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Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： ZUO Qian XU Ding-qiao YUE Shi-jun FU rui-jia TANG Yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole *** further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune *** this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are ***,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further ***,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

Parity-dependent skin effects and topological properties in the multilayer nonreciprocal Su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： jia-rui Li Cui jiang Han Su Di Qi Lian-Lian Zhang Wei-jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian Su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

Determination of the chromosomal position effects for plug-and-play application in the Myxococcus xanthus chassis cells

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Synthetic and Systems Biotechnology 2024年第3期9卷 540-548页

作者： Xin-jing Yue jia-rui Wang Jun-ning Zhao Zhuo Pan Yue-zhong Li State Key Laboratory of Microbial Technology Institute of Microbial TechnologyShandong UniversityQingdaoPR China

The chromosomal position effect can significantly affect the transgene expression,which may provide an efficient strategy for the inauguration of alien genes in new hosts,but has been less explored *** bacterium Myxococcus xanthus harbors a large circular high-GC genome,and the position effect in this chassis may result in a thousand-fold expression variation of alien natural *** this study,we conducted transposon insertion at TA sites on the *** genome,and used enrichment and dilution indexes to respectively appraise high and low expression potentials of alien genes at insertion *** enrichment sites are characteristically distributed along the genome,and the dilution sites are overlapped well with the horizontal transfer *** experimentally demonstrated the enrichment sites as high expression integration sites(HEISs),and the dilution sites unsuitable for gene integration *** work highlights that HEISs are the plug-and-play sites for efficient expression of integrated genes.

关键词： Position effect High expression integration sites(HEISs) Myxococcus xanthus Tn-seq

Surface growth approach for bulk reconstruction in the AdS/BCFT correspondence

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Chinese Physics C 2024年第6期48卷 222-231页

作者：方西浩陈方中孙佳睿 School of Physics and Astronomy Sun Yat-Sen UniversityGuangzhou 510275China

In this study,we extend the surface growth approach for bulk reconstruction into the Ad S spacetime with a boundary in the Ad S/BCFT *** show that the geometry in the entanglement wedge with a boundary can be constructed from the direct growth of bulk extremal surfaces layer by ***,we observe that the surface growth configuration in BCFT can be connected with the defect multi scale entanglement renormalization ansatz(MERA)tensor ***,we investigate the entanglement of purification within the surface growth process,which not only reveals more refined structure of entanglement entropy in the entanglement wedge but also suggests a selection rule for surface growth in the bulk reconstruction.

关键词： AdS/CFT correspondence gauge/gravity duality models of quantum gravity

Scintillation Arc from FRB 20220912A

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 134-142页

作者： Zi-Wei Wu Robert AMain Wei-Wei Zhu Bing Zhang Peng jiang jia-rui Niu Jin-Lin Han Di Li Ke-jia Lee Dong-Zi Li Yuan-Pei Yang Fa-Yin Wang rui Luo Pei Wang Chen-Hui Niu Heng Xu Bo-Jun Wang Wei-Yang Wang Yong-Kun Zhang Yi Feng De-jiang Zhou Yong-Hua Xu Can-Min Deng Yu-Hao Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Max-Planck-Institut für Radioastronomie Bonn 53121Germany Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Nevada Center for Astrophysics and Department of Physics and Astronomy University of NevadaLas VegasNV 89154USA CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa Department of Astronomy Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Cahill Center for Astronomy and Astrophysics California Institute of TechnologyPasadena 91125USA South-Western Institute For Astronomy Research Yunnan UniversityKunming 650504China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China CSIRO Space and Astronomy Epping 1710Australia Department of Astronomy School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Guangxi Key Laboratory for Relativistic Astrophysics Department of PhysicsGuangxi UniversityNanning 530004China

We present the interstellar scintillation analysis of fast radio burst(FRB)20220912A during its extremely active episode in 2022using data from the Five-hundred-meter Aperture Spherical Radio Telescope(FAST).We detect a scintillation arc in the FRB’s secondary spectrum,which describes the power in terms of the scattered FRB signals’time delay and Doppler *** arc indicates that the scintillation is caused by a highly localized *** analysis favors a Milky Way origin of the ionized interstellar medium(IISM)for the localized scattering medium but cannot rule out a host galaxy *** present our method for detecting the scintillation arc,which can be applied generally to sources with irregularly spaced bursts or *** methods could help shed light on the complex interstellar environment surrounding the FRBs and in our Galaxy.

