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利用海气耦合模式预测的大尺度环流进行热带气旋年频数的预测试验

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热带气象学报 2013年第1期29卷 37-46页

作者：贾小龙陈丽娟 LUO jing-jia 国家气候中心/中国气象局气候研究开放实验室北京100081 Climate Variation Predictability and Applicability Research Program Research Institute for Global ChangeJapan Agency for Marine-Earth Science and Technology

基于对热带气旋生成频数和大尺度环流相关关系的分析,利用SINTEX-F海气耦合模式预测的大尺度大气环流信息,通过提取模式预测较好与热带气旋生成密切相关的有用信息,建立了一个基于动力模式预测结果的南海和西太平洋热带气旋年频数预测模... 详细信息

基于对热带气旋生成频数和大尺度环流相关关系的分析,利用SINTEX-F海气耦合模式预测的大尺度大气环流信息,通过提取模式预测较好与热带气旋生成密切相关的有用信息,建立了一个基于动力模式预测结果的南海和西太平洋热带气旋年频数预测模型,并对1982—2010年的热带气旋生成频数进行预测试验与检验。SINTEX-F海气耦合模式能够较好预测部分与热带气旋生成密切相关的大尺度环流特征,其中包括热带气旋活动区域的海平面气压、对流层风垂直切变、850 hPa热带辐合带和850 hPa 90°E附近的越赤道气流。利用这些大尺度环流建立的预测因子与热带气旋生成频数有很好的相关关系,利用这些预测因子建立的多元回归预测模型对热带气旋频数的拟合率为0.8(相关系数,超过99.9%的信度检验)。预测模型的交叉检验结果表明模型整体预测效果较好。交叉检验预测结果与实况热带气旋频数的相关为0.71(超过了99.9%的信度检验),距平同号率为82.8%。但模型对热带气旋异常年的预测误差较大。

关键词： CGCM 大尺度环流热带气旋气候预测

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白灵菇多糖对运动小鼠氧化应激的影响

基因组学与应用生物学 2020年第2期39卷 895-901页

作者：贾靖西安工程大学体育部西安710043

体外研究表明,白灵菇多糖具有较高的清除自由基能力。然而,白灵菇多糖在体内对运动引起的氧化应激的影响尚不清楚。本研究将100只SPF级雄性昆明小鼠随机分为5组,低剂量组、中剂量组和高剂量组昆明小鼠分别按照50 mg·kg^-1·d^-1、100 m... 详细信息

体外研究表明,白灵菇多糖具有较高的清除自由基能力。然而,白灵菇多糖在体内对运动引起的氧化应激的影响尚不清楚。本研究将100只SPF级雄性昆明小鼠随机分为5组,低剂量组、中剂量组和高剂量组昆明小鼠分别按照50 mg·kg^-1·d^-1、100 mg·kg^-1·d^-1和200 mg·kg^-1·d^-1的剂量灌胃白灵菇多糖溶液,对照组和模型组昆明小鼠灌胃等体积的蒸馏水,连续灌胃4周。研究显示,白灵菇多糖溶液以浓度依赖性方式提高了小鼠的力竭游泳时间(p<0.05)。白灵菇多糖以浓度依赖性方式降低了小鼠血清AST、ALT和CK水平,并显著减少了骨骼肌的病理变化(p<0.05)。白灵菇多糖以剂量依赖方式升高力竭游泳小鼠体内SOD、CAT和GSH-PX水平,并降低了MDA水平(p<0.05)。此外,对小鼠灌胃白灵菇多糖可以剂量依赖方式提高小鼠血清总抗氧化活性(p<0.05)。上述研究表明,白灵菇多糖可有效提高力竭游泳小鼠的抗疲劳能力,减轻运动引起的心肌、肝脏、骨骼肌和氧化应激损伤,提高机体的抗氧化能力。

关键词：白灵菇多糖氧化应激力竭游泳抗氧化运动损伤

Prediction of ENSO using multivariable deep learning

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Atmospheric and Oceanic Science Letters 2023年第4期16卷 51-56页

作者： Yue Chen Xiaomeng Huang jing-jia Luo Yanluan Lin Jonathon S.Wright Youyu Lu Xingrong Chen Hua jiang Pengfei Lin Ministry of Education Key Laboratory for Earth System Modeling and Department for Earth System Science Tsinghua UniversityBeijingChina Institute for Climate and Application Research(ICAR)/CICFEM/KLME/ILCEC Nanjing University of Information Science and TechnologyNanjingChina Ocean and Ecosystem Sciences Division Fisheries and Oceans CanadaBedford Institute of OceanographyDartmouthNova ScotiaCanada National Marine Environmental Forecasting Center State Oceanic AdministrationBeijingChina State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

