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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-bin ling Qiao-Nan Shan Xu-Yong wei Rui wang Chang-Ku jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang Nan jiang Kun zhang Zhao-jie Su Zhi-hai Peng Ren Lang Tao jiang Qiang He lin-Sen Ye Yang Yang yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian jian-Hua Shi Bo wang jiang liu Qian Lu wei Rao Jin-Zhen Cai Tao Lv jia-Yin Yang Pu-Sen wang lin zhong Jing-Sheng Ma Qi-Gen li Sheng-Dong Wu Chang-jiang Lu Cai-De Lu Dong-Hua zhang Xuan wang Zi-Qiang li Mu-jian Teng Jun-jie li Wen-Tao jiang jian-Hua li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu wei Qiu Guo-yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang jian Zhou Gang Chen ying-Peng Zhao li li Ze-Min Hu Qi-jie Luo zhong-Zhou Si bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection

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Chinese Medical Journal 2010年第18期123卷 2571-2575页

作者： DAI Ning li De-zhi CHEN Ji-chao CHEN yu-sheng GENG Rong HU ying-hui YANG Jing-ping DU Juan HU Cheng-ping zhang wei li jia-shu yu Qin WAN Huan-ying MU Lan zhong Xiao-ning wei li-ping MA jian-jun wang Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi wang Rui-qin HE Bei wang Si-qin wang Zhan-wei ZHAO Su-rui GAO Zhan-cheng Department of Respiratory and Critical Care Medicine Department of Microbiology Peking University People's Hospital Beijing 100044 China Department of Respiratory Medicine Fujian Provincial Hospital Fuzhou Fujian 350001 China Department of Respiratory Medicine Beijing Children's Hospital Affiliated to Capital Medical University Beijing 100045 China Department of Respiratory Medicine Third Affiliated Hospital of the Inner Mongolia Medical College Baotou Inner Mongolia 014010 China Department of Respiratory Medicine Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Department of Respiratory Medicine Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Respiratory Medicine First Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 Department of Respiratory Medicine Lianyungang First People's Hospital Affiliated to Xuzhou Medical College Lianyungang Jiangsu 222002 China Department of Respiratory Medicine First Hospital of Lanzhou University Lanzhou Gansu 730000 China Department of Respiratory Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200025 China Department of Respiratory Medicine Aerospace Central Hospital Beijing 100049 China Department of Respiratory Medicine First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Respiratory Medicine Third Affiliated Hospital of Guangzhou Medical College Guangzhou Guangdong 510150 China Department of Respiratory Medicine Lanzhou Pulmonary Hospital Lanzhou Gansu 730046 China Institute of Respiratory Disease First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Respiratory Medicine Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Respiratory Medicine No.263 Clinical Section of the Military General Hospital of Beijing Beijing 101149 Department of Respiratory Medicine Nanfang Hospital Affiliated to Sout

Background Acinetobacter baumanii （A. baumanii ） remains an important microbial pathogen resulting in nosocomialacquired infections with significant morbidity and mortality. The mechanism by which nosocomial bacteria, like A. baumanii, attain multidrug resistance to antibiotics is of considerable interest. The aim in this study was to investigate the spread status of antibiotic resistance genes, such as multiple 13-1actamase genes and aminoglycoside-modifying enzyme genes, from A. baumanii strains isolated from patients with lower respiratory tract infections （LRTIs）. Methods Two thousand six hundred and ninety-eight sputum or the bronchoalveolar lavage samples from inpatients with LRTIs were collected in 21 hospitals in the mainland of China from November 2007 to February 2009. All samples were routinely inoculated. The isolated bacterial strains and their susceptibility were analyzed via VITEK-2 expert system. Several kinds of antibiotic resistant genes were further differentiated via polymerase chain reaction and sequencing methods. Results Totally, 39 A. baumanii strains were isolated from 2698 sputum or bronchoalveolar lavage samples. There was not only a high resistant rate of the isolated A. baumanfi strains to ampicillin and first- and second-generation cephalosporins （94.87%, 100% and 97.44%, respectively）, but also to the third-generation cephalosporins （ceftriaxone at 92.31%, ceftazidine at 51.28%） and imipenem （43.59%） as well. The lowest antibiotic resistance rate of 20.51% was found to amikacin. The OXA-23 gene was identified in 17 strains of A. baumanii, and the AmpC gene in 23 strains. The TEM-1 gene was carried in 15 strains. PER-1 and SHV-2 genes were detected in two different strains. Aminoglycoside-modifying enzyme gene aac-3-1a was found in 23 strains, and the aac-6＂lb gene in 19 strains, aac-3-1a and aac-6＂lb genes hibernated in three A. baumanfi strains that showed no drug-resistant phenotype. Conclusions A. baumanii can carry multiple drug-re

