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Sorafenib plus transarterial chemoembolization vs sorafenib alone for patients with advanced hepatocellular carcinoma: A systematic review and meta-analysis

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World Journal of Hepatology 2024年第1期16卷 91-102页

作者： Hong-Jie Yang Bin Ye jia-xu liao Lei Lei Kai Chen Department of Radiology The Sixth People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Department of Oncology The Sixth People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Department of Pharmacy The Affiliated Taizhou People's Hospital of Nanjing Medical UniversityTaizhou 225300Jiangsu ProvinceChina

BACKGROUND Although the past decade has seen remarkable advances in treatment options for hepatocellular carcinoma(HCC),the dismal overall prognosis still envelops HCC *** comparative trials have been conducted to study whether transarterial chemoembolization(TACE)could improve clinical outcomes in patients receiving sorafenib for advanced HCC;however,the findings have been *** To study the potential synergies and safety of sorafenib plus TACE vs sorafenib alone for treating advanced HCC,by performing a systematic review and *** This study was conducted following the PRISMA statement.A systematic literature search was conducted using the Cochrane Library,Embase,PubMed,and Web of Science *** included in the present work were collected from patients diagnosed with advanced HCC receiving sorafenib plus TACE or sorafenib *** synthesis and meta-analysis were conducted using Review Manager *** The present study included 2780 patients from five comparative clinical trials(1 was randomized control trial and 4 were retrospective studies).It was found that patients receiving sorafenib plus TACE had better prognoses in terms of overall survival(OS),with a combined hazard ratio(HR)of 0.65[95%confidence interval(95%CI):0.46–0.93,P=0.02,n=2780].Consistently,progression free survival(PFS)and time to progression(TTP)differed significantly between the sorafenib plus TACE arm and sorafenib arm(PFS:HR=0.62,95%CI:0.40–0.96,P=0.03,n=443;TTP:HR=0.73,95%CI:0.64-0.83,P<0.00001,n=2451).Disease control rate(DCR)was also significantly increased by combination therapy(risk ratio=1.36,95%CI:1.02-1.81,P=0.04,n=641).Regarding safety,the incidence of any adverse event(AE)was increased due to the addition of TACE;however,no significant difference was found in grade≥3 *** The combination of sorafenib with TACE has superior efficacy to sorafenib monotherapy,as evidenced by prolonged OS,PFS,and TTP,as well as increase

关键词： Hepatocellular carcinoma Sorafenib Transarterial chemoembolization Systematic review Meta-analysis

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Bayesian inference of neutron-skin thickness and neutron-star observables based on effective nuclear interactions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 97-105页

作者： jia Zhou Jun xu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

We have obtained the constraints on the density dependence of the symmetry energy from neutron-skin thickness data by parityviolating electron scatterings and neutron-star observables using a Bayesian approach,based on the standard Skyrme-HartreeFock(SHF)model and its extension as well as the relativistic mean-field(RMF)*** the neutron-skin thickness data(neutron-star observables)mostly constrain the symmetry energy at subsaturation(suprasaturation)densities,they may more or less constrain the behavior of the symmetry energy at suprasaturation(subsaturation)densities,depending on the energy-density functional *** showing the final posterior density dependence of the symmetry energy,we also compare the slope parameters of the symmetry energy at 0.10 fm-3as well as the values of the symmetry energy at twice saturation density from three effective nuclear *** present work serves as a comparison study based on relativistic and non-relativistic energy-density functionals,for constraining the nuclear symmetry energy from low to high densities using a Bayesian approach.

关键词： symmetry energy neutron skin neutron star

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Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III

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Chinese Journal of Natural Medicines 2024年第4期22卷 291-292页

作者： DU Jinfa liao Pan LU xu State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700China Medical Botanical Garden China Pharmaceutical UniversityNanjing 210009China

Paclitaxel,a tetracyclic diterpenoid,has garnered attention for its potent anti-cancer properties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its natural sources are extremely limited,as it is derived exclusively from the bark of endangered genus Taxus plants,which contain paclitaxel in very low concentrations(0.01%−0.05%)[2-3].Recent advances in synthetic biology present promising opportunities to enhance paclitaxel levels in Taxus cell cultures or to enable the reconstitution of its production in heterologous hosts,such as yeast or tobacco(Nicotiana benthamiana).

