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Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency catheter ablation

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Journal of Geriatric Cardiology 2024年第2期21卷 200-210页

作者： Qing YAN jia-Qi LIANG Yi-De YUAN Yuan LI jia-Li FAN Wen-Huan WU Pan XU jia-hong xue Department of Cardiovascular Medicine the Second Affiliated Hospital of Xi’an Jiaotong UniversityShaanxiChina Department of Cardiovascular Medicine Zichang People’s HospitalShaanxiChina Department of Ultrasound Xijing HospitalAir Force Military Medical UniversityShaanxiChina

BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin *** study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency catheter ablation(RFCA).METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an jiaotong University were included in this *** participants were grouped based on cumulative TyG index values tertiles within 3 months after *** regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF *** predictive value of all risk factors was assessed by receiver operating curve *** There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence increased with increasing cumulative TyG index values *** adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)=4.949,95%CI:1.778–13.778,P=0.002]and the high cumulative TyG index group(HR=8.716,95%CI:3.371–22.536,P<0.001)had a higher risk of AF recurrence than those in the low cumulative TyG index *** restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulative TyG index *** considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)=0.847,95%CI:0.797–0.897,P<0.001].CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after *** longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.

关键词： atrial fibrillation index

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Phosphatidic Acid （PA） PP2A Activity and PIN1 Binds PP2AA1 to Regulate Polar Localization

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Molecular Plant 2013年第5期6卷 1692-1702页

作者： hong-Bo Gao Yu-jia Chu hong-Wei xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chineseacademy of Sciences 200032 Shanghai People's Republic of China

Phospholipase D （PLD） exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid （PA）. Protein kinases and phosphatases, such as mammalian target of rapa- mycin （mTOR）, Protein Phosphatase 1 （PP1） and Protein Phosphatase 2C （PP2C）, are PA-binding proteins that execute crucial regulatory functions in both animals and plants. PA participates in many signaling pathways by modulating the enzymatic activity and/or subcellular localization of bound proteins. In this study, we demonstrated that PLD-derived PA interacts with the scaffolding A1 subunit of Protein Phosphatase 2A （PP2A） and regulates PP2A-mediated PIN1 dephos- phorylation in Arabidopsis. Genetic and pharmacological studies showed that both PA and PP2A participate in the regu- lation of auxin distribution. In addition, both the phosphorylation status and polar localization of PIN1 protein were affected by PLD inhibitors, Exogenous PA triggered the membrane accumulation of PP2AA1 and enhanced the PP2A activity at membrane, while PLD inhibition resulted in the reduced endosomal localization and perinuclear aggregation of PP2AA1. These results demonstrate the important role of PLD-derived PA in normal PP2A-mediated PIN dephosphoryl- ation and reveal a novel mechanism, in which PA recruits PP2AA1 to the membrane system and regulates PP2A function on membrane-targeted proteins. As PA and PP2A are conserved among eukaryotes, other organisms might use similar mechanisms to mediate multiple biological processes.

关键词： phosphatidic acid (PA) PP2A PIN1 phosphorylation polar localization.

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Surface-induced Microstructure and Performance Changes in P3HT Ultrathin Films

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Chinese Journal of Polymer Science 2024年第6期42卷 805-814页

作者： hong-Tao Shan jia-Xin He Bing-Yan Zhu xue-Ting Cao Ying-Ying Yan jian-Jun Zhou hong Huo Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing100875China

