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The response and anti-stress mechanisms of nitrifying sludge under long-term exposure to Cd Se quantum dots

Journal of Environmental Sciences 2024年第1期135卷 174-184页

作者： Linkai Guo Lei Yang yongxiang ren Shen Cui Xiaotong Li jia Wang Jun Lan Haoqi Lu Yuchao Wang Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Key Lab of Northwest Water Resource Environment and EcologyMinistry of EducationXi’an University of Architecture and TechnologyXi’an 710055China

The wide application of CdSe quantum dots(QDs)increases its stress risk to sewage treatment *** study evaluated the response of nitrification performance,floc characteristics and microbial community of nitrifying sludge under long-term exposure to CdSe *** showed CdSe QDs(≥1 mg/L)would decrease the activity of ammonia monooxygenase(AMO).Under the stress of 30 mg/L CdSe QDs,the activity of AMO was reduced by 66%,while the activities of hydroxylamine oxidase and nitrite oxidoreductase were enhanced by 19.1%and 26%,***,the final nitrification effects were not adversely affected,and the production rates of NO_(2)^(-)-N and NO_(3)^(-)-N were ***,CdSe QDs improved biomass concentration in sludge and maintained the stability of sludge *** throughput sequencing analysis showed that CdSe QDs evidently reduced the abundance and diversity of microbial community in nitrifying *** abundances of amino acid metabolism and lipid metabolism were ***,CdSe QDs decreased the fluorescence intensity of tryptophan-like protein from 2,326 to 1,179 *** loosely bound extracellular polymeric substances(EPSs)and from 3,792 to 3,117 *** tightly bound *** relieve CdSe QD stress,the polysaccharide content increased from0.31 to 0.61 mg/g MLSS and intracellular antioxidant defense was *** CdSe QD level increasing to 30 mg/L,the total antioxygenic capacity and the activities of catalase were enhanced up to 411%and 143.2%,***,CdSe QDs had little adverse effects on cell membrane integrity,microbial metabolism and the abundance of Nitrospirae.

关键词： Quantum dots Activated sludge Extracellular polymeric substances Microbial community Antioxidant effect

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Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence

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Biomedical and Environmental Sciences 2024年第2期37卷 146-156页

作者： LIAO Zhen Yu YANG Shuo HU Song LIU jia MAO yong Jun SUN Shu Qin Department of Geriatrics the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were *** SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic *** multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)*** Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 *** of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased ***2 rs4586 and MMP-2 rs14070 exhibited the most significant *** CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

关键词： Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

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鸭肠炎病毒UL24/C基因酵母双杂交诱饵载体构建及鉴定

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中国预防兽医学报 2018年第6期40卷 481-485页

作者：高兴红贾仁勇遵义医学院贵州省普通高等学校传染病与生物安全特色重点实验室贵州遵义563000 四川农业大学禽病防治研究中心四川成都611130 四川农业大学预防兽医研究所四川成都611130 动物疫病与人类健康四川省重点实验室四川成都611130

为构建DEV UL24/C蛋白的酵母双杂交的诱饵载体,本研究以DEV CHv株基因组DNA为模板,经一步法克隆构建pGBKT7-UL24/C诱饵质粒,质粒转化酵母菌株后进行自激活活性检测、免疫印迹检测和毒性检测。结果显示,诱饵质粒pGBKT7-UL24/C插入片段大... 详细信息

为构建DEV UL24/C蛋白的酵母双杂交的诱饵载体,本研究以DEV CHv株基因组DNA为模板,经一步法克隆构建pGBKT7-UL24/C诱饵质粒,质粒转化酵母菌株后进行自激活活性检测、免疫印迹检测和毒性检测。结果显示,诱饵质粒pGBKT7-UL24/C插入片段大小为510 bp,且未发生基因突变;pGBKT7-UL24/C质粒转化Y2HGold菌株后的自激活检测显示诱饵菌株无自激活活性,免疫印迹检测表明该诱饵菌株成功表达DEV UL24/C蛋白,毒性检测表明该诱饵蛋白对宿主菌Y2HGold无毒性作用。综上表明,未研究正确构建了UL24/C基因酵母双杂交诱饵载体Y2HGold(pGBKT7-UL24/C),为筛选与DEV UL24蛋白相互作用蛋白、探究DEV UL24蛋白功能及分子机制奠定了基础。

