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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Broadband Acoustic Meta-structures Fabricated by Additive Manufacturing

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材料导报 2020年第11期34卷 11001-11002页

作者： jia xiao HONG Minghui YAN Ming Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3117583Singapore

Acoustic meta-structures,because of their flexible and unprecedented proprieties,such as negative dynamic density,negative bulk modulus and refractive index of negative,near-zero or extremely large value,enable new applications to manipulate sound waves propagation and control energy transfer[1].Over the past decades,the development of acoustic meta-structures has not only provided advanced functionalities but also tackled the problem of limited device ***,the meta-structures are explored based on two different kinds of unit cells:locally resonant and non-resonant *** acoustic components with the Helmholtz resonator[2],membrane structure[3]or other structured composites were investigated to realize local *** this circumstance,their resonant behaviors are sensitive to the frequency,where the desirable properties can be obtained in the vicinities of the resonant ***,they suffer from the inherent“narrow band”,resulting in large sound attenuation when the frequency is off *** the non-resonant meta-structures,the unit cell with convoluted waveguides such as space-coiling sound channels[4],labyrinthine[5]or tapered structures[6]were proposed to achieve unusual effective properties over a wider ***,the impedance mismatch between the meta-structure and the environmental fluid leads to a large energy reflection and sound attenuation inside the waveguides due to thermo-viscous loss in the narrow sound ***,it is still an open problem in both industry and academia to optimize the broadband performance of the meta-structure devices.

关键词： narrow sound sizes

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Resilience assessment and optimization method of city road network in the post-earthquake emergency period

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 765-779页

作者： Wang Haoran xiao jia Li Shuang Zhai Changhai Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information TechnologyHarbin Institute of TechnologyHarbin 150090China

The post-earthquake emergency period,which is a sensitive time segment just after an event,mainly focuses on saving life and restoring social *** improve the seismic resilience of city road networks,a resilience evaluation method used in the post-earthquake emergency period is *** road seismic damage index of a city road network can consider the influence of roads,bridges and buildings along the roads,*** road capacity after an earthquake.A function index for a city road network is developed,which reflects the connectivity,redundancy,traffic demand and traffic function of the *** optimization model for improving the road repair order in the post-earthquake emergency period is also developed according to the resilience evaluation,to enable decision support for city emergency management and achieve the best seismic resilience of the city road *** optimization model is applied to a city road network and the results illustrate the feasibility of the resilience evaluation and optimization method for a city road network in the post-earthquake emergency period.

关键词： city road network post-earthquake emergency period traffic demand resilience evaluation optimization model

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Zero-Magnetic-Field Spin Splitting of Polaron＇s Ground State Energy Induced by Rashba Spin-Orbit Interaction

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Communications in Theoretical Physics 2006年第4X期46卷 761-765页

作者： LIU jia xiao Jing-Ling College of Physics and Electromechanics Inner Mongolia University for Nationalities Tongliao 028043 China

We study theoretically the ground state energy of a polaron near the interface of a polar-polar semiconductor by considering the Rashba spin-orbit （SO） coupling with the Lee-Low-Pines intermediate coupling method. Our numerical results show that the Rashba SO interaction originating from the inversion asymmetry in the heterostructure splits the ground state energy of the polaron. The electron area/density and vector dependence of the ratio of the SO interaction to the total ground state energy or other energy composition are obvious. One can see that even without any external magnetic field, the ground state energy can be split by the Rashba SO interaction, and this split is not a single but a complex one. Since the presents of the phonons, whose energy gives negative contribution to the polaron＇s, the spin-splitting states of the polaron are more stable than electron＇s.

关键词： asymmetric heterostructures spintronics triangular potential approximation Rashba spin-orbit interaction

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Has LIGO detected primordial black hole dark matter?——tidal disruption in binary black hole formation

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Research in Astronomy and Astrophysics 2020年第11期20卷 303-311页

作者： Yuan Gao xiao-jia Zhang Meng Su Department of Physics The University of Hong KongHong Kong SARChina Department of Earth Sciences The University of Hong KongHong Kong SARChina Department of Physics and Laboratory for Space Research The University of Hong KongHong Kong SARChina

The frequent detection of binary mergers of^30 M⊙black holes(BHs)by the Laser Interferometer Gravitational-Wave Observatory(LIGO)rekindled researchers’interest in primordial BHs(PBHs)being dark matter(DM).In this work,we investigated PBHs distributed as DM with a monochromatic mass of 30 M⊙and examined the encounter-capture scenario of binary formation,where the densest central region of DM halo ***,we paid special attention to the tidal effect by the supermassive black hole(SMBH)*** doing so,we discovered a necessary tool called loss zone that complements the usage of loss *** found that the tidal effect is not prominent in affecting binary formation,which also turned out to be insufficient in explaining the totality of LIGO’s event rate estimation,especially due to a microlensing event constraining the DM fraction in PBH at the mass of interest from near unity to an order ***,an early-universe binary formation scenario proves so prevailing that the LIGO signal in turn constrains the PBH fraction below one ***,people should put more faith in alternative PBH windows and other DM candidates.

