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A Framework for Distributed Semi-supervised Learning Using Single-layer Feedforward Networks

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Machine Intelligence Research 2022年第1期19卷 63-74页

作者： Jin xie San-Yang Liu jia-xi chen School of Mathematics and Statistics Xidian UniversityXi’an 710071China

This paper aims to propose a framework for manifold regularization(MR) based distributed semi-supervised learning(DSSL) using single layer feed-forward neural network(SLFNN). The proposed framework, denoted as DSSL-SLFNN is based on the SLFNN, MR framework, and distributed optimization strategy. Then, a series of algorithms are derived to solve DSSL problems. In DSSL problems, data consisting of labeled and unlabeled samples are distributed over a communication network, where each node has only access to its own data and can only communicate with its neighbors. In some scenarios, DSSL problems cannot be solved by centralized algorithms. According to the DSSL-SLFNN framework, each node over the communication network exchanges the initial parameters of the SLFNN with the same basis functions for semi-supervised learning(SSL). All nodes calculate the global optimal coefficients of the SLFNN by using distributed datasets and local updates. During the learning process, each node only exchanges local coefficients with its neighbors rather than raw data. It means that DSSL-SLFNN based algorithms work in a fully distributed fashion and are privacy preserving methods. Finally, several simulations are presented to show the efficiency of the proposed framework and the derived algorithms.

关键词： Distributed learning(DL) semi-supervised learning(SSL) manifold regularization(MR) single layer feed-forward neural network(SLFNN) privacy preserving

Radiomics in the diagnosis and treatment of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 346-351页

作者： Chun jiang Yi-Qi Cai jia-jia Yang Can-Yu Ma jia-xi chen Lan Huang Ze xiang jian Wu Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Zhejiang University School of Medicine Hangzhou 310030China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China

Hepatocellular carcinoma(HCC)is a common malignant *** present,early diagnosis of HCC is dif-ficult and therapeutic methods are *** can achieve accurate quantitative evaluation of the lesions without invasion,and has important value in the diagnosis and treatment of *** fea-tures can predict the development of cancer in patients,serve as the basis for risk stratification of HCC patients,and help clinicians distinguish similar diseases,thus improving the diagnostic ***-more,the prediction of the treatment outcomes helps determine the treatment *** is also helpful in predicting the HCC recurrence,disease-free survival and overall *** review summa-rized the role of radiomics in the diagnosis,treatment and prognosis of HCC.

关键词： Hepatocellular carcinoma Radiomics Diagnosis Prognosis Treatment

Role of tumor-associated macrophages in common digestive system malignant tumors

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 596-616页

作者： Yue Shen jia-xi chen Ming Li Ze xiang jian Wu Yi-Jin Wang Department of Dermatology Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of Pathology Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina Department of Clinical Laboratory Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina School of Medicine Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina

Many digestive system malignant tumors are characterized by high incidence and mortality *** evidence has revealed that the tumor microenvironment(TME)is involved in cancer initiation and tumor ***-associated macrophages(TAMs)are a predominant constituent of the TME,and participate in the regulation of various biological behaviors and influence the prognosis of digestive system *** can be mainly classified into the antitumor M1 phenotype and protumor M2 *** latter especially are crucial drivers of tumor invasion,growth,angiogenesis,metastasis,immunosuppression,and resistance to *** are of importance in the occurrence,development,diagnosis,prognosis,and treatment of common digestive system malignant *** this review,we summarize the role of TAMs in common digestive system malignant tumors,including esophageal,gastric,colorectal,pancreatic and liver *** TAMs promote the development of tumors,and how they act as potential therapeutic targets and their clinical applications are also described.

关键词： Tumor-associated macrophages Digestive system malignant tumors Tumor development Therapeutic targets Clinical applications

Novel therapeutic evaluation biomarkers of lipid metabolism targets in uncomplicated pulmonary tuberculosis patients

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Signal Transduction and Targeted Therapy 2021年第2期6卷 496-506页

作者： jia-xi chen Yu Shuai Han Shan-Qiang Zhang Zhi Bin Li Jing chen Wen-Jing Yi Huai Huang Ting-Ting Jjiang Ji-cheng Li Institute of Cell Biology and Department of Cardiology of the Second Afliated Hospital Zhejiang University School of Medicine310058 HangzhouChina The Medical Research Center of Yue Bei People's Hospital Shantou University Medical College512025 ShaoguanChina Department of Histology and Embryology Shaoguan University School of Medicine512025 ShaoguanChina Taizhou Hospital of Zhejiang Prowince afliated to Wenzhou Medical University 318050 TaizhouChina

