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Biomedical and Environmental Sciences 2016年第12期29卷 898-901页

作者： jia Hai xian HAN Jun Hua LI Hu Zhong LIANG Dong DENG Tao Tao CHANG Su Ying China National Center for Food Safety Risk Assessment Beijing 100022China Institute of Nutrition and Food Hygiene Beijing Center for Diseases Prevention and ControlBeijing 200023China United Nations Children's Fund Beijing 200600China

In the Chinese national nutrition surveys, fortified foods were not investigated separately from the base diet, and the contribution of fortified foods to micronutrients intake is not very clear. This study investigated the diet, including fortified foods and food supplements, of urban pregnant women and analyzed the intake of calcium, iron,and zinc to assess the corresponding contributions of fortified foods, food supplements, and the base diet. The results demonstrated that the base diet was the major source of calcium, iron, and zinc, and was recommended to be the first choice for micronutrients intake. Furthermore, consumption of fortified foods and food supplements offered effective approaches to improve the dietary intake of calcium, iron, and zinc in Chinese urban pregnant women.

关键词： Mineral intake Base diet Fortifiedfood Food Supplements

Theoretical Study on the Nitrogen-rich Derivatives Based on 1,2,4-Triazole and 1,2,3-Triazole Rings:an Extended Family of Power Performance Energetic Materials

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Chinese Journal of Structural Chemistry 2021年第9期40卷 1113-1121,1107页

作者： jia Jing-xian PANG Yu YANG Jing LI Min-xian MENG xiang-Jun GAO Xiao-Zhen LIU Li-Hua LRJ Meng-Na Department of Chemistry Tangshan Normal CollegeTangshan 063000China Yangquan Municipal Key Laboratory of Quantum Manipulation Shanxi Institute of TechnologyYangquan 045000China

The geometric and electronic structures of the derivatives of 4-nitro-5-(5-nitroimino-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate(named A~J)are explored employing density functional theory(DFT)calculations at the B3LYP/6-311G^(**)level of *** on the optimized molecular structures,the heats of formation(HOF)are obtained,and the electronic properties,density and molecular sensitivity by characteristic heights(H_(50))are ***,the detonation performances(detonation velocity,detonation pressure)are estimated via Kamlet-Jacobs(K-J)*** B(H50=29.4 cm,ρ=1.91 g/cm^(3),Q=1563.04 cal/g,P=36.05 GPa,D=8.95 km/s)and H(H_(50)=31.9 cm,ρ=1.80 g/cm^(3),Q=1610.09 cal/g,P=37.31 GPa,D=9.12 km/s)have positive HOFs and remarkable insensitivity and good detonation performance,strongly suggesting them as the acceptable new-type *** initiating power surpasses conventional primary explosives,such as *** outstanding detonation power of compounds B and H contributes to its future prospects as a promising green primary explosive.

关键词： 4-nitro-5-(5-nitroimino-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate high energy density materials density functional theory explosive

Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG Le Mei ZHENG Qi LIU Xiao jia LI xian xian Veronica Lim CHEN Qi ZHAO Zhong Hua WANG Shu Yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

星状神经节阻滞联合YS1001P治疗仪治疗急性脑梗死伴吞咽困难临床观察

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河北医科大学学报 2024年第09期45卷 1002-1006页

作者：赵鹏姚玉婷贾贤达肖志娟李燕沈文河北北方学院附属第二医院神经内科河北北方学院附属第二医院功能科河北北方学院附属第二医院康复科

目的探讨星状神经节阻滞联合YS1001P治疗仪治疗急性脑梗死伴吞咽困难的临床效果。方法选取河北北方学院附属第二医院急性脑梗死伴吞咽困难患者80例，按照随机数字表法分为2组，每组40例。2组均行卒中后对症治疗，包含控制血压和血糖... 详细信息

目的探讨星状神经节阻滞联合YS1001P治疗仪治疗急性脑梗死伴吞咽困难的临床效果。方法选取河北北方学院附属第二医院急性脑梗死伴吞咽困难患者80例，按照随机数字表法分为2组，每组40例。2组均行卒中后对症治疗，包含控制血压和血糖、抗血小板聚集、调节脂代谢、改善脑循环、营养脑神经以及并发症的防治等，在此基础上采用吞咽和神经肌电刺激仪YS1001P治疗，研究组额外行星状神经节阻滞治疗，20 d后采用洼田饮水试验评价患者临床疗效。采用藤岛一郎吞咽障碍评分和电视X线透视下吞咽造影检查(videofluroscopic swallowing study, VFSS)比较治疗前和治疗后2组的吞咽功能，比较对照组和研究组治疗前后血清神经生长因子(nerve growth factor, NGF)和脑源性神经营养因子(brain-derived neurotrophic factor, BDNF)含量变化情况。结果治疗后，研究组藤岛一郎吞咽障碍评分高于对照组(P<0.05),口腔期、咽期、误吸评分及VFSS评分总分高于对照组(P<0.05),洼田饮水试验分级优于对照组(P<0.05),研究组治疗总有效率95.00%高于对照组77.50%(P<0.05),研究组血清NGF和BDNF含量高于对照组(P<0.05)。结论星状神经节阻滞联合YS1001P治疗仪治疗急性脑梗死伴吞咽困难的临床效果较好，患者吞咽功能改善明显，其作用机制可能与提高神经营养水平有关。

