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Chemical Research in Chinese Universities 2010年第5期26卷 683-686页

作者： ZHANG Yong-feng jia yan-yan nie Hai-liang yan Xing-juan WANG Li HUANG Ru-dan Department of Chemistry Beijing Institute of Technology Beijing 100081 P. R. China

Three new Keggin polyoxometalates, [Zn（phen）3]2[SiW12O40]＇5H2O（1）, [Co（phen）3]2[SiW12O40]（2） and [Ni（phen）3]2[SiW12O40].2H2O（3）（phen=1,10＇-phenanthroline） have been hydrothermally synthesized and characterized by elemental analysis, IR, crystal X-ray diffraction, thermogravimetric analyses（TGA） and fluorescence tech- niques. Complex 1, crystallized in the triclinic space group Pi, consists of one [SiW12O40]4 anion, two discrete [Zn（phen）3]^2＋ cations and five crystal water molecules. Complexes 2 and 3 have the similar configuration to complex 1, but they crystallized in the monoclinic space group C2/c. Variable-temperature magnetic susceptibilities of complexess 2 and 3 reveal antiferromagnetism and ferromagnetism, respectively.

关键词： Polyoxometalate Phen Organic-inorganic compound Hydrothermal synthesis

WGCNA Reveals Key Roles of IL8 and MMP-9 in Progression of Involvement Area in Colon of Patients with Ulcerative Colitis

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Current Medical Science 2018年第2期38卷 252-258页

作者： Xue LIN Jin LI Qiu ZHAO Jue-rong FENG Qian GAO jia-yan nie Department of Gastroenterology Zhongnan Hospital of Wuhan University Hubei Clinical Center & Key Lab of Intestinal& Colorectal Diseases Wuhan 430071 China

Ulcerative colitis （UC） is a chronic inflammatory disease and its involvement area in colon is influenced by a complex network of gene interactions. We analyzed the weighted gene co-expression networks in mieroarray dataset from colonic mucosa of patients with UC and identified one gene co-expression module that was highly associated with the progression of involved area in UC colon （Pearson coefficient=0.81, P〈0.0001）. In total, 523 hub genes in this module were found to be involved in immune system process after enrichment analysis in Gene Ontology. By the STRING and Cytoscape analysis, we observed that interleukin-8 （IL- 8） and matrix metalloproteinase-9 （MMP-9） were centered in the network of hub genes. We then detected the expression of IL-8 and MMP-9 in mucosa from left-sided colon of patients using quantitative PCR and immunofluorescence assay respectively. Both quantitative PCR and immunofluorescence assay revealed the expression levels of IL-8 and MMP-9 were significantly different among the healthy controls, left-sided colitis group and pancolitis group （P〈0.05）. IL-8 and MMP-9 were detected with an enhanced expression in pancolitis as compared with leftsided colitis and healthy controls, respectively （P〈0.05）. This study demonstrates that immune system process is indispensable in the progression of disease in colon, and identifies that IL-8 and MMP-9 play potential critical roles for the progression.

关键词： ulcerative colitis weighted gene co-expression network analysis interleukin-8 matrix metalloproteinase-9

Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats

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Military Medical Research 2023年第1期10卷 1-16页

作者： Lu-Yao Li Jie Han Lan Wu Cheng Fang Wei-Guang Li jia-Min Gu Tong Deng Chang-jiang Qin jia-yan nie Xian-Tao Zeng Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Gastrointestinal Surgery Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Stomatology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Urology Zhong‑nan Hospital of Wuhan UniversityWuhan 430071China

Background: Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia(BPH) has not been well understood. Hence, this study aimed to investigate the regulation of BPH on gut microbiota composition and ***: We analyzed gut samples from rats with BPH and healthy control rats, the gut microbiota composition and metabonomics were detected by 16S rDNA sequencing and liquid chromatography tandem mass spectrometry(LC–MS/MS).Results: High-throughput sequencing results showed that gut microbiota beta-diversity increased(P0.05), Bacteroidetes(46.54% vs. 41.64%,P>0.05), Clostridia(50.89% vs. 54.66%, P>0.05), Ruminococcaceae(25.67% vs. 20.56%, P>0.05). LC–MS/MS of intestinal contents revealed that differential metabolites were mainly involved in cellular processes, environmental information processing, metabolism and organismal systems. The most important pathways were global and overview maps, lipid metabolism, amino acid metabolism, digestive system and endocrine system. Through enrichment analysis, we found that the differential metabolites were significantly enriched in metabolic pathways, steroid hormone biosynthesis,ovarian steroidogenesis, biosynthesis of unsaturated fatty acids and bile secretion. Pearson correlation analysis(R=0.94) showed that there was a strong correlation between Prevotellaceae, Corynebacteriaceae, Turicibacteraceae,Bifid

