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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 945-967页

作者： jia-Li Hu Mei-Jin Huang Halike Halina Kun Qiao Zhi-Yuan Wang jia-jie lu Cheng-Liang Yin Feng Gao Department of Gastroenterology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Digestive Disease Urumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Oncology 920th Hospital of PLA Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination *** is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of *** also affects the prognosis of GC *** reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour ***,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still *** To investigate inflammatory-related biomarkers in predicting the prognosis of GC *** constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO *** patients from the GSE26253 cohort were used for *** and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was *** calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the *** decision curve analysis results were plotted to quantify and assess the clinical value of the *** set enrichment analysis was performed to explore the potential regulatory pathways *** relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and ***,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy *** A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was *** prognostic analysis revealed that the risk score was a separate prognostic factor in GC *** to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group ha

关键词： Gastric cancer Inflammation Immune infiltration Prognosis signature Subt

Retrospective analysis of patients with hepatocellular carcinoma complicated with human immunodeficiency virus infection after hepatectomy

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3851-3864页

作者： jia-jie lu Shuai Yan Lin Chen Lin-Ling Ju Wei-Hua Cai Jin-Zhu Wu Department of Hepatobiliary Surgery Nantong Third People's HospitalMedical School of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Medical School Nantong UniversityNantong 226300Jiangsu ProvinceChina Institute of Liver Disease Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Hepatobiliary Surgery Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer death worldwide,with a 5-year relative survival rate of approximately 18%.The similarity between incidence and mortality(830000 deaths per year)underscores the bleak prognosis associated with the *** is the fourth most common malignancy and the second leading cause of cancer death in *** patients with HCC have a history of chronic liver disease such as chronic hepatitis B virus(HBV)or hepatitis C virus(HCV)infection,alcoholism or alcoholic steatohepatitis,nonalcoholic fatty liver disease,or nonalcoholic *** diagnosis and effective treatment are the keys to improving the prognosis of patients with *** the total number of human immunodeficiency virus(HIV)-infected patients is declining globally the incidence of HCC is increasing in HIVinfected patients,especially those who are coinfected with HBV or *** a result,people infected with HIV still face unique challenges in terms of their risk of developing *** To investigate the survival prognosis and clinical efficacy of surgical resection in patients with HCC complicated with HIV *** The clinical data of 56 patients with HCC complicated with HIV admitted to the Third Affiliated Hospital of Nantong University from January 2013 to December 2023 were retrospectively *** these,27 patients underwent hepatectomy(operation group)and 29 patients received conservative treatment(nonoperation group).All patients signed informed consents in line with the provisions of medical *** general data,clinicopathological features and prognoses for the patients in the two groups were analyzed and the risk factors related to the prognoses of the patients in the operation group were *** The median disease-free survival(DFS)and overall survival(OS)of HIV-HCC patients in the surgical group were 13 months and 17 months,respectively,and the median OS of patients in the nonsurgic

关键词： Hepatocellular carcinoma Human Immunodeficiency virus Liver resection Retrospective analysis Prognosis

Clinical characteristics of sentinel polyps and their correlation with proximal colon cancer: A retrospective observational study

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World Journal of Clinical Cases 2019年第20期7卷 3217-3225页

作者： Man Wang jia-jie lu Wen-jie Kong Xiao-Jing Kang Feng Gao Department of Gastroenterology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina

BACKGROUND Colorectal cancer is a common malignant tumor of the digestive *** relationship between sentinel polyps(rectal polyps with proximal colon cancer)and proximal colon cancer has received extensive attention in recent ***,there is still no clear conclusion regarding the *** To investigate the clinical characteristics of sentinel polyps and their correlation with proximal colon *** A retrospective analysis of 2587 patients with rectal polyps from January 2006 to December 2017 was *** to whether or not proximal colon cancer was diagnosed,the patients were divided into either a sentinel polyp group(192 patients)or a pure rectal polyp group(2395 patients).The endoscopic features,clinicopathological features,therapeutic effects,and short-term prognosis were analyzed and compared between the two *** The mean age of patients in the sentinel polyp group was generally higher than that of the pure rectal polyp group,and the positivity rates of anemia,stool occult blood,and tumor markers of the sentinel polyp group were also significantly higher than those in the rectal polyp group(χ^2=90.56,P<0.01;χ^2=70.30,P<0.01;χ^2=92.80,P<0.01).The majority of the patients in the sentinel polyp group had multiple polyps,large polyps,adenomatous polyps,or sessile polyps(χ^2=195.96,P<0.01;χ^2=460.46,P<0.01;χ^2=94.69,P<0.01;χ^2=48.01,P<0.01).Most of the proximal colon cancers were Duke’s A and B stages in the sentinel polyp *** the pure rectal polyp group,2203 patients underwent endoscopic treatment,and all of the patients were cured and *** the sentinel polyp group,65 patients underwent radical operation,and 61 patients received endoscopic submucosal dissection or endoscopic mucosal ***,21 patients were lost to follow-up after 6-12 mo,and the loss rate was 10.94%.A total of 63.16%of patients experienced remission without tumor recurrence or metastasis,33.33%of patients experienced tum