关键词：脑梗死吞咽困难星状神经节阻滞

Si/TiO2 carbon fiber core encapsulated in hierarchical multiple MXene@Co-MoS2 shells for constructing a free-standing anode of lithium storage

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Rare Metals 2024年第9期43卷 4222-4233页

作者： xian-ping Du Ying Huang jia-ming Wang Zhen-he Feng Xu Sun MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions School of Chemistry and Chemical Engineering Northwestern Polytechnical University Shanghai Institute of Space Power-Sources Ningbo Institute of Northwestern Polytechnical University

Silicon-based（Si-based） materials offer more possibilities for generating new portable electronic devices due to their high specific capacities. However, their inferior electrical conductivity and volume expansion during cycling seriously limit their development. The optimum solution is to select specific materials to establish an exceptionally conductive and volume buffer structure,which can assist Si materials in developing their excellent lithium storage properties. In this study, Si particles were confined in TiO2carbon fibers（TiO2CFs） via electrospinning, after which they were encapsulated with MXene and Co-MoS2（CMS） nanosheets to fabricate hierarchical ST-2@MXene@CMS films. TiO2CF, MXene and CMS were employed to establish a coherent conductive network with one-, two-and three-dimensional electronic pathways to permit the unimpeded flow of electrons inside the electrode material. TiO2CF, MXene and CMS acted precisely as multilayered buffers to ameliorate the volume change of Si particles during cycling. In addition, the CMS nanosheets were involved in lithium storage, contributing to the final electrochemical performance. Ultimately, the ST-2@MXene@CMS films served as free-standing electrodes, avoiding the impact of inactive interfaces on the electrochemical performance and fulfilling the lightweight requirement for new energy storage devices.

关键词： Co-MoS2 nanosheets Hierarchical structure Lithium-ion batteries MXene Si particles

Recent advances in electrocatalytic generation of indole-derived radical cations and their applications in organic synthesis

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Chinese Chemical Letters 2024年第4期35卷 106-123页

作者： Wei Zhou Xi Chen Lin Lu xian-Rong Song Mu-jia Luo Qiang Xiao Key Laboratory of Organic Chemistry of jiangxi Province Jiangxi Science&Technology Normal UniversityNanchang 330013China

Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines. Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles. Remarkable achievements in electrocatalytic indolederived radical cation-mediated indole functionalization have been realized so far. This review comprehensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp~2)–H functionalization, dearomative 2,3-difunctionalization, and ring-opening reaction, emphasizing the vital single electron oxidation steps of indoles, the substrates scope and limitations, and the reaction mechanisms.

关键词： Electrocatalysis Indole radical cation C-H functionalizatin Dearomative 2 3-difunctionalization

Molecular Design and Property Prediction of High Density 4-Nitro-5-(5-nitro-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate Derivatives as the Potential High Energy Explosives

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Chinese Journal of Structural Chemistry 2022年第2期41卷 123-131,I0011页

作者： YANG Jing PANG Yu LI Min-xian YANG Ge-Fei jia Jing-xian MENG xiang-Jun LIU Li-Hua YANG Xiao-Chun GAO Xiao-Zhen Department of Chemistry Tangshan Normal CollegeTangshan 063000China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Yangquan Municipal Key Laboratory of Quantum Manipulation Shanxi Institute of TechnologyYangquan 045000China

To search for potential energetic materials with large energy density and acceptable thermodynamics and kinetics stability,twelve derivatives of 4-nitro-5-(5-nitro-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate(named A~L)are designed and analyzed by using density functional theory(DFT)calculations at the B3LYP/6-311G**level of *** molecular heats of formation(HOF),electronic structures,impact sensitivity(H_(50)),oxygen balance(OB)and density(ρ)are investigated by isodesmic reaction method and physicochemical ***,the detonation velocity(D)and detonation pressure(P)are calculated to study the detonation performance by Kamlet-Jacobs(K-J)*** results show that new molecule J(H_(50)=36.9 cm,ρ=1.90g/cm^(3),Q=1912.46 cal/g,P=37.82 GPa,D=9.22 km/s,OB=0.00),compound A(H_(50)=27.9 cm,ρ=1.93 g/cm^(3),Q=1612.93 cal/g,P=38.90 GPa,D=9.19 km/s)and compound H(H_(50)=37.3 cm,ρ=1.97 g/cm^(3),Q=1505.06cal/g,P=37.20 GPa,D=9.01 km/s)present promising effects that are far better RDX and HMX as the high energy density *** calculations can provide useful information for the molecular synthesis of novel high energy density materials.