关键词： Paclitaxel biosynthesis Baccatin III Cytochrome P450 Taxane oxetanase 1 Heterologous reconstitution

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Even-odd layer-dependent multiferroic in freestanding rare-earth orthorhombic perovskite

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 151-157页

作者： Shaowen xu Fanhao jia Ning Dai School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Physics College of ScienceHangzhou Dianzi UniversityHangzhou 310018China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

Freestanding oxide perovskites possess strong interlayer coupling between adjacent atomic layers,thus exerting a determinative effect on the magnetism and ferroelectricity of these atomic-scale ***,we propose an effective strategy to manipulate magnetism and ferroelectricity in freestanding rare-earth orthorhombic perovskite via modulation of layer *** performing first-principles calculations,an even-odd oscillation is demonstrated in few-layer GdAlO_(3)perovskite(GAP).Specifically,odd-layer systems with charged atomic layers are ferromagnetic polar metals,while even-layer systems are antiferromagnetic ferroelectric *** thickness-dependent magnetic phase transition originates from carrier doping,as rationalized by the Stoner ***,we demonstrate the promotion of in-plane ferroelectricity via the concurrent application of two distinct antiferrodistortive displacements,each driven by formation and breaking of *** multiferroic phases may emerge in other transition metal oxide perovskites supporting multiple valence states,e.g.,few-layer Gd MO_(3)(M=V,Cr,Mn,and Ni).This work puts forward a strategy for layer thickness engineering of magnetism and ferroelectricity in 2D oxide perovskite multiferroic materials.

关键词： few-layer rare-earth perovskite multiferroicity size effect first principles calculations

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Contribution of high-latitude permafrost regions in the Northern Hemisphere to global wildfire carbon emissions

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Science China Earth Sciences 2024年第10期67卷 3239-3251页

作者： Xingru ZHU Xiyan xu Gensuo jia Key Laboratory of Regional Climate-Environment for East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Wildfires are major disturbances in permafrost ecosystems, with increasing frequency and intensity in recent years. In permafrost regions, wildfires not only burn surface and subsurface organic matter but also accelerate permafrost thawing,releasing significant amounts of greenhouse gases such as carbon dioxide and methane into the atmosphere. However, the contribution of high-latitude permafrost regions in the Northern Hemisphere to global wildfire carbon emissions remains poorly understood. This study integrates remote sensing data and ground observations to analyze the contributions of aboveground and belowground fuel combustion in high-latitude permafrost regions to global wildfire carbon emissions from 2002 to 2020, as well as the spatiotemporal variations in these contributions. Our findings indicate that permafrost regions contribute approximately11.96% of global wildfire carbon emissions, with aboveground emissions accounting for approximately 3.94% of global aboveground emissions and belowground emissions contributing approximately 63.57% of global belowground emissions. The contribution of high-latitude permafrost regions to global emissions peaked in July and August, whereas the continuous permafrost zones(areas with more than 90% permafrost coverage) showed the most significant increase in June and July. The contributions of both aboveground and belowground emissions from high-latitude permafrost regions to global wildfire emissions have been increasing, primarily due to the reduction in global wildfire emissions, in contrast with the rising emissions from wildfires in high-latitude permafrost regions. This study highlights the significant role of wildfires, particularly the combustion of belowground biomass in high-latitude permafrost regions, in global carbon emissions. The decomposition and combustion of organic carbon in permafrost regions due to wildfires release more greenhouse gases into the atmosphere, potentially amplifying the positive feedback

关键词： Wildfire Permafrost Carbon emissions Climate change Belowground fuel consumption

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Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp^(3) C—H Bonds with Iodine(III)

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Chinese Journal of Chemistry 2024年第5期42卷 505-510页

作者： Hao jia Nan Li Chunmei Tang Yajuan Wang Yonghao Xi Rongbao liao Wei xu Fufang Wu Xiaobao Shen Hongbin Zhai Biomass Oligosaccharides Engineering Technology Research Center of Anhui Province Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational InstitutionsFuyang Normal UniversityFuyangAnhui236037 China Institute of Marine Biomedicine Shenzhen PolytechnicShenzhenGuangdong518055 China State Key Laboratory of Chemical Oncogenomics Shenzhen Engineering Laboratory of Nano Drug Slow-ReleasePeking University Shenzhen Graduate SchoolShenzhenGuangdong518055 China

A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling *** and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.

关键词： Alkyl sp^(3)C—H bonds Chlorination Bromination Oxidation Iodine(III) C—H activation Radical Photocatalysis

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Joint Probability Analysis and Prediction of Sea Ice Conditions in liaodong Bay

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Journal of Ocean University of China 2024年第1期23卷 57-68页

作者： liao Zhenkun DONG Sheng TAO Shanshan HUA Yunfei jia Ning College of Engineering Ocean University of ChinaQingdao 266100China Shuifa Planning and Design Co. Ltd.Jinan 250100China National Hazards Mitigation Service Beijing 100194China