关键词： fast radio burst scintillation FRB 20220912A

盾构施工扰动对天津结构性黏土动力特性影响的试验研究

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天津大学学报（自然科学与工程技术版） 2024年第7期57卷 768-778页

作者：加瑞杨岗郑刚天津大学建筑工程学院天津300350 天津大学滨海土木工程结构与安全教育部重点实验室天津300350

盾构隧道施工扰动会改变周围土体的应力、应变状态,破坏土的结构性,从而影响隧道后期的地震响应.通过共振柱试验和动单剪试验,分析了施工扰动对天津结构性黏土动剪切模量和阻尼比的影响.试验结果表明:施工扰动程度越大,平均应力归一化... 详细信息

盾构隧道施工扰动会改变周围土体的应力、应变状态,破坏土的结构性,从而影响隧道后期的地震响应.通过共振柱试验和动单剪试验,分析了施工扰动对天津结构性黏土动剪切模量和阻尼比的影响.试验结果表明:施工扰动程度越大,平均应力归一化动剪切模量的初始值越小(应力释放程度较大的D4试样的平均应力归一化动剪切模量初始值为无应力释放的D1试样的74%),在相同剪应变下的归一化动剪切模量越小,动剪切模量的衰减速率越快,在相同剪应变下的阻尼比越大;土的结构性越弱,初始动剪切模量越小(无水泥掺量的B1试样的初始动剪切模量为4%水泥掺量的B4试样的59%),在相同剪应变下的动剪切模量越小,动剪切模量衰减速率越快,在相同剪应变下的阻尼比越大.盾构隧道施工扰动对结构性黏土动力特性的影响机理为:施工扰动会使结构性黏土的结构破损、结构性减弱,从而导致其归一化动剪切模量减小,动剪切模量衰减速率增大,阻尼比增大.因此,在进行盾构隧道抗震设计时应考虑前期施工扰动引起的结构性黏土的结构破损对动剪切模量的影响.

关键词：结构性黏土施工扰动动剪切模量阻尼比共振柱试验

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论解释性行政规则的司法审查

行政法学研究 2024年第4期 112-123页

作者：牛佳蕊天津师范大学法学院天津300387

解释性行政规则是蕴含大量行政专业性判断的行政规范性文件,它往往决定了法律规范的实际含义,产生着相较于法律规范更为直接的效力,存在侵害行政相对人合法权益的法律风险,引发了诸多司法争议。为了实现有效的司法监督,其一,可引入“立... 详细信息

解释性行政规则是蕴含大量行政专业性判断的行政规范性文件,它往往决定了法律规范的实际含义,产生着相较于法律规范更为直接的效力,存在侵害行政相对人合法权益的法律风险,引发了诸多司法争议。为了实现有效的司法监督,其一,可引入“立法机关授权意图标准”,首先对行政机关的“制定权限”进行判断;其二,完善当前形式合法性审查标准,调整“超越职权”“抵触上位法”“权利义务”等标准的具体适用,酌情审查“专家参与”和“公众参与”等程序;其三,构建合理性审查标准体系,这包括“行政机关是否准备了替代解释”“新旧解释性行政规则是否一致”“解释是否符合立法目的”“解释性行政规则是否具有行政专业性”等审查标准。

关键词：解释性行政规则行政专业性形式合法性实质合法性司法审查

黄-红色缅甸黄龙玉颜色和光谱特征的定量研究

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岩石矿物学杂志 2024年第3期43卷 652-662页

作者：牛佳睿郭颖中国地质大学(北京)珠宝学院北京100083

利用傅立叶红外光谱仪、激光拉曼光谱仪、紫外-可见分光光度计、能量色散X射线荧光光谱仪、电子探针X射线显微分析仪和X-Rite SP62手持式分光光度计对黄-红色缅甸黄龙玉样品进行了颜色特征、化学组成以及光谱学特征的研究,分析缅甸黄龙... 详细信息