关键词： 4-nitro-5-(5-nitro-1,2,4-triazol-3-yl)-2H-1,2,3-triazolate energetic materials density functional theory explosive

Experimental Device of Emittance Improvement on the H- Multicusp Source

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Experimental Device of Emittance Improvement on the H- Multi...

Bufalin-induced cardiotoxicity: new findings into mechanisms

作者： ZHENG Xia jia xian-lu

In order to further enhance the beam intensity and reduce the emittance,Based on the 15-20 mA DC H multicusp source with an obtained beam intensity of 15 mA two steps are taken in the ***, the length of source body is increased,and secondly,the cesium vapor is added to the H multicusp source discharge chamber. The length of H multicusp source body is increased from the 152 mm to 228 mm,height increased by

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Chinese Journal of Natural Medicines 2020年第7期18卷 550-560页

作者： LI Min WANG Xi-Jie ZHAO Qi WANG jia-xian XING Hong-Yan ZHANG Yi-Zhe ZHANG Xue-Xia ZHI Yang-Yang LI Hua MA Jing China State Institutes of Pharmaceutical Industry National Shanghai Center for New Drug Safety Evaluation and Research Shanghai 201203China Shanghai InnoStar Bio-Tech Co. Ltd.Shanghai 201203China Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjing 211100China Department of Research and Development HELP Stem Cell TherapeuticsNanjing 211100China

Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine *** cardiotoxicity clearly limits its application to patients living in ***,an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse *** investigate the cardiotoxicity of bufalin using human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.003–0.1μmol·L–1),human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.03–0.3μmol·L–1)and eight human cardiac ion channel currents(0.01–100μmol·L–1)combined with an impedance-based bioanalytical and patch clamp *** effect of bufalin on the contractility in hiPSC-CMs,which has been shown to strengthen myocardial contractility,accelerate conduction,and increase beating rate at the earlier stage of administration,whereas weakened myocardial contractility,abolished conduction,and ceased beating rate at the later stage of *** decreased the action potential duration(Action potential duration at 30%,50%and 90%repolarization),cardiac action potential amplitude,and maximal depolarization rate and depolarized the resting membrane potential of *** beating rates of hiPSC-CMs were markedly increased at 0.03μmol·L–1,while were weakened at 0.3μmol·L–1 after *** blocks INav1.5 in a concentration-dependent manner with half maximal inhibitory concentration of 74.5μmol·L–*** respectively increased the late sodium current and Na+-Ca2+exchange current with a concentration for 50%of maximal effect of 2.48 and 66.06μmol·L–1 in ***,bufalin showed no significant effects on other cardiac ion channel *** enhancement of the late sodium current is one of the main mechanism for cardiotoxicity of bufalin.

关键词： Bufalin Cardiomyocytes Cardiotoxicity Ion channels Stem cell

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基于相对失真测度的感兴趣区域编码

光子学报 2007年第4期36卷 754-758页

作者：邓家先黄艳海南大学信息学院海口570228

提出了一种基于相对失真测度的率失真斜率提升感兴趣区域编码算法.通过计算感兴趣区域与背景之间的相对失真确定感兴趣区域的率失真斜率提升幅度,使得实际感兴趣区域与背景的相对失真尽可能逼近给定值.本算法不需要对小波域的系数进行... 详细信息

提出了一种基于相对失真测度的率失真斜率提升感兴趣区域编码算法.通过计算感兴趣区域与背景之间的相对失真确定感兴趣区域的率失真斜率提升幅度,使得实际感兴趣区域与背景的相对失真尽可能逼近给定值.本算法不需要对小波域的系数进行比特平面提升,而是通过提升率失真斜率实现.解码器不需要进行小波域系数的逆提升,且提升大小不受比特平面限制,可以精确到步骤.适合给定感兴趣区域与背景之间的相对失真,也适合交互式图像等感兴趣区域编码.相对失真改变时,不需要重新对图像进行比特平面编码,只要提升感兴趣区域斜率然后重新组织码流即可,避免了比特平面提升的感兴趣区域编码算法缺陷.仿真结果表明,本算法能够精确根据给定感兴趣区域与背景的平均相对失真组织码流,实际结果十分接近给定值.

关键词：图像处理率失真斜率提升感兴趣区域编码比特平面提升