWS was required at 10 mA·cm-2under alkaline condition Meanwhile,RRM/CC exhibited excellent pH-independent durability.

关键词： Bifunctional Electrocatalyst Overall water splitting Ru RuO2

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Paleogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

引用

Science China Earth Sciences 2024年第4期67卷 1290-1325页

作者： jia LIU Ai SONG Lin ding Tao SU Zhekun ZHOU CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Paleontology Yunnan UniversityKunming 650500China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

The Paleogene is a crucial period when terrestrial and marine ecosystems recovered from major disruptions and gradually approached their modern *** the Qinghai-Tibetan Plateau and its surrounding regions,the Paleogene also represents a significant phase of tectonic evolution in the Qinghai-Tibetan Plateau-Himalaya orogeny,reorganization of Asian climates,and evolution of *** to limitations in research conditions and understanding,there are still many controversies regarding stratigraphic divisions in the Qinghai-Tibetan Plateau and its surrounding *** recent years,extensive studies on sedimentary petrology,magnetostratigraphy,and isotope dating have been conducted in the *** fossils have been discovered and reported,contributing to a more systematic understanding of *** studies have laid a solid foundation for the comprehensive investigation of the stratigraphy,biotas and paleogeographic evolution of the Qinghai-Tibetan Plateau and its surrounding regions during the *** this paper,we integrate recent research on fossils,isotopic dating,magnetostratigraphy,and geochemistry to refine the stratigraphic divisions and correlation framework of different tectonic units in the region,building upon previous *** the Second Tibetan Plateau Scientific Expedition and Research,the knowledge of Paleogene floras has gradually *** paper discusses the biostratigraphic significance of extinct and newly appeared taxa based on the latest dating results of these plant *** new understanding of fossil species such as the“Eucalyptus”and Arecaceae establishes connections between the Paleogene flora of the Qinghai-Tibetan region and the biotas of Gondwana,specifically Oceania and South *** evolutionary history of key taxa near the Yarlung Zangbo suture zone indicates that the collision between the Indian and Eurasian plates occurred approximately 65-54 *** reconstructions,based o

关键词： Qinghai-Tibetan Plateau Fossils Biostratigraphy Paleoenvironment Paleogeography Paleogene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：