关键词： Sentinel polyps Rectal polyps Proximal colon cancer Ascending colon cancer Transverse colon cancer

Association of Helicobacter pylori infection with colorectal polyps and malignancy in China

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 582-591页

作者： Man Wang Wen-jie Kong Jing-Zhan Zhang jia-jie lu Wen-jia Hui Wei-Dong Liu Xiao-Jing Kang Feng Gao Department of Gastroenterology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina

BACKGROUND Gastric Helicobacter pylori(***)infection is related to chronic gastritis,gastroduodenal ulcer,and gastric malignancies;whether this infection is related to colorectal polyps and colorectal cancer(CRC),remains *** To investigate the relationship between gastric *** infection and the risk of colorectal polyps and *** We retrospectively analyzed 3872 patients with colorectal polyps who underwent colonoscopy and pathological *** also analyzed 304 patients with primary *** characteristics of these patients were compared with those of the control group,which included 2362 patients with the normal intestinal *** subjects completed a 14C-urea breath test,bidirectional gastrointestinal endoscopy,and a biopsy on the same *** on the number,size,location,and pathology of the polyps,the location,and pathology of the CRC,the detection of ***,and the incidence of ***-associated atrophic gastritis or intestinal metaplasia were obtained.A logistic regression model was used to analyze the relationship between gastric infection due to ***,and the incidence of colorectal polyps and *** The prevalence of *** infection was higher in the multiple polyps group than in the solitary polyp group and the control group[95%confidence interval(CI)=1.02-1.31,P=0.03;95%CI:2.12-2.74,P<0.001].The patients with adenomatous polyps had a higher incidence of *** infection than patients with non-adenomatous polyps[59.95%vs 51.75%,adjusted odds ratio(OR)=1.41,95%CI:1.24-1.60,P<0.01].Patients with ***-associated atrophic gastritis or intestinal metaplasia were at high risk of CRC(adjusted OR=3.46,95%CI:2.63-4.55,P<0.01;adjusted OR=4.86,95%CI:3.22-7.34,P<0.01,respectively).The size and location of the polyps,the histopathological characteristics and the location of CRC were not related to *** *** Our study demonstrates that the incidence of gastric *** infection and ***-assoc

关键词： Helicobacter pylori Atrophic gastritis Intestinal metaplasia Polyps Colorectal cancer Gastrointestinal neoplasms

Embracing connected intelligence with the YuanOS architecture:one OS kit for all

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Frontiers of Computer Science 2024年第1期18卷 1-3页

作者： Haibo CHEN Ning jia jie YIN Institute of Parallel and Distributed Systems School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China OS Kernel Lab Huawei Technologies Co.Ltd.Beijing 100085China

Operating system abstracts hardware and creates application execution environment,and thus is the key pillar for IT *** its first invention in 1956,operating system has been evolved over three main stages:Mainframe,PC&Internet,Mobile Internet[1].Now,the entire society is firmly stepping towards the connected intelligence era[2],how should operating system be evolved to embrace this new era?

关键词： hardware execution connected

Epidemiological,clinical,and histological presentation of celiac disease in Northwest China

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World Journal of Gastroenterology 2022年第12期28卷 1272-1283页

作者： Man Wang Wen-jie Kong Yan Feng jia-jie lu Wen-jia Hui Wei-Dong Liu Zi-Qiong Li Tian Shi Mei Cui Zhen-Zhu Sun Feng Gao Department of Gastroenterology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Pathology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina

BACKGROUND Research on celiac disease(CD)in northwest China is still in its *** present,large-sample data on the epidemiological,clinical,and pathological characteristics of CD are *** To investigate the epidemiological,clinical,and pathological characteristics of CD in northwest *** The clinical data of 2884 patients with gastrointestinal(GI)symptoms were retrospectively *** immunoglobulin A(IgA)and anti-tissue transglutaminase(tTG)IgA levels were examined in all *** and colonoscopy were performed in patients with positive anti-tTG IgA and deficient total IgA *** of the duodenal and ileal villi was examined and histopathological examinations were *** modified Marsh–Oberhuber classification system was used to grade villous atrophy in the duodenum or distal *** patients’Helicobacter pylori(***)infection status was compared in terms of clinical presentation and Marsh *** analyses were performed using the t-test or chi-square *** Among the 2884 patients,73 were positive for serum anti-tTG IgA,and 50 were diagnosed with *** CD detection rate was significantly higher in Kazakhs(4.39%)than in Uyghurs(2.19%),Huis(0.71%),and Hans(0.55%).The main symptoms of CD were chronic diarrhea,anorexia,anemia,fatigue,weight loss,sleep disorders,osteopenia,and *** body mass index of patients with CD was significantly lower than that of patients without CD.A total of 69 patients with positive serum anti-tTG IgA and two patients with deficient total IgA levels underwent GI *** revealed crypt hyperplasia and/or duodenal villous atrophy,mainly manifested as nodular mucosal atrophy,grooves,and *** difference in *** infection rates was not statistically significant between CD and non-CD patients but was significantly different among CD patients with different Marsh *** Among the patients with GI symptoms in northwestern China,t

