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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-jia yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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社会工作参与民族地区乡村振兴研究

安徽农业科学 2024年第14期52卷 250-256页

作者：杨承钢杨佳佳安徽师范大学法学院安徽芜湖241000 哈尔滨学院文法学院黑龙江哈尔滨150086

乡村振兴战略是中华民族伟大复兴历史征程中的重大任务,对推进农业农村现代化和实现共同富裕等都具有十分重要的意义。尤其是部分民族地区,乡村经济社会发展相对滞后,已成为乡村振兴的重点和难点。从社会工作参与的角度,分析了民族地区... 详细信息

乡村振兴战略是中华民族伟大复兴历史征程中的重大任务,对推进农业农村现代化和实现共同富裕等都具有十分重要的意义。尤其是部分民族地区,乡村经济社会发展相对滞后,已成为乡村振兴的重点和难点。从社会工作参与的角度,分析了民族地区乡村振兴的探索实践并进行反思,论述了社会工作参与的必要性与可行性,进而提出具体路径:立足发展思维,培育乡村人才;运用情感逻辑,参与乡村治理;利用优势视角,共建乡村文化。

关键词：社会工作民族地区乡村振兴

植物营养素(复合寡糖)对滴灌水果番茄生长和土壤酶活性的影响

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节水灌溉 2024年第6期 121-127页

作者：韩雨禄尹娟杨震范家杨李升宁夏大学土木与水利工程学院银川750021 旱区现代农业水资源高效利用教育部工程中心银川750021 宁夏节水灌溉与水资源调控工程技术研究中心银川750021

为了摸清采用不同施量的植物营养素(复合寡糖)和灌溉定额对温室水果番茄生长、产量、品质及土壤酶活性的影响。试验在温室中种植水果番茄品种“嘉红100”,设置3个灌溉定额:5550 m^(3)/hm^(2)(W1)、6375 m^(3)/hm^(2)(W2)、7200 m^(3)/hm... 详细信息

为了摸清采用不同施量的植物营养素(复合寡糖)和灌溉定额对温室水果番茄生长、产量、品质及土壤酶活性的影响。试验在温室中种植水果番茄品种“嘉红100”,设置3个灌溉定额:5550 m^(3)/hm^(2)(W1)、6375 m^(3)/hm^(2)(W2)、7200 m^(3)/hm^(2)(W3)和3个复合寡糖施用量:168 g/hm^(2)(P1)、336 g/hm^(2)(P2)、504 g/hm^(2)(P3),CK处理作为对照组,总共10个处理,测定并分析不同处理对水果番茄生长、产量、品质和成熟期土壤中相关酶活性的影响。结果表明,灌溉定额和复合寡糖对水果番茄的生长有着一定的促进作用。水果番茄产量和灌溉水利用效率随着灌溉定额和复合寡糖的增加而增加,灌溉定额过高,会导致品质降低。在试验条件下,当灌水定额一定时,复合寡糖施用的越多,对产量和品质的提升越有利。对于土壤中的脲酶,复合寡糖用量的增加会提高其酶活性,P3用量的复合寡糖效果最好,灌溉定额过多会降低其活性;对于蔗糖酶,W2P1处理的蔗糖酶活性最高,酶活性随灌溉定额的增加先升高后降低。综上所述,推荐宁夏吴忠地区温室水果番茄种植采用的水-植物营养素耦合模式为W2P3(灌溉定额6375 m^(3)/hm^(2),复合寡糖504 g/hm^(2))。

关键词：复合寡糖温室滴灌番茄生长品质酶活性水-植物营养素耦合

基于自回归小波神经网络的机械臂自适应滑模控制

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空间控制技术与应用 2024年第3期50卷 68-76页

作者：杨佳吴佩林杨理寇东山余斌重庆理工大学重庆400054 重庆市能源互联网工程技术研究中心重庆400054

针对机械臂存在模型不确定和未知扰动的问题,提出一种动力学模型参数分块逼近的神经网络非奇异终端滑模(nonsingular terminal sliding mode, NTSM)控制方法.为加快系统跟踪误差的收敛速度,避免传统终端滑模存在的奇异性问题,采用一种... 详细信息