Currently,the management of pulmonary tuberculosis(TB)lacks potent medications and accurate efficacy evaluation *** view of the fact that the host lipids are the important energy source of Mycobacterium tuberculosis(Mtb),UPLC-MS/MS based on lipid metabolism was used to monitor the plasma lipid spectrum of TB patients from the initial diagnosis to *** analysis showed that TB patients presented aberrant metabolism of phospholipids,glycerides,and *** the treatment,the abnormal expression of Cer(d18:1/24:0),CerP(d18:1/20:3),LPE(0:0/22:0),LPA(0:0/16:0),and LPA(0:0/18:0)in TB patients were gradually normalized,indicating that the intervention of lipid metabolism could block energy metabolism and inhibit the cell wall synthesis of ***,the increase in ceramide(Cer)levels could promote autophagosome-lysosome ***(0:0/16:0)and LPA(0:0/18:0)had a great potential in the early diagnosis(both sensitivity and specificity were 100%)and efficacy evaluation(both sensitivity and specificity were 100%)of TB,indicating that the above lipid metabolites could be used as potential biomarkers for TB.

关键词： metabolism tuberculosis patients

Sex, age, and annual incidence of primary total knee arthroplasty： a university affiliated hospital survey of 3118 Chinese patients

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Chinese Medical Journal 2012年第22期125卷 3952-3955页

作者： YANG Bo YU jia-kuo GONG xi chen Lian-xu WANG Yong-jian WANG jian MA Dong Peking Univ Hosp 3 Inst Sports Med Beijing 100191 Peoples R China

Background In recent years, the number of patients undergoing primary total knee arthroplasty in China has rapidly increased. However, the incidence of primary total knee arthroplasty is unknown. The purpose of this study was to investigate the sex, age and, annual incidence of primary total knee arthroplasty based on 3118 Chinese patients who underwent the procedure during the period of 2000-2011. Methods Total knee arthroplasties were performed on 511 males and 2607 females in our hospital during the period of 2000-2011. The sex, age, and annual incidence of primary total knee arthroplasty were evaluated. Results The annual incidence of primary total knee arthroplasty increased from 35 knees in 2000 to 681 knees in 2011. The average annual percentage increase in incidence was 33.2%. Females accounted for 83.2% of the patients who underwent primary total knee arthroplasty. In both males and females, the highest incidence was observed in the group aged 65-74 years. Conclusions This study demonstrated a rapid increase in the incidence of primary total knee arthroplasty in our Chinese study population. The sex and age incidence of primary total knee arthroplasty in our study population differed from those reported in Western populations.

关键词： total knee arthroplasty osteoarthritis epidemiology," incidence," sex

多级质谱法测定Axinastatin 1环肽序列及其断裂机理研究

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化学学报 2007年第3期65卷 233-238页

作者：齐崴贾辰熙何志敏乔斌天津大学化工学院化学工程研究所天津300072

对具有抗癌活性的海洋环肽Axinastatin 1进行化学合成.采用多级质谱法对合成环肽进行序列测定.线性前体测序依据bx-yz断裂路径,在同一张MS2谱中利用b和y离子所提供序列信息的互补来实现.环肽测序依据bx→bx-1断裂路径,每一级MS由b离子的... 详细信息

对具有抗癌活性的海洋环肽Axinastatin 1进行化学合成.采用多级质谱法对合成环肽进行序列测定.线性前体测序依据bx-yz断裂路径,在同一张MS2谱中利用b和y离子所提供序列信息的互补来实现.环肽测序依据bx→bx-1断裂路径,每一级MS由b离子的C端碰撞掉一个氨基酸残基直到MS6,得到2套b离子,根据它们所提供序列信息的互补可准确测定环肽序列并推断其环结构,同时观察到b离子重排现象.讨论了上述断裂与重排的路径和机理,并利用半经验量子化学PM3和AM1两种算法计算了碎片的生成焓,验证了路径的合理性.由离子b5PN的生成焓偏高和其重排间的联系尝试提出过渡结构假设.