利用傅立叶红外光谱仪、激光拉曼光谱仪、紫外-可见分光光度计、能量色散X射线荧光光谱仪、电子探针X射线显微分析仪和X-Rite SP62手持式分光光度计对黄-红色缅甸黄龙玉样品进行了颜色特征、化学组成以及光谱学特征的研究,分析缅甸黄龙玉的颜色与光谱特性之间的定量关系。结果表明,缅甸黄龙玉主要由SiO_(2)组成,含少量Fe、Cu、Cr等过渡金属元素,属于隐晶质石英质玉。在CIE D65标准光源和N9孟塞尔中性背景下,缅甸黄龙玉的明度与色调角具有高度的相关性,Fe含量的变化对其明度和色调角具有显著影响。通过紫外-可见吸收光谱的一阶导数可以推断缅甸黄龙玉中针铁矿和赤铁矿的相对含量,且随着主波谷的位置向长波方向偏移,缅甸黄龙玉的颜色会从黄色调向红色调转变。

关键词：缅甸黄龙玉光谱特征颜色颜色成因

基于局部时空的多峰优化算法及其在PID控制中的应用

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计算机学报 2024年第6期47卷 1323-1340页

作者：赵宏李珈瑞刘静西安电子科技大学广州研究院广州510555

多峰优化问题(MultiModal Optimization Problems,MMOPs)需要同时找到问题的多个高精度全局最优解,它需要算法具有较强的全局搜索能力且能很好地平衡种群的多样性和收敛性.当前在处理MMOPs时通常面临以下难点:(1)现有方法通常只考虑到... 详细信息

多峰优化问题(MultiModal Optimization Problems,MMOPs)需要同时找到问题的多个高精度全局最优解,它需要算法具有较强的全局搜索能力且能很好地平衡种群的多样性和收敛性.当前在处理MMOPs时通常面临以下难点:(1)现有方法通常只考虑到进化过程中种群的当前状态(如常用的贪婪选择策略),容易导致种群陷入局部最优;(2)传统的随机搜索策略在复杂搜索空间内难以快速有效找到全局最优解;(3)当前设计的多峰优化算法往往需要手工设置参数(如变异因子和交叉因子等),而参数的大小将直接影响种群的多样性和收敛性.针对上述难点,本文提出了一种新的基于局部时空的多峰优化(Localized Time-Distance-based Multimodal Optimization,LTDMO)算法,主要包括三个贡献点:首先,提出了结合随机搜索和定向引导的变异(Random and Direction-based Mutation,RDM)策略,利用随机变异增加种群中个体的多样性,并通过划分邻域将整个种群分成不同的可重叠子种群,在局部搜索空间内进行变异操作来更好地定位全局最优解,从而避免个体陷入局部最优.其次,提出了基于时间局部性原理的拥挤选择(Locality-based Crowding Selection,LCS)策略,利用进化过程中的时间局部性记录对当前个体更有潜力的进化方向,并在此方向上生成新的子代,使种群进一步向全局最优解收敛.最后,提出了自适应参数控制(Self-adaptive Parameter Control,SPC)策略,基于个体进化信息自适应调整算法的参数值,降低算法在进化过程中对变异因子和交叉因子的参数敏感性.本文将LTDMO算法在CEC'2013测试集上进行实验,并将结果与其他11种多峰优化算法对比,表明LTDMO算法能有效处理较多的全局最优复杂多峰优化问题,具体地,在F1~F5、F8和F10问题上峰值率和成功率均达到100%;在具有较多局部最优的多峰优化问题(F6和F7)上,LTDMO算法的峰值率达到86%以上,这优于9种其他对比算法的性能;在处理复合多峰优化问题时,LTDMO算法在处理F11、F12、F14、F16问题上性能达到最优.同时将LTDMO算法在比例-积分-微分(Proportional-Integral-Derivative,PID)控制器上进行应用,结果表明LTDMO算法能为PID控制器找到多种最优控制参数,使系统达到稳定状态且误差更小.

关键词：多峰优化问题邻域变异时间局部性自适应调整参数 PID控制