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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li wei-Quan Xu jia-Bao Liao wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang wei Pi Sheng Hu Haifeng Bao Na Yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer

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BIOCELL 2023年第9期47卷 2081-2099页

作者： GAOZHONG LI FUXIN LI ning wei QING jia Department of Gastroenterology Zibo Central HospitalZibo255036China

Background:This study was aimed at identifying natural killer(NK)cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer(GC)***:We obtained NK cell-related genes from various databases,followed by Cox regression analysis and molecular typing to identify prognostic *** immune algorithms and enrichment analyses were used to investigate the mutations,immune status,and pathway variations among different *** key prognostic genes were assessed using the least absolute shrinkage and selection operator(Lasso)regression analysis and univariate Cox regression ***,the risk score(RS)prognosis model was constructed based on the selected important prognostic genes.A Receiver Operating Characteristics(ROC)curve was plotted for analyzing the robustness of the ***,the decision and calibration curves were used for assessing the reliability and prediction accuracy of the proposed ***‘pRRophetic’R software package was utilized for predicting the half-maximal inhibitory concentration(IC50)of immunotherapy and chemotherapy ***:We screened 21 prognostic genes and three molecular subtypes and found that the C1 subtype had the worst ***,the pathways promoting tumor proliferation,such as epithelial-mesenchymal transition were significantly *** results also showed that the macrophages in the M2 stage were significantly infiltrated in the C1 subtype,and there was significant overexpression in the C1 subtype,accompanied by a severe inflammatory *** C1 was highly sensitive to drugs like 5-fluorouracil and *** ROC,calibration curve,and decision curve showed that the risk model was robust and strongly ***:Overall,our proposed NK cell-related RS model can be used as a more accurate prediction index for GC patients,providing a valuable contribution to personalized medicine.

关键词： Natural killer cells Gastric cancer Risk model Molecular typing

凡纳滨对虾肌质钙结合蛋白纯化鉴定、理化特性及抗原表位分析

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食品科学 2025年第2期46卷 30-37页

作者：陈伟周军君陈雅纯贾英民马爱进北京工商大学食品与健康学院北京100048

以凡纳滨对虾(Penaeus vannamei)为原料,分离纯化和鉴定过敏原肌质钙结合蛋白(sarcoplasmiccalcium-binding protein,SCP),对其理化性质(免疫活性、热稳定性、pH值稳定性及消化稳定性)、二级结构和抗原表位进行研究。结果表明:采用蛋白... 详细信息

以凡纳滨对虾(Penaeus vannamei)为原料,分离纯化和鉴定过敏原肌质钙结合蛋白(sarcoplasmiccalcium-binding protein,SCP),对其理化性质(免疫活性、热稳定性、pH值稳定性及消化稳定性)、二级结构和抗原表位进行研究。结果表明:采用蛋白粗提、硫酸铵分级沉淀、阴离子交换层析等步骤纯化得到的蛋白分子质量为21.6 kDa,经鉴定,该蛋白为凡纳滨对虾SCP,肽段覆盖率达93.26%。凡纳滨对虾SCP具有较强的免疫活性,在热处理温度≥65℃和强酸强碱条件下免疫活性减弱;SCP对肠液消化具有较强的稳定性,而对胃液消化稳定性较差。凡纳滨对虾SCP的二级结构中α-螺旋、β-折叠、β-转角和无规卷曲的相对含量分别为26%、16.9%、17.5%、39.6%。利用生物信息学工具结合免疫学技术最终预测识别出8条凡纳滨对虾SCP抗原表位。

关键词：凡纳滨对虾肌质钙结合蛋白稳定性抗原表位

Graph-decomposed k-NN searching algorithm on road network

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Frontiers of Computer Science 2024年第3期18卷 243-245页

作者： wei jiaNG Bo ning Guanyu LI Mei BAI Xiao jia Fangliang wei Faculty of Information Science and Technology Dalian Maritime UniversityDalian 116026China jiangxing Intelligence Inc. Shenzhen 518100China

1 Introduction The k-NN(k Nearest Neighbors)searching problem on road network constitutes a crucial aspect of location-oriented services,which has boasted the practical implications.

关键词： services searching network

Climate or Carbon Mitigation Engineering Management

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Engineering 2022年第10期17卷 17-21页

作者： Yi-Ming wei jia-ning Kang weiming Chen Center for Energy and Environmental Policy Research&School of Management and Economics Beijing Institute of Technology&Beijing Key Laboratory of Energy Economics and Environmental ManagementBeijing 100081China

*** Carbon mitigation engineering,also known as climate engineering internationally,is an umbrella term of engineering measures targeted at combating climate change and achieving carbon *** or mitigation engineering can be commonly divided into three categories based on technological principles[1]:(1)carbon dioxide removal(CDR),which has the potential to achieve negative emissions by removing atmospheric carbon dioxide[2].

