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Machine learning based on metabolomics unveils neutrophil extracellular trap-related metabolic signatures in non-small cell lung cancer patients undergoing chemoimmunotherapy

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World Journal of Clinical Cases 2024年第20期12卷 4091-4107页

作者： Yu-Ning Li jia-lin su Shu-Hua Tan Xing-Long Chen Tian-Li Cheng Zhou jiang Yong-Zhong Luo Le-Meng Zhang School of Life and Health Sciences Hunan University of Science and TechnologyXiangtan 411201Hunan ProvinceChina Department of Thoracic Medicine Hunan Cancer HospitalChangsha 410013Hunan ProvinceChina

BACKGROUND Non-small cell lung cancer(NSCLC)is the primary form of lung cancer,and the combination of chemotherapy with immunotherapy offers promising treatment options for patients suffering from this ***,the emergence of drug resistance significantly limits the effectiveness of these therapeutic ***,it is imperative to devise methods for accurately detecting and evaluating the efficacy of these *** To identify the metabolic signatures associated with neutrophil extracellular traps(NETs)and chemoimmunotherapy efficacy in NSCLC *** In total,159 NSCLC patients undergoing first-line chemoimmunotherapy were *** first investigated the characteristics influencing clinical *** levels of NETs and cytokines were measured by commercial *** chromatography tandem mass spectrometry quantified plasma metabolites,and differential metabolites were *** absolute shrinkage and selection operator,support vector machine-recursive feature elimination,and random forest algorithms were *** using plasma metabolic profiles and machine learning algorithms,predictive metabolic signatures were *** First,the levels of circulating interleukin-8,neutrophil-to-lymphocyte ratio,and NETs were closely related to poor efficacy of first-line *** were classed into a low NET group or a high NET group.A total of 54 differential plasma metabolites were *** metabolites were primarily involved in arachidonic acid and purine *** key metabolites were identified as crucial variables,including 8,9-epoxyeicosatrienoic acid,L-malate,and bis(monoacylglycerol)phosphate(18:1/16:0).Using metabolomic sequencing data and machine learning methods,key metabolic signatures were screened to predict NET level as well as chemoimmunotherapy *** The identified metabolic signatures may effectively distinguish NET levels and predict clinical

关键词： Non-small cell lung cancer Chemoimmunotherapy Neutrophil extracellular traps Metabolomics Machine learning

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RNA-based nanomedicines and their clinical applications

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Nano Research 2023年第12期16卷 13182-13204页

作者： lin-jia su Zi-Han Ji Mo-Xi Xu jia-Qing Zhu Yi-Hai Chen Jun-Fei Qiao Yi Wang Yao-Xin lin CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100149China Department of Breast surgery Harbin Medical University Cancer HospitalHarbin 150081China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Institute of Bioengineering and Institute of Materials Science&Engineering École Polytechnique Fédérale de Lausanne(EPFL)Lausanne1015Switzerland

RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of *** include antisense oligonucleotides(ASOs),small interfering RNAs(siRNAs),endogenous microRNAs(miRNAs),messenger RNAs(mRNAs),clustered regularly interspersed short palindromic repeats-associated protein 9(CRISPR/Cas9),single guide RNAs(sgRNAs),as well as RNA *** therapeutic agents exert their effects through various mechanisms such as gene inhibition,addition,replacement,and *** advancement of RNA biology and the field of RNA therapy has paved the way for the development and utilization of RNA-based nanomedicine in human *** remarkable example of RNA-based nanomedicine is the mRNA-based vaccines including mRNA-1273(Moderna)and BNT162b2(Pfizer/BioNTech)that have been successfully employed in response to the coronavirus disease 2019(COVID-19)*** review aims to highlight the advantages of RNA-based nanomedicines,provides an overview of significant developments in delivery systems,elucidates the molecular mechanisms of action underlying RNA-based nanomedicines,and discusses their clinical ***,the review will address the existing challenges and innovations in delivery platforms while exploring the future possibilities for these promising RNA-based nanomedicines.

