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Journal of Genetics and Genomics 2009年第2期36卷 99-107页

作者： Yunfei Zhang guangyu Cao Li-jia Qu Hongya gu National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University Beijing 100871 China

MYB transcription factors compose one of the largest transcription factor families in Arabidopsis, which play important roles in vari- ous developmental processes as well as defense responses against environmental stresses. In this study, we report the characterization of AtMYB17 gene, a putative R2R3 type MYB gene family member in Arabidopsis. AtMYB17 was found exclusively localized in nuclear, with an activation domain at its C-terminus. AtMYBI7 was highly expressed in inflorescences and siliques, especially at early flower developmental stages. The level of AtMYB17 transcripts was also found to increase after imbibition during seed germination and gradually concentrate to the shoot apex. Bioinformatics analysis identified several binding sites of LEAFY （LFY） and AGL15 in the promoter re- gion of AtMYB17. Promoter-guS fusion analysis showed that the LFY binding sites were important in fine-tuning regulation of the spatio-temporal expression ofAtMYB17 in transgenic plants. Moreover, AtMYB17 was up-regulated in 35S：：AGL15 plants. Taken together, our data suggest that LFY may be involved in the regulation of AtMYB17, possibly together with AGL 15, and thereafter in early inflores- cence development and seed germination.

关键词： AtMYB17 transcription factor Arabidopsis LEAFY AGL 15

Real-World COVID-19 Vaccine Protection Rates against Infection in the Delta and Omicron Eras

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Research 2023年第4期6卷 583-594页

作者： Yuru Zhu jia gu Yumou Qiu Song Xi Chen Center for Statistical Science Peking UniversityBeijingChina Department of Statistics Iowa State UniversityAmesIAUSA School of Mathematical Science and guanghua School of Management Peking UniversityBeijingChina Pazhou Lab GuangzhouChina

The real-world vaccine protection rates(VPRs)against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection are critical in formulating future vaccination strategies against the *** on a varying coefficient stochastic epidemic model,we obtain 7 countries’real-world VPRs using daily epidemiological and vaccination data,and find that the VPRs improved with more vaccine *** average VPR of the full vaccination was 82%(SE:4%)and 61%(SE:3%)in the pre-Delta and Deltadominated periods,*** Omicron variant reduced the average VPR of the full vaccination to 39%(SE:2%).However,the booster dose restored the VPR to 63%(SE:1%)which was significantly above the 50%threshold in the Omicron-dominated *** analyses show that the existing vaccination strategies have significantly delayed and reduced the timing and the magnitude of the infection peaks,respectively,and doubling the existing booster coverage would lead to 29%fewer confirmed cases and 17%fewer deaths in the 7 countries compared to the outcomes at the existing booster taking *** call for higher full vaccine and booster coverage for all countries.

关键词： vaccine vaccination doses

Catalytic performance improvement of volatile organic compounds oxidation over MnO_(x) and GdMnO_(3) composite oxides from spent lithium-ion batteries:Effect of acid treatment

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Chinese Journal of Chemical Engineering 2021年第6期34卷 278-288页

作者： Mingming guo Lizhong Liu jia-nan gu Hongbo Zhang Xin Min jianxing Liang Jinping jia Kan Li Tonghua Sun School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China Shanghai Institute of Pollution Control and Ecology Security Shanghai 200092China Shanghai Engineering Research Center of SolidWaste Treatment and Resource Recovery Shanghai 200240China

In this work,cathode materials of spent lithium-ion ternary batteries are recovered and used as metal precursor to prepare multi-metal oxides MnO_(x)(SY)and GdMnO_(3)(SY)via combustion method and sol-gel method,***,a series of MnO_(x)(SY)-n and GdMnO_(3)(SY)-n(n=0.05,0.10,1.00,4.00,n represents the dilute HNO_(3) concentration)catalysts are fabricated by acid treatment of MnO_(x)(SY)and GdMnO_(3)(SY)samples and catalytic activities of oxygenated VOCs oxidation over all the prepared catalysts are *** evaluation results show that acid-treated MnO_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples perform the optimum VOCs removal efficiency respectively,which may be attributed to their obvious enhancement of physicochemical *** detail,Mn O_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples exhibit the larger specific surface area,bigger amount of surface high-valence metal ions(Mn^(4+),Co^(3+),Ni^(3+)),more abundant adsorbed oxygen species and better low-temperature reducibility,which can play a crucial role in the significant improvement of VOCs *** situ DRIFTS results imply that the possible main intermediates are-OCO,-COO and-C-O species produced during VOCs *** by-products are further determined via TD/GC-MS analysis.