关键词： dioxide removing carbon

Rescaled Range Permutation Entropy:A Method for Quantifying the Dynamical Complexity of Extreme Volatility in Chaotic Time Series

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Chinese Physics Letters 2020年第9期37卷 15-20页

作者： jia-Chen Zhang wei-Kai Ren ning-De Jin School of electrical and information engineering Tianjin UniversityTianjin 300072China

Information entropy,as a quantitative measure of complexity in nonlinear systems,has been widely researched in a variety of *** the development of a nonlinear dynamic,the entropy is faced with severe challenges in dealing with those signals exhibiting extreme *** order to address this problem of weighted permutation entropy,which may result in the inaccurate estimation of extreme volatility,we propose a rescaled range permutation entropy,which selects the ratio of range and standard deviation as the weight of different fragments in the time series,thereby effectively extracting the maximum *** analyzing typical nonlinear systems,we investigate the sensitivities of four methods in chaotic time series where extreme volatility *** with sample entropy,fuzzy entropy,and weighted permutation entropy,this rescaled range permutation entropy leads to a significant discernibility,which provides a new method for distinguishing the complexity of nonlinear systems with extreme volatility.

关键词： entropy extreme nonlinear

Ecosystem service of green infrastructure for adaptation to urban growth:function and configuration

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Ecosystem Health and Sustainability 2018年第5期4卷 20-31页

作者： Yun-Cai Wang jia-Ke Shen wei-ning Xiang Department of Landscape Architecture Center for Ecophronetic Practice ResearchCollege of Architecture and Urban PlanningTongji UniversityShanghaiChina Department of Geography and Earth Sciences the University of North Carolina at CharlotteCharlotteNCUSA

Objectives:(1)to explore what kind of green infrastructure(GI)meets the demand for urban ecological security of rapid urbanization areas;(2)to figure out how to determine the specific function and configuration of GI from ecosystem service requirements of urban ecological ***:(1)Through the literature review,this article summarizes the function and structure evolution of GI in order to adapt to urban growth.(2)Standing on the imperfect ecological functions and unreasonable spatial configurations,this article builds up a conceptual model for the optimization of green infrastructure ecosystem services to meet the demand for the green infrastructure pattern needed by urban ***:The optimization framework consists of four central function modules and its regulating and controlling mechanisms,incuding:(1)Balancing supply and demand of GI's ecosystem service;(2)Measuring and evaluating GI's ecosystem services;(3)Elevating and optimizing GI's ecosystem service;(4)Building urban ecological security patterm with high efficiency of GI's ecosystem ***,this framework provides guidance for the planning and design of GI and the urban ecological security pattern building in rapid urbanization areas based on ba lancing supply and demand of GI's ecosystem ***:The conceptual model of Gl's ecosystem service optimization based on balan-cing supply and demand shows a new path to meet the needs of urban growth and build a city's ecological security pattern through upgrading and optimizing GI.

关键词： Green infrastructure ecosystem service urban growth balancing supply and demand optimization framework

Synthesis and Electrochemical Behavior of Electroactive Bistetrathiafulvalene-attached Thiacalix[4]arene Assemblies

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Chemical Research in Chinese Universities 2012年第5期28卷 828-832页

作者： ZHAO Bang-tun LI jia-jia ZHOU Zhen YAN Zhen-ning ZHU wei-min College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang 471022P R.China Department of Chemistry Zhengzhou UniversityZhengzhou 450001P R.China

Tetrabromoalkylthiacalix[4]arenes（1a and 1b） reacted with excess bis（tetraethylammonium）-bis（1,3- dithiole-2-thione-4,5-dithiol）zincate（2） to give thiacalix[4]arene-thiones（3a and 3b） in the presence of Na2S. Two novel bistetrathiafulvalene-attached thiacalix[4]arene assemblies（5a and 5b） formed via triethyl phosphite-mediated cross-coupling of thiacalix[4]arene-thiones（3a and 3b） and 4,5-biscyanoethylthio-1,3-dithiole-2-one（4）. All the four new compounds were characterized by 1H NMR, 13C NMR, IR, MS spectra and elemental analysis. Meanwhile, the structures of thiacalix[4]arene-thiones（3a and 3b） were identified by X-ray analysis. In addition, the cyclic voltammograms of the resulting thiacalix[4]arenes containing electroactive TTF units（5a and 5b） were provided.

关键词： Thiacalixarene Tetrathiafulvalene X-Ray diffraction Cyclic voltammetry