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Facile synthesis of suvorexant,an orexin receptor antagonist,via a chiral diazepane intermediate

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Chinese Chemical Letters 2015年第1期26卷 103-107页

作者： Yin Chen Yan Zhou Jun-Hong Li jia-quan sun Gui-Sen Zhang Systems Biology Theme Department of Biomedical EngineeringCollege of Life Science and TechnologyHuazhong University of Science and Technology jiangsu Nhwa Pharmaceutical Co. Ltd.

A facile synthesis of suvorexant, an orexin receptor antagonist, is described. The key intermediate 6 was prepared from R-3-aminobutyric acid through protection, condensation, deprotection, cyclization, and hydrogenation steps. The title product was obtained with a total yield of 31% （〉99% ee） after eight linear steps using commercially available raw materials.

关键词： Synthesis Suvorexant Chiral diazepane

Spatial-temporal difference between nitrate in groundwater and nitrogen in soil based on geostatistical analysis

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Journal of Groundwater Science and Engineering 2023年第1期11卷 37-46页

作者： Xiu-bo sun Chang-lai Guo Jing Zhang jia-quan sun jian Cui Mao-hua Liu Shenyang Center of Geological Survey CGSShengyang 110000China Shenyang jianzhu University Shengyang 110168China

The study of temporal and spatial variations of nitrate in groundwater under different soil nitrogen environments is helpful to the security of groundwater resources in agricultural *** this paper,based on 320 groups of soil and groundwater samples collected at the same time,geostatistical analysis and multiple regression analysis were comprehensively used to conduct the evaluation of nitrogen contents in both groundwater and *** May to August,as the nitrification of groundwater is dominant,the average concentration of nitrate nitrogen is 34.80 mg/L;The variation of soil ammonia nitrogen and nitrate nitrogen is moderate from May to July,and the variation coefficient decreased sharply and then increased in *** is a high correlation between the nitrate nitrogen in groundwater and soil in July,and there is a high correlation between the nitrate nitrogen in groundwater and ammonium nitrogen in soil in August and nitrate nitrogen in soil in *** May to August,the area of low groundwater nitrate nitrogen in 0-5 mg/L and 5-10 mg/L decreased from 10.97%to 0,and the proportion of high-value area(greater than 70 mg/L)increased from 21.19%to 27.29%.Nitrate nitrogen is the main factor affecting the quality of *** correlation analysis of nitrate nitrogen in groundwater,nitrate nitrogen in soil and ammonium nitrogen shows that they have a certain period of *** areas with high concentration of nitrate in groundwater are mainly concentrated in the western part of the study area,which has a high consistency with the high value areas of soil nitrate distribution from July to August,and a high difference with the spatial position of soil ammonia nitrogen distribution in August.

关键词： Groundwater Nitrate Soil Spatial-temporal variation Geostatistical analysis

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机油泵修正齿轮的研究

内燃机工程 1984年第3期5卷 43-49页

作者：贾安全孙绍冬上海船用柴油机研究所

本文叙述了油泵修正齿轮的设计方法,采用这种修正方法可以使泵的尺寸小,流量大,改善齿轮的啮合工作条件,减小泵的噪声,提高泵的效率。

关键词：修正齿轮齿数机油泵卸荷槽齿顶圆啮合角齿侧间隙

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma jia Liu Xiang Xia Ning Xu Wen sun jianjun Du jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

光伏并网系统参与电压调节的有功和无功协调控制策略研究

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电工电能新技术 2017年第8期36卷 23-29页

作者：王宁高朋贾清泉孙玲玲白钰电力电子节能与传动控制河北省重点实验室燕山大学河北秦皇岛066004 国网河北省电力公司石家庄供电分公司河北石家庄050093 国网河北省电力公司元氏县供电分公司河北石家庄051130

针对配电网线路阻抗大、分布式光伏并网系统无功调压能力有限,导致光伏电源在有功出力较大时并网点(PCC)电压越上限问题,在深入分析光伏系统PCC电压特性基础上,提出一种光伏逆变器有功和无功协调控制策略。在该控制策略下,光伏系统实时... 详细信息