In this work,poly(3-hexylthiophene)(P3HT)ultrathin films(P3HT-T)were prepared by spin-coating a dilute P3HT solution(in a toluene:o-dichlorobenzene(Tol:ODCB)blend with a volume ratio of 80:20)with ultrasonication and the addition of the nucleating agent bicycle[2.2.1]heptane-2,3-dicarboxylic acid disodium salt(HPN-68L)on glass,Si wafers and indium tin oxide(ITO)*** electrical and mechanical properties of the P3HT-T ultrathin films were investigated,and it was found that the conductivity and crack onset strain(COS)were simultaneously improved in comparison with those of the corresponding pristine P3HT film(P3HT-0,without ultrasonication and nucleating agent)on the same substrate,regardless of what substrate was ***,the conductivity of P3HT-T ultrathin films on different substrates was similar(varying from 3.7 S·cm^(-1)to 4.4 S·cm^(-1)),yet the COS increased from 97%to 138%by varying the substrate from a Si wafer to *** grazing-incidence wide-angle X-ray diffraction(GIXRD),UV-visible(UV-Vis)spectroscopy and atomic force microscopy(AFM),we found that the solid order and crystallinity of the P3HT-T ultrathin film on the Si wafer are highest,followed by those on glass,and much lower on ***,the surface energy and roughness of three substrates were investigated,and it was found that the polar component of the surface energyγp plays a critical role in determining the crystalline microstructures of P3HT ultrathin films on different *** work indicates that the P3HT ultrathin film can obviously improve the stretchability and simultaneously retain similar electrical performance when a suitable substrate is *** findings offer a new direction for research on stretchable CP ultrathin films to facilitate future practical applications.

关键词： P3HT ultrathin film Substrate Crystalline microstructures Polar component of the surface energy Electrical and stretchable performances

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Interplay between Microscopic Structures and Macroscopic Viscoelastic Properties of Polyampholyte Gels

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Chinese Journal of Polymer Science 2024年第9期42卷 1360-1367,I0008页

作者： You-Cai xue Yi-Ming Yang Di jia Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Polyampholyte gels,which have hierarchical structures,exhibit excellent self-healing properties and have great promise for biomaterials and *** investigated the relationship between microscopic structures and macroscopic viscoelastic properties of polyampholyte gels and found three factors influencing their viscoelastic properties,including the chemical crosslinking bonds,topological entanglements controlled by monomer concentration,and the ionic *** strength plays a major role on the strength of ionic bonds.A crossover point of elastic modulus and loss modulus was observed in the dynamic frequency sweeps at low monomer concentration or low chemical crosslinking density for gels with intermediate strength of ionic *** solid-liquid transition signaled by the crossover point is a typical feature of dynamic associated gels,representing the dynamical association-dissociation of the ionic bonds and full relaxation of the topological entanglements in the gel *** the crossover point disappears when the ionic bonds are too weak or too strong to form“permanent”***,in the non-linear yielding measurement,gels with intermediate strength of the ionic bonds are ductile and yield at very large shear strain due to the self-healing properties and the dynamic association-dissociation of the ionic *** the self-healing properties disappear when the ionic bond strength is too weak or too *** work reveals the mechanism of how the dynamic association-dissociation of ionic bonds influences both the linear and non-linear viscoelastic properties of the polyampholyte gels.

关键词： Polyampholyte gel Ionic bond Topological entanglement Self-healing Hierarchical structure

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“逍遥”的字源意象与“道”之三位一体

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河北学刊 2020年第3期40卷 108-113页

作者：贾学鸿扬州大学文学院江苏扬州225002

"逍遥"是《庄子》对理想人生的描述,其概念意涵却不确定。汉晋以前的典籍"逍遥"与"消摇"并存,从字源考察,其词义内核中有先民制陶流程的投影。"逍遥"的各种歧解,或都关涉陶艺事象的某个侧面。"鲲鹏"寓言是作者阐述"逍遥"内涵的创造,隐... 详细信息

"逍遥"是《庄子》对理想人生的描述,其概念意涵却不确定。汉晋以前的典籍"逍遥"与"消摇"并存,从字源考察,其词义内核中有先民制陶流程的投影。"逍遥"的各种歧解,或都关涉陶艺事象的某个侧面。"鲲鹏"寓言是作者阐述"逍遥"内涵的创造,隐喻的是天地之气,透射着《庄子》对宗教神的怀疑。大鹏"抟扶摇而上"是无为随化、顺势旋升、混同万物、不辩小大的道性显现。鲲鹏、逍遥、道三位一体。"逍遥"意蕴的发散性,与《易传》"取物观象"的思维模式一致。"逍遥"意象的整体直观特点与逻辑概念的抽象性疏离,但表现无所不包、不可言说的本体之道,具有独特的优势。

