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Epigenetics effect on pathogenesis of thyroid-associated ophthalmopathy

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1441-1448页

作者： jia-min cao Nuo Wang Shi-Ying Hou Xin Qi Wei Xiong Department of Ophthalmology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Ophthalmology Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

Thyroid-associated ophthalmopathy(TAO)is an autoimmune *** studies have found the aberrant epigenetics in TAO,including DNA methylation,noncoding RNAs,and histone *** genes have an aberrant level of methylation in *** example,higher levels are found in CD14,MBP,ANGLE1,LYAR and lower levels in DRD4 and ***-coding RNAs are involved in the immune response(miR-146a,miR-155,miR-96,miR-183),fibrosis regulation(miR-146a,miR-21,miR-29),adipogenesis(miR-27)and are thought to play roles in *** is also related to the clinical activity score(miR-Let7d-5p)and may be a predictor of glucocorticoid therapy(miR-224-5p).The quantities of H4 in TAO are increased compared with euthyroid control subjects,and the role of histone modifications in Graves*disease may lead to better understanding of its role in *** studies are needed to explain the role of epigenetics in TAO and provide potential therapeutic strategies.

关键词： thyroid-associated ophthalmopathy epigenetics DNA methylation non-coding RNA histone modification

Pharmacodynamic study in multi-animal models on the efficacy and optimal dosage of antiviral oral liquid for children

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Traditional Medicine Research 2023年第11期8卷 34-44页

作者： Ying-Li Xu jia-min cao Lin Zhang Rong-Hua Zhao Lei Bao Shan-Shan Guo Zhi Dai Xiao-Lan Cui Liang Wang Jing Sun Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Neurology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China.

Antiviral Oral Liquid(AOL)is an adult medicine in the Chinese Pharmacopoeia used to treat upper respiratory infections such as *** has shown promising clinical efficacy in relieving flu-like symptoms such as fever,inflammation,and pharyngalgia both in adults and ***,the instruction manual does not specify the exact usage and dosage of AOL for *** this article,we set 6 dosage ranges:0.2,0.5,0.7,0.9,1.1,1.4 mL/kg/d,according to its dosage for adults and the conversion method between adult and children *** six animal models were used to evaluate the effectiveness of AOL in different *** results indicated that AOL could reduce the lung index,virus load,and expression of proinflammatory cytokines in the *** could improve pathological changes and prolong the survival time of mice infected by the Influenza A virus(H1N1)A/PR/8/34 strains at 0.5–0.9 mL/kg/d concentrations in different *** four dose groups of 0.7–1.4 mL/kg/d could significantly inhibit the ear shell swelling caused by xylene and reduce the rabbit body temperature induced by lipopolysaccharide(P<0.01,P<0.05).All the five dosage groups of 0.2–1.1 mL/kg/d could inhibit the increase of peritoneal capillary permeability induced by glacial acetic acid(P<0.01).AOL at 0.7 and 0.9 mL/kg/d reduced the painful writhing times in young mice induced by glacial acetic(P<0.01).These results indicated that the optimal dose of AOL in antiviral,antipyretic,anti-inflammatory,and analgesic effects is 0.7 mL/kg/d.

关键词： antiviral oral liquid clinical application in children antiviral activity anti-inflammatory activity analgesic activity

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing cao Chenglin Cai Guangming Wang min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

高效液相色谱法测定保健食品胶囊剂硬胶囊壳中的合成着色剂

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食品安全质量检测学报 2017年第6期8卷 2105-2110页

作者：高家敏曹进丁宏中国食品药品检定研究院北京100050

目的建立高效液相色谱法(high performance liquid chromatography,HPLC)测定保健食品胶囊剂硬胶囊壳中合成着色剂的分析方法。方法硬胶囊壳用热水溶解,加入聚酰胺粉吸附着色剂,用甲醇-甲酸(V:V,6:4)洗脱天然着色剂,再用乙醇-氨水-水(V:... 详细信息

目的建立高效液相色谱法(high performance liquid chromatography,HPLC)测定保健食品胶囊剂硬胶囊壳中合成着色剂的分析方法。方法硬胶囊壳用热水溶解,加入聚酰胺粉吸附着色剂,用甲醇-甲酸(V:V,6:4)洗脱天然着色剂,再用乙醇-氨水-水(V:V:V,7:2:1)解吸合成着色剂,随后使用HPLC检测新红、柠檬黄、苋菜红、靛蓝、胭脂红、日落黄、亮蓝、赤藓红8种合成着色剂,外标法定量。结果 8种合成着色剂均可得到良好的分离,在5~200μg/m L范围内线性良好,相关系数均大于0.999,平均回收率(n=9)均在90%以上。应用该方法对10批保健食品胶囊剂彩色硬胶囊壳中的合成着色剂进行测定,均检出国家标准GB 2760-2014《食品安全国家标准食品添加剂使用标准》允许使用的合成着色剂。结论该方法准确、可靠,适用于保健食品胶囊剂硬胶囊壳中合成着色剂的测定。

关键词：保健食品硬胶囊壳合成着色剂高效液相色谱法

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-min Xu Ke Wang jia-Zhu Wen Li-Kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang Xiao Ding Huang Yunyi Yiyu Liu jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

HAPE3D—a new constructive algorithm for the 3D irregular packing problem

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Frontiers of Information Technology & Electronic Engineering 2015年第5期16卷 380-390页

作者： Xiao LIU jia-min LIU An-xi cao Zhuang-le YAO School of Civil and Transportation Engineering South China University of Technology School of Information Science and Engineering Shenyang University of Technology College of Ocean Science and Engineer Shanghai Maritime University

We propose a new constructive algorithm, called HAPE3 D, which is a heuristic algorithm based on the principle of minimum total potential energy for the 3D irregular packing problem, involving packing a set of irregularly shaped polyhedrons into a box-shaped container with fixed width and length but unconstrained height. The objective is to allocate all the polyhedrons in the container, and thus minimize the waste or maximize profit. HAPE3 D can deal with arbitrarily shaped polyhedrons, which can be rotated around each coordinate axis at different angles. The most outstanding merit is that HAPE3 D does not need to calculate no-fit polyhedron(NFP), which is a huge obstacle for the 3D packing problem. HAPE3 D can also be hybridized with a meta-heuristic algorithm such as simulated annealing. Two groups of computational experiments demonstrate the good performance of HAPE3 D and prove that it can be hybridized quite well with a meta-heuristic algorithm to further improve the packing quality.

关键词： 3D packing problem Layout design Simulation Optimization Constructive algorithm Meta-heuristics