针对机械臂存在模型不确定和未知扰动的问题,提出一种动力学模型参数分块逼近的神经网络非奇异终端滑模(nonsingular terminal sliding mode, NTSM)控制方法.为加快系统跟踪误差的收敛速度,避免传统终端滑模存在的奇异性问题,采用一种非奇异终端滑模面.利用多组自回归小波神经网络(self-recurrent wavelet neural network, SRWNN)分块逼近系统未知的动力学模型参数,并采用自适应更新律调整权重.通过积分控制项补偿SRWNN的逼近误差,并使用Lyapunov稳定性理论证明了系统稳定性.使用MATLAB进行仿真分析,分块SRWNN滑模控制与滑模控制、整体SRWNN滑模控制相比,关节角度跟踪误差的平均稳态误差分别降低了31.9%、76.5%,表明此方法是一种可靠、有效的轨迹跟踪控制方法.

关键词：自回归小波神经网络非奇异终端滑模动力学模型轨迹跟踪

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小批量多返工生产系统瞬态性能分析和优化

控制与决策 2024年第8期39卷 2746-2754页

作者：贾之阳倪泽军王遵君王钢北京理工大学自动化学院北京100081

随着智能制造和绿色制造战略的提出,实际生产对小批量定制化加工的需求日益增加,同时为了进一步提高生产制造的加工效率和产品质量,返工生产线在企业中的应用也日益频繁.基于小批量生产背景,针对应用随机故障机器和有限缓冲区的多返工... 详细信息

随着智能制造和绿色制造战略的提出,实际生产对小批量定制化加工的需求日益增加,同时为了进一步提高生产制造的加工效率和产品质量,返工生产线在企业中的应用也日益频繁.基于小批量生产背景,针对应用随机故障机器和有限缓冲区的多返工生产系统,进行瞬态性能分析,并对多返工系统进行生产调度.为定量分析该生产系统的瞬态性能,通过马尔科夫分析方法建立系统的数学模型,提出一种动态的分解和聚合算法来预测系统的生产率、消耗率、在制品库存等瞬态性能指标,并基于仿真对比实验验证所提出算法的精确性和有效性.此外,针对返工生产系统在劳动力有限的情景下,采用优化算法对各机器效率进行合理分配来优化系统的生产性能.最后,根据劳动力分配实验结果总结分配策略,为该系统的生产运行提供决策支持.

关键词：生产系统返工生产伯努利机器瞬态分析

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初中历史结构化教学的基本理念与实现路径

教学与管理 2024年第1期 55-58页

作者：严立明杨佳攀福建省长汀县馆前中学福建龙岩366306 福建省龙岩市教育科学研究院福建龙岩361000

“碎片化知识”既不利于学生自主建构认知体系,又影响学生学科核心素养的培育。结构化教学是化解“碎片化教学”的有效措施。在结构化教学基本理念的指导下,历史结构化教学可从以下几个方面开展:一是融通素养内涵,确定整体化目标;二是... 详细信息

“碎片化知识”既不利于学生自主建构认知体系,又影响学生学科核心素养的培育。结构化教学是化解“碎片化教学”的有效措施。在结构化教学基本理念的指导下,历史结构化教学可从以下几个方面开展:一是融通素养内涵,确定整体化目标;二是整合教学内容,建构系列化知识;三是聚焦学习主题,设计逻辑化问题;四是触发学习动力,实施体系化评价。

关键词：初中历史结构化教学知识结构化

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng jia-Cong Liu Xing-Bo Han Jin-Ling Qi jia Huang Ke-Ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen jian-jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu jia-Wei yang Xue-Juan yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Anion-induced electrolyte chemistry enables high energy density primary battery for ultralow-temperature conditions

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Science China Chemistry 2024年

