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Solvent and catalyst free azo-Michael addition under high-speed vibration milling

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Science China Chemistry 2012年第7期55卷 1252-1256页

作者： LI YuJin CAO YongWen XU FengShuang FANG WenMing YU WuBin jia jianhong GAO jianRong State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology Zhejiang University of TechnologyHangzhou 310032China

Under the high-speed vibration milling conditions,the solvent and catalyst-free azo-Michael addition of chalcone derivatives and amines was found to proceed efficiently in excellent yields at ambient temperature in short reaction time.In most cases,conventional side reactions were avoided and thus quantitative yields were achieved.The influences of the vibration frequency and reaction time on the azo-Michael addition were investigated.

关键词：迈克尔催化剂振动研磨偶氮免费溶剂 Michael加成反应时间

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

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Chinese Journal of Chemical Engineering 2022年第8期35卷 244-252页

作者： Baolong Niu Min Li jianhong jia Lixuan Ren Xin Gang Bin Nie Yanying Fan Xiaojie Lian Wenfeng Li College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024China Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength&Structural Impact Institute of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030001China

Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.

关键词： Hyaluronic acid Amorphous calcium phosphate Fluorescent carbon nanoparticles pH-sensitive Tumor targeting

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倾斜钻孔揭露地质信息投影计算方法应用研究

水利水电快报 2024年第2期45卷 24-28页

作者：任自强贾建红许琦张广厦叶健薛永明长江三峡勘测研究院有限公司(武汉) 湖北武汉430074 水利部水网工程与调度重点实验室湖北武汉430010

为探索倾斜钻孔的应用,以克服钻探施工环境限制,通过对任意方位角和倾角的倾斜钻孔与所需地质剖面空间关系的研究,提出一种把倾斜钻孔揭露的地质信息准确投影到所需地质剖面上的方法。在倾斜钻孔的倾斜方向与所需地质剖面走向不一致的... 详细信息

为探索倾斜钻孔的应用,以克服钻探施工环境限制,通过对任意方位角和倾角的倾斜钻孔与所需地质剖面空间关系的研究,提出一种把倾斜钻孔揭露的地质信息准确投影到所需地质剖面上的方法。在倾斜钻孔的倾斜方向与所需地质剖面走向不一致的条件下,通过对倾斜钻孔揭露地质信息的起始和终止位置进行投影换算,进而得到符合实际地质特征的剖面。将所提出的方法应用于南水北调中线引江补汉工程勘察实践中,结果表明:该方法能够有效利用倾斜钻孔揭露信息;应用此方法进行倾斜钻孔勘探,不仅可以克服地表复杂的钻探施工环境,而且可以有效减少钻探进尺、提高勘察效率、节约勘察成本。

关键词：倾斜钻孔钻孔勘察钻孔揭露信息地质剖面引江补汉工程

Effects of water molecules on luminescence in europium and terbium coordination polymers with p-fluorobenzoic acid as ligand

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Journal of Rare Earths 2024年第7期42卷 1258-1264页

作者： Xiaoqi Zhao Puyan Hao Yami Ling Mengzhen jia Rui Zhu jiawen Liu Qiang Xu jianhong Zhou Collaborative Innovation Center of Rare-Earth Optical Functional Materials and Devices Development Baoji Key Laboratory of Micro-Nano Optoelectronics and Terahertz TechnologySchool of Physics and Opto-Electronic TechnologyBaoji University of Arts and Sciences

Our previous experimental observations show that the crystal structure of lanthanide luminescent complexes synthesized in aqueous solution usually contains a large number of coordination water molecules or free water molecules.In order to probe the influence of water molecules on luminescent processes of lanthanide complexes,the photoluminescence properties of Ln-FBA（Ln=Eu and Tb,FBA=p-fluorobenzoic acid） coordination polymers at different ambient temperatures,in different solvents and aqueous DMSO solutions with different volume concentrations were systematically investigated.The experiment results show that the presence of water molecules can promote the energy transfer from FBA ligand to Ln3+,at the same time,can cause luminescent non-radiation quenching of lanthanide ions.In addition,the variation of emission intensity ratio of 615 nm/591 nm peaks of Eu3+with increasing the volume concentration of H2O can be potentially used for the quantitatively detection of water traces in organic solve nts.In order to suppress the non-radiation quenching caused by the water molecules,Ln-FBA（Ln=Eu and Tb） coordination polymers were embedded into the PVP matrix to prepare Ln-FBA@PVP hybrid materials.The photoluminescence investigation indicates that PVP can not only block the quenching effect of water molecules on luminescence,but also effectively sensitize Eu3+and Tb3+luminescence.These experimental conclusions are useful for probing the influence of water molecules on luminescent processes of lanthanide complexes,quantitatively detecting water traces in organic solvents and enhancing the photoluminescence intensity in lanthanide complexes.

关键词： Lanthanide complexes Luminescent quenching Photoluminescence Rare earths

Model Test of Deformation Evolution and Multi Factor Prediction of Anchorage Slope Stability under Rainfall Condition

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Journal of Earth Science 2020年第6期31卷 1109-1120页

作者： Tingyao Wu jianhong jia Nan jiang Chuanbo Zhou Xuedong Luo Yuqing Xia Faculty of Engineering China University of GeosciencesWuhan 430074China Three Gorges Geotechnical Consultants Co. Ltd.Wuhan 430074China

The stability of the anchorage slope on the Baiyang Yangtze River Highway Bridge in Yichang,China,was investigated under different rainfall conditions using model test,numerical simulation,and factor analysis.The results of the study are as follows:(1)with the increase of rainfall intensity,the change of earth pressure can be divided into three stages.However,when the rainfall intensity was larger than a certain value,the change of earth pressure of cut slope became two stages;with the increase of rainfall intensity,pore water pressure increased with the increase of rainfall time,while at a certain stage after the rainfall,the pore water pressure in the cut slope did not decrease immediately,but increased for a period of time.(2)When the rainfall stopped,the stability coefficient of the anchorage slope continued to decrease,then slowly increased,and finally tended to be gentle.Meanwhile,when the rainstorm reached a certain intensity,the main factor that restricted the rainfall infiltration rate became the geotechnical permeability coefficient of the cut slope,which was no longer the rainfall intensity.(3)Factor analysis shows that the rainfall intensity and rainfall duration were the most important factors for anchorage slope stability,while earth pressure,pore water pressure and slope displacement were much less significant.