关键词： Spent lithium-ions batteries Acid treatment Multi manganese-based oxides and perovskite VOCs oxidation

Chinese scientific productivity ranking the fifth

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中华医学杂志(英文版) 2004年第1期 156-157页

作者： gu jia, CMJ

Ultra-high cycle fatigue behavior of high strength steel with carbide-free bainite/martensite complex microstructure

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 285-292页

作者： Xue-xia Xu Yang Yu Wen-long Cui Bing-zhe Bai jia-lin gu Laboratory of Advanced Materials Department of Materials Science and Engineering Tsirtghua University Beijing 100084 China

The ultra-high cycle fatigue behavior of a novel high strength steel with carbide-free bainite/martensite （CFB/M） complex microstructure was studied. The ultra-high cycle fatigue properties were measured by ultrasonic fatigue testing equipment at a frequency of 20 kHz. It is found that there is no horizontal part in the S-N curve and fatigue fracture occurs when the life of specimens exceeds 10^7 cycles. In addition, the origination of fatigue cracks tends to transfer from the surface to interior of specimens as the fatigue cycle exceeds 10^7, and the fatigue crack originations of many specimens are not induced by inclusions, but by some kind of ＂soft structure＂. It is shown that the studied high strength steel performs good ultra-high cycle fatigue properties. The ultra-high fatigue mechanism was discussed and it is suggested that specific CFB/M complex microstructure of the studied steel contributes to its superior properties.

关键词： high strength steel ultra-high cycle fatigue bainite martensite fatigue behavior

Comparing containment measures among nations by epidemiological effects of COVID-19

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National Science Review 2020年第12期7卷 1847-1851页

作者： jia gu Han Yan Yaxuan Huang Yuru Zhu Haoxuan Sun Yumou Qiu Songxi Chen Center for Statistical Science Peking University guanghua School of Management Peking University School of Mathematical Sciences Sichuan University Yuanpei College Peking University Center for Data Science Peking University Department of Statistics Iowa State University

The coronavirus disease 2019 (COVID-19) has evolved to a global pandemic since its inception in December *** have responded to the epidemics with different levels of responses and containment *** the unprecedented pressure on nations’healthcare systems and the deaths so far,there is an urgent need to evaluate the effects of the containment measures,which would be useful for countries to plan for their responses to counter the first or possibly the second wave of the epidemic.

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Comparison of two types of colectomy in treating slow transit constipation with or without melanosis coli

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World Journal of Gastroenterology 2015年第33期21卷 9736-9740页

作者： Ji-Wei Sun jia-Ni gu Peng Du Wei Chen Department of Anal and Rectal Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

AIM: To compare the follow-up outcomes of ileosigmoidal anastomosis(ISA) and caecorectal anastomosis(CRA) in patients with slow transit constipation(STC) with or without melanosis coli(MC).METHODS: We collected the clinical data of 48 STC patients with or without MC from May 2002 to May ***-six patients underwent CRA(14 with MC) and 22 cases received ISA(14 with MC).A 3-year postoperative follow-up was ***: CRA improved the quality of life [evaluated by the gastrointestinal quality of life index(GIQLI)] in patients without MC,but was inferior to ISA in stool frequency and Wexner and GIQLI scores for MC *** the CRA group,patients with MC suffered worse outcomes than those without ***: CRA is more suitable for STC patients without MC; however,for STC patients with MC,ISA is a better choice.

关键词： Constipation Melanosis coli Caecorectal anastomosi

Discrepancy in fine root turnover estimates between diameter-based and branch-order-based approaches:a case study in two temperate tree species

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Journal of Forestry Research 2012年第4期23卷 575-581页

作者： SUN Jing-jue gu jia-cun WANG Zheng-quan School of Forestry Northeast Forestry UniversityHarbin 150040China

Fine root turnover plays a key role in carbon （C） budgets and nutrients cycles in forest ecosystems. However, the difference between branch-order-based and diameter-based approaches in estimating fine root turnover is still unclear. We studied root biomass turnover based on multiplying root standing biomass by turnover rate （inverse of median root longevity） in two Chinese temperate tree species, Fraxinus mand- shurica Rupr. and Larix gmelinii Rupr. The minirhizotron （MR） tech- nique was used to estimate longevities for first and second order roots, and total roots （R,o,al） apparent on the MR tube surface. The correspond- ing biomass for each root group was estimated by soil monolith. The difference in biomass turnover between Rtotal and the sum of the first and second order roots was used to represent the discrepancy between di- ameter- and order-based approaches. First order roots had shorter life spans and higher biomass turnover rates than the second order roots in both species. Biomass turnover estimated by the order-based method for F. mandshurica and L. gmelinii were 155.4 *** 158.9 g.m2.a-1, respectively, in comparison with 99.5 g.m^-2-a^-1 and 117.7 g.m^-2.a^-1 estimated by the diameter-based method, indicating that the diameter-based approach underestimated biomass turnover. The most probable reason was that the order-based method enhanced separation of the heterogeneous root population into relatively homogenous root groups with varying turnover rates. We conclude that separating fine root pool into different branch orders can improve the accuracy of estimates for fine root turnover, as well as the understanding of the belowground C allocation and nutrient cycling at ecosystem level.