Sea ice conditions in liaodong Bay of China are often described by sea ice grades,which classify annual sea ice conditions based on the annual maximum sea ice thickness(AM-SIT)and annual maximum floating ice extent(AM-FIE).The joint probability distribution of AM-SIT and AM-FIE was established on the basis of their data pairs from 1949/1950 to 2019/2020 in liaodong *** joint intensity index of the sea ice condition in the current year is calculated,and the joint classification criteria of the sea ice grades in past years are established on the basis of the joint intensity index series.A comparison of the joint criteria with the 1973 and 2022 criteria revealed that the joint criteria of the sea ice grade match well,and the joint intensity index can be used to quantify the sea ice condition over the years.A time series analysis of the sea ice grades and the joint intensity index sequences based on the joint criteria are then *** show a decreasing trend of the sea ice condition from 1949/1950 to 2019/2020,a mutation in 1990/1991,and a period of approximately 91 years of the sea ice *** addition,the Gray-Markov model(GMM)is applied to predict the joint sea ice grade and the joint intensity index of the sea ice condition series in future years,and the error between the results and the actual sea ice condition in 2020/2021 is small.

关键词： sea ice grade ice thickness floating ice extent liaodong Bay copula

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Data-driven Reactive Power Optimization of Distribution Networks via Graph Attention Networks

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 874-885页

作者： Wenlong liao Dechang Yang Qi Liu Yixiong jia Chenxi Wang Zhe Yang Wind Engineering and Renewable Energy Laboratory Ecole Polytechnique Federale de Lausanne(EPFL)Lausanne 1015Switzerland the College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China the Department of Electrical and Electronic Engineering(Energy Digitalization Laboratory) The University of Hong KongHong KongChina the Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Reactive power optimization of distribution networks is traditionally addressed by physical model based methods,which often lead to locally optimal solutions and require heavy online inference time *** improve the quality of the solution and reduce the inference time burden,this paper proposes a new graph attention networks based method to directly map the complex nonlinear relationship between graphs(topology and power loads)and reactive power scheduling schemes of distribution networks,from a data-driven *** graph attention network is tailored specifically to this problem and incorporates several innovative features such as a self-loop in the adjacency matrix,a customized loss function,and the use of max-pooling ***,a rulebased strategy is proposed to adjust infeasible solutions that violate *** results on multiple distribution networks demonstrate that the proposed method outperforms other machine learning based methods in terms of the solution quality and robustness to varying load ***,its online inference time is significantly faster than traditional physical model based methods,particularly for large-scale distribution networks.

关键词： Reactive power optimization graph neural network distribution network machine learning data-driven

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Barrier Option Pricing in Regime Switching Models with Rebates

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 849-861页

作者： Yue-xu ZHAO jia-yong BAO School of Economics Hangzhou Dianzi UniversityHangzhou 310018China School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China

This paper is concerned with the valuation of single and double barrier knock-out call options in a Markovian regime switching model with specific *** integral formulas of the rebates are derived via matrix Wiener-Hopf factorizations and Fourier transform techniques,also,the integral representations of the option prices are ***,the first-passage time density functions in two-state regime model are *** applications,several numerical algorithms and numerical examples are presented.

关键词： option pricing Markovian regime switching Wiener-Hopf factorization Fourier transform

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Field Study of HPTRM Combined with Vegetation and Anchor to Protect Newly Excavated Expansive Soil Slope

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Journal of Earth Science 2024年第4期35卷 1277-1288页

作者： Yingzi xu xuhang liao Linqiang Tang Lin Li College of Civil&Architectural Engineering Guangxi UniversityNanning530004China Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Nanning530004China Guangxi Transport Vocational and Technical College Nanning530004China Department of Civil&Architectural Engineering Tennessee State UniversityTennessee37209NashvilleUSA

Anchor reinforced vegetation system(ARVS)comprises high performance turf reinforcement mats(HPTRM),vegetation and *** is a new attempt to apply the system in expansive soil slope *** goal of this paper was to evaluate the effectiveness of ARVS in protecting newly excavated expansive soil *** field tests on the bare slope,grassed slope and ARVS protective slope were carried out,including natural and artificial *** the test,the soil water content,soil deformation,and anchor axial force were monitored,and then the slope protection mechanism of ARVS was *** was found that ARVS can effectively protect expansive soil slopes compared with bare slopes and grassed *** vegetation and HPTRM form a reinforced turf,and the anchors fix it to the slope surface,thus restraining the expansion *** axial force on the anchor of ARVS includes frictional resistance and tensile force transmitted by HPTRM,which is maximum at the early stage of *** neutral point of the anchor of ARVS moves deeper under atmospheric action,but the vegetation and HPTRM on the slope surface can limit this movement.

关键词： expansive soil slope anchor reinforced vegetation system high performance turf reinforcement mats field test slope protection

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