关键词： RNA-based nanomedicine conjugate-based delivery system nanoparticle-based delivery system clinical trial

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Paleogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1290-1325页

作者： jia LIU Ai SONG lin DING Tao su Zhekun ZHOU CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Paleontology Yunnan UniversityKunming 650500China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

The Paleogene is a crucial period when terrestrial and marine ecosystems recovered from major disruptions and gradually approached their modern *** the Qinghai-Tibetan Plateau and its surrounding regions,the Paleogene also represents a significant phase of tectonic evolution in the Qinghai-Tibetan Plateau-Himalaya orogeny,reorganization of Asian climates,and evolution of *** to limitations in research conditions and understanding,there are still many controversies regarding stratigraphic divisions in the Qinghai-Tibetan Plateau and its surrounding *** recent years,extensive studies on sedimentary petrology,magnetostratigraphy,and isotope dating have been conducted in the *** fossils have been discovered and reported,contributing to a more systematic understanding of *** studies have laid a solid foundation for the comprehensive investigation of the stratigraphy,biotas and paleogeographic evolution of the Qinghai-Tibetan Plateau and its surrounding regions during the *** this paper,we integrate recent research on fossils,isotopic dating,magnetostratigraphy,and geochemistry to refine the stratigraphic divisions and correlation framework of different tectonic units in the region,building upon previous *** the Second Tibetan Plateau Scientific Expedition and Research,the knowledge of Paleogene floras has gradually *** paper discusses the biostratigraphic significance of extinct and newly appeared taxa based on the latest dating results of these plant *** new understanding of fossil species such as the“Eucalyptus”and Arecaceae establishes connections between the Paleogene flora of the Qinghai-Tibetan region and the biotas of Gondwana,specifically Oceania and South *** evolutionary history of key taxa near the Yarlung Zangbo suture zone indicates that the collision between the Indian and Eurasian plates occurred approximately 65-54 *** reconstructions,based o

关键词： Qinghai-Tibetan Plateau Fossils Biostratigraphy Paleoenvironment Paleogeography Paleogene

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DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

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Science China Chemistry 2024年第6期67卷 2070-2078页

作者： Xing Xu Xi Zeng Xin lin Shiyan lin Shanshan Liang Tian Tian Rui su jia Song Chaoyong Yang Collaborative Innovation Center of Chemistry for Energy Materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and Materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation Center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

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Parity-dependent skin effects and topological properties in the multilayer nonreciprocal su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： jia-Rui Li Cui jiang Han su Di Qi Lian-Lian Zhang Wei-jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

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Impact of Media Information on Social Response in Disasters:A Case Study of the Freezing‑Rain and Snowstorm Disasters in Southern China in 2008

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International Journal of Disaster Risk Science 2024年第1期15卷 73-87页

作者： jia He Wenjing Duan Yuxuan Zhou Yun su College of Geographic Science and Tourism Xinjiang Normal UniversityUrumqi 830054China Xinjiang Laboratory of Lake Environment and Resources in Arid Zone Urumqi 830054China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster Ministry of EducationBeijing Normal UniversityBeijing 100875China

Disaster information content is an objective mapping of disaster situations,social response,and public *** response to emergency is an important mechanism for implementing and guaranteeing emergency management of major natural hazard-related *** how disaster information content affects social response to emergencies is helpful for managing risk communication and efficient disaster *** on the 2008 freezing-rain and snowstorm disasters in southern China,this study used Python to extract 7,857 case-related media reports and applied natural language processing for text *** used three typical cases to identify and analyze disaster media report content and the relationship between these reports and the social response to the *** categories of disaster response-such as prewarning and forecasting,announcements by the authorities,and social mobilization-appeared in the disaster information in the media,along with disaster impact information,that is,real-time disaster *** response information and an appropriate amount of disaster impact information played important roles in prewarning,disaster relief,public opinion guidance,and social stability maintenance and can serve important functions in communicating with all stakeholders of emergency management,assisting or influencing emergency departments or individuals in decision making,and eliminating "information islands." Empathy caused the general public to become "disaster responders" through receiving *** and an excess of negative information may have a perverse amplification effect on public opinion and increase the unpredictability of the disaster situation and the risk of social crisis.

关键词： Emergency management Freezing-rain and snowstorm disasters Media reports on disasters Social response to emergencies China

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Paleogene integrative stratigraphy, biotas and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding regions

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Science China Earth Sciences 2024年

作者： jia LIU Ai SONG lin DING Tao su Zhekun ZHOU Institute of Paleontology Yunnan University CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences State Key Laboratory of Tibetan Plateau Earth System Environment and Resources (TPESER) Institute of Tibetan Plateau ResearchChinese Academy of Sciences