关键词：逍遥字源意象陶艺事象天地隐喻三位一体

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“鸡鸣”古歌与班固《咏史》典故源流考

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山西大学学报(哲学社会科学版) 2023年第1期46卷 38-45页

作者：贾学鸿扬州大学文学院

班固《咏史》诗通过叙写“缇萦救父”故事抒发自身感慨，并将缇萦的形象凝缩在“鸡鸣”古歌的典故中。借“鸡鸣”意象抒发情感源于《诗经》,其中郑风《女曰鸡鸣》以“鸡鸣”交代谈话时间，《风雨》通过风雨中的鸡鸣起兴，《齐风·鸡鸣... 详细信息

班固《咏史》诗通过叙写“缇萦救父”故事抒发自身感慨，并将缇萦的形象凝缩在“鸡鸣”古歌的典故中。借“鸡鸣”意象抒发情感源于《诗经》,其中郑风《女曰鸡鸣》以“鸡鸣”交代谈话时间，《风雨》通过风雨中的鸡鸣起兴，《齐风·鸡鸣》和《小雅·庭燎》则保存着周代“鸡人呼旦”的礼乐仪式信息。司时卫士模拟鸡鸣报时，曲调雄壮高亢，直到汉代军中和宫廷依然沿用，并配乐收入乐府，但也带来曲调和风格的分化。《史记·项羽本纪》的“四面楚歌”,或是军中“鸡鸣歌”的变调。楚调激昂凄婉，与缇萦的急切心情相契合。“鸡鸣”典故承载着班固的激情，也凸显出班诗内敛、含蓄的学者型诗风。将事象、文化背景融入一个名词性典故，是汉代文人诗叙事兼抒情的艺术特色，也是汉诗由实用性向审美性的过渡。钟嵘评价《咏史》“质木无文”,是基于南朝的审美观念，有失公允。

关键词：鸡鸣歌礼乐《诗经》《咏史》用典

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《尧典》与《逍遥游》对炎帝部落文化的关联性叙事

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山西大学学报(哲学社会科学版) 2017年第1期40卷 1-8页

作者：贾学鸿扬州大学文学院

《尚书·尧典》和《庄子·逍遥游》对于帝尧禅让所作的叙述,是两种不同的流传版本,《逍遥游》尧让天下于许由的寓言,是《尧典》中尧向四岳禅让历史的投影。《逍遥游》中的四子,是由《尧典》中的四岳转换而来。历史上的四岳,是炎帝部落... 详细信息

《尚书·尧典》和《庄子·逍遥游》对于帝尧禅让所作的叙述,是两种不同的流传版本,《逍遥游》尧让天下于许由的寓言,是《尧典》中尧向四岳禅让历史的投影。《逍遥游》中的四子,是由《尧典》中的四岳转换而来。历史上的四岳,是炎帝部落的四位首领,也是四大部落后裔所居之山的名称。炎帝部族的高山崇拜与祖先崇拜结合在一起,山神同时也是祖先神。帝舜指派炎帝后裔伯夷为秩宗,应出于祭祀四大名山的需要。《逍遥游》中的藐姑射山及其神人,是对炎帝部族高山崇拜的改造。

关键词：《尚书·尧典》《庄子·逍遥游》炎帝文化关联节点艺术改造

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《诗经》政治批判诗对先秦星象观的吸纳与解构——试析《小雅·大东》的星象描写

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山西大学学报(哲学社会科学版) 2018年第1期41卷 16-24页

作者：贾学鸿扬州大学文学院

依天象定人事是上古敬天思想的反映。《诗经》中约有百分之五的篇目谈到星象,其中政治批判诗《小雅·大东》涉及的星象众多。《大东》对星象的描写主要有三种方式,并与诗作所抒发的情感相对应。一是直赋其事,寄托失落、责难之情。二是... 详细信息