关键词：环肽测序串联质谱断裂机理

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胰蛋白酶交联聚体的制备及性质研究

化学学报 2008年第16期66卷 1929-1934页

作者：王梦凡贾辰熙齐崴何志敏天津大学化工学院化学工程研究所天津300072

交联酶聚体(CLEA)是一种新型的无载体固定化技术.以胰蛋白酶为模型体系,系统地研究了CLEA技术的制备工艺、应用条件、稳定性及结构形貌.(1)在制备工艺中考察了各步骤对CLEA酶活保留的影响,重点分析了沉淀剂浓度、类型的影响,结果表明100... 详细信息

交联酶聚体(CLEA)是一种新型的无载体固定化技术.以胰蛋白酶为模型体系,系统地研究了CLEA技术的制备工艺、应用条件、稳定性及结构形貌.(1)在制备工艺中考察了各步骤对CLEA酶活保留的影响,重点分析了沉淀剂浓度、类型的影响,结果表明100%乙醇是较为理想的沉淀剂;(2)在应用条件确定中测定CLEA的最适催化温度为70℃,最适催化pH为9.0,并解释了温度-活性、pH-活性曲线的漂移现象;(3)稳定性研究结果表明CLEA技术大幅提高了胰蛋白酶的热稳定性、溶剂稳定性,且无酶泄漏;(4)在形貌表征中分别利用扫描电子显微镜、光学显微镜和激光粒度分析对CLEA的微观结构进行了多尺度研究,着重讨论了其独特结构与优良特性间的关系.本文所得结论为胰蛋白酶CLEA的应用提供基础数据,并为CLEA技术应用于其它酶种提供参考。

关键词：胰蛋白酶交联酶聚体固定化酶的稳定性

基于用户需求分类与重要度评价的产品创新方法研究

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包装工程 2017年第16期38卷 87-92页

作者：张芳兰贾晨茜燕山大学秦皇岛066004

目的为了提升用户需求驱动的产品创新设计满意度,提出一种基于用户需求分类与重要度评价的产品创新方法。方法通过Kano模型分析方法实现用户需求分类,利用四象限模型识别重要用户需求。建立用户满意度与产品质量之间的函数关系并定义调... 详细信息

目的为了提升用户需求驱动的产品创新设计满意度,提出一种基于用户需求分类与重要度评价的产品创新方法。方法通过Kano模型分析方法实现用户需求分类,利用四象限模型识别重要用户需求。建立用户满意度与产品质量之间的函数关系并定义调整系数,从而获取用户需求重要度,并结合重要用户需求实现产品创新。结论以家用电动洗车器的用户需求分析为例,对于基于Kano模型的用户需求分类和重要度评价方法进行了验证。

关键词：用户需求需求分类重要度评价产品创新

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中国柳莺属鸟类分类研究进展

动物学杂志 2012年第3期47卷 134-146页

作者：朱磊贾陈喜孙悦华中国科学院动物研究所北京100101 中国科学院研究生院北京100049

柳莺属(Phylloscopus)是广泛分布于旧大陆地区的小型食虫鸟类,目前全世界已知66种,其中约50种见于亚洲。该属鸟类外部形态十分相近且同域分布种数较多,历来是鸟类分类学中的研究难点及热点。2003年贾陈喜等介绍了20世纪90年代以来发表... 详细信息

柳莺属(Phylloscopus)是广泛分布于旧大陆地区的小型食虫鸟类,目前全世界已知66种,其中约50种见于亚洲。该属鸟类外部形态十分相近且同域分布种数较多,历来是鸟类分类学中的研究难点及热点。2003年贾陈喜等介绍了20世纪90年代以来发表的分布于我国的柳莺属鸟类新种及相关分类学变动,涉及3个新描述种和9个由亚种提升的种,共计30种26亚种。2003年以来关于柳莺属鸟类的分类学研究取得了许多新的成果,同时我国境内也发现了一些新的分布记录。综合最新的文献及分布资料,整理得知我国现有柳莺属鸟类41种31亚种,与2003年的状况相比已有较大的变化。主要表现在:新描述种方面,德国学者Martens等2008年描述了黄腹柳莺(***)种组中的一新种———华西柳莺(***);2010年瑞典学者Alstrm等报道在越南和老挝地区新发现的灰岩柳莺(***)已被证实在我国有分布;亚种提升为种方面,如日本柳莺(***)自极北柳莺(***)中独立,冠纹柳莺(***)和西南冠纹柳莺(***)分开等;分类地位再评议方面,如灰头鹟莺(Seicercusxanthoschistos)实为灰头柳莺(***)等;新分布纪录方面,如欧柳莺(***)在内蒙古达里诺尔湖地区发现确切记录等。现今对柳莺属鸟类分类学方面的研究已明显呈现出传统形态学、分子遗传学、声谱分析及野外鸣声回放实验等新老技术手段相整合,多方面多角度地阐述问题的局面。中国是世界柳莺属鸟种分布最多的国家(其中有9种仅在或主要于我国境内繁殖),但我国鸟类学者关于该属鸟类的研究工作并不多见。柳莺属鸟类在分类学和进化生物学等领域具有重要的研究价值,我国鸟类学工作者应当引起足够的重视和关注。

关键词：柳莺属分类分布