关键词： Benign prostatic hyperplasia Gut microbiota Intestinal metabolites Microbial diversity

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Preparation and characterization of a new magnetic fluid with good low temperature resistance

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Nano Research 2025年第1期18卷 477-486页

作者： Shilin nie Decai Li ✉1 Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Tribology in advanced equipment Tsinghua UniversityBeijing 100084China

Magnetic fluids are a type of novel functionalmaterial that has emerged over the past two decades, whichhave found applications in various aspects of production anddaily life. However, the application of conventional magneticfluids in low-temperature environments is severely limited andoften unsatisfactory. To address this issue, we havedeveloped a new magnetic fluid with excellent low-temperatureresistance. Initially, bare Fe_(3)O_(4) magnetic nanoparticles(FMNPs) were synthesized via co-precipitation without aprotective gas. Subsequently, these particles were modified using polyethylene glycol (PEG)-4000 as a surfactant. Thebare and modified FMNPs (MFMNPs) were characterized using X-ray diffraction (XRD), vibrating sample magnetometer(VSM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetricanalysis-differential thermal gravimetric (TGA-DTG) analysis. The rheological properties, low-temperature resistance of themagnetic fluid were also evaluated. The characterization results indicate that the MFMNPs are spherical andmonodisperse, with a narrow size distribution and a mean particle size of approximately 12 nm. Furthermore, the FTIRspectra and TGA-DTA results suggest that PEG-4000 is linked to the bare Fe_(3)O_(4) particles via hydrogen bonding, indicatingsuccessful modification of the Fe_(3)O_(4) magnetic nanoparticles using PEG. VSM measurements demonstrate that surfacemodification does not alter the crystal morphology or superparamagnetic of Fe_(3)O_(4). However, it does reduce the saturationmagnetization from 68.17 to 54.75 emu/g. Additionally, the prepared magnetic fluid exhibits shear thinning and magneticviscosity effects. It also exhibits excellent low-temperature resistance, maintaining good fluidity without freezing even at -60 ℃. In summary, these results collectively indicate that the new low-temperature resistant magnetic fluid developed in thisstudy is stable and has broad application prospects.

关键词： magnetic fluid low-temperature resistance polyethylene glycol ethylene glycol aqueous solution superparamagnetic

舒林酸对人结肠癌细胞凋亡及相关基因表达谱的作用

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世界华人消化杂志 2008年第25期16卷 2826-2830页

作者：聂家艳黄杰安唐国都刘诗权广西医科大学第一附属医院消化内科广西壮族自治区南宁市530021

目的:观察舒林酸对人结肠癌Lovo细胞株凋亡的影响,以及舒林酸作用后的该细胞基因表达谱改变.方法:应用透射电镜,流式细胞仪观察舒林酸作用48h、72h对Lovo细胞凋亡的影响;基因芯片法检测舒林酸作用前后Lovo细胞的差异表达基因.结果:经舒... 详细信息

目的:观察舒林酸对人结肠癌Lovo细胞株凋亡的影响,以及舒林酸作用后的该细胞基因表达谱改变.方法:应用透射电镜,流式细胞仪观察舒林酸作用48h、72h对Lovo细胞凋亡的影响;基因芯片法检测舒林酸作用前后Lovo细胞的差异表达基因.结果:经舒林酸处理后细胞有典型的凋亡小体形成;经舒林酸0.6、0.9、1.2mmol/L作用后,细胞凋亡率与对照组比较明显升高(48h:4.2±1.04,4.26±0.28,7.51±2.09vs1.81±0.91;72h:6.21±0.56,7.48±1.45,10.40±1.30vs2.06±1.43;均P<0.05).与含有17101个cDNA的基因芯片杂交,筛选出差异表达基因1013条,其中178条为凋亡相关基因(表达上调82条,下调96条),占所有差异表达基因的17.87%.结论:舒林酸具有诱导Lovo细胞发生凋亡的作用,上调或下调某些凋亡相关基因的表达可能是其诱导凋亡的分子机制之一.