关键词： Celiac disease Epidemiology Gastrointestinal symptoms Pathology Helicobacter pylori infection

Molecular Ferroelastic Induced by Mono-/Double-Protonation Strategy

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Chinese Journal of Chemistry 2024年第15期42卷 1706-1712页

作者： jia-Qi luo Meng-Meng lun Qiang-Qiang jia Zhi-jie Wang Hai-Feng lu Yi Zhang Da-Wei Fu Institute for Science and Applications of Molecular Ferroelectrics Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal UniversityJinhuaZhejiang 321004China Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and Applications of Molecular FerroelectricsSoutheast UniversityNanjingJiangsu 211189China

Molecular ferroelastics with the natural features of mechanical flexibility and switchable spontaneous strain have attracted widespread attention in the scientific community due to their potential applications in tunable gratings,flexible memorizers,strain sensors,and intelligent ***,most designs of molecular ferroelastics remain in the stage of blind exploration,posing a challenge to achieve a functional ferroelastic more ***,we have successfully obtained a molecular ferroelastic,[Me_(2)NH(CH_(2))_(2)NH_(3)](ReO_(4))_(2)(Me_(2)NH(CH_(2))_(2)NH_(3)=N,N-dimethylethylenediammonium),under the guidance of the mono-/double-protonation ***_double-protonated[Me_(2)NH(CH_(2))_(2)NH_(3)](ReO_(4))_(2) undergoes a paraelastic-ferroelastic phase transition with the Aizu notation of 2/mFi at 322 ***,the theoretical calculation and experimental measurement simultaneously show that[Me_(2)NH(CH_(2))_(2)NH_(3)](ReO_(4))_(2) possesses good mechanical flexibility,because its elastic modulus(E)of 8.26 GPa and hardness(H)of 0.45 GPa are smaller than the average values of organic crystals(E of 12.05 GPa and H of 0.5 GPa),which makes it promising to apply in wearable pressure sensors,implantable medical sensors,high-precision tuners,*** work further enriches the molecular ferroelastic family and demonstrates that mono-/double-protonation is one of the effective molecular modification strategies for designing ferroelastics.

关键词： Molecular crystal Ferroelastic Mono-/double-protonation Mechanical flexibility Phase transition Crystal engineering Computational chemistry Molecular dynamics

Diophantine equations and Fermat's last theorem for multivariate(skew-)polynomials

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 159-173页

作者： PAN jie jia Yu-ming LI Fang School of Mathematical Sciences Zhejiang UniversityHangzhou 310058China Henan Experimental High School Zhengzhou 450003China

Fermat’s Last Theorem is a famous theorem in number theory which is diﬃcult to ***,it is known that the version of polynomials with one variable of Fermat’s Last Theorem over C can be proved very *** aim of this paper is to study the similar problems about Fermat’s Last Theorem for multivariate(skew)-polynomials with any characteristic.

关键词： Fermat's last theorem polynomial ring skew polynomial ring

The Relationship Between the Atmospheric Environment and Road Traffic Fatalities — Shandong Province, China, 2012–2021

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China CDC weekly 2024年第13期6卷 267-271页

作者： Tao Wang jie Chu Zhiying Yao Li Yang Zilong lu Ge Tian Xiaolei Guo Cunxian jia Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department for Chronic and Non-Communicable Disease Control and Prevention Shandong Center for Disease Control and PreventionJinanShandong ProvinceChina

Introduction:This study aims to analyze the potential impact of the meteorological environment and air pollutants on road traffic ***:Road traffic fatality data in Shandong Province from 2012 to 2021 were obtained from the Population Death Information Registration Management *** and air pollutant data for the same period were collected from the *** Oceanic and Atmospheric Administration and the Ecological Environment Monitoring Center of Shandong Province,***’s correlation and ridge regression were used to analyze the impact of the meteorological environment and air pollutants on road traffic ***:From 2012 to 2021,there were 163,863 road traffic fatality *** results of the ridge regression analysis showed that the daily average temperature was negatively correlated with total fatalities and passengers and positively correlated with pedestrians,nonmotorized drivers,and motorized *** daily minimum temperature was negatively correlated with total fatalities and positively correlated with motorized *** daily maximum temperature was positively correlated with both pedestrian and nonmotorized *** daily accumulated precipitation was negatively correlated with *** duration was positively correlated with both nonmotorized and motorized *** particulate matter(PM_(10))and nitrogen dioxide(NO_(2))were positively correlated with total fatalities,pedestrians,and nonmotorized *** dioxide(SO_(2))was positively correlated with total fatalities but negatively correlated with nonmotorized drivers,passengers,and motorized ***:Atmospheric factors associated with the occurrence of road traffic fatalities include air temperature,daily accumulated precipitation,sunshine duration,and air pollutants such as PM_(10),NO_(2),and SO_(2).

关键词： Ecological dioxide sunshine