作者： Zi-Hang Xue Hao-Jie Liang Yong-Li Heng jia-Lin yang Edison Huixiang Ang Hong-Yan Lü Hong Yu Dong-Mei Dai Dai-Huo Liu Chuan-Yu Zheng Wei Guo Xing-Long Wu Department of Chemistry Northeast Normal University MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal University Natural Sciences and Science Education National Institute of Education Nanyang Technological University State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials Northwestern Polytechnical University School of Chemistry and Chemical Engineering Henan Normal University Key Laboratory of Organo-Pharmaceutical Chemistry of jiangxi Province Gannan Normal University

Lithium/fluorinated-carbon（Li/CFx） primary batteries are widely used in defense and military fields due to their stable discharge plateau, low self-discharge rate, and adaptability across a wide temperature range. However, enhancing their overall energy density and discharge capacity at low temperatures remains a critical challenge. Herein, we report a strategically designed LiBF4-based sulfite/carboxylate electrolyte, where the anion-involved solvation structure significantly enhances electrochemical kinetics by reducing the desolvation barrier. Simultaneously, it introduces a radical reaction mechanism that contributes to additional capacity. As a result, the Li/CFxprimary batteries with this formulated electrolyte deliver a specific capacity of 2,257.15 mAh g-1at 25 °C. More importantly, when operating at -40 °C, the batteries exhibit an exceptionally high discharge capacity of 1,549.4 m Ah g-1and an energy density of 2,868.6 Wh kg-1. Even at -60 °C, the Li/CFxcells achieve a specific capacity of 444.3 mAh g-1and an energy density of 821.8 Wh kg-1at 0.1 C, significantly outperforming previously reported organic-based liquid electrolytes. This work offers a viable strategy for enhancing the specific capacity and energy density of primary batteries in extreme environments, providing valuable insights for future developments.

关键词：

突发公共卫生事件视域下北京市公共卫生人力资源建设现状研究

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中国全科医学 2024年第31期27卷 3919-3925页

作者：顾梅赵宁李进杨佳首都医科大学公共卫生学院北京市100069

背景公共卫生人力资源建设是完善公共卫生体系、提高突发公共卫生事件应急处理能力的关键。目的分析突发公共卫生事件发生后北京市公共卫生人力资源建设现状、优势与不足,提出完善北京市公共卫生人力资源建设的对策建议。方法于2022年6... 详细信息

背景公共卫生人力资源建设是完善公共卫生体系、提高突发公共卫生事件应急处理能力的关键。目的分析突发公共卫生事件发生后北京市公共卫生人力资源建设现状、优势与不足,提出完善北京市公共卫生人力资源建设的对策建议。方法于2022年6—9月,从《北京市卫生机构人力基本信息调查表》《北京市社区卫生工作统计资料汇编》中收集2016—2021年的公共卫生人员数量及年龄、学历、职称等信息,分析突发公共卫生事件发生后北京市专业和基层公共卫生人力资源的数量、结构及配置情况。结果2019—2021年,北京市专业公共卫生机构公共卫生人员总数由15157人增至16048人,具有研究生学历的人员占比增长0.93个百分点,拥有高、中级职称的人员占比分别增长2.29、3.87个百分点;基层公共卫生人员总数由3701人增至4017人,具有本科及以上学历的人员占比增长5.36个百分点,拥有高、中级职称的人员占比分别增长0.72、1.70个百分点。2019—2021年,每万常住人口疾控力量配比由1.68人降至1.57人,每千常住人口专业公共卫生机构卫生人员数由0.70人增至0.73人,每万人口基层公共卫生人员数由1.72人增至1.84人。结论突发公共卫生事件发生后,北京市公共卫生人力资源总量增长,人员配备缺口尚存,公共卫生机构梯队建设强化,各机构人力资源质量不均衡,公共卫生人力职称结构趋于合理。建议明确公共卫生人员配置标准,补齐公共卫生人力资源缺口;优化公共卫生人才培养模式,提升公共卫生人力资源质量;完善公共卫生人力发展保障机制,吸引并留住人才。

关键词：公共卫生卫生人力初级卫生保健人才结构北京