关键词：鸭肠炎病毒 UL24基因酵母双杂交诱饵载体

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Ultrasound-guided paravertebral nerve block anesthesia for percutaneous endoscopic laser unroofing treatment of symptomatic simple renal cysts—An innovative ambulatory surgery mode

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Asian Journal of Urology 2024年第1期11卷 65-71页

作者： jia Hu Yuan Zhang yong Liu Xiao Yu Shaogang Wang Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Objective:This study was designed to evaluate the feasibility,efficacy,and safety of percutaneous ureteroscopy laser unroofing as an ambulatory surgery for symptomatic simple renal cysts under multilevel paravertebral nerve block ***:From December 2015 to September 2017,33 simple renal cyst patients who had surgical indications were *** ultrasound guidance,the T10/T11,T11/T12,and T12/L1 paravertebral spaces were identified,and 7-10 mL 0.5%ropivacaine was injected at each *** a puncture needle was placed inside the cyst cavity under ultrasonic monitoring.A guidewire was introduced followed by sequential dilation up to 28/30 *** extra parenchymal portion of the cyst wall was dissociated and incised using a thulium laser,and a pathological examination was ***:Sensory loss to pinprick from T8 to L1 and sensory loss to ice from T6 to L2 were observed in all *** of the patients complained of pain during *** serious complications occurred *** the surgery,all patients recovered their lower limb muscle strength quickly,got out of bed,resumed oral feeding,and left the hospital within 24 h of *** pathologic diagnosis of all cyst walls was a simple renal *** mean follow-up was 35.8 *** the end of follow-up,the cyst units were reduced in size by more than 50%compared to the preoperative size,and no patient experienced a ***:Multi-level paravertebral nerve block for percutaneous ureteroscopy laser unroofing as an ambulatory surgery mode is feasible,safe,and effective for the treatment of simple renal cysts in selected patients.

关键词： Paravertebralnerve blockanesthesia Percutaneous puncture Simplerenalcyst Unroofing Ambulatorysurgery

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A semi-analytical pressure and rate transient analysis model for inner boundary and propped fractures exhibiting dynamic behavior under long-term production conditions

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Petroleum Science 2024年第4期21卷 2520-2535页

作者： Lin-Song Cheng Chong Cao Quan-Yu Pan Pin jia ren-Yi Cao Zhi-Kai Wang Jun-Jie Shi College of Petroleum Engineering China University of Petroleum (Beijing) Sinopec Petroleum Exploration and Production Research Institute CNOOC Research Institute State Key Laboratory of Water Resources Protection and Utilization in Coal Mining

The loss of hydrocarbon production caused by the dynamic behavior of the inner boundary and propped fractures under long-term production conditions has been widely reported in recent studies. However,the quantitative relationships for the variations of the inner boundary and propped fractures have not been determined and incorporated in the semi-analytical models for the pressure and rate transient analysis. This work focuses on describing the variations of the inner boundary and propped fractures and capturing the typical characteristics from the pressure transient curves.A generalized semi-analytical model was developed to characterize the dynamic behavior of the inner boundary and propped fractures under long-term production conditions. The pressure-dependent length shrinkage coefficients, which quantify the length changes of the inner zone and propped fractures, are modified and incorporated into this multi-zone semi-analytical model. With simultaneous numerical iterations and numerical inversions in Laplace and real-time space, the transient solutions to pressure and rate behavior are determined in just a few seconds. The dynamic behavior of the inner boundary and propped fractures on transient pressure curves is divided into five periods: fracture bilinear flow(FR1),dynamic PFs flow(FR2), inner-area linear flow(FR3), dynamic inner boundary flow(FR4), and outer-area dominated linear flow(FR5). The early hump during FR2 period and a positive upward shift during FR4period are captured on the log-log pressure transient curves, reflecting the dynamic behavior of the inner boundary and propped fractures during the long-term production *** transient pressure behavior will exhibit greater positive upward trend and the flow rate will be lower with the shrinkage of the inner boundary. The pressure derivative curve will be upward earlier as the inner boundary shrinks more rapidly. The lower permeability caused by the closure of un-propped fractures in the inner zo

关键词： Semi-analytical model Length shrinkage Dynamic behavior Boundary changes Transient behavior

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黄病毒E蛋白N-糖基化研究进展

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中国预防兽医学报 2019年第8期41卷 864-867页

作者：潘昱婷贾仁勇四川农业大学禽病防治研究中心四川成都611130 四川农业大学预防兽医研究所四川成都611130 动物疫病与人类健康四川省重点实验室四川成都611130

糖基化是蛋白质一种重要的翻译后修饰调控机制。在真核细胞中,糖基化的合成主要包括:N糖基化、O糖基化及糖基磷脂酰肌醇锚3种途径。新生肽链合成时或合成后,糖链与肽链中特定序列(Asn-X-Thr/Ser,其中X为除脯氨酸外的任意氨基酸)的天冬酰... 详细信息

糖基化是蛋白质一种重要的翻译后修饰调控机制。在真核细胞中,糖基化的合成主要包括:N糖基化、O糖基化及糖基磷脂酰肌醇锚3种途径。新生肽链合成时或合成后,糖链与肽链中特定序列(Asn-X-Thr/Ser,其中X为除脯氨酸外的任意氨基酸)的天冬酰胺(N)相连接,所以将该糖基化类型称为N连接糖链,又称N糖基化[1]。在真核细胞中,N糖基化的合成在内质网和高尔基体中完成,糖蛋白中N连接聚糖在内质网中将预先生成的寡糖转运至新生肽链的天冬酰胺残基中,再将其转移至高尔基体内进一步修饰,并在高尔基体糖苷酶和糖基转移酶的作用下.

关键词： N-糖基化 E蛋白糖基磷脂酰肌醇翻译后修饰病毒新生肽链真核细胞天冬酰胺

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Microstructure and water-swelling mechanism of red-bed mudstone in the Xining region,Northeastern Tibetan Plateau

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2537-2551页

作者： Huan Guan yong ren Sixiang Ling Xiyong Wu Tao Yu Xian Li Sen Wang Chunwei Sun School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China Faculty of Geosciences and Engineering Southwest Jiaotong UniversityChengdu611756China Moe Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China Guangzhou Metro Design and Research Institute Co Ltd. Guangzhou510010China Chengdu City Construction Investment Group Co Ltd. Chengdu610036China

This paper examines the effect of the microstructure and electrical conductivity(EC)on the swelling ratio and pressure in red-bed mudstone sampled from arid areas in the Xining region in the northeastern Tibetan Plateau.A series of laboratory tests,including swelling experiments,X-ray diffraction(XRD),and scanning electron microscope(SEM),was carried out for mechanical and microstructural *** coupled influence of the EC and microstructural parameters on the expansion ratio and pressure was investigated,and the weight coefficients were discussed by the entropy weight *** results revealed an increasing exponential trend in EC,and the maximum swelling speed occurred at an EC of approximately 10 μS/*** addition,a method for predicting the expansion potential is proposed based on the microstructure,and its reliability is verified by comparing with swelling experimental *** addition,according to the image analysis results,the ranges of the change in the clay minerals content(CMC),the fractal dimension(FD),the average diameter(AD)of pores,and the plane porosity(PP)are 23.75%-53%,1.08-1.17,7.53-22.45 mm,and 0.62%-1.25%,***,mudstone swelling is negatively correlated with the plane porosity,fractal dimension and average diameter and is linearly correlated with the clay mineral ***,the weight values prove that the microstructural characteristics,including FD,AD,and PP,are the main factors influencing the expansion properties of red-bed mudstones in the Xining *** on the combination of macro and micro-analyses,a quantitative analysis of the swelling process of mudstones can provide a better reference for understanding the mechanism of expansion behavior.

关键词： Mudstones Microstructure Swelling characteristics Electrical conductivity(EC) Scanning electron microscope Water-swelling

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Mechanism of high-energy pulsed current-assisted rolling of 08AL carbon steel ultra-thin strip

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Journal of Iron and Steel Research International 2024年第2期31卷 416-427页

作者： Zhong-kai ren Ya-nan Xu jia-zhao Chen He Li Rui-lin Yuan Zhen-hua Wang Tao Wang Xiao Liu College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment(Ministry of Education) Taiyuan University of TechnologyTaiyuan030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710016ShaanxiChina

To improve the plastic deformation performance of a 08AL carbon steel ultra-thin strip,a pulsed electric field was integrated into the plastic processing of the ultra-thin strip,and the effects of high-energy current on its deformation ability were ***-assisted tensile tests were employed,and the results clarified that the pulsed current could reduce the activation energy of faults and promoted dislocation slip within grains and at grain boundaries,leading to a decrease in the deformation resistance of the metal and an increase in its plastic *** the current density of 2.0 A/mm2,the yield strength,tensile strength,and elongation of the rolled sample reached 425 MPa,467 MPa,and 12.5%,*** the rolling process,it was found that the pulsed current promoted the dynamic recrystallization of the ultra-thin strip,reduced its dislocation density and deformation resistance,and promoted the coordinated deformation of the metal.

关键词： 08AL ultra-thin strip High-energy pulsed current Mechanical property Dislocation density Dynamic recrystallization

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Diagnosis of poorly differentiated adenocarcinoma of the stomach by confocal laser endomicroscopy:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1481-1486页

作者： jia-Xin Lou yong Wu Muren Huhe Jing-Jie Zhang Dong-Wu jia Zhen-Yu jiang Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotou 014030Inner Mongolia Autonomous RegionChina Medical Innovation Center The Fourth Military Medical UniversityXi'an 710000Shaanxi ProvinceChina

BACKGROUND In recent years,confocal laser endomicroscopy(CLE)has become a new endoscopic imaging technology at the microscopic level,which is extensively performed for real-time in vivo histological *** can be performed to distinguish benign from malignant *** this study,we diagnosed using CLE an asymptomatic patient with poorly differentiated gastric *** SUMMARY A 63-year-old woman was diagnosed with gastric mucosal lesions,which may be gastric cancer,in the small curvature of the stomach by *** consented to undergo CLE for morphological observation of the gastric *** the combination of CLE diagnosis and postoperative pathology,the intraoperative CLE diagnosis was considered to be *** to our experience,CLE can be performed as the first choice for the diagnosis of gastric *** CLE has several advantages over pathological *** believe that CLE has great potential in the diagnosis of benign and malignant gastric lesions.

关键词： Confocal laser endomicroscopy Poorly differentiated gastric adenocarcinoma Diagnosis Early stage Case report

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Wear-resistant CoCrNi multi-principal element alloy at cryogenic temperature

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Science Bulletin 2024年第2期69卷 227-236页

作者： Yue ren Qing Zhou Dongpeng Hua Zhuobin Huang Yulong Li Qian jia Peter Gumbsch Christian Greiner Haifeng Wang Weimin Liu State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China Institute for Applied Materials Karlsruhe Institute of TechnologyKarlsruhe 76131Germany IAM-ZM MicroTribology CenterμTC Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Fraunhofer IWM Freiburg 79108Germany State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Traditional high strength engineering alloys suffer from serious surface brittleness and inferior wear performance when servicing under sliding contact at cryogenic ***,we report that the recently emerging CoCrNi multi-principal element alloy defies this trend and presents dramatically enhanced wear resistance when temperature decreases from 273 to 153 K,surpassing those of cryogenic austenitic *** temperature-dependent structure characteristics and deformation mechanisms influencing the cryogenic wear resistance of CoCrNi are clarified through microscopic observation and atomistic *** is found that sliding-induced subsurface structures show distinct scenarios at different deformation *** cryogenic condition,significant grain refinement and a deep plastic zone give rise to an extended microstructural gradient below the surface,which can accommodate massive sliding deformation,in direct contrast to the strain localization and delamination at 273 ***,the temperature-dependent cryogenic deformation mechanisms(stacking fault networks and phase transformation)also provide additional strengthening and toughening of the subsurface *** features make the CoCrNi alloy particularly wear resistant at cryogenic conditions and an excellent candidate for safety–critical applications.

关键词： Multi-principal element alloy Cryogenic temperature Wear CoCrNi

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