关键词： black hole physics dark matter gravitational waves quasars supermassive black holes

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A first-principles study on electronic structures and elastic properties of metal dopedα-Fe(N)high nitrogen steel

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Journal of Iron and Steel Research International 2017年第1期24卷 103-110页

作者： Ji-chun Yang Xiang-jun Liu Gui-xiao jia xiao-yang Fu School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina

The binding energies,electronic structures and elastic properties of Ti,V,Cr,Mn,Co,Ni and Mg dopedα-Fe（N）systems have been investigated using a first-principles *** calculated results show that the dopings of Ti,V,Cr and Co improve the stability ofα-Fe（N）,and the stability ofα-Fe（N）is slightly weakened by Mn and Ni,and the doping of Mg is *** Ti,V,Cr and Mn dopedα-Fe（N）systems in which the doping metals are on the left side of Fe in the element periodic table andα-Fe（N）systems doped by Co and Ni on the right side of Fe,their corresponding cohesive forces decrease with decreasing atomic radius of the doping *** obvious interaction exists among M3 d,Fe4s3p3d and N2 *** these doping systems,metal atoms lose electrons,while N gains *** of Ti,V,Cr and Mn inα-Fe（N）strengthen the interaction between N and the surrounding metals,and it is not apparent for the dopings of Co,Ni and *** calculations of Fe15 MN systems show that,except for the Fe15 MgN system,shear modulus G and Young modulus E of Fe15 MN systems are improved,and the bulk modulus Bslightly decreases,namely,total elastic properties are *** magnitude change rule of E reflecting the cohesive force between atoms is consistent with that for the binding energies.

关键词： First principle High nitrogen steel Metal nitride Electronic structure Elastic property

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Improved QO-STBC for three and four transmit antennas

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The Journal of China Universities of Posts and Telecommunications 2010年第4期17卷 42-46页

作者： jia Ming-ru xiao Li-ping College of Information Science and Engineering Yanshan Universitys Qinhuangdao 066004 China

A new quasi-orthogonal space-time block code （QO-STBC） based on ABBA code with lower decoding complexity and higher bit error statistics （BER） performance was proposed by U. Park recently, which can obtain full transmission rate and full diversity. In this article, the authors proposed an improved U. Park scheme based on rotational ABBA code. For eliminating the interference terms resulting from neighboring signals during signal detection, two different matrixes are used. And independent decoding can be realized when maximum-likelihood decoding at the receiver is used. Simulation results demonstrate that the BER performance is improved dramatically without increasing the decoding complexity compared with U. Park scheme.

关键词： independent decoding multiple antennas QO-STBC

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Groupoids,Discrete Mechanics,and Discrete Variation

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Communications in Theoretical Physics 2008年第9期50卷 545-550页

作者： GUO jia-Feng jia xiao-Yu WU Ke ZHAO Wei-Zhong School of Mathematical Science Capital Normal University Beijing 100037 China

After introducing some of the basic definitions and results from the theory of groupoid and Lie algebroid,we investigate the discrete Lagrangian mechanics from the viewpoint of groupoid theory and give the connection ... 详细信息

关键词： groupoids Lie algebroids discrete field discrete variational principle

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Chlorobenzenes in waterweeds from the Xijiang River (Guangdong section) of the Pearl River

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Journal of Environmental Sciences 2007年第10期19卷 1171-1177页

作者： DU Qing-ping jia xiao-shan HUANG Cai-na Faculty of Environmental Science and Engineering Guangdong University of Technology Guangzhou 510006 China School of Environmental Science and Engineering Sun Yat-sen University Guangzhou 510275 China

The Xijiang River is the major source of water for about 4.5 millions of urban population and 28.7 millions of rural population. The water quality is very important for the health of the rural population. The concentration and distribution of chlorobenzenes （CBs） in both water and waterweeds collected from 4 stations in the Xijiang River （Gangdong section） of the Pearl River in April and November were determined. The result showed that nearly every congener of CBs was detected. The total contents of CBs （ZCBs） in the river water ranged from 111.1 to 360.0 ng/L in April and from 151.9 to 481.7 ng/L in November, respectively. The pollution level of CBs in the water in April was higher than that in November. The contents of ZCBs in waterweeds ranged from 13.53×10^2μg/g to 38.27×10^2μg/g dry weight （dw）. There was no significant difference between April and November in waterweeds. The distribution of CBs in roots, caulis, and leaves of Vallisneria spiralis L. showed different patterns. The leaves mainly contained low-molecular-weight CBs （DCBs）, whereas the roots accumulated more PCBs and HCBs. The average lgBCFlip （bioconcentration factor） of CBs ranged from 0.64 to 3.57 in the waterweeds. The spatial distribution character of CBs in the Xijiang River was： Fengkai County 〈 Yunan County 〈 Yun＇an County 〈 Gaoyao County according to the ZCBs, and the pollution deteriorated from the upstream to the downstream of the Xijiang River. Further analysis demonstrated that the discharge of waste containing CBs may be the main source of CBs pollution in the Xijiang River .

关键词： chlorobenzenes pollution water water weeds distribution bioconcentration factor

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A REVERSE ORDER IMPLICIT Q-THEOREM AND THE ARNOLDI PROCESS

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Journal of Computational Mathematics 2002年第5期20卷 519-524页

作者： Gui-zhi Chen Zhong-xiao jia Department of Mathematics Nanjing University Nanjing 210093China Department of Mathematical Sciences Tsinghua University Beijing 100084China

Presents a study that investigated the generalization of the reverse order implicit Q-theorem and its truncated version to the unsymmetric case. Background on the application of the Arnoldi process formulations for a ... 详细信息

关键词： implicit Q-theorem reverse order implicit Q-theorem truncated version Arnoldi process

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