针对配电网线路阻抗大、分布式光伏并网系统无功调压能力有限,导致光伏电源在有功出力较大时并网点(PCC)电压越上限问题,在深入分析光伏系统PCC电压特性基础上,提出一种光伏逆变器有功和无功协调控制策略。在该控制策略下,光伏系统实时跟踪监测PCC电压变化,PCC电压不越限时,逆变器按最大功率点跟踪(MPPT)输出;PCC电压越上限时,优先利用逆变器剩余容量进行无功调压,若剩余容量不足,调节逆变器有功输出,并动态计算有功、无功最佳输出值,保证将PCC电压调节至满足要求的前提下,实现逆变器有功输出最大化、无功输出最佳化。算例结果验证了控制策略的有效性。

关键词：光伏并网系统电压越限有功和无功协调控制策略逆变器剩余容量

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang jia-Qian Ju Jing-Cai Liu Shao-Chen sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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Construction of Power Trading Supply Guarantee System of High Proportion of Hydropower in the Southwest Power Grid Under Extreme Climate Scenarios

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Dianwang Jishu/Power System Technology 2025年第1期49卷 113-123页

作者： Wen, Xu Zhou, quan sun, Tian Yang, Yang Mao, Rui Wen, Siao Southwest Branch of State Grid Corporation of China Sichuan Province Chengdu 610041 China Beijing Power Trading Center Co. Ltd. Xicheng District Beijing 100031 China

Currently, the Southwest Power Grid is promoting the construction of a new power system. The southwest power grid has a large-scale integration of clean energy, mainly hydropower, which depends on the weather. The system operation is facing serious challenges due to the lack of reliable power supply and the frequent occurrence of extreme climate. Firstly, this paper introduces China's Southwest Power Grid and market operation pattern. Secondly, learning from the power supply issues in the Sichuan-Chongqing region of the Southwest Power Grid under the extreme drought, and high-temperature climate scenarios in the summer of 2022, and based on the perspectives of the regional power grid and the marketization, the paper summarizes the four shortcomings of current power supply scheme of Southwest Power Grid, namely limited warning levels, short supply cycle, limited supply space, and a single supply resource. Therefore, research methods and framework for the power supply of Southwest Power Grid are proposed based on the concept of "double-level, full-lifecycle, full-space, and full-resources" ("one-double three-full"). Thirdly, the power trading system for supply sufficiency in Southwest Power Grid under extreme climate scenarios is constructed: 1) proposing the concept and level determination method of power supply warning and response for regional power grids, and constructing a double-level power trading supply warning and response mechanism for "provincial power grid + regional power grid";2) proposing medium and long term interruptible power supply varieties and constructing a "medium and long term + spot + emergency" full-lifecycle power trading supply guarantee system;3) proposing the concept of inter-regional and intra-provincial market power supply, designing spatiotemporal exchange transactions of large-scale hydropower and constructing a "inter-regional + inter-provincial + intra-provincial" full-space power trading system for supply sufficiency;4) proposing p

关键词： Commerce

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Effect of Actual Cooling Rate of Ladle Stream on Persistent Metallurgical Performance of a Given Tundish

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Journal of Iron and Steel Research International 2014年第10期21卷 915-922页

作者： Hai-bo sun jia-quan ZHANG State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing

To evaluate the effect of actual cooling rate of liquid steel in the ladle on the metallurgical performances of a tundish, a transient and coupled computational model was developed to reveal the flow fields, temperature fields, residence time distribution of the molten steel and the inclusion removal efficiency in a typical single-strand tundish with given geometry and process parameters. The results showed that, with the decrease of the ladle stream cooling rate, the temperature difference of bulk flow at the outlet of tundish over a normal casting period decreased from 11.3 to 2.6 K, and the dead volume fraction of the tundish decreased from 17.58% to 14. 35%, while the inclusion removal efficiency was increased especially for the inclusions with the diameter less than 50 μm, whose removal ratio could be increased by 20.62%. When the cooling rate was less than 0.3 K · min-1 , however, the variation rates of the three evaluation criterions above declined significantly, which suggested that a critical value existed for the effect of the cooling rate of ladle stream on the tundish performances. The establishment of the critical ladle stream cooling rate should be very important to achieve persistent metallurgical properties of tundish over the whole casting stage, together with the reasonable ladle insulation design.

关键词： critical cooling rate ladle stream tundish performance fluid flow thermal buoyancy force, residencetime distribution