关键词： anchorage slope model test rainfall condition safety factor analysis

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong jianhong Dong Ziwei Fan Mengxian jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis.Microglia,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative diseases.Lactate has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of lactate.Lactylation is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various diseases.This review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting lactate.Finally,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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官能化聚烯烃的进展和应用

化工进展 2022年第5期41卷 2487-2503页

作者：余世勤赵鑫鹏郑艳严亮贾建洪余海斌浙江工业大学化学工程学院浙江杭州310014 中国科学院宁波材料技术与工程研究所浙江宁波315201 宁波捷傲创益新材料有限公司浙江宁波315040

官能化聚烯烃是由聚烯烃改性后得到的产物,一般通过交联改性、共聚改性、固相力化学改性和接枝改性等方法制备,可应用于黏附、能源和封装等多重领域。基于聚烯烃高通量低成本的优势,聚烯烃接枝改性利用自由基反应直接向聚烯烃链上引入... 详细信息

官能化聚烯烃是由聚烯烃改性后得到的产物,一般通过交联改性、共聚改性、固相力化学改性和接枝改性等方法制备,可应用于黏附、能源和封装等多重领域。基于聚烯烃高通量低成本的优势,聚烯烃接枝改性利用自由基反应直接向聚烯烃链上引入极性单体,较为经济便捷。聚烯烃接枝改性按反应条件的不同,又可分为溶液接枝、熔融接枝、辐射接枝、固相接枝和悬浮接枝。在接枝改性过程中,接枝率和接枝效率受多种因素影响,如聚烯烃型号、接枝单体、引发剂、共单体和反应条件等。本文综述了聚烯烃接枝改性不同接枝方法的研究进展,分析了各种接枝方法的优势和短板,并将接枝改性过程中的影响因素进行了总结。文章依据聚烯烃的可控自由基接枝改性和金属催化改性以及官能化聚烯烃的应用,展望了聚烯烃可控改性和官能化聚烯烃规模化生产。

关键词：聚烯烃官能化聚合物接枝改性合金复合材料

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数字化转型对物流企业供应链管理的影响

物流科技 2022年第18期45卷 105-109页

作者：贾建鸿叶春明上海理工大学管理学院上海200093

结合供给侧结构性改革的提出以及“2035年远景目标”,文章选取2015—2020年112家交通运输、仓储和邮政业上市公司面板数据作为研究对象,将数字化转型拆分成三个维度分别进行实证检验,探究数字化转型对物流企业供应链管理的影响;结果表... 详细信息

结合供给侧结构性改革的提出以及“2035年远景目标”,文章选取2015—2020年112家交通运输、仓储和邮政业上市公司面板数据作为研究对象,将数字化转型拆分成三个维度分别进行实证检验,探究数字化转型对物流企业供应链管理的影响;结果表明数字化技术转型、数字化效益转型和数字化创新能力转型均对物流企业供应链管理有显著影响,在此基础上提出相关建议,以期促进我国物流企业供应链管理的升级。

关键词：数字化转型供应链管理物流企业

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“时-空耦合”活细胞合成量子点

合成生物学 2022年第2期3卷 385-398页

作者：贾剑红杨玲玲刘安安庞代文南开大学药物化学生物学国家重点实验室化学学院分析科学研究中心天津市生物传感及分子识别重点实验室天津300071 武汉大学高等研究院化学与分子科学学院湖北武汉430072

细胞是生命活动的基本单位。随着材料学、化学和生物学等多学科交叉日益加深,借助活细胞内代谢途径合成无机纳米材料的研究受到广泛关注,同时也拓展了合成生物学的研究领域。然而,活细胞合成无机纳米材料主要以胞内生物大分子为模板,且... 详细信息

细胞是生命活动的基本单位。随着材料学、化学和生物学等多学科交叉日益加深,借助活细胞内代谢途径合成无机纳米材料的研究受到广泛关注,同时也拓展了合成生物学的研究领域。然而,活细胞合成无机纳米材料主要以胞内生物大分子为模板,且依赖单一生化反应途径,产物的尺寸、形貌和性质均难以人为调控。自2009年,本课题组通过人为设计、巧妙耦合活细胞内的硒代谢途径和重金属离子解毒途径,发展出“时-空耦合”活细胞合成策略,在真菌、细菌和哺乳动物细胞内原位合成了不同组成、尺寸和性能的无机半导体荧光纳晶(量子点)。在从物质和能量代谢的角度研究活细胞合成机理的基础上,将活细胞合成体系简化,设计构建了无细胞的准生物体系,成功合成了多种纳米材料,同时也验证了“时-空耦合”策略的正确性。本文将总结评述“时-空耦合”活细胞合成量子点的策略、机理及其在生物标记、生物成像和病原微生物与重金属离子检测等方面的应用,并简要介绍准生物体系。同时,将阐明目前活细胞合成策略面临的挑战。随着合成生物学的发展,通过“时-空耦合”活细胞合成策略可以将无机功能材料“自然地”融入生物体系,赋予生物体系超常的能力,拓展合成生物学。

关键词：量子点活细胞合成代谢调控