本文基于残差神经网络和观测数据构建了一套深度学习多因子预报测模型,以改进厄尔尼诺-南方涛动(ENSO)的预报.该模型基于最大信息系数进行因子时空特征提取,并根据泰勒图的评估标准可自动确定关键预报因子进行预报.该模型在超前8个月以... 详细信息

本文基于残差神经网络和观测数据构建了一套深度学习多因子预报测模型,以改进厄尔尼诺-南方涛动(ENSO)的预报.该模型基于最大信息系数进行因子时空特征提取,并根据泰勒图的评估标准可自动确定关键预报因子进行预报.该模型在超前8个月以内的预报性能要优于当前传统的业务预报模式.2011–2018年间,该模型的预报性能优于多模式集成预报的结果.在超前6个月预报时效上,模型预报相关性可达0.82,标准化后的均方根误差仅为0.58°C,多模式集成预报的相关性和标准化后的均方根误差分别为0.70和0.73°C.该模型春季预报障碍问题有所缓解,并且自动选取的关键预报因子可用于解释热带和副热带热动力过程对于ENSO变化的影响.

关键词： ENSO预报深度学习春季预报障碍多维时空预报因子

Codelivery of dihydroartemisinin and chlorin e6 by copolymer nanoparticles enables boosting photodynamic therapy of breast cancer with low-power irradiation

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Regenerative Biomaterials 2023年第1期10卷 1060-1072页

作者： jing jia Wenping Chen Long Xu Xuewen Wang Min Li Bin Wang Xiangyu Huang Tao Wang Yang Chen Mengdie Li Dan Tian Junyang Zhuang Xinhua Lin Ning Li Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research School of PharmacyFujian Medical UniversityFuzhou 350122China Key Laboratory of Nanomedical Technology(Education Department of Fujian Province) School of PharmacyNano Medical Technology Research InstituteFujian Medical UniversityFuzhouFujian 350122China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China School and Hospital of Stomatology Fujian Stomatological HospitalFujian Medical UniversityFuzhou 350002China Department of Hepatobiliary Surgery Fuzhou Second HospitalFuzhou 350007China

Given that chemotherapy as a stand-alone therapeutic strategy may not be sufficient to effectively treat cancer,there is increasing interest in combination of chemotherapy and alternative *** therapy has the advantages of high selectivity and low side effects,so the combination of photodynamic therapy and chemotherapy has become one of the most appealing strategies for tumor *** this work,we constructed a nano drug codelivery system(PPDC)to realize the combined treatment of chemotherapy and photodynamic therapy through encapsulating chemotherapeutic drug dihydroartemisinin and photosensitizer chlorin e6 in *** potentials,particle size and morphology of nanoparticles were characterized by dynamic light scattering and transmission electron *** also investigated the reactive oxygen species(ROS)generation and drug release *** antitumor effect in vitro was investigated by methylthiazolyldiphenyl-tetrazolium bromide assays and cell apoptosis experiments,and the potential cell death mechanisms were explored by ROS detection and Western blot *** in vivo antitumor effect of PPDC was evaluated under the guidance of fluorescence *** work provides a potential antitumor treatment approach and expands the application of dihydroartemisinin for breast cancer therapy.

关键词： dihydroartemisinin photodynamic therapy combination therapy nano drug delivery systems

TREATMENT OPTIONS FOR PATIENTS WITH RECURRENT OVARIAN CANCER:A REVIEW OF 54 CASES

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Chinese Medical Sciences Journal 2006年第1期21卷 11-15页

作者： Ying Jin Ling-ya Pan Hui-fang Huang Keng Shen Ming Wu jia-xin Yang jing-he Lang Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the efficacy of treatment options for patients with recurrent ovarian *** From 1990 to 2000, 54 patients with recurrent ovarian cancer primarily treated in Peking Union Medical College Hospital were selected and *** the clinical data related to the recurrent tumor were ***-side P values for differences in survival were calculated by the Cox regression *** The platinum-free interval >6 months and the surgery followed by salvage chemotherapy prolonged survival time of the patients with recurrent ovarian cancer (95% CI=0.153-0.987, P=0.047; 95% CI=1.611-10.914, P=0.003, respectively).The increased number of chemotherapy cycles (> 10 months) offered some benefit on the survival (95% CI=0.110-1.090, P=0.070).The initiation of treatment and chemotherapy regiments failed to demonstrate an improvement in *** The treatment options for patients with recurrent ovarian cancer depend on the platinum-free-interval of the patients.A strategy of secondary surgical cytoreduction followed by salvage chemotherapy is suggested for the patients with platinum-sensitive disease.