关键词： Fraxinus mandshurica root life span root longevity Larix gmelinii minirhizotron soil monolith

Study on Vortex-Induced Motions of A New Type of Deep Draft Multi-Columns FDPSO

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China Ocean Engineering 2018年第1期32卷 1-13页

作者： gu jia-yang XIE Yu-lin ZHAO Yuan LI Wen-juan TAO Yan-wu HUANG Xiang-hong Marine Equipment and Technology Institute Jiangsu University of Science and Technology Zhenjiang 212003 China School of Naval Architecture and Marine Engineering Jiangsu University of Science and Technology Zhenjiang 212003China Marine Design & Research Institute of China Shanghai 200011 China

A numerical simulation and an experimental study on vortex-induced motion（VIM） of a new type of deep draft multi-columns floating drilling production, storage and offloading（FDPSO） are presented in this paper. The main dimension, the special variable cross-section column and the cabin arrangement of the octagonal pontoon are introduced based on the result. The numerical simulation is adapted to study the effects of current incidence angles and reduced velocities on this platform’s sway motion response. The 300 m water depth equivalent truncated mooring system is adopted for the model tests. The model tests are carried out to check the reliability of numerical simulation. The results consist of surge, sway and yaw motions, as well as motion trajectories. The maximum sway amplitudes for different types of offshore platform is also studied. The main results show that the peak frequencies of sway motion under different current incidence angles and reduced velocities vary around the natural frequency. The analysis result of flow field indicates that the change of distribution of vortex in vertical presents significant influences on the VIM of platform. The trend of sway amplitude ratio curve of this new type FDPSO differs from the other types of platform. Under 45° current incidence angle, the sway amplitude of this new type of FDPSO is much smaller than those of other types of offshore platform at 4.4 ≤ V;≤ 8.9. The typical ‘8’ shape trajectory does not appear in the platform’s motion trajectories.

关键词： FDPSO multi-columns vortex-induced motion(VIM) model tests variable cross-section column

Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia

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Current Medical Science 2024年第4期44卷 799-808页

作者： Tong-yuan LIU Xing FU Ying YANG jia gu Min XIAO Deng-ju LI Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective The metabolic reprogramming of acute myeloid leukemia(AML)cells is a compensatory adaptation to meet energy requirements for rapid *** study aimed to examine the synergistic effects of glutamine deprivation and metformin exposure on AML *** SKM-1 cells(an AML cell line)were subjected to glutamine deprivation and/or treatment with metformin or bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide(BPTES,a glutaminase inhibitor)or *** viability was detected by Cell Counting Kit-8(CCK-8)assay,and cell apoptosis and reactive oxygen species(ROS)by flow *** blotting was conducted to examine the levels of apoptotic proteins,including cleaved caspase-3 and poly(ADP-ribose)polymerase(PARP).Moreover,the human long noncoding RNA(lncRNA)microarray was used to analyze gene expression after glutamine deprivation,and results were confirmed with quantitative RT-PCR(qRT-PCR).The expression of metallothionein 2A(MT2A)was suppressed using *** growth and apoptosis were further detected by CCK-8 assay and flow cytometry,respectively,in cells with MT2A *** Glutamine deprivation or treatment with BPTES inhibited cell growth and induced apoptosis in SKM-1 *** lncRNA microarray result showed that the expression of MT family genes was significantly upregulated after glutamine ***2A knockdown increased apoptosis,while proliferation was not affected in SKM-1 *** addition,metformin inhibited cell growth and induced apoptosis in SKM-1 *** glutamine deprivation and metformin enhanced the sensitivity of SKM-1 cells to ***,the combination of glutamine deprivation with metformin exhibited synergistic antileukemia effects on SKM-1 *** Targeting glutamine metabolism in combination with metformin is a promising new therapeutic strategy for AML.

关键词： glutamine metformin acute myeloid leukemia metallothionein