The Paleogene is a crucial period when terrestrial and marine ecosystems recovered from major disruptions and gradually approached their modern states. In the Qinghai-Tibetan Plateau and its surrounding regions, the Paleogene also represents a significant phase of tectonic evolution in the Qinghai-Tibetan Plateau-Himalaya orogeny, reorganization of Asian climates, and evolution of biodiversity. Due to limitations in research conditions and understanding, there are still many controversies regarding stratigraphic divisions in the Qinghai-Tibetan Plateau and its surrounding regions. In recent years,extensive studies on sedimentary petrology, magnetostratigraphy, and isotope dating have been conducted in the region. Numerous fossils have been discovered and reported, contributing to a more systematic understanding of biostratigraphy. These studies have laid a solid foundation for the comprehensive investigation of the stratigraphy, biotas and paleogeographic evolution of the Qinghai-Tibetan Plateau and its surrounding regions during the Paleogene. In this paper, we integrate recent research on fossils, isotopic dating, magnetostratigraphy, and geochemistry to refine the stratigraphic divisions and correlation framework of different tectonic units in the region, building upon previous studies. Since the Second Tibetan Plateau Scientific Expedition and Research, the knowledge of Paleogene floras has gradually expanded. This paper discusses the biostratigraphic significance of extinct and newly appeared taxa based on the latest dating results of these plant species. The new understanding of fossil species such as the “Eucalyptus” and Arecaceae establishes connections between the Paleogene flora of the Qinghai-Tibetan region and the biotas of Gondwana, specifically Oceania and South America. The evolutionary history of key taxa near the Yarlung Zangbo suture zone indicates that the collision between the Indian and Eurasian plates occurred approximately 65–54 Ma. Paleoeleva

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Anti-OX40 Antibody Combined with HBc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

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Biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU jia jia su Qiu Dong YI Yao SHEN Li Ping BI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(HBc VLPs)therapy using a mouse colon cancer *** Humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with HBc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with HBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that HBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with HBc *** Combination therapy of anti-h OX40 and HBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody Hepatitis B core virus-like particles Tumor Combination therapy

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Water–solid contact electrification and catalysis adjusted by surface functional groups

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Nano Research 2024年第4期17卷 3344-3351页

作者： Yusen su Andy Berbille Zhong lin Wang Wei Tang CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China Georgia Institute of Technology AtlantaGA 30332-0245USA

Chemical functional groups on solid surfaces greatly influence contact electrification(CE)at water–solid *** studies of their effects mainly swapped materials or bonded related molecules to a substrate,introducing other factors of *** work aims at unambiguously demonstrating the role of functional groups in water-polymer *** study the contribution of functional groups,by using ion coupled plasma etching to modify a high-density polyethylene(HDPE)film,a polymer with a naturally quasi-null charge transfer ***(HDPE–F)and hydroxyl(HDPE–OH)functional groups are generated and endowed HDPE with charge withdrawing ***–F withdraws 2.5–2.7 times more charges than HDPE–***,the surface charges accumulated generate electrostatic forces,altering the droplets *** phenomenon provides another approach to study CE,helping to evaluate the contribution of electrons to solid–liquid ***,employing HDPE–F to perform contact-electro-catalysis shows its activity is 2.4 times higher than that of commercial fluorinated films.

关键词： contact-electro-catalysis charge transfer solid–liquid interfaces contact electrification

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Cooperative Anti-Jamming and Interference Mitigation for UAV Networks: A Local Altruistic Game Approach

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China Communications 2024年第2期21卷 183-196页

作者： Yueyue su Nan Qi Zanqi Huang Rugui Yao Luliang jia College of Electronic Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China School of Space Information Space Engineering UniversityBeijing 101416China

To improve the anti-jamming and interference mitigation ability of the UAV-aided communication systems, this paper investigates the channel selection optimization problem in face of both internal mutual interference and external malicious jamming. A cooperative anti-jamming and interference mitigation method based on local altruistic is proposed to optimize UAVs’ channel selection. Specifically, a Stackelberg game is modeled to formulate the confrontation relationship between UAVs and the jammer. A local altruistic game is modeled with each UAV considering the utilities of both itself and other UAVs. A distributed cooperative anti-jamming and interference mitigation algorithm is proposed to obtain the Stackelberg equilibrium. Finally, the convergence of the proposed algorithm and the impact of the transmission power on the system loss value are analyzed, and the anti-jamming performance of the proposed algorithm can be improved by around 64% compared with the existing algorithms.

关键词： channel selection cooperative antijamming and interference mitigation local altruistic game Stackelberg game unmanned aerial vehicle(UAV)

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