关键词： recurrent ovarian cancer surgery chemotherapy

Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma

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Chinese Medical Journal 2010年第6期123卷 730-733页

作者： WANG jing-yu XU Xiao-yuan jia jing-hui WU Chi-hong GE Ruo-wen Department of Infectious Disease Peking University First HospitalBeijing 100034China Department of Biological Science National University of SingaporeSingapore 117543Singapore

Background Hepatocellular carcinoma （HCC） is one of the deadliest cancers worldwide. In order to investigate the molecular biologic mechanism of HCC＇s development, we studied the expressions of SE-1, CD105 and CD31 in tumor endothelial cells （TECs） of HCC and in the serum of rats. Methods We analyzed the expressions of SE-1, CD31 and CD105 in rat HCC tumor tissues using immunohistochemistry （IHC）. Twenty HCC bearing rats and eighteen normal rats were examined for the expressions of SE-1, CD31 and CD105 antigens in serum by enzyme-linked immunosorbent assay （ELISA）. Results SE-1, CD31 and CD105 antigens were detected both in HCC tissue and in normal liver tissue with higher expressions of CD31 and CD105 in HCC while the SE-1 antigen expression was higher in normal liver. Similarly, serum CD31 and CD105 in rats with HCC were significantly increased compared with normal rats （t=-2.8628, P=0.0086; t=4.4922, P 〈0.0001, respectively）. In contrast, SE-1 antigen in HCC rat serum was significantly decreased compared with normal rats （t=3.4983, P=-0.0011）.Conclusion SE-1, CD31 and CD105 are closely related with liver tumor angiogenesis, which is similar to their performances in terms of their expressions in the serum.

关键词： hepatocellular carcinoma tumor angiogenesis endothelial cell immunohistochemistry enzyme-linked immunosorbent assay

Gouy-Chapman双电层模型在蒙脱石长程膨胀中应用

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大连理工大学学报 2010年第2期50卷 239-244页

作者：贾景超杨庆大连理工大学土木工程学院岩土工程研究所辽宁大连116024 大连理工大学海岸和近海工程国家重点实验室辽宁大连116024

对于蒙脱石晶层间的长程膨胀是否符合双电层理论众多研究者观点不一.采用Gouy-Chapman双电层模型,基于前人试验数据,从膨胀压力-晶层间距关系以及晶层间距-电解质浓度关系两个方面对模型进行验证.结果表明,在没有晶层间水合力影响的情况... 详细信息

对于蒙脱石晶层间的长程膨胀是否符合双电层理论众多研究者观点不一.采用Gouy-Chapman双电层模型,基于前人试验数据,从膨胀压力-晶层间距关系以及晶层间距-电解质浓度关系两个方面对模型进行验证.结果表明,在没有晶层间水合力影响的情况下Gouy-Chapman模型能够很好地拟合试验数据,说明长程膨胀符合双电层理论.另外,将Gouy-Chapman模型与其简化形式进行了对比,结果表明,当晶层间的双电层作用较弱时(Kd>1),两种模型曲线近乎重合,此时可以用简化模型代替精确模型.

关键词：膨胀土蒙脱石 Gouy-Chapman双电层模型长程膨胀

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan jing Dong Bixian Chen Lujie jia jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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许景澄与晚清海防建设

社会科学家 2010年第2期25卷 148-151页

作者：贾菁菁南开大学历史学院天津300071

晚清海军初创,驻外公使许景澄接负重任,在德国勘验定远、镇远、济远三舰,主持订购并参与设计经远、来远二舰。甲午战后,北洋海军重建,又再度领命在德购舰。许景澄上疏《条陈海军应办事宜》,锐意革新海防;亲诣船厂考求船制,辑著《外国师... 详细信息

晚清海军初创,驻外公使许景澄接负重任,在德国勘验定远、镇远、济远三舰,主持订购并参与设计经远、来远二舰。甲午战后,北洋海军重建,又再度领命在德购舰。许景澄上疏《条陈海军应办事宜》,锐意革新海防;亲诣船厂考求船制,辑著《外国师船表》十二卷,对晚清海防建设助益匪浅。

关键词：许景澄晚清海防购舰