依天象定人事是上古敬天思想的反映。《诗经》中约有百分之五的篇目谈到星象,其中政治批判诗《小雅·大东》涉及的星象众多。《大东》对星象的描写主要有三种方式,并与诗作所抒发的情感相对应。一是直赋其事,寄托失落、责难之情。二是循名责实,由星象名称联想到它应有而实际不具备的功能,表达的是嘲笑与讽刺。三是根据星宿的形状作形象的比喻,表达对社会不公的愤怒。三种展示方式使情感的表现力度呈盘升走势。诗中斗星的"西柄之揭",凸显诗歌的秋怨主题。《大东》对星象的艺术化呈现,与先秦星象家所作的描述形成巨大反差,折射出周王朝的衰落,以及人们对星象崇拜观念的质疑与解构。

关键词：《诗经·大东》星象描写政治批判情感颠覆

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《诗经》月意象的赋比兴书写琐议

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山西大学学报(哲学社会科学版) 2019年第6期42卷 47-52页

作者：贾学鸿扬州大学文学院

《诗经》书写月亮意象兼用赋、比、兴三种方式。以月赋事,涉及时间的物化与抽象,通过展现月亮的某种属性,表达特定时间、心理时间或不确定的时间,实现叙事性章节的纪时功能,或暗示事件背景、抒发个性化情感。月作为喻体,借助月光的皎洁... 详细信息

《诗经》书写月亮意象兼用赋、比、兴三种方式。以月赋事,涉及时间的物化与抽象,通过展现月亮的某种属性,表达特定时间、心理时间或不确定的时间,实现叙事性章节的纪时功能,或暗示事件背景、抒发个性化情感。月作为喻体,借助月光的皎洁、灵动和月亮运行的明暗圆缺、周而复始,彰显生命哲学理念。以月起兴,从月意象的正反两重意义着眼,或抒发忧愁怨恨,或烘托美貌,凸显出先民思维的发散性、贯通性与含蓄性。"月离于毕"被视为降雨征兆,是把月亮和水划入同一系列,与《周易》有相通之处。月食被看作灾异,承载的是天人感应观念。开掘《诗经》深韵,须从诗句之本义切入。

关键词：诗经月意象赋比兴文本义

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Climatic impacts induced by winter wheat irrigation over North China simulated by the nonhydrostatic RegCM4.7

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Advances in Climate Change Research 2024年第2期15卷 197-210页

作者： jia WU Zhen-Yu HAN xue-Jie GAO Zheng-jia LIU National Climate Centre China Meteorological AdministrationBeijing 100081China Key Laboratory for Climate Studies China Meteorological AdministrationBeijing 100081China Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China

Quantification of the impact of winter wheat irrigation on the climate and the occurrence of extreme climatic events over North China is crucial for regional adaptation *** related studies mainly focused on the impact on surface processes;however,few focused on the effects of extreme events using high-resolution nonhydrostatic regional climate ***,the 9-km-resolution nonhydrostatic RegCM4.7 was coupled with a crop irrigation scheme and an updated winter wheat irrigation dataset to better simulate irrigation *** experiments were conducted with and without winter wheat irrigation to isolate the effects of *** showed that irrigation simulation reduces the model biases in temperature,precipitation,latent heat flux,soil moisture,sensitive heat flux,and top-layer soil ***,it also reduces the bias and increases the correlation with observations obtained in irrigated areas,especially in summer,indicating better representation of irrigation *** wheat irrigation tends to cause substantial cooling of the local surface maximum,minimum,and mean air temperatures(by-1.68,-0.34,and-0.79℃,respectively)over irrigated areas of North China,with the largest changes observed in relation to maximum ***,precipitation is found to increase during spring and summer,which is strongly related to water vapor transport in the lower levels of the *** analyses indicated that the number of annual mean hot days decrease(-13.9 d),whereas the number of both comfort days(+10.2 d)and rainy days(days with total precipitation greater than 1 mm:+6.6 d)increase over irrigated areas,demonstrating beneficial feedback to human perception and ***,although the heat wave risk increases(number of annual mean heat wave days:+5.8 d),the impact is limited to small areas within irrigated ***,no notable change was found in terms of heavy rainfall events and precipitation intensity

关键词： Nonhydrostatic regional climate model Irrigation effect Extreme events North China

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