关键词：结肠癌舒林酸基因芯片流式细胞术

HBeAg阴性与阳性原发性肝癌临床和病毒相关因素分析

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世界华人消化杂志 2008年第32期16卷 3696-3699页

作者：邹传鑫聂家艳戴绍军陈海燕谢明周东斌湖北省荆州中心医院消化内科湖北省荆州市434100 湖北省荆州市第二人民医院消化内科湖北省荆州市434100

目的:研究HBeAg阴性与HBeAg阳性的原发性肝癌患者临床特点和病毒相关因素的差异,并探讨研究其临床意义.方法:对1356例原发性肝癌患者的门诊及住院病历进行回顾性调查,以HBeAg阴性的原发性肝癌患者为对照组,HBeAg阳性的原发性肝癌患者为... 详细信息

目的:研究HBeAg阴性与HBeAg阳性的原发性肝癌患者临床特点和病毒相关因素的差异,并探讨研究其临床意义.方法:对1356例原发性肝癌患者的门诊及住院病历进行回顾性调查,以HBeAg阴性的原发性肝癌患者为对照组,HBeAg阳性的原发性肝癌患者为试验组.分析两组上消化道出血率、AFP水平、乙型肝炎病毒DNA定量和肝组织病理学指标的差异.结果:HBeAg阴性原发性肝癌996例,占73.4%;HBeAg阳性原发性肝癌360例,占26.6%.HBeAg阴性组合并上消化道出血的比例为22.2%,显著高于HBeAg阳性组的11.9%(χ2=17.70,P<0.01).HBeAg阳性组乙型肝炎病毒DNA定量在各级对数值上均显著高于HBeAg阴性组(χ2=298,P<0.005).HBeAg阴性组肝纤维化分期≥3的比例为46.9%,高于HBeAg阳性组的33.1%(χ2=7.27,P=0.007).AFP水平在两组间无明显差异.结论:HBeAg阴性原发性肝癌肝组织学损害程度重于HBeAg阳性原发性肝癌,更易合并肝性门静脉高压症所致的上消化道出血,预后较差.HBeAg阴性患者更要警惕原发性肝癌的发生.

关键词：原发性肝癌肝炎e抗原上消化道出血 DNA 组织学 AFP

Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

Biomass materials for zinc-based sustainable and green energy storage devices:Strategy and mechanism

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Nano Research 2025年第1期18卷 294-314页

作者： Xiaotong yang Xiaoxin nie Chenke Tang Yiyang Xiao Qiongguang Li Du Yuan Meng Yao College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004China College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Anhui Province International Research Center on Advanced Building Materials School of Materials and Chemical EngineeringAnhui Jianzhu UniversityHefei 230601China

As next-generation rechargeable alternatives,zincbased energy storage devices(ZESs)are being intensely explored due to their merits of abundant resource,low cost,safety and environmental ***,ZESs face a succession of critical challenges on pursuing advancing performance,including the stability and kinetics of cathode,stability and transport of zinc electrolyte,reversibility and deep utilization of metallic Zn ***,possessing unique molecular structures with abundant functionals groups,motivates the interdisciplinary field emerging from biomass and aqueous rechargeable *** its high compatibility with ZES design,we here summarize the application of biomass materials in ZESs from the aspects of cathode,electrolyte,membrane/separator and Zn anode,with their corresponding operational mechanisms and attractive functionalities from polymeric ***,the outlooks and perspectives are provided,regarding current challenges and future *** anticipate our minireview paves way on exploring the roles of biomass in aqueous rechargeable batteries.

关键词： zinc biomass materials skeleton/host coating solid-electrolyte interphase(SEI)

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu jianye Xie Runxue Zhou Jin Deng Weihong nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel