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Acquired methemoglobinemia in a third trimester puerpera and her premature infant with sodium nitrite poisoning:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5151-5158页

作者： Dong-Sheng Fei Yang Gao xue-jiao Bao Yu-jia Tang Yi-Lu Lin jia-xi xu jia-Ning Zhang Bo-Wen Liu Kai Kang Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical UniversityHarbin 150027Heilongjiang ProvinceChina

BACKGROUND The common cause of sodium nitrite poisoning has shifted from previous accidental intoxication by exposure or ingestion of contaminated water and food to recent alarming intentional intoxication as an employed method of suicide/*** subsequent formation of methemoglobin(MetHb)restricts oxygen transport and utilization in the body,resulting in functional hypoxia at the tissue *** clinical practice,a mismatch of cyanotic appearance and oxygen partial pressure usually contributes to the identification of *** recognition of characteristic mismatch and accurate diagnosis of sodium nitrite poisoning are prerequisites for the implementation of standardized systemic *** SUMMARY A pregnant woman was admitted to the Department of Critical Care Medicine at the First Affiliated Hospital of Harbin Medical University due to consciousness disorders and drowsiness 2 h before ***,she developed vomiting and cyanotic *** woman underwent orotracheal intubation,invasive mechanical ventilation(IMV),and correction of internal environment disturbance in the *** premature infant was born with a higher-than-normal MetHb level of 3.3%,and received detoxification with methylene blue and vitamin C,supplemental vitamin K1,an infusion of fresh frozen plasma,as well as respiratory support via orotracheal intubation and *** day 3 after admission,the puerpera regained consciousness,evacuated the IMV,and resumed enteral *** was then transferred to the maternity ward 24 h *** day 7 after admission,the woman recovered and was discharged without any *** MetHb can cross through the placental *** of MetHb both reflects severity of the sodium nitrite poisoning and serves as feedback on therapeutic effectiveness.

关键词： Sodium nitrite poisoning Methemoglobinemia Methemoglobin Third trimester puerpera Premature infant Placental barrier Methylene blue Case report

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Mass Spectrometric Fragmentation of 1-(Benzyloxycarbonyl)amino-2-alkyl/cycloalkyl Thioacetates:a Thioester Pyrolysis-type Rearrangement under Electron Impact Ionization

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Chinese Chemical Letters 2006年第8期17卷 1069-1072页

作者： Shu xu jia xi xu Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Beijing 100871

The mass spectrometric fragmentation of 1-（benzyloxycarbonyl）amino-2-alkyl/cycloalkyl thioacetates has been studied with the aid of mass-analysed ion kinetic energy spectrometry under electron impact ionization. All compounds show a tendency to eliminate a ketene, thioacetic acid, and benzyl carbamate molecule, or an acetyl and benzyloxy radicals. A thioester pyrolysis-type rearrangement under electron impact ionizations was observed.

关键词： Electron impact ionization mass spectrometry rearrangement thioacetate.

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Synthesis,Structure and Antitumor Activities of Tridccapeptide PSPP3 from Papaver Somniferum Pollen

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Chinese Chemical Letters 1999年第2期10卷 115-116页

作者： jia xi xu Sheng JIN(College of Chemistry and Molecular Engineering, Peking University, Beijing 100871) Coll. of Chem. and Molec. Eng. Peking University Beijing 100871 China

Five analogs and five segments of the Papavor Somniferum pollen tridecapeptidePSPP3 were designed and synthesized by using solid-phase peptide synthesis method. Theirinhibitive activities to human liver tumor cell Bel-7402 were assayed by MTT method and theirsecondary structures in solution were determined by CD spectra. The relationship of the structureand activity was discussed.

关键词： Pollen peptide anti-tumor activity structure and activity

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NEW HETEROCYCLIC SYSTEM SYNTHESIS IV.4a, 5,6, 12-TETRAHYDRO-1H-1,3-OXAZ1NO [3,2-d][1,5]-BENZOTHIAZEPINE-1-ONE

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Chinese Chemical Letters 1992年第3期3卷 181-182页

作者： jia xi xu Sheng JIN Department of Chemistry Peking UniversityBeijing 100871

Addition of a-carbonylketenes, generated from 2-diazo-1, 3-diaryl-1, 3-propandione or 2-diazo-1-phenyl-1,3-butandione by heating, to 2,4-diaryl-2,3-dihydro-[1,5]-benzothiazepines gave 2,3-disubstituted-4a, 6-diaryl-4a... 详细信息

关键词： Ph HZ CI PI TETRAHYDRO-1H-1,3-OXAZ1NO BENZOTHIAZEPINE-1-ONE IV

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A New Rearrangement Reaction of 2-Phenyl Substituted Benzothiazepine with Ethoxycarbonyl Carbene─Mechanism of the Reaction and Structure of the Product

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Chinese Chemical Letters 1999年第8期10卷 625-628页

作者： Hong Zhong WANG Dan YAO Ruo xi LAN jia xi xu Sheng JIN (College of Chemistry and Molecular Engineering, Peking University, Beijing 100871) Coll. of Chem. and Molec. Eng. Peking University Beijing 100871 China

2,3-Dihydro-2-phenyl-4-(4-methoxyphenyl)-1, 5-benzothiazepine reacts with ethoxycarbonyl carbene to give an unexpected compound 2,3-disubstituted-4H-1,4-benzothiazine Ⅲ. It was found to be a new rearrangement reactio... 详细信息

关键词： Benzothiazepine ethoxycarbonyl carbene rearrangement reaction

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Cerebrotendinous xanthomatosis presenting with schizophrenia-like disorder:A case report

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World Journal of Psychiatry 2023年第11期13卷 967-972页

作者： Chen-xi Ling Shu-Zhan Gao Ri-Dong Li Shu-Qing Gao Yue Zhou xi-jia xu Department of Psychiatry the Affiliated Brain Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Psychiatry Nanjing Brain HospitalMedical SchoolNanjing UniversityNanjing 210029Jiangsu ProvinceChina Department of Radiology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Psychiatry Nanjing Qinglongshan Mental HospitalNanjing 211123Jiangsu ProvinceChina Department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Cerebrotendinous xanthomatosis(CTX)is a rare autosomal recessive lipid-storage disorder caused by mutations in *** manifestations in CTX are rare and nonspecific,and they often lead to considerable diagnostic and treatment *** SUMMARY A 33-year-old female patient admitted to the psychiatric ward for presentation of delusions,hallucinations,and behavioral disturbance is *** patient presented with cholestasis,cataract,Achilles tendon xanthoma,and cerebellar signs in adulthood and with intellectual disability and learning difficulties in *** the characteristic CTX findings on imaging were obtained,a pathological examination of the Achilles tendon xanthoma was *** therapy was then initiated after the diagnosis was clarified by genetic *** hospitalization in the psychiatric ward,the nonspecific psychiatric manifestations of the patient posed difficulty in *** the patient’s history of CTX was identified,the patient was diagnosed with organic schizophrenia-like disorder,and psychotic symptoms were controlled by replacement therapy combined with antipsychotic *** Psychiatrists should be aware of CTX,its psychiatric manifestations,and clinical features and avoid misdiagnosis of CTX for timely intervention.

关键词： Cerebrotendinous xanthomatosis Psychotic symptom CYP27A1 gene mutation Novel likely pathogenic variant Case report

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The transcription factor NAC102 confers cadmium tolerance by regulating WAKL11 expression and cell wall pectin metabolism in Arabidopsis

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Journal of Integrative Plant Biology 2023年第10期65卷 2262-2278页

作者： Guang Hao Han Ru Nan Huang Li Hong Hong jia xi xu Yi Guo Hong Yu Huan Wu Wei Wei Chen Research Center for Plant RNA Signaling College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 310036China Warwick‐Hangzhou RNA Signaling Joint Laboratory School of Life SciencesUniversity of WarwickWarwick CV47ALUnited Kingdom State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China

Cadmium(Cd) toxicity severely limits plant growth and development. Moreover, Cd accumulation in vegetables, fruits, and food crops poses health risks to animals and humans. Although the root cell wall has been implicated in Cd stress in plants, whether Cd binding by cell wall polysaccharides contributes to tolerance remains controversial, and the mechanism underlying transcriptional regulation of cell wall polysaccharide biosynthesis in response to Cd stress is unknown. Here, we functionally characterized an Arabidopsis thaliana NAC-type transcription factor, NAC102, revealing its role in Cd stress responses. Cd stress rapidly induced accumulation of NAC102.1, the major transcript encoding functional NAC102, especially in the root apex. Compared to wild type(WT) plants, a nac102 mutant exhibited enhanced Cd sensitivity, whereas NAC102.1-overexpressing plants displayed the opposite phenotype. Furthermore, NAC102 localizes to the nucleus, binds directly to the promoter of WALL-ASSOCIATED KINASE-LIKE PROTEIN11(WAKL11), and induces transcription, thereby facilitating pectin degradation and decreasing Cd binding by pectin. Moreover, WAKL11 overexpression restored Cd tolerance in nac102mutants to the WT levels, which was correlated with a lower pectin content and lower levels of pectin-bound Cd. Taken together, our work shows that the NAC102-WAKL11 module regulates cell wall pectin metabolism and Cd binding, thus conferring Cd tolerance in Arabidopsis.

关键词： cadmium stress cell wall NAC102 transcriptional regulation WAKL

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DESIGN，SYNTHESIS　AND　ACTIVITIES　OF　ANALOGS　AND　SEGMENTS　OF　THE　PAPAVER　SOMNIFERUM　POLLEN　PEPTIDE　PSPP2~1

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Chinese Chemical Letters 1995年第11期6卷 941-942页

作者： jia xi xu Sheng JIN (School of Chemistry and Molecular Engineering, Peking University, Beijing 100871)(National Laboratory of Applied Organic Chemistry at Lanzhou University, Lanzhou 730000)Meng Shen CAI (School of Pharmaceutical Sciences, Beijing Medical Beijing Univ Sch Chem & Mol Engn Beijing 100871 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China Beijing Med Univ Sch Pharmaceut Sci Beijing 100083 Peoples R China

Four analogs and three segments of the Papaver somniferum pollen peptide 2 (PSPP2)were desiged and synthesized by using Merrifield solid phase peptide synthesis method. Their antitumour activities were detrminde by the tetrazolium salt MTT (3-(4,5-dimethylthiazol-2-yl)-2,5diphenyl tetraolium bromide) method and the relationship of tructure -activity was discussed.

关键词： PSPP2~1 PEPTIDE POLLEN SOMNIFERUM ANALOGS ACTIVITIES

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THE STUDY ON THE WATER SOLUBLE PEPTIDES IN PAPAVER SOMNIFERUM POLLEN EXTRACTION,PURIFICATION,SEQUENCE DETERMINATION AND SYNTHESIS

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Chinese Chemical Letters 1993年第3期4卷 213-214页

作者： jia xi xu Sheng JIN Department of Chemistry Peking University Beijing 100871

Four peptides PSPP1,PSPP2,PSPP3 and PSPP4 were purified from the water-extract of Papaver somniferum *** sequences,with 21,17,13 and 16 amino acid residues respectively,have been determined by Edman degradation-N-terminal ***2, PSPP3 and PSPP4 were synthesized using solid phase *** immunopromotive activities of PSPP1,PSPP2,PSPP3,PSPP4 and the initially separated sample PSPP have been also observed by the methods of counting erythrocyte rosette forming cells(ERFC) and T-lymphocyte transformation test in vitro.

关键词： PSPP Th THE STUDY ON THE WATER SOLUBLE PEPTIDES IN PAPAVER SOMNIFERUM POLLEN EXTRACTION,PURIFICATION,SEQUENCE DETERMINATION AND SYNTHESIS Gly

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NEW　HETEROCYCLIC　SYSTEM　SYNTHESIS　VI．　THE　CYCLOADDITION　DERIVATIVES　OF　1，5－BENZOTHIAZEPINE　AND　1，5－BENZODIAZEPINE

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Chinese Chemical Letters 1994年第7期5卷 557-560页

作者： jia xi xu Sheng JIN(Department of Chemistry, Peking University, Beijing 100871)

Dihydro-1H-1, 5-benzodiazepines and 1-benzoy1-2, 3-dihydro-1H-1H-1,5-benzodiazepines react with .α-carbonylkelenes, generated from 2-diazo-1,3-diphenyl-1,3-propandione or 2-diazo-1-phenyl-1,3-butandione by heating, to give 4a,5, 6, 12-letralydro- 1H,7H-1,3-oxazino[3,2-d][1,5]-benzodiazepine-1-ones,a new ring system. 2, 3-Dihydro-1H-1,5-benzodiazepines also afford,dducts of H-N bond,with a carbonylketenes, 2-aryt-1-(2-benzoyl-phenylacelyl)-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepines. Addition of henzonitrile N-phenylimine,yielde in situ from the N-phenyl benzenecarbohydrazic chloride,to 2, 4-diaryl-2, 3-dihydro-1,5-benzothiazepines and 1H-1,5-benzodiazepine gave 3a, 5-diaryl-1, 3-diphenyl-3a, 4, 5, 11 tetralydro-3H-1, 2, 4-triazolo [4, 3-d][1. 5]benzothiazepine and 3H,6H-1, 2, 4 triazolo[4, 3-d][1, 5] benzodiazpine, respectively.

关键词： VI SYNTHESIS CYCLOADDITION SYSTEM HETEROCYCLIC AND BENZODIAZEPINE

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