关键词： Acinetobacter baumanii lower respiratory tract infections β-lactamase drug-resistant gene

Long-term analysis of clear nights using satellite data considering astronomical sites in western China

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Research in Astronomy and Astrophysics 2020年第6期20卷 96-108页

作者： Zi-Huang Cao li-Yong liu Yong-Heng Zhao Lu Feng Hugh RAJones Huang Shen Jin-Xin Hao Yan-jie Xue Yong-Qiang Yao Jing Xu Ali Esamdin Zhao-Xiang Qi jian-Rong Shi jian li yuan Tian Zheng wang Tai-Sheng Yan Xia wang jian-ping Xiong Si-Cheng yu Jun-Bo zhang Zhi-Xia Shen yun-ying jiang jia Yin Guang-Xin Pu Peng wei Chun-hai Bai Guo-jie Feng Lu Ma Teng-Fei Song jian-Feng wang jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou Shi-Long liao Zhi-Song Cao Dong-wei Fan yun-Fei Xu Chang-Hua li Yi-Han Tao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism.Communication University of China Beijing 100024China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China yunnan Observatories Chinese Academy of SciencesKunming 650216China

A large ground-based optical/infrared telescope is being planned for a world-class astronomical site in *** cloud-free night percentage is the primary meteorological consideration for evaluating candidate *** data from GMS and NOAA satellites and the MODIS instrument were utilized in this research,covering the period from 1996 to *** data analysis benefits from overlapping results from different independent teams as well as a uniform analysis of selected sites using GMS+NOAA *** significant ground-based monitoring is needed to validate these findings,we identify three different geographical regions with a high percentage of cloud-free conditions(~83%on average),which is slightly lower than at Mauna Kea and Cerro Armazones(~85%on average)and were chosen for the large international projects TMT and ELT *** study finds evidence that cloud distributions and the seasonal changes affected by the prevailing westerly winds and summer monsoons reduce the cloud cover in areas influenced by the *** is consistent with the expectations from climate change models and is suggestive that most of the identified sites will have reduced cloud cover in the future.

关键词： methods statistical-site testing-atmospheric effects-MODIS

Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

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World Journal of Gastroenterology 2022年第31期28卷 4417-4430页

作者： Zi-Xuan Shen Dan-Dan Wu jie Xia Xian-Bo wang Xin Zheng Yan Huang Bei-ling li zhong-Ji Meng Yan-Hang Gao Zhi-ping Qian Feng liu Xiao-Bo Lu jia Shang Hua-Dong Yan yu-Bao Zheng Wen-Yi Gu Yan zhang jian-Yi wei Wen-Ting Tan Yi-Xin Hou Qun zhang Yan Xiong cong-cong Zou Jun Chen Ze-bing Huang Xiu-Hua jiang Sen Luo yuan-yuan Chen Na Gao Chun-Yan liu wei yuan Xue Mei Jing li Tao li Xin-Yi Zhou Guo-Hong Deng Jin-Jun Chen Xiong Ma hai li Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of HealthShanghai Jiao Tong UniversityShanghai 200001China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 430418Hubei ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China Tianjin Institute of Hepatology Nankai University Second People’s HospitalTianjin 300102China Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054XinjiangChina Department of Infectious Diseases Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases Hwamei HospitalThe Second Hospital of NingboUniversity of Chinese Academy of SciencesNingbo 315153Zhejiang ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 5

BACKGROUND Autoimmune liver disease(AILD)has been considered a relatively uncommon disease in China,epidemiological data for AILD in patients with cirrhosis and acute decompensation(AD)is *** To investigate the prevalence,outcome and risk factors for AILD in cirrhotic patients complicated with AD in *** We collected data from patients with cirrhosis and AD from two prospective,multicenter cohorts in hepatitis B virus endemic *** were regularly followed up at the end of 28-d,90-d and 365-d,or until death or liver transplantation(LT).The primary outcome in this study was 90-d LTfree ***-on-chronic liver failure(ACLF)was assessed on admission and during 28-d hospitalization,according to the diagnostic criteria of the European Association for the Study of the liver(EASL).Risk factors for death were analyzed with logistic regression *** In patients with cirrhosis and AD,the overall prevalence of AILD was 9.3%(242/2597).Prevalence of ACLF was significantly lower in AILD cases(14%)than those with all etiology groups with cirrhosis and AD(22.8%)(Pliary cirrhosis(PBC),autoimmune hepatitis(AIH)and PBC-AIH overlap syndrome(PBC/AIH)were 50.8%,28.5%and 12.0%,*** ACLF patients,the proportions of PBC,AIH and PBC/AIH were 41.2%,29.4% and 20.6%.28-d and 90-d mortality were 43.8% and 80.0% in AILD-related *** etiology of AILD had no significant impact on 28-d,90-d or 365-d LTfree mortality in patients with cirrhosis and AD in both univariate and multivariate *** bilirubin(TB),hepatic encephalopathy(HE)and blood urea nitrogen(BUN)were independent risk factors for 90-d LT-free mortality in multivariate *** development of ACLF during hospitalization only independently correlated to TB and international normalized *** AILD was not rare in hospitalized patients with cirrhosis and AD in China,among which PBC was the m

关键词： Prevalence Autoimmune liver disease Cirrhosis and acute decompensation Mortality Acuteon-chronic liver failure

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu Feng Hugh RAJones jian li Jing Xu li-Yong liu Teng-Fei Song jian-Feng wang Hua-lin Chen Yan-jie Xue Huang Shen Yong-Heng Zhao Zhao-Xiang Qi jian-Rong Shi yuan Tian Zheng wang Xia wang Jin-liang Hou Jin-Ming Bai Ji Yang Xu Zhou Yong-Qiang Yao jia Yin Ali Esamdin Guang-Xin Pu Peng wei Chun-hai Bai Guo-jie Feng Lu Ma Xuan zhang yu liu Chong Pei Zhi-Xia Shen yun-ying jiang jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou Xu Yang Jun-Bo zhang Shi-Long liao Dong-wei Fan yun-Fei Xu jian-ping Xiong Tai-Sheng Yan Xi zhang Chang-Hua li Yi-Han Tao Si-Cheng yu Zhi-Song Cao Hong-Shuai wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

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超空泡高速航行体动力学建模与控制设计

哈尔滨工业大学学报 2010年第9期42卷 1351-1355页

作者：王京华张嘉钟于开平魏英杰黄文虎吕瑞哈尔滨工业大学航天学院哈尔滨150001

为了研究超空泡航行体的动力学建模和控制问题,根据空泡膨胀独立性原理,研究了空泡的记忆效应及其对空泡形态的影响,详细计算了超空泡航行体各部分所受的流体动力,计算过程中还考虑了空化器的定向效应和空泡尾部的上飘变形,研究了航行... 详细信息

为了研究超空泡航行体的动力学建模和控制问题,根据空泡膨胀独立性原理,研究了空泡的记忆效应及其对空泡形态的影响,详细计算了超空泡航行体各部分所受的流体动力,计算过程中还考虑了空化器的定向效应和空泡尾部的上飘变形,研究了航行过程中尾翼效率变化规律,建立了超空泡航行体非线性动力学模型.设计了基于输入输出精确线性化的鲁棒极点配置控制器,深度跟踪性能较好,不足之处是控制输入饱和问题和滑行力的不利影响.为解决输入饱和问题,设计了预测控制方法并通过约束航行体尾部和空泡壁的距离使尾部不与空泡壁相接触,避免了滑行力的出现,有利于减少摩擦阻力,提高了航行体的运动稳定性.

关键词：超空泡记忆效应超空泡航行体滑行力预测控制

中国多巴胺能PET联合葡萄糖代谢PET脑显像在帕金森病临床应用专家共识

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中国临床神经科学 2024年第4期32卷 361-372页

作者：左传涛刘丰韬田梅管一晖张宏鲁佳荧李欣忆琚紫昭葛璟洁吴平张军罗巍豆晓锋于聪聪钟燕金晨涛周瑞侯海峰占宏伟卢洁王瑞民李彪尹雅芙李雪娜朱小华朱元凯兰晓莉姜磊何勇田蓉范岩孙夕林赵军富丽萍蒋韩马晓芬张丽霞丁正同王坚中国认知科学学会分子影像分会复旦大学附属华山医院核医学/PET中心上海200235 复旦大学附属华山医院神经内科上海200040 浙江大学医学院附属第二医院核医学科/PET中心杭州310009 复旦大学附属华山医院放射科上海200040 浙江大学医学院附属第二医院神经内科杭州310009 首都医科大学宣武医院放射与核医学科北京100053 中国人民解放军总医院第一医学中心核医学科北京100853 上海交通大学医学院附属瑞金医院核医学科上海200025 上海交通大学医学院附属新华医院核医学科上海200092 中国医科大学附属第一医院核医学科沈阳110001 华中科技大学同济医学院附属同济医院核医学科武汉430030 华中科技大学同济医学院附属协和医院核医学科武汉430022 广东省人民医院核医学科广州510080 武汉大学中南医院核医学科武汉430071 四川大学华西医院核医学科成都610041 北京大学第一医院核医学科北京100034 哈尔滨医科大学附属第四医院核医学科哈尔滨150001 同济大学附属东方医院核医学科上海200120 中日友好医院核医学科北京100029 福建医科大学附属协和医院PET/CT室福州350001 广东省第二人民医院核医学科广州510317 浙江省中医院核医学科杭州310006 中国认知科学学会分子影像分会杭州310009

多巴胺能正电子发射断层扫描(PET)脑显像是目前诊断帕金森病的重要依据,但其对帕金森综合征的鉴别能力有限。葡萄糖代谢PET显像中不同的脑代谢模式为进一步鉴别诊断提供可能。文中在前期PET脑显像相关技术操作和临床应用专家共识的基础... 详细信息

多巴胺能正电子发射断层扫描(PET)脑显像是目前诊断帕金森病的重要依据,但其对帕金森综合征的鉴别能力有限。葡萄糖代谢PET显像中不同的脑代谢模式为进一步鉴别诊断提供可能。文中在前期PET脑显像相关技术操作和临床应用专家共识的基础上,对开展多巴胺能联合葡萄糖代谢显像进行系统梳理,征求专家意见后形成本专家共识。旨在规范帕金森综合征患者的多巴胺能显像及葡萄糖代谢显像的技术操作,为医生提供报告解读建议,进一步指导多巴胺能与葡萄糖代谢PET脑显像联合应用在帕金森相关疾病中的临床实践流程。

关键词：帕金森综合征帕金森病正电子发射断层扫描多巴胺能显像葡萄糖代谢显像联合应用

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重力场中超空泡形态的数值仿真研究

舰船科学技术 2008年第5期30卷 110-114页

作者：张学伟魏英杰张嘉钟王聪于开平哈尔滨工业大学航天学院黑龙江哈尔滨150001

根据Logvinovich独立膨胀原理,发展了一种用于计算在重力场中定常和非定常自然和通气超空泡形态的计算方法,运用该方法对重力场中超空泡形态进行数值仿真。结果表明,在重力作用下超空泡不再是对称的椭球体,自然超空泡和通气超空泡在非... 详细信息

根据Logvinovich独立膨胀原理,发展了一种用于计算在重力场中定常和非定常自然和通气超空泡形态的计算方法,运用该方法对重力场中超空泡形态进行数值仿真。结果表明,在重力作用下超空泡不再是对称的椭球体,自然超空泡和通气超空泡在非定常扰动下的形态特性和动力特性存在较大差异,当流场压力线性变化时,自然超空泡的空泡数呈线性变化,但长度呈非线性变化,而通气超空泡的空泡数和空泡长度都呈非线性变化。

关键词：自然超空泡通气超空泡重力独立膨胀原理非定常数值仿真

Progress in the investigation of potash resources in western China

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China Geology 2018年第3期1卷 392-401页

作者： Mian-ping Zheng Xian-hua Hou Yong-sheng zhang En-yuan Xing Hong-pu li Hong-wei Yin Chang-qing yu Ning-jun wang Xiao-lin Deng Zhao wei zhong-ying Miao jia-ai zhong Fan wang Fu Fan Xue-fei zhang Xu-ben wang Tu-qiang liu wei-gang Kong MNR Key Laboratory of Saline Lake Resources and Environments Institute of Mineral ResourcesCAGSBeijing 100037China Qaidam Integrated Geological Exploration Institute of Qinghai Province Golmud 816000China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210093China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Dazhou Heng Cheng Energy (Group) CO. LTD. Dazhou 635000China Institute of Geology of China Chemical Geology and Mine Bureau Zhuozhou 072754China Chengdu University of Technology Chengdu 610059China Sichuan Geological Survey Chengdu 610081China

Through the study of the geological conditions of potash deposits in China from recent years,a new understanding of potash theories has arisen that appropriate Chinese geological *** progress and substantial breakthroughs have been gained in the direction and management of potash prospecting: (1) Important breakthroughs in continental potassium prospecting:The "Quaternary gravel type deep potassium rich brine metallogenic model in western Qaidam" ensures Quaternary deep potassium rich brine prospecting will grow new KCl resources by 350 Mt,providing a resource guarantee for meeting the Chinese demand for sylvite.(2) The Marine facies potash prospecting shows good prospects: the determination of the new type of Triassic polyhalite potash ore deposits in Sichuan provide an important scientific basis for the establishment of exploration planning and the selection of exploration target areas for polyhalite minerals in the Sichuan Basin;The "two-storey potash deposits model" in southwestern yunnan has been confirmed,which indicates prospects for the exploration of potash in the deeper Marine facies in southwestern yunnan are likely to be *** discovery of a high concentration of rich bromite salt and potash salt in the Paleogene of the Kuqa depression and the southwestern Tarim region provides strong support for the likelihood large-scale potash deposits exist in these regions.

关键词： Potash deposits theory Potash basin Resource quantity Potassium bearing brine